Recursos de colección

Universidad Nacional de La Plata (74.783 recursos)

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vol. 29, no. 04

Mostrando recursos 1 - 20 de 24

  1. Antinociceptive and antipyretic activities of methanol extract Amaranthus caudatus linn

    Ashok Kumar, Bagepalli Srinivas; Lakshman, Kuruba; Jayaveera, Korala Konta Narsimha; Shekar, Devangam Sheshadri; Muragan, Chinna SwamyVel
    The methanolic extract of whole plant of Amaranthus caudatus Linn. (MEAC), was tested for antinociceptive (using hot plate method, acetic acid writhing and tail immersion) and antipyretic (using yeast induced pyrexia) activities using mice and rats at doses of 200 and 400 mg/kg body weight. MEAC significantly (p < 0.05) inhibited acetic acid induced writhing and also significantly delayed the reaction time of mice to thermal stimulation produced by the hot plate and hot water in tail immersion test. MEAC significantly (p < 0.01) reduced fever induced by yeast. These results suggest that the MEAC has exhibited significant antinociceptive and...

  2. Atividade antimicrobiana das folhas de Casearia sylvestris Swart

    Schneider, Naira F.Z.; Moura, Neusa F. de; Mendonça, Luciene C.; Denardim, Rosiane B.N.
    A atividade antimicrobiana das folhas da espécie Casearia sylvestris foi determinada utilizando a metodologia Concentração Inibitória Mínima (CIM) e Concentração Letal Mínima (CLM). Foram testados o extrato bruto e as frações hexânica, clorofórmica, acetato de etila e o óleo essencial da espécie C. sylvestris, sendo que todos demonstraram atividade antimicrobiana. Entre as frações testadas, a hexânica apresentou melhor CIM frente a Staphylococcus aureus e óleo essencial apresentou atividade bacteriostática e bactericida frente Escherichia coli.

  3. Tecnovigilância: a qualidade dos produtos para saúde em hospital da rede sentinela

    Manfredi, Márcia A. B.; Menoncin, Sergio M.; Santos, Thalita G.
    Neste trabalho realizou-se um estudo da qualidade dos produtos para a saúde em um Hospital da Rede Sentinela com o objetivo de subsidiar a ANVISA e melhorar a segurança na utilização destes produtos. O estudo teve caráter quantitativo e foi realizado no período de fevereiro de 2006 a maio de 2008. Foram analisados 376 produtos para a saúde. A ocorrência de queixas técnicas de artigos médico-hospitalares (197) foram maiores do que queixas técnicas de medicamentos (179). O principal problema encontrado nos artigos médico-hospitalares foi a ausência do produto ou parte dele da embalagem original (29%). Nas queixas técnicas de medicamentos,...

  4. Anthocyanins content and chemical composition of the essential oil of three blackberry cultivars from southern Brazil

    Andrade, Juliana M. M.; Apel, Miriam A.; Ramirez, Maria Rosana; Raseira, María C. B.; Pereira, José F. M.; Henriques, Amélia T.
    In this work, fruits of three cultivars, Caingangue, Cherokee and Guarani, originated from collections from Embrapa, Pelotas, Rio Grande do Sul, were analyzed concerning the anthocyanin content and the essential oils composition. The anthocyanin content were determined by spectrophotometry, resulting in 0.606 ± 0.018 g/ 100 g, 0.728 ± 0.020 g/100 g and 0.854 ± 0.065 g/ 100 g expressed as cyanidin-3- glucoside, for the three cultivars, respectively. The essential oils were obtained by hydrodistillation in a Clevenger apparatus and the chemical characterization was performed by GC-FID and GCMS. The oil composition of Caingangue cultivar presented predominance of monoterpenes, especially...

  5. Bioactive components from Gynandropsis gynandra leaves for antinociceptive activity

    Ghoghare, Ujwala R.; Nirmal, Sunil A.; Pawar, Pratap B.; Pal, Subodh C.; Mandal, Subhash C.
    Gynandropsis gynandra Linn. (Capparadiaceae) leaves are used in the treatment of pain traditionally. In order to evaluate its scientific validity, leaves were extracted successively to produce various extracts. These extracts were screened for antinociceptive activity using hot plate test and acetic acid-induced writhing test in mice at the dose of 100 mg/kg, intraperitoneally. Aqueous extract was found most active in both the tests. Further it was fractionated into four major fractions and were screened by the same tests at the dose of 25 mg/kg, i.p. Results showed that AQI fraction is most active and may responsible for the antinociceptive action. GC-MS analysis of AQI fraction showed...

  6. Influencia del proceso de microencapsulación sobre el efecto farmacológico de los lípidos presentes en las semillas de Cucurbita pepo L.

