Mota, F; Silva, E; Varela, P; Azenha, A; Massa, A
Pereira, TM; Vieira, AP; Fernandes, JC; Sousa-Basto, A
Though used occasionally, systemic therapies in severe childhood psoriasis have not been systematically investigated. Cyclosporin A (CysA) is effective in adults with severe psoriasis but there are no extensive data regarding the efficacy and safety of its use in childhood psoriasis. In this paper, we describe six children aged between 11 months and 13 years (average: 7.6 years) treated with CysA microemulsion formulation for severe psoriasis, who had been unresponsive to other treatments. The CysA dose ranged from 2 to 4 mg/kg/day, for periods varying from 8 to 105 weeks (mean: 54 weeks). Dose tapering was gradual after lesion improvement...
Resende, C; Araújo, C; Vieira, AP; Ventura, F; Brito, C
Schimmelpenning syndrome (SS) includes an organoid nevus that follows the lines of Blaschko and defects of brain, eyes, bones, or other systems. We report a case of a 3-month old female infant, who presented with several thin plaques, with irregular borders, yellowish color, which had a verrucous appearance, following the lines of Blaschko, mainly occupying the left side of posterior trunk, the left face, the right side of the anterior trunk, and the right upper limb. These plaques had been present since birth. In addition, she had a flat salmon to yellow nevus on the left parietal and temporal region...
Resende, CI; Gomes, J; Duarte, ML; Brito, C
Pilomatricoma is a relatively common benign skin neoplasm originating from the hair follicle matrix cells. β-Catenin is a subunit of the cadherin protein complex. It acts as an intracellular signal transducer that influences cell differentiation and proliferation. This protein was recently involved in the formation of hair follicle-related tumours, including pilomatricomas. Tuberous sclerosis (TS) is an inherited neurocutaneous disease, which is characterised by pleomorphic features involving many organs, hamartomas in multiple organ systems and by the fact that it is usually diagnosed early in life. We reported a case of a Caucasian patient with TS and a giant pilomatricoma, both...
Resende, CI; Araújo, C; Vieira, AP; Brito, C
Gomes, J; Parente, J; Ferreira, L; Viana, I; Vale, E
Objectives: To determine clinical and histopathological differences between melanoma associated with
nevus (MAN) and de novo melanoma (MN).
Methods: Retrospective study of all cases of cutaneous melanoma diagnosed between 2001 and 2009 in Centro de
Dermatologia Médico-Cirúrgica de Lisboa.
Results: Of the 397 melanomas included, 52.6% were of feminine sex and 47.4% of the masculine. Of these melanomas
only 9.3% were histologically associated with nevus, with discrete predominance of cases in the feminine sex (54%,
p=0,033). In the group of the MAN the average of ages was slightly inferior (56,5 vs 59,3 years, p=0,577). The trunk
was the preferential localization of all the melanomas (42.1%, p=0,005). Histologically...
Parente, J; Gomes, J; Viana, I; Vale, E
Introduction: Malignant melanoma may present a great variety of histopathological patterns. Besides
the classic forms of melanoma, there are a number of variants that have been described, such as polypoid, verrucous,
desmoplastic, myxoid, chondroid, balloon-cell, rhabdoid, animal-type, amelanotic, spitzoid, nevoid. The aim of this
study was to characterize the rare histopathologic variants of malignant melanoma observed in a Dermatopathology
Laboratory in a period of 15 years (1995-2009). Material and Methods: Analized data included: patient age and sex,
clinical diagnosis, melanoma location, Breslow and Clark level, presence of ulceration and follow-up. These variants
were grouped according to architectural, cytologic and/or stromal changes. Results: Eighty-seven rare histopathologic
Machado, A; Ferreira, C; Lopes, M; Pereira, T; Pardal, F
Segura Palacios, JM; Boixeda, P; Rocha, J; Alcántara González, J; Alonso Castro, L; Daniel Rodríguez, C
Valdigem, GL; Pereira, T; Macedo, C; Duarte, ML; Oliveira, P; Ludovico, P; Sousa-Basto, A; Leão, C; Rodrigues, F
Modifications in social habits together with the increase of emigration have contributed not only to increased dermatophytoses but also to an altered etiology. During the last few years, Braga has suffered a radical change from a rural to a cosmopolitan life-style.
A statistical study of dermatophytoses and the etiology of their causative agents was performed by a retrospective survey carried out among patients of Hospital de São Marcos, Braga, Portugal, from 1983-2002. In this study, a total of 10,003 patients were analyzed.
Over this period the frequency of dermatophytoses, as defined by the recovery of a dermatophyte in culture, was found to...
Gomes, J; Pereira, T; Vilarinho, C; Duarte, ML; Brito, C
Vilarinho, C; Ventura, F; Brito, C
Rocha, J; Duarte, ML; Marques, H; Torres, F; Tavares, P; Silva, A; Brito, C
Gomes, J; Ventura, F; Duarte, ML; Brito, C
Botelho-Gomes, JM; Veira, AP; Navarro, J; Maré, R; Tavares, P; Brito, C
Gomes, J; Vilarinho, C; Ventura, F; Vieira, AP; Brito, C
Vilarinho, C; Ventura, F; Vieira, AP; Bastos, MJ; Teixeira, M; Brito, C
Resende, C; Araújo, C; Gomes, J; Brito, C
Bleomycin is a chemotherapeutic agent used in the treatment of different tumours. It has several side effects, including flagellate hyperpigmentation, which is a unique and a well-documented side effect of bleomycin therapy. We report a case of a 23-year-old woman with a personal history of ovarian dysgerminoma, who developed flagellate hyperpigmentation on trunk after bleomycin therapy.
Resende, C; Araújo, C; Duarte, ML; Brito, C
A 70-year-old woman with a recent diagnosis of dermatomyositis (DM) presented to the dermatology department for study of a probably paraneoplastic syndrome. On examination, we observed discrete, indurated, reddish, painful plaques and nodules on her abdomen and both thighs. A cutaneous biopsy from an abdominal nodule, performed as part of the paraneoplastic workup, was suggestive of cutaneous lymphangitis carcinomatosa, secondary to unknown malignancy. An extensive investigation to locate the site of the primary tumour revealed no specific findings. A course of palliative chemotherapy with cisplatin and 5-fluorouracil was then given, but the patient's condition deteriorated and 6 months after her...
Resende, C; Araújo, C; Vieira, AP; Brito, C
Dermal melanocytoses include a variety of congenital and acquired melanocytic lesions characterised by the presence of multiple spindle-shaped dendritic melanocytes in the dermis. These lesions are commonly found in the skin of Asians, but they can also appear in Caucasians. The Mongolian spot, nevi of Ota and Ito are the most common morphological forms. We report a case of a 24-year-old Caucasian woman presented with a 10-months history of progressive darkening of the right side of her upper back. Cutaneous examination revealed a macular blue-grey hyperpigmentation of the right side of her upper back. Biopsy specimen from the macule showed...