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Repositório Comum (25.334 recursos)

É um repositório para instituições de ensino e investigação produtoras de literatura científica cuja dimensão ainda não justifica a criação de um repositório próprio. Permite integrar instituições, grupos ou indivíduos na infra-estrutura do projecto, nomeadamente através das pesquisas do Portal RCAAP e da B-On.

NCIR - Artigos

Mostrando recursos 1 - 20 de 21

  1. Macroprolactinomas: avaliação da resposta aos agonistas dopaminérgicos

    Santos, MJ; Almeida, R; Marques, O

  2. Impact of EGFR genetic variants on glioma risk and patient outcome

    Costa, BM; Viana-Pereira, M; Fernandes, R; Costa, S; Linhares, P; Vaz, R; Pinheiro, C; Lima, J; Soares, P; Silva, A; Pardal, F; Amorim, J; Nabiço, R; Almeida, R; Alegria, C; Pires, MM; Pinheiro, C; Carvalho, E; Oliveira, P; Lopes, JM; Reis, RM
    BACKGROUND: The epidermal growth factor receptor (EGFR) regulates important cellular processes and is frequently implicated in human tumors. Three EGFR polymorphisms have been described as having a transcriptional regulatory function: two single-nucleotide polymorphisms in the essential promoter region, -216G/T and -191C/A, and a polymorphic (CA)(n) microsatellite sequence in intron 1. We aimed to elucidate the roles of these EGFR polymorphisms in glioma susceptibility and prognosis. METHODS: We conducted a case-control study with 196 patients with glioma and 168 cancer-free controls. Unconditional multivariate logistic regression models were used to calculate ORs and 95% confidence intervals. A Cox regression model was used to evaluate associations...

  3. Primary spinal glioblastoma: A case report and review of the literature

    Morais, N; Mascarenhas, L; Soares- Fernandes, JP; Silva, A; Magalhães, Z; Moreira da Costa, JA
    Primary spinal glioblastoma (GBM) is a rare disease, with an aggressive course and a poor prognosis. We report a case of a 19-year-old male with a 4-week history of progressive weakness in both lower limbs, which progressed to paraparesis with a left predominance and difficulty in initiating urination over a week. Spine magnetic resonance imaging (MRI) showed an intramedullary expansile mass localised between T6 and T11. We performed a laminotomy and laminoplasty between T6 and T11 and the tumour was partially removed. Histopathological study was compatible with GBM. The patient was administered focal spine radiotherapy with chemotherapy with temozolamide. Serial...

  4. Um final feliz: causa rara de hipotonia cervical em lactente

    Sampaio, B; Silva, A; Costa, JA; Pereira, A; Silva, H

  5. Primary angiitis of the central nervous system: an infrequent form of presentation

    Jordão, MJ; Almeida, F; Moreira da Costa, JA; Rocha, J
    INTRODUCTION: Primary angiitis of the central nervous system (CNS) is a rare disease. Clinical signs and symptoms include headache and cognitive disorders associated to multifocal neurological deficits. A definitive diagnosis can only be achieved by means of a cerebromeningeal biopsy. CASE REPORT: We describe the case of a 15-year-old male who first reported lower back pain and progressive paresis of the right lower limb, later followed by laterocollis on the right side. Magnetic resonance (MR) scanning of the brain and spinal cord revealed a pseudotumoral lesion in the right cerebellum and two lesions in the spinal cord. Dexamethasone was administered and surgical resection...

  6. Cranial nerve cavernous malformations causing trigeminal neuralgia and chiasmal apoplexy: report of 2 cases and review of literature

    Morais, N; Mascarenhas, AL; Soares-Fernandes, JP; Moreira da Costa, JA

  7. Primary Bilateral Thalamic Astrocytoma Presenting With Head Tremor, Ataxia, and Dementia

    Machado, A; Ribeiro, M; Rodrigues, M; Ferreira, C; Almeida, R; Santana, I; Castro, L; Carpenter, S

  8. Prognostic value of MGMT promoter methylation in glioblastoma patients treated with temozolomide-based chemoradiation: a Portuguese multicentre study

    Costa, BM; Caeiro, C; Guimarães, I; Martinho, O; Jaraquemada, T; Augusto, I; Castro, l; Osório, L; Linhares, P; Honavar, M; Resende, M; Nabiço, R; Almeida, R; Alegria, C; Pires, M; Pinheiro, C; Carvalho, E; Lopes, JM; Costa, P; Damasceno, M; Reis, RM
    Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The identification of novel molecular prognostic markers of GBM has recently been an area of great interest in neuro-oncology. The methylation status of the MGMT gene promoter is currently a promising molecular prognostic marker, but some controversial data have precluded its clinical use. We analyzed MGMT methylation by methylation-specific PCR in 90 GBM patients from four Portuguese hospitals, uniformly treated with radiotherapy combined with concomitant and adjuvant temozolomide (Stupp protocol). The Kaplan-Meier method was used to construct survival curves, and the log-rank test and a Cox-regression model were used...

