Recursos de colección

Universidad Nacional de La Plata (74.538 recursos)

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vol. 27, no. 06

Mostrando recursos 1 - 20 de 24

  1. Can ursodeoxycholic acid be considered as an alternative treatment for postmenopausal osteoporosis?

    Erim, Gulcan; Toker, Serdar; Toker, Aysun
    Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to bone fracture. Bone tissue undergoes constant remodeling. Under the physiologic conditions, bone formation and resorption are in a fair balance. After the third decade of life, bone resorption exceeds bone formation and leads to osteopenia and, in severe situations, osteoporosis. The result is fragile bones and an increased risk for fracture with even minimal trauma. Postmenopausal osteoporosis is thought to result from gonadal (ie, estrogen) deficiency. Estrogen deficiency have been reported to make decrease in 1-25 vitamin D, PTH levels...

  2. Vitíligo: Actualización Bibliográfica

    Fernández Hernández, Nubia; Pérez Davison, Gema; Gregorio, Martínez Sánchez
    El vitíligo es uno de los desórdenes más frecuentes de hipopigmentación de la piel caracterizado por manchas de color blanco rosáceo, desprovistas de melanocitos identificables. El vitíligo resulta de una compleja interacción entre factores ambientales, genéticos e inmunológicos lo que contribuye en última instancia a la destrucción del melanocito. Su etiología no es bien conocida, se postulan varias teorías para explicar la pérdida de melanocitos epidérmicos. Con independencia de los resultados de las investigaciones más recientes, las estrategias de tratamientos persiguen el objetivo de restablecer la integridad funcional de los melanocitos y por tanto de la epidermis de pacientes con vitíligo. La terapia es combinada y depende...

  3. Eficácia e segurança da tigeciclina, o primeiro antibiótico da classe das glicilciclinas

    Bencke, Amanda; Heineck, Isabela
    Nos últimos anos, observou-se uma importante escalada no surgimento de cepas resistentes aos agentes disponíveis. A classe das glicilciclinas foi desenvolvida com o objetivo de superar tais mecanismos de resistência, e a tigeciclina é o primeiro antibiótico desta classe aprovada para comercialização. Este trabalho avaliou a eficácia e segurança da tigeciclina através de revisão da literatura científica e constatou que, para as indicações aprovadas, o fármaco é comparável aos agentes classicamente utilizados. No entanto, vem sendo usado para várias outras indicações sem benefício comprovado.

  4. Biological activity and isolated compounds in Sapindus saponaria L. and other plants of the genus Sapindus

    Pelegrini, Denise D.; Tsuzuki, Joyce K.; Amado, Ciomar A. B.; Cortez, Diógenes A. G.; Ferreira, Izabel C. P.
    Species of Sapindus (Sapindaceae) are widespread throughout the tropics (e.g., Brazil, China and India). The present report is based on available data and references on species of this genus. The main substances found in plants of the genus Sapindus are acetylated triterpenic saponin and acyclic sesquiterpene oligoglycosides. These plants have antimicrobial, spermicidal, antiulcer, hepatoprotective, molluscicidal, fungicidal and anti-inflammatory activity. In Brazil, the fruit of Sapindus saponaria L. is employed in folk medicine in the treatment of ulcers and external wounds.

  5. Preliminary antimicrobial and cytotoxic activities of n-Hexane extract of Jatropha pandurifolia

    Akhter, Afsana; Rahman, Mohammad S.; Ahsan, Monira
    The plant Jatropha pandurifolia (Euphorbiaceae) has ethnopharmacological reputation of being used as a healing agent in Bangladesh. In this study, preliminary screenings were conducted to look at the antimicrobial susceptibility and cytotoxicity of the plant extract. The n-hexane extract of the plant was subjected to screening for inhibition of microbial growth by the disc diffusion method and the average zone of inhibition was found 12-21 mm at a concentration of 500 μg/disc. The extract was also subjected to brine shrimp lethality bioassay for primary cytotoxicity evaluation and it revealed significant cytotoxicity with LC50 of 4.67 μg/ml. This is the first...

  6. Cytotoxicity of dehydrocrotonin (a nor-clerodane from Croton cajucara) on human lymphocytes

    Lemos, Telma M. A. M.; Aoyama, Hiroshi; Cavagis, Alexandre D. M.
    Trans-Dehydrocrotonin, a 19-nor-clerodane, is the major norditerpene obtained from Croton cajucara, a Brazilian medicinal plant which presents important biological effects, such as antineoplastic and antiulcerogenic activities. In this work, we analyzed the effect of this sesquiterpene lactone on normal human lymphocytes. The cell viability was verified after treatment for 24 and 72 h with trans-dehydrocrotonin, in the presence and absence of phytohemagglutin (specific mitogen for this cell), through three endpoints to assess cytotoxicity in vitro: MTT reduction (mitochondrial function), protein quantification (cell number) and phosphatase activity (cell metabolism). When the cells were treated with dehydrocrotonin in the presence of mitogen,...

