Recursos de colección

Universidad Nacional de La Plata (75.269 recursos)

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vol. 29, no. 06

Mostrando recursos 1 - 20 de 32

  1. Choleretic activity of five species of baccharis ("carquejas") used as phytotherapics in Argentinean traditional medicine

    Cifuente, Diego A.; Gianello, José C.; María, Alejandra O.M.; Petenatti, Elisa M.; Petenatti, Marta E.; Del Vitto, Luis A.; Tonn, Carlos C.
    Seveal Baccharis species known as "carquejas" are used in Argentinean folk medicine as phytotherapics. B. crispa, B. articulata, B. trimera, B. sagittalis and B. triangularis have been evaluated for their choleretic activity using Wistar rats. B. sagittalis and B. triangularis showed a significant choleretic activity (bile flow of 1.631 ± 0.089 and 1.598 ± 0.196 μl/min/g liver, respectively). B. crispa, B. trimera showed moderate activity and B. articulata exhibited the same choleretic property that the control. Only, B. articulata and B. crispa are informed as official drugs in the Argentinean Pharmacopoeia. In addition, phytochemical constituents and botanical characters are reported

  2. Enhancement of antibiotic activity by Cordia verbenacea DC

    Matias, Edinardo F.F.; Santos, Karla K. A.; Almeida, Thiago S.; Costa, José G.M. da; Coutinho, Henrique D.M.
    Escherichia coli is known to produce enterotoxins whose properties and its role in diarrheal disease has been extensively investigated. Some species of Staphylococcus are often recognized as etiological agents of many animal and human opportunistic infections. This study is the first test of change in resistance of antibiotic activity by Cordia verbenacea DC. against multiresistant strains of Escherichia coli and Staphylococcus aureus. In this study, the hexane and methanol extract of Cordia verbenacea DC. were tested for antibacterial activity alone and in combination with aminoglycosides against bacterial strains. The synergy of the methanolic and hexane were verified by microdilution method....

  3. Factors influencing utilization of different types of sulphonylureas amongst type 2 diabetes patients

    Huri, Hasniza Z.; Wei, Amy T.-L.; Pendek, Rokiah; Sulaiman, Che Z.; Widodo, Riyanto T.
    Sulphonylureas (SUs) are commonly prescribed in Malaysia and also worldwide. However, very limited information is available on their pattern of use and appropriateness of its utilization. Age, concurrent use of drugs such as beta blocker, salicylate and frusemide and also renal impairment were found to have influence on the selection of different types of SUs.

  4. A simple LC-ESI-MS method for the determination of norvancomycin in rat plasma and application to pharmacokinetic study

    Yang, Xuezhi; Hu, Lufeng; Lin, Guanyang; Xu, Ren-ai; Zhang, Yu; Chen, Linzi; Zhu, Lihe; Zhao, Feng; Wang, Xianqin
    A simple and sensitive LC-ESI-MS method for determination of norvancomycin in plasma was developed and validated over the concentration range of 20-2,000 ng/mL. After addition of vancomycin as internal standard (IS), protein precipitation with 5 % trichloroacetic acid was employed for the sample preparation. Chromatographic separation was performed on a Zorbax SB-C18 (100 mm×2.1 mm, 3.5 μm) column with 10:90 (v/v) acetonitrile-0.1 % formic acid as mobile phase. The MS data acquisition was accomplished by selective ions monitoring (SIM) mode with positive electrospray ionization (ESI) interface. The limit of quantification (LOQ) was 20 ng/mL. For inter-day and intra-day tests, the precision (RSD) for the entire validation was...

  5. Antibacterial activity of phenylpropanoids derived from cinnamic acid

    Mascotti, María L.; Bisogno, Fabricio; Lima, Beatriz; Kurina-Sanz, Marcela; Feresin, Gabriela E.; Enriz, Ricardo Daniel; Giannini, Fernando Angel
    In this work, we present antibacterial activity of a 22 phenylpropanoids derived from cinnamic acid, recently reported as antifungal agents by our group. Some of these compounds are commercial, others are natural products and some of them were obtained by synthesis. Antibacterial activity was determined in two stages. At first, a screening was made by an easy, economic and fast assay using a commercial lyophilized of Gram (+) bacteria. Compounds that showed activity at the screening were tested against Gram (+) and Gram (-) pathogens.

  6. Development of in vitro-in vivo correlation for nimesulide loaded ethylcellulose microparticles

    Khan, Shujaat A.; Ahmad, Mahmood; Shoaib, Harris M.; Murtaza, Ghulam; Aamir, Muhammad N.; Kousar, Rozina; Rasool, Fatima; Madni, Asadullah
    A predictive in vitro-invivo correlation (IVIVC) can empower in vitro dissolution as a surrogate for in vivo bioavailability / bioequivalence. IVIVCs can decrease regulatory burden by decreasing the number of biostudies required in support of a drug product. The present study concerns the establishment of in vitro-in vivo correlation for three different sustained release nimesulide loaded ethylcellulose microparticulate formulations (M1, M2 and M3) and conventional tablet (100 mg Nimaran®-Novartis, Pakistan). In vitro dissolution study was conducted in phosphate buffer pH 6.8 stirred at 50 rpm and 37 ± 0.5ºC. A validated HPLC method was adopted to conduct bioavailability studies in...

  7. Antidiarrheal activity of Guazuma ulmifolia Lam. (Sterculiaceae)

    Michelin, Daniele C.; Almeida, Glalber C. de; Galina, Karen Janaina; Lopes, Gisely C.; Nakamura, Celso Vataru; Dias Filho, Benedito Prado; Ueda Nakamura, Tânia; Salgado, Hérida R.N.; Mello, João Carlos Palazzo de
    The high incidence of diarrhea in the population demands a search for new therapeutic options and easy access, mainly from plant-based sources. Leaves and bark of Guazuma ulmifolia Lam. (Sterculiaceae) are popularly employed against diarrhea. However, no information was found in the literature about this supposed property of the drug. In this study we evaluated in vivo antidiarrheal activity of stem bark extracts from G. ulmifolia in mice, and in vitro antimicrobial activity against Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella sp., Shigella flexneri, and Pseudomonas aeruginosa by using the microdilution method. The n-BuOH semipurified fraction (GU#3) significantly reduced intestinal...

  8. Determination of montelukast sodium and levocetirizine dihydrochloride in combined pharmaceutical dosage form by RP-HPLC

    Rote, Ambadas R.; Niphade, Vaishali S.
    A simple, rapid, sensitive and economical method has been developed for the simultaneous determination of montelukast sodium and levocetirizine dihydrochloride in combined tablet dosage form. The method was based on high performance liquid chromatography using zidovudine as an internal standard. The separation was carried out with a Eurosphere 100 C18 column (250×4.6 mm ID, 5 μm) and mobile phase 0.05 % orthophosphoric acid: methanol (10:90 v/v) at flow rate 1.2 ml/min. The UV detection was carried out at wavelength 225 nm.The method was validated statistically and by performing recovery study.

  9. Attainment and characterization of ternary complexes of simvastatin-cyclodextrin-hydrossoluble polymers

    Takahashi, Andrea I.; Ferraz, Humberto G.
    The purpose of this study was to attain and characterize ternary complexes of simvastatin, β-cyclodextrin (βCD) and different polymers, and then select those that lead to a greater increase in drug solubility. The complexes were prepared with the co-evaporation method and the polymers used were polyethylene glycol 1500, polyethylene glycol 4000, povidone, copovidone, crospovidone, maltodextrin and hydroxypropyl methyl cellulose. The characterization of complexes was carried out through aqueous solubility, DSC and TG. There was an increase in solubility for all the complexes prepared with βCD and the different polymers, but only when crospovidone and maltodextrin were used was there a...

  10. Psychopharmacological activities of acorus calamus roots in rat and mice models

    Rajangam, Jayaraman; Thiyagarajan, Anitha; Joshi, Vishal D.; Palei, Narahari
    Acorus calamus (Araceae) is commonly known in India as sweet flag and has been used in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the methanolic extract of Acorus calamus roots (MEAC) was assessed for different psychopharmacological activities in rats and mice by evaluation of general, exploratory behaviour, phenobarbitone sodium-induced sleeping time and muscle relaxant activity. The extract at doses 100 mg/kg and above exhibited a reduction in spontaneous activity and a decrease in exploratory behavioural pattern was observed. Also a significant reduction in muscle relaxant activity and potentiated phenobarbitone sodium-induced sleeping time in mice was noted in MEAC treated...

  11. Topical formulation with Cordia verbenacea essential oil and glycolic acid

    Leonardi, Gislaine R.; Rigon, Roberta B.; Cavallini, Míriam Elias; Polacow, María L. O.; Araújo, Marina R.; Andreollo, Nelson A.
    This study evaluated the effect of Cordia verbenacea essential oil (CV) and glycolic acid 70 % (GA), isolated and associated, on Wistar rats back skin. A base gel was added to 2 % of CV and/or 10 % of GA, thus forming 4 formulations: 1) GA + CV, 2) CV, 3) GA, and 4) gel base. All formulation had their final pH adjusted to 3,5 and were applied once daily, for 15 consecutive days, on 4 areas with 1 cm2, while another area without application (control). Statistical analysis of biopsies showed no difference in epidermis thickness and stratum corneum. Among fibroblast counts there was a...

  12. Determination of inorganic elements in sunscreen by using energy dispersive x-ray fluorescence

    Melquiades, Fábio; Appoloni, Carlos R.; Lonni, Audrey; Ferreira, Diego D.D.; Lopes, Fábio
    Nowadays there are no official in vitro methods to determine TiO2, ZnO or other inorganic elements in sunscreen cosmetics. The objective of this work is to determine the concentration of several inorganic elements in sunscreen composition, without sample preparation, by employing a portable Energy Dispersive X-Ray Fluorescence (EDXRF) device. Particularly in the case of TiO2 and ZnO, the aim is also to estimate their Sun Protection Factor (SPF) due to the physical protection barrier. A sensitivity curve for the determination of inorganic elements in sunscreen, with atomic numbers ranging from 19 to 35, is presented. Fifteen commercial samples with different...

  13. Formulation and optimization of directly compressible floating tablets of famotidine using 23 factorial design

    Nalawade, Pravin; Somvanshi, Amol; Dand, Neha; Kadam, Vilasrao; Hirlekar, Rajashree
    The aim of the present investigation was to develop a modified release effervescent floating drug delivery system of famotidine for 12 h dosage regimen to improve its bioavailability. Effervescent floating tablets were prepared by direct compression method taking into account its advantages over wet granulation by using directly compressible excipients like Carbopol® 71G and Cellactose® 80. The incorporation of sodium bicarbonate aided in the buoyancy with effervescent approach. The prepared tablets were evaluated for floating lag time (FLT), total floating time (TFT), in vitro drug release along with general parameters. 23 factorial design was used for optimization. The tablets showed desired release of more than 98 %...

  14. Metoprolol tartrate-ethylcellulose tabletted microparticles: formulation and in vitro evaluation

    Rasool, Fatima; Ahmad, Mahmood; Murtaza, Ghulam; Khan, Haji M. S.; Khan, Shujaat A.
    This study introduced a novel phase separation technique for the microencapsulation of metoprolol tartrate as a model. Non-solvent addition coacervation technique was employed for the loading of drug into ethylcellulose, a hydrophobic plastic polymer. Dichloromethane (DCM) and paraffin oil were employed as solvent and non-solvent, respectively. Microparticle batches abbreviated as M1, M2 and M3 were formulated by embedding 1 g of drug into 1 g, 2 g and 3 g of polymer, respectively followed by direct compression into tabletted microparticulate batches named a T1, T2 and T3, respectively. The drug and polymer remained intact in encapsulated form as confirmed by FTIR, XRD...

  15. Prescripción y dispensación de medicamentos para el hipotiroidismo en la ciudad de Córdoba, Argentina

    Higa, Valeria M.; Correa Salde, Viviana; Ravetti, Soledad; Arce Miranda, Julio E.; Fonsfría, Lucas D.; Palma, Santiago D.; Paraje, María Gabriela
    Se analizaron las características de prescripción y dispensación de medicamentos en una población de pacientes hipotiroideos, así como el conocimiento de los mismos sobre su terapia. Se trabajó con un procedimiento normalizado analizando 948 prescripciones médicas en 42 farmacias comunitarias de Córdoba (Argentina). Los laboratorios autorizados para elaborar medicamentos con levotiroxina fueron siete, en 12 concentraciones distintas (desde 25 a 300 μg). En este estudio una sola marca abarcó el 59 % de las prescripciones médicas. El 85 % de los usuarios fueron mujeres, principalmente entre 41-60 años. En cuanto al uso del medicamento el 78 % manifestó tomar el mismo una vez al día y...

  16. New 2-chloro-7-methylquinoline amine analogues as possible antimycotic agents

    Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Kumar, Rajiv; Panda, Bibhu P.
    A series of N-[(2-chloro-7-methylquinolin-3-yl)methyl]-(substituted)-aniline/butan-1-amine/cyclohexamine derivatives (4a-n) & N-benzyl-1-(2-chloro-7-methylquinolin-3-yl)methanamine (4o) was designed and synthesized based on the structural requirements essential for allylamine / benzylamine antimycotics. Compounds (4a-o) were synthesized by nucleophilic substitution reaction of 2-chloro-3-(chloromethyl)-7- methylquinoline with substituted aromatic/aliphatic primary amine in absolute ethanol in presence of triethylamine. The structures of all new products were confirmed by IR, 1H & 13C-NMR and mass spectral data. The newly synthesized compounds were screened in-vitro for their antifungal activity against Aspergillus niger MTCC 281, Aspergillus flavus MTCC 277, Monascus purpureus MTCC 369 and Penicillium citrinum NCIM 768 by cup plate method. Preliminary screening of compounds (4a-o) revealed that compounds viz. 4a, 4b,...

  17. Development and validation of an UV-spectrophotometric method for the dissolution studies of sitagliptin tablets

    Ravanello, Aline; Dadalt, Gabriele; Torres, Bruna G. S.; Hurtado, Felipe K.; Marcolino, Ana I. P.; Rolim, Clarice M. B.
    A simple UV-spectrophotometric method was developed and validated for the analysis and dissolution studies of sitagliptin phosphate in tablets. Specificity test indicated an adequate UV detection at 267 nm. The method was validated regarding Specificity/accuracy/precision (RSD < 2 %), linearity (r2 = 0.9999), and partial robustness. Tablets uniformity was 102.52 % (RSD = 2.54 %). The method was applied for the determination of the drug in commercial tablet preparations and proved to be reliable for quantification It was also used for the comparison of dissolution profiles of sitagliptin tablets. After dissolution tests comparing eight different conditions through dissolution efficiency (DE),...

  18. Investigation