  9. Abcesso isolado do clivus achados em ressonância magnética convencional: estudo de difusão

    Fernandes, JS; Valle, JM; Morais, N; Ribeiro, M; Magalhães, Z; Moreira da Costa, JA; Rocha, J

  10. A acuidade da Ressonância Magnética e da biopsia estereotáxica no diagnóstico de lesões cerebrais

    Filipe, MA; Soares, A; Alegria, C

  11. Complicações da Radiocirurgia no tratamento de MAV´s cerebrais

    Brás, MA; Oliveira, L; Alegria, C

  12. Tratamento de gliomas de baixo grau em áreas (mais) eloquentes

    Morais, N; Moreira da Costa, JA

  13. Envolvimento meníngeo em caso de esclerodermia localizada

    Carvalho, R; Fernandes, J; Ribeiro, M; Morais, N; Moreira da Costa, JA; Magalhães, Z; Rocha, J

  14. Diffusion-weighted MR imaging findings in an isolated abscess of the clivus

    Soares-Fernandes, JP; Valle-Folgueral, JM; Morais, N; Ribeiro, M; Moreira da Costa, JA
    We report the finding of restricted diffusion in an isolated abscess of the clivus and discuss the imaging differential diagnosis, with an emphasis on the usefulness of diffusion-weighted imaging.

  15. Afastadores Interespinhosos: resultados e indicações cirúrgicas

    Morais, N; Moreira da Costa, JA

  16. Hematoma subdural raquidiano

    Ribeiro, M; Cerqueira, J; Fernandes, J; Alegria, C; Rocha, J
    Spinal subdural haematoma is a rare pathology and may cause severe neurological deficit. In this paper a case of acute spinal subdural haematoma of multifactorial etiology--traumatic versus iatrogenic--is presented, in which the clinical evaluation, Computerized Tomography and Magnetic Resonance were of utmost importance as far as the early diagnosis is concerned, allowing therefore decompressive surgery to avoid neurological deficit development.

  17. Giant cell glioblastoma: review of the literature and illustrated case

    Valle-Folgueral, JM; Mascarenhas, L; Costa, JA; Vieira, F; Soares-Fernandes, J; Beleza, P; Alegria, C
    Giant cell glioblastoma is an infrequent variety of glioblastoma (5% of the cases). It has deserved a separate category in the World Health Organization classification of grade IV tumors. The clinical, imaging, histological and immunohistochemical characteristics, and the genetic alterations are reviewed. Treatment and prognosis are discussed and updated. The case of a patient that survived 19 months and died of spinal leptomeningeal metastases is illustrated.

  18. Fibromuscular dysplasia with dissecting basilar aneurysm: Endovascular treatment

    Ribeiro, M; Soares-Fernandes, J; Rocha, J; Machado, A; Cerqueira, J; Moreira da Costa, JA; Reis, J

  19. Difficulties diagnosing spinal subdural hemorrhage in a hypo-coagulated patient due to simultaneous symptomatic subdural cranial hemorrhage

    Mascarenhas, L
    A hypo-coagulated 58-year-old female complained of headaches right after being exposed to the first pressure waves generated during an exhibition of fireworks. The day after she presented with seizures and the CT scan showed subdural hemorrhage over the left frontoparietal sulci. Eight hours after admission she disclosed left lower limb hypo-esthesia, i.e. a finding not attributable to the cranial hemorrhage. Four hours later sphincter dysfunction and paraparesis were also present with a left predominance. This was due to a T12-L1 subdural extramedullary hemorrhage. The patient was operated and showed a favorable outcome. Hypo-coagulated patients with cranial hemorrhage require prolonged surveillance...

  20. Pharmacological versus microvascular decompression approaches for the treatment of trigeminal neuralgia: clinical outcomes and direct costs

    Lemos, L; Alegria, C; Oliveira, J; Machado, A; Oliveira, P; Almeida, A
    In idiopathic trigeminal neuralgia (TN) the neuroimaging evaluation is usually normal, but in some cases a vascular compression of trigeminal nerve root is present. Although the latter condition may be referred to surgery, drug therapy is usually the first approach to control pain. This study compared the clinical outcome and direct costs of (1) a traditional treatment (carbamazepine [CBZ] in monotherapy [CBZ protocol]), (2) the association of gabapentin (GBP) and analgesic block of trigger-points with ropivacaine (ROP) (GBP+ROP protocol), and (3) a common TN surgery, microvascular decompression of the trigeminal nerve (MVD protocol). Sixty-two TN patients were randomly treated during...

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