  7. Avaliação preliminar da atividade biológica e toxicidade aguda de Vitex gardneriana Schauer (Verbenaceae)

    Sá Barreto, Lívia C.L.; Cunha Filho, Marcílio; Souza, Ivone A.; Fraga, María do Carmo C. A.; Xavier, Haroudo Satiro
    O presente trabalho investigou pela primeira vez a atividade biológica e a toxicidade aguda de Vitex gardneriana Schauer, planta de utilização popular encontrada no sertão nordestino do Brasil. A toxicidade aguda, determinada por via oral e intraperitoneal, e diferentes atividades farmacológicas (antimicrobiana, anti-inflamatória, analgésica e hipnótica) foram pesquisadas utilizando soluções aquosas dos extratos brutos das cascas do caule e das folhas. Não se detectou sinais de toxicidade em nenhuma das doses testadas (250-2000 mg/kg). Foram encontrados relevantes efeitos farmacológicos nos extratos das folhas, que apresentaram ações anti-edematogênicas, antinociceptivas e sedantes. Os resultados encontrados corroboram a utilização popular de V. gardneriana...

  8. Regulamentação de radiofármacos: União Européia, Estados Unidos e Brasil

    Oliveira, Ralph Santos
    Após uma breve introdução este artigo relata e a experiência da União Européia, dos Estados Unidos e do Brasil, na regulamentação de radiofármacos, elencando os principais atos normativos e identificando as principais ações tomadas até o presente momento.

  9. Acute toxicity study of commercial antifungal drugs using Poecilia reticulata

    Mascotti, María L.; Enriz, Ricardo Daniel; Giannini, Fernando Angel
    Commercial antifungal drugs possess important side effect; being toxicity the main limitation of such compounds. We report here a study of acute toxicity of four well-known commercial antifungal drugs; two of them used in human medicine (griseofulvine and miconazole) and the other two used against phytopatogens fungi (carbendazin and benomil). Toxic effects of these compounds were evaluated using an acute toxicity test on fish of the specie Poecilia reticulata.

  10. Radical scavenging capacity of Piper arboreum and Piper tuberculatum (Piperaceae)

    Regasini, Luis O.; Cotinguiba, Fernando; Siqueira, Janaina R.; Bolzani, Vanderlan S.; Silva, Dulce; Furlan, Maysa; Katto, Masuo J.
    In the scope of our ongoing researchers on antioxidant compounds, twenty four extracts and fractions obtained from Piper arboreum Aublet and Piper tuberculatum Jacq. (Piperaceae) were screened for radical scavenging capacity (RSC) by using DPPH colorimetric assay. The strongest activity was found in ethyl acetate fractions from the leaves of P. arboreum (IC50 = 5.70 μg/mL) and P. tuberculatum (IC50 = 8.40 μg/mL). Hydromethanol fractions of the leaves of P. tuberculatum and P. arboreum showed moderate RSC, with values of IC50 (μg/mL) of 11.9 and 19.2, respectively. Additionally, a brief phytochemical study of the ethyl acetate fraction of P. arboreum...

  11. Antimicrobial activity of plants used in the prevention and control of bovine mastitis in Southern Brazil

    Avancini, César; Wiest, José M.; Haas, Juliana Schulte; Poser, Gilsane Lino von; Dall'Agnol, Rodrigo
    Based on informal interview, ethnoveterinary information about plants used in the prevention and control of bovine mastitis in Southern Brazil were obtained. Alternanthera brasiliana (L.) Ktze. ("penicilina"), Foeniculum vulgare Mill ("funcho"), Aloe arborescens Mill. ("babosa"), Achillea millefolium L. ("mil-em-rama"), Baccharis trimera (Less.) DC. ("carqueja"), Solidago chilensis Meyer ("lanceta"), Symphythum officinale L. ("confrei"), Sambucus nigra L. ("sabugueiro"), Chenopodium ambrosioides Linn. ("erva Santa Maria"), Mentha sp. ("hortelã"), Ocimum basilicum L. ("alfavaca"), Parapiptadenia rigida (Benth.) Brean ("angico-vermelho"), Allium sativum L. (alho), Cuphea carthagenensis (Jacq.) Macbr. ("sete-sangrias"), Sida rhombifolia L. ("guanxuma"), Phytolacca dioica L. ("umbu") and Solanum mauritianum Scop ("fumeiro-brabo") were cited as helpful....

