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É um repositório para instituições de ensino e investigação produtoras de literatura científica cuja dimensão ainda não justifica a criação de um repositório próprio. Permite integrar instituições, grupos ou indivíduos na infra-estrutura do projecto, nomeadamente através das pesquisas do Portal RCAAP e da B-On.

PED - Artigos

Mostrando recursos 1 - 20 de 42

  1. Ghrelin and obestatin: Different role in fetal lung development?

    Nunes, S; Nogueira-Silva, C; Dias, E; Moura, RS; Correia-Pinto, J
    Ghrelin and obestatin are two proteins that originate from post-translational processing of the preproghrelin peptide. Various authors claim an opposed role of ghrelin and obestatin in several systems. Preproghrelin mRNA is significantly expressed in airway epithelium throughout lung development, predominantly during the earliest stages. The aim of this study was to evaluate the role of ghrelin and obestatin in fetal lung development in vitro. Immunohistochemistry studies were performed at different gestational ages in order to clarify the expression pattern of ghrelin, GHS-R1a, obestatin and GPR39 during fetal lung development. Fetal rat lung explants were harvested at 13.5 days post-conception (dpc)...

  2. A new case of autosomal recessive agammaglobulinaemia with impaired pre-B cell differentiation due to a large deletion of the IGH locus

    Milili, M; Antunes, H; Blanco-Betancourt, C; Nogueiras, A; Santos, E; Vasconcelos, J; Castro e Melo, J; Schiff, C
    Males with X-linked agammaglobulinaemia (XLA) due to mutations in the Bruton tyrosine kinase gene constitute the major group of congenital hypogammaglobulinaemia with absence of peripheral B cells. In these cases, blockages between the pro-B and pre-B cell stage in the bone marrow are found. The remaining male and female cases clinically similar to XLA represent a genotypically heterogeneous group of diseases. In these patients, various autosomal recessive disorders have been identified such as mutations affecting IGHM, CD79A, IGLL1 genes involved in the composition of the pre-B cell receptor (pre-BCR) or the BLNK gene implicated in pre-BCR signal transduction. In this...

  3. Novel ABCA3 mutations as a cause of respiratory distress in a term newborn

    Gonçalves, JP; Pinheiro, L; Costa, M; Silva, A; Gonçalves, A; Pereira, A
    We report here the case of a term female newborn that developed severe respiratory distress soon after birth. She was found to be a compound heterozygote for both novel mutations in the ABCA3 gene. ABCA3 deficiency should be considered in mature babies who develop severe respiratory distress syndrome.

  4. Mauriac syndrome still exists

    Dias, J; Martins, S; Carvalho, S; Marques, O; Antunes, A
    BACKGROUND/OBJECTIVE: Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, growth and puberty delay, and the presence of elevated transaminases and serum lipids. The aim of this study was to describe the patients from a pediatric diabetic population that fulfill the criteria of MS. MATERIALS AND METHODS: A retrospective analysis of the pediatric diabetic population with diagnostic criteria of MS currently followed at Hospital de Braga, was performed. RESULTS: From a population of 91 patients with DM1 18 years, 6...

  5. O atraso de desenvolvimento nas crianças com anemia por deficiência de ferro. Poderá ser revertido pela terapêutica com ferro?

    Antunes, H; Gonçalves, S; Teixeira-Pinto, A; Costa-Pereira, A
    OBJECTIVE: To compare development of 17 children aged 12 months with iron deficiency anaemia (IDA) and 18 controls without IDA after a 3-months follow-up period and iron therapy in the IDA group. SUBJECTS AND METHODS: Development of all children was evaluated using the Griffith's Scale. Data was collected on parent's social class and education, breast-feeding, number of siblings and clinical nutritional status. RESULTS: At 12 months children with IDA had significantly lower development scores--mean (sd)--than those without IDA: 112(5) vs. 121(7). At 15 months, after iron therapy, there were no significant differences between cases and controls. Non-IDA children showed significantly lower development scores at 15...