    López Hernández, Orestes D.; Núñez Figueredo, Yanier; Menéndez Castillo, Rosa A.; Nogueira Mendoza, Antonio; Reyes T., Maria I.; Toledo S., Carlos; Pérez S., Enma; Agüero Fernández, Sara
    Las semillas de Cucurbita pepo L., por su elevado porcentaje de aceite fijo, son ricas en ácidos grasos poliinsaturados, fitoesteroles, tocoferoles y carotenoides, empleándose tradicionalmente como antiinflamatorio en el tratamiento de la hiperplasia benigna prostática. La microencapsulación mediante secado por aspersión del extracto lipídico de las semillas de Cucurbita pepo L., empleando polímeros naturales modifica el estado de agregación del extracto, permitiendo así presentarlo en forma sólida para elaborar tabletas o cápsulas. La microencapsulación le confiere una mayor biodisponibilidad, lográndose un efecto antiinflamatorio con dosis inferiores al extracto lipídico sin microencapsular originado por el alto grado de dispersión que le...

  7. Synthesis and antibacterial activity of some 2,4,6-trisubstituted-1,3,5-triazines

    Singh, Udaya Pratap; Das, Aparoop; Chetia, Dipak; Bhattacharya, Ashokanshu; Subhaschandra, Yadav Pankajkumar; Kumar, Vikas; Bhat, HansRaj
    A series of 2,4-bis(substitutedphenyl)-6-(4-(4-substitutedphenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine were synthesised, characterised by FT-IR, 1H NMR, 13C NMR, mass and elemental analysis and evaluated for in vitro antibacterial activity against three gram positive and gram negative bacteria by disk diffusion test and agar dilution technique with reference to streptomycin as standard. The antibacterial data revealed that compounds 2,4-bis(substitutedphenyl)-6-(4-(4-nitrophenyl)thiazol-2-yl)-1,3,5-triazine- 2,4,6-triamine had significant activity against the tested gram negative organism in reference to standard. However, these were nearly inactive against gram positive organisms.

  8. Transdermal delivery of probenecid: the effects of vehicles and enhancers on permeation through pig skin

    Lhez, Lucía; Allemandi, Daniel A.; Palma, Santiago D.; Pappano, Nora B.; Debattista, Nora B.
    Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comparatively to lipophilic vehicle (vaseline), carbopol dispersions seen to be more convenient as vehicle for topical administration of probenecid. The results obtained from this study may be helpful in the development...

  9. High throughput simultaneous assay of atenolol and chlortalidone in combined dose tablets by liquid chromatography and capillary zone electrophoresis

    Patto, Daniela C.S.; Leite, Heitor O.A.; Tavares, Vanessa F.; Almeida, Mariana M. de; Lima, Cibele R. R. C.; Alves, João M. P.; Prado, Maria S. A.; Hackmann, Erika R. M. K.; Santoro, Maria Ines Rocha Miritello; Singh, Anil K.
    New fast liquid chromatographic and capillary zone electrophoresis methods were developed and validated for simultaneous determination of atenolol and chlortalidone in combined dose tablets. The reversed phase HPLC method was carried out on a CN LiChrosorb® (125 x 4 mm, 5 μm) column. The CZE method was carried out on an uncoated fused-silica capillary of 30 cm x 75 μm i.d. with 25 mmol L-1 sodium tetraborate, pH 9.4. The total analysis time was <6 and <2.5 min for HPLC and CZE methods, respectively. Both methods can be used for stability studies as well.

  10. Caracterização de filmes isolados de etilcelulose: avaliação das propriedades de hidratação e permeabilidade

    Alves, Bruno R. V.; Reis, Adriano V.; Albuquerque Cavalcanti, Osvaldo
    Neste trabalho propusemos o desenvolvimento de filmes isolados constituídos de etilcelulose contendo novo aditivo de formulação, o alfa-glucoligossacarídeo (α-GOS), além do tensoativo Tween® 80, sendo este material candidato à aplicação ao processo de revestimento de formas farmacêuticas orais, destinadas à liberação cólon-específico. A partir de filmes isolados foram realizadas avaliações das propriedades de hidratação (índice de intumescimento) e permeabilidade através da transmissão de vapor d’água (TVA). Resultados evidenciaram que as incorporações dos aditivos proporcionaram maior hidratação e influência na permeabilidade dos filmes. A presença do α-GOS gerou a formação de novo material com habilidade filmogênica e com elevado grau de...