  12. Equivalencia farmacéutica de comprimidos conteniendo Metronidazol 500 mg

    Volonté, María Guillermina; Ruiz, María Esperanza; Rubini, Agustina; Pozzo, Ricardo
    Metronidazol (MTZ) es un antibacteriano, antiprotozoario y antihelmíntico ampliamente utilizado en infecciones de distinto origen. La finalidad de este trabajo fue determinar la Equivalencia Farmacéutica (EF) de los distintos productos, formulaciones sólidas de administración oral conteniendo 500 mg de MTZ, disponibles en el mercado farmacéutico argentino, en el momento del presente estudio. Se analizaron comprimidos de catorce marcas, todas ellas dentro de su período de validez de uso. Los ensayos realizados fueron: evaluación de rótulos y prospectos, descripción de los comprimidos, identidad y contenido de MTZ, uniformidad de unidades de dosificación, ensayo de disolución y perfiles de disolución. Se concluyó que no todas las especialidades medicinales conteniendo...

  13. Analysis of the influence of five variables on an established immunoaffinity chromatography procedure to purify a picchia pastoris yeast derived-HBsAg for pharmaceutical use

    Valdes, Rodolfo; Medina, Yenisley; Fernández, Eutimio G.; Geada, Déborah; Ferro, Williams; Álvarez, Tatiana; Padilla, Sigifredo; Guevara, Yaryse; Tamayo, Andrés; Gomez, Leonardo; Montero, José; Figueroa, Alejandro; Calas, Gisela; García A., Cristina
    Immunoaffinity chromatography (IAC) has a wide application in protein purification. The aim of the study was to investigate the influence of five operational factors on an IAC procedure to purify a yeast derived-Hepatitis B surface antigen (rHBsAg) for pharmaceutical use. The immunosorbent adsorption capacity of the rHBsAg is affected at 4 °C. The applied antigen concentration, 100-1000 μg mL-1, does not have influence on this IAC efficiency. The residence time, applied antigen amount and column geometry have a significant influence on the adsorption and elution capacity, and recovery of the rHBsAg. There is a marked retention of the rHBsAg into the matrix,...

  14. Caracterização farmacobotânica de Peumus boldus (Monimiaceae) e avaliação de atividades biológicas do alcalóide boldina

    Schwanz, Melissa; Nunes, Eliana; Konrath, Eduardo L.; Vendruscolo, Giovana S.; Silva, Márcia Vignoli da; Henriques, Amélia T.; Mentz, Lilian Auler
    Peumus boldus Molina (Monimiaceae) is a medicinal plant known in Brazil as "boldo" or "boldo-do-chile", and its leaves are popularly used in digestive and hepatic diseases. A pharmacobotanical study was carried out, macro and microscopically features were illustrated and described, in an attempt to complement the fourth edition of the Brazilian Pharmacopoea monograph. Some special characters can be used to identify this drug: revolute margined leaves, typical color and texture, covering stellate trichomes, secretory cells, hypoestomatic mesophyll, anomocytic stomata, and crystals. Boldine, the major alkaloid found in this species, exhibited potent antioxidant activity and an unprecedented anticholinesterasic effect, both demonstrated through autobiographic assays.

  15. Antinociceptive activity of the essential oil and fractions of pterodon emarginatus vogel seeds

    Dutra, Rafael C.; Trevizani, Raphael; Pittella, Federico; Barbosa, Nádia R.
    In the present study the antinociceptive property of Pterodon emarginatus Vog. (Leguminosae) seeds essential oil (EO) and fractions was investigated. The writhing test induced by acetic acid, paw licking induced by formalin and hot plate tests were performed in Swiss albino mice (n = 8-10/group), by oral route at doses of 100, 300 and 500 mg/kg. The EO, hexanic (HF) and buthanolic (BF) fractions reduced (p < 0.01) the abdominal contortions (100 mg/kg = 22.75 ± 4.03, 14.38 ± 3.41 and 24.6 ± 4.48; 300 mg/kg = 14.00 ± 5.81, 12.13 ± 3.19, and 25.88 ± 2.78; 500 mg/kg =...