  6. Prevalência do anticorpo contra o vírus da Hepatite A numa população do norte de Portugal

    Cunha, I; Antunes, H
    AIM: To find the prevalence of antibody to hepatitis A virus in the population of the North of Portugal. MATERIAL AND METHODS: Ten General Practitioners were asked to provide blood samples from patients who would need blood tests for any reason other than acute hepatitis, during January and February 1996. In this way, 381 samples were obtained for assessment of anti hepatitis A virus antibodies using a commercial radioimmunassay ELISA. All subjects gave their informed consent and answered to a protocol regarding age, sex, geographic area, number of people per household and sewage systems. The statistics were performed using SPSS. RESULTS: The 381 subjects were...

  7. Determinantes da colonização materna e da infecção neonatal por Streptococcus do grupo B

    Areal, A; Moreira, M; Nunes, S; Faustino, MA; Cardoso, L; Sá, C
    Aim and Objective: During the past three decades, group B Streptococcus (GBS) neonatal infection has been the subject of little research. The aim of this study was to evaluate the association between maternal risk factors, as established by the Center for Disease Control and Prevention (CDC), and maternal colonization. We also analysed the association between risk factors present in newborns and early-onset GBS disease. Study design: Cross-sectional study. Population: All pregnant women admitted for delivery in our institution and their newborns, between 1st February and 31st July 2005. Methods: Maternal and neonatal characteristics were collected from hospital clinical data, including information on risk...

  8. Caso radiológico

    Nascimento, J; Gomes, M; Moreira, C; Macedo, F

  9. Chediak-Higashi syndrome: pathognomonic feature

    Antunes, H; Pereira, A; Cunha, I

  10. Diagnosing Schmidt Syndrome in Adolescence

    Costa, M; Martins, S; Mota, F; Marques, O; Antunes, A
    A poli-endocrinopatia auto-imune tipo II divide-se em 2 síndromes: o síndrome de Schmidt, que se caracteriza pela associação entre a doença de Addison (DA) e tiroidite auto-imune, e o síndrome de Carpenter, em que há associação entre estas e diabetes tipo 1. É uma patologia rara, particularmente em idade pediátrica. Apresenta-se o caso de uma adolescente de 14 anos, do sexo feminino, orientada para a consulta do Grupo Endocrinológico Pediátrico por hipotiroidismo primário, no contexto de tiroidite de Hashimoto, estando medicada há cerca de 1 mês com levotiroxina. Negava sintomatologia característica ou infecções recentes. Na observação apresentava cabelo fino e...

  11. El síndrome de Mauriac todavía existe

    Dias, J; Martins, S; Carvalho, S; Marques, O; Antunes, A
    BACKGROUND/OBJECTIVE: Mauriac syndrome (MS) is a rare complication of type 1 diabetes mellitus (DM1). It is related to low insulin concentrations and is less common since longer-acting insulins became available. It is characterized by hepatomegaly, growth and puberty delay, and the presence of elevated transaminases and serum lipids. The aim of this study was to describe the patients from a pediatric diabetic population that fulfill the criteria of MS. MATERIALS AND METHODS: A retrospective analysis of the pediatric diabetic population with diagnostic criteria of MS currently followed at Hospital de Braga, was performed. RESULTS: From a population of 91 patients with DM1 18 years, 6...