  11. Morfoanatomia foliar de Rauvolfia sellowii Müll. Arg., Apocynaceae

    Baratto, Leopoldo; Duarte, Márcia do Rocio; Moraes Santos, Cid Aimbiré de
    Rauvolfia sellowii Müll. Arg. (Apocynaceae), uma árvore nativa brasileira rica em alcaloides indólicos, é conhecida como "pau-pra-tudo" e utilizada popularmente como hipocolesterolêmica, hipoglicêmica e anti-hipertensiva. O presente trabalho teve como objetivo caracterizar morfoanatomicamente a folha desta planta medicinal, a fim de contribuir para o controle de qualidade e autenticidade desta espécie. O material vegetal foi fixado e submetido às microtécnicas usuais. Como características destacam-se: folhas simples, glabras, lanceolado-obovadas, de mesofilo dorsiventral e lâmina hipoestomática, com estômatos paracíticos e epiderme uniestratificada, revestida por cutícula estriada; nervura central biconvexa e pecíolo plano-convexo, ambos com um feixe vascular bicolateral em forma de arco aberto; laticíferos, amiloplastos e drusas de oxalato de...

  12. Antiglycation, antiplatelets aggregation, cytotoxic and phytotoxic activities of Nepeta suavis

    Hussain, Javid; Khan, Farman-ullah; Gilani, Syed A.; Abbas, Ghulam; Ahmed, Sagheer; Khan, Arif-ullah; Ullah, Wasi; Choudhary, Muhammad I.
    Nepeta suavis Stapf. (Lamiaceae), one of the ignored species for testing biological activities, was studied. In present research, the Nepeta suavis fractions: chloroform (FC), ethyl acetate (FE) and aqueous (FW) were evaluated for platelet aggregation, antiglycation, cytoxicity, and phytotoxicity. FE showed 65.60% antiglycation activity against the protein glycation while the other fractions showed less than 50% inhibitory potential. The FW inhibited arachidonic acid (AA) and platelet activating factor (acetyl-glyceryl-ether-phosphorylcholine, PAF) induced platelet aggregation. FE showed significant cytotoxicity against brine shrimp larvae with LD50 of 41.3 μg/ml. Phytotoxic studies of FC, FE and FW against Lemna minor showed 77.5-100% inhibitory effects...

  13. A new antibacterial pyridinoside from a Streptomyces species

    Barman, Ranjan K.; Gafur, Mohammad A.; Rahman, Bytul M.; Khondkar, Proma
    A new compound, 8-propionate-2-β-(D+)-glucosyl-9,10-pyranopyridine, was isolated from the chloroform extract of a Streptomyces species. The structure of the compound was confirmed by spectroscopic techniques including UV, IR, HR-ESI-MS, 1H-NMR, 13C-NMR, 1H-1H COSY and HMBC (long range coupling) spectra. The compound showed significant antibacterial activity against Gram-positive bacteria. The minimum inhibitory concentrations (MIC) of the isolated compound against Bacillus megaterium, Streptococcus β-haemolyticus, Bacillus subtilis, Escherichia coli, Salmonella typhi and Shigella dysenteriae were found to be 0.16, 0.08, 0.08, 0.04, 0.08 and 0.08 μM, respectively.

  14. Development, evaluation and optimization of baclofen oral floating tablet

    Singh, Akhilesh V.; Pandey, Rishabh D.; Nath, Lila K.; Das, Anudwipa
    The present investigation concerns the development of a floating matrix tablet, which after oral administration prolong the gastric residence time and increases bioavailability of drugs, which are predominantly absorbed from gastric region .With this aim, floating dosage form containing baclofen as drug, and different grades of HPMC as release retarding polymer was prepared. Sodium bicarbonate and citric acid were used as gas generating agents. Some factors were investigated concerning the effect of release retarding polymer on drug release behaviors like t50% and t90%. A 32 factorial design was applied to optimize the drug release profile. The amounts of HPMC K4M(X1)...

  15. Study of nimesulide release from ethylcellulose microparticles and drug-polymer compatibility analysis

    Khan, Shujaat A.; Ahmad, Mahmood; Aamir, Muhammad N.; Murtaza, Ghulam; Rasool, Fatima; Akhtar, Muhammad
    The aim of this study was to formulate ethyl cellulose (EC) microparticles for sustained release of nimesulide and study the effect of processing variables, drug to polymer ratio and also study the drug polymer compatibility. The microparticles were prepared by coacervation (temperature change) technique. Physical properties, such as particle size, entrapment efficiency, release pattern and morphological characteristics were investigated by in vitro dissolution, SEM, FTIR, XRD, DSC and TGA in order to optimize the formulation of the microparticles. With the increase of polymer concentration there was an increase in size and drug entrapment efficiency of microparticles. There was a decrease...