  16. Transferencia de materia hacia la solución en la extracción de productos bioactivos de vegetales y su degradación en mezclas de solventes

    Gatti, Walter Omar; Jeandupeux, René; Cafferata, Lázaro F. R.
    Se ha realizado una evaluación analítica cuantitativa de la extracción de la droga antimalárica natural artemisinina, presente en plantas silvestres de Artemisia annua L., utilizando mezclas de etanol 70% (v/v) - agua. El objetivo ha sido encontrar una justificación de la reducida recuperación de esa droga en los procesos de su aislamiento ya indicados en la literatura y que conducen a la obtención de rendimientos que no corresponden con el dosaje inicial de la droga en el material vegetal fresco. Los resultados de este trabajo podrían ser de utilidad para interpretar situaciones análogas en el aislamiento de productos naturales provenientes...

  17. Síntesis enzimática de alcamidas en sistemas no acuosos y ensayo de su bioactividad In vitro

    Molina Torres, Jorge; Santos Escobar, Fernando; González-Arnao, María T.; Ramírez-Chávez, Enrique; Sánchez Pavón Esmeralda
    Se sintetizaron diez moléculas de alcamidas usando la enzima Novozym lipasa B de Candida antartica en tolueno anhidro. Como sustrato de la reacción se utilizaron ácidos grasos y ésteres de ácidos grasos en presencia de isobutilamina o feniletilamina. El equilibrio de las reacciones se alcanzó entre 24 y 48 h, con niveles de conversión de 35,9 a 99,2%, obteniéndose mayor efectividad de reacción utilizando feniletilamina. Los ensayos de bioactividad de ocho de las alcamidas obtenidas, sobre el crecimiento de bacterias Gram(+) reflejaron que las alcamidas con el sustituyente feniletil, son más activas que con el isobutilo. Los ensayos frente a bacterias Gram(-), no manifestaron inhibición.

  18. Participation of GABA-benzodiazepine receptor complex in the anxiolytic effect of Passiflora alata Curtis (Passifloraceae)

    Provensi, Gustavo; Nöel, François; Lopes, Daniela V.S.; Fenner, Raquel; Betti, Andresa H.; Costa, Fernanda de; Morais, Everton C.; Grosmann, Grace; Rates, Stela M.K.
    Passiflora alata Curtis is used in Brazilian folk medicine and also by pharmaceutical industry due to its tranquilizing properties. In this work, the central activity of an aqueous (AQ) and an hydroethanolic (HE) leaves extracts were evaluated in elevated plus maze, barbiturate sleeping time, open field and [3H]flunitrazepam binding assays. The only effect presented by AQ (300 mg/kg, p.o.) was on the barbiturate sleeping time, indicating a hypnotic effect. The HE extract (300 and 600 mg/kg, p.o.) also increased the barbiturate sleeping time and reduced the locomotor activity (at 600 mg/kg, p.o.), pointing to a sedative effect. In addition HE showed...

  19. Birefringent emulsions stabilized with steareth-2 and steareth-21

    Pasquali, Ricardo C.; Taurozzi, Melina P.; Sacco, Natalia; Bregni, Carlos
    In this research, birefringent emulsions stabilized with Steareth-2 and Steareth-21 were studied. Some authors attributed to them a liquid-crystalline structure, although the microphotographs presented by them as an evidence of such structure actually suggest the presence of solid crystals instead of liquid crystals. The purposes of this paper are to determine the true cause of the birefringence of this type of emulsions and to study how the composition of the oily phase influences the stability and the birefringence. Six emulsions stabilized with a mixture of Steareth-2 and Steareth-21 were prepared, each one with a different emollient. Four of them were birefringent while two were isotropic. The...

  20. Automedicação entre adultos na área de abrangência de uma Unidade Saúde da Família

    Vosgerau, Milene Z. S.; Soares, Darli A.; Souza, Regina K. T.
    Este artigo objetivou estimar a prevalência e os fatores associados à automedicação entre adultos de 20 a 59 anos residentes na área de abrangência de uma Unidade Saúde da Família de Ponta Grossa, Paraná, entre 2006 e 2007. A pesquisa consistiu em estudo transversal de base populacional. A seleção dos sujeitos realizou-se por amostragem sistemática. Entrevistou-se 374 pessoas. O período recordatório utilizado foi de 7 dias. Para a análise estatística utilizou-se os testes de qui-quadrado e razão de prevalência. Como resultado, a prevalência de automedicação foi de 24,9%. Foram consumidos 119 medicamentos entre aqueles que se automedicaram. Dos medicamentos citados, 43,7% eram analgésicos. A dipirona sódica foi...

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