  12. Peutz-Jeghers syndrome: capsule endoscopy to stage disease

    Antunes, H; Nascimento, J; Peixoto, P

  13. Lymphadenopathy after BCG vaccination in a child with chronic granulomatous disease

    Vieira, AP; Vasconcelos, J; Fernandes, JC; Antunes, H; Sousa-Basto, A; Macedo, C; Zaman, A; Santos, E; Melo, JC; Roos, D

  14. Exposição das crianças ao fumo ambiental do tabaco em casa e no carro

    Precioso, J; Araújo; Machado, J; Samorinha, C; Calheiros, J; Becoña, E; Ravara, S; Vitória, P; Rosas, M; Bonito, J; Antunes, H

  15. Choque tóxico por streptococcus B hemoliticus do grupo A

    Pontes, T; Antunes, H
    In the last years has been observed an increased incidence of invasive group A beta-hemolytic streptococcal infections, including the toxic shock syndrome. The most common portal of entry is the skin and mucous membranes. The toxic shock syndrome can occurred as a rare complication of pharyngitis. The association between varicella and the use of nonsteroidal antiinflammatory drugs with necrotizing fasciitis by Streptococcus pyogenes has been discussed without reach at consensus, but some authors disapproved the use of nonsteroidal antiinflammatory drugs in this viral infection. The authors reported the clinical case of a 12 year old adolescent, that 15 days after...

  16. Iron deficiency anemia in infants. Preliminary development results at five years

    Antunes, H; Gonçalves, S; Teixeira-Pinto, A; Costa-Pereira, A; Tojo-Sierra, R; Aguiar, A
    INTRODUCTION: Research, mostly conducted in developing countries, have suggested short and long term developmental delay in children who had iron-deficiency anemia (IDA) in their early life. This study aims to evaluate the development of 5-years old children who were diagnosed IDA at 9 months of age. METHODS: 27 children with IDA diagnosed at 9 months of age and 28 non-anemic controls were followed-up until they were 5 years old. At 9 months of age and at 5 years of age, blood samples were collected for blood count, iron, transferrin and ferritin. Children with hemoglobin < 110 g/l and ferritin < 12 ng/ml were...

  17. Um final feliz: causa rara de hipotonia cervical em lactente

    Sampaio, B; Silva, A; Costa, JA; Pereira, A; Silva, H

  18. A infecção peri-natal por Streptococcus agalactiae pode ser evitada: prevalência da colonização em parturientes no Hospital de S. Marcos, factores de risco e sua relação com a infecção peri-natal

    Areal, A; Nunes, S; Moreira, M; Faustino, MA; Cardoso, L; Sá, C
    ntrodução: O Streptococcus agalactiae (SGB) é o agente mais frequente de infecção neonatal precoce, sendo possível a sua prevenção. Em Portugal é desconhecida a prevalência de mulheres colonizadas por SGB. O estudo da Unidade de Vigilância Pediátrica refere uma prevalência nacional de infecção neonatal por SGB de 0,5:1000 nados-vivos. Objectivo: Determinar a prevalência da colonização materna e da infecção perinatal por SGB no Hospital de S. Marcos, Braga (HSM), de modo a avaliar a importância da implementação do rastreio universal e o uso de medidas profiláticas. Método: De 1 de fevereiro a 31 de julho de 2005 foi realizado um...

  19. Comportamentos de risco e excesso de peso na adolescência: revisão da literatura

    Rosa, MF; Gonçalves, S; Antunes, H
    A adolescência é uma fase de maior vulnerabilidade para o envolvimento em comportamentos de risco. Paralelamente, o excesso de peso pode ter implicações pessoais e inter-pessoais que podem pôr em causa o bem-estar psicológico dos adolescentes e potenciar o envolvimento em comportamentos de risco. Objectivo: Analisar estudos sobre comportamentos de risco (ferimentos auto-infligidos e consumo de substâncias) num contexto de obesidade ou sobrepeso na adolescência, observando o papel que certas variáveis psico-sociais podem ter na sua moderação. Métodos: Pesquisa de livros e em bases de dados de artigos científicos sobre o tema. Resultados: Os resultados das investigações que procuram associações...

  20. Tuberculose em idade pediátrica: características, incidência e distribuição geográfica (2000-2010)

    Gonçalves, JP; Cerqueira, A; Machado, C; Carvalho, F; Cruz, S; Gonçalves, A; Martins, S

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