  16. Free radical scavenging and anti-inflammatory activities of the extracts of Astraeus hygrometricus (Pers.) Morg.

    Biswas, Gunjan; Sarkar, Sagartirtha; Acharya, Krishnendu
    The present study was aimed to evaluate free radical scavenging and anti-inflammatory potential of extracts of Astraeus hygrometricus - a tropical wild edible mushroom. Free radical scavenging potential of crude, boiled and ethanolic extracts was studied using different in vitro antioxidant models. The anti-inflammatory activity of the potential extract was evaluated in carrageenan and dextran induced acute and formalin induced chronic inflammatory model in mice. Among all the extracts, ethanolic extract possesses significant in vitro superoxide anion, hydroxyl radical scavenging and lipid peroxidation inhibition activities. The IC50 values of ethanolic extracts of A. hygrometricus represented 357.95, 81.2 and 87.96 μg/ml...

  17. Caracterização e avaliação da qualidade de matérias-primas de difosfato de primaquina

    Bertol, Charise D.; Stulzer, Hellen Karine; Cruz, Ariane P.; Tagliari, Mónika P.; Segatto Silva, Marcos Antonio
    Este trabalho objetivou caracterizar e avaliar a qualidade de matérias-primas (MPs) de primaquina de diferentes fornecedores, designadas amostras A, B, C e D. Os resultados de características físicas, solubilidade, faixa de fusão, perda por dessecação e identificação mostraram estar de acordo com o preconizado pelas literaturas oficiais para todas as amostras. Os difratogramas apontaram que todas as MPs apresentaram características cristalinas semelhantes. Nas imagens obtidas por microscopia eletrônica de varredura a amostra D demonstrou um tamanho maior de partícula. A pureza do fármaco por titulação potenciométrica, variou de 98,8 a 101,1% para todas as amostras, estando de acordo com as...

  18. Caracterização das folhas e cascas da Rhamnidium elaeocarpum Reissek

    Oliveira, Tiago B.; Soares, Rebeca L.; Tresvenzol, Leonice M.F.; Branquinho, Daniella S. P.; Bara, María Teresa. F.; Fiuza, Tatiana S.; Rezende, Maria H.; Paula, José R. de
    As folhas e cascas da Rhamnidium elaeocarpum Reissek (Rhamnaceae), conhecida como cafezinho, são utilizadas popularmente no Brasil para reduzir o prurido das gengivas de crianças no início da dentição e para dores estomacais. O objetivo desse trabalho foi realizar a caracterização das folhas, cascas do caule e cascas da raiz da R. elaeocarpum. Observou-se que as folhas são opostas cruzadas simples, hipoestomáticas, apresentando tricomas tectores sobre as nervuras. As cascas das raízes possuem cicatrizes ou fendas na face externa e fratura fibrosa na face interna. Verificou-se a presença de flavonóides, alcalóides, saponinas e taninos em todas as amostras. Esses resultados...

  19. Caracterização farmacognóstica da Celtis iguanaea (Jacq.) Sargent

    Paula, Márcio A.; Couto, Renê O.; Bara, María Teresa. F.; Rezende, Maria H.; Paula, José R. de; Costa, Elson A.
    Celtis iguanaea (Jacq.) Sargent (Ulmaceae) é conhecida popularmente como esporão-de-galo e amplamente utilizada na medicina popular brasileira. O objetivo desse trabalho foi realizar o estudo farmacognóstico das folhas e caules jovens da C. iguanaea através de análises macro e microscópicas, triagem fitoquímica, ensaios de pureza (umidade, cinzas totais e insolúveis em ácido) e determinação dos teores de polifenóis e flavonóides totais. As folhas são anfiestomáticas, apresentando grande quantidade de tricomas tectores, litocistos e estômatos na epiderme abaxial. Na triagem fitoquímica foram detectados mucilagem, flavonóides e cumarinas. Os teores de umidade, cinzas totais, cinzas insolúveis em ácido, polifenóis e flavonóides totais encontrados, foram de 7,05 ± 0,22 %,...

  20. Analgesic and neuropharmacological effects of Xanthium indicum leaves

    Akter, Raushanara; Hasan, Raquibul; Hossain, Mokarram; Jamila, Mariam; Mazumder, Mohammed Ehsanul H.; Rana, Sohel; Rahman, Shafiqur
    The present study investigated analgesic and some neuropharmacological effects of hydromethanolic extract of the leaves of Xanthium indicum Koenig in mice models. The analgesic activity was evaluated using hot plate ant tail immersion methods, and acetic acid-induced writhing test. The neuropharmacological effects were determined using hole-cross, open field, and thiopental-induced sleeping time tests. The extract, at the doses of 100, 200 and 400 mg/kg, produced a dose dependent and significant (p < 0.05-0.001) increase in pain threshold in hotplate test. However, in tail immersion method, the extract at 200 and 400 mg/kg dose levels displayed a significant (p < 0.05-0.001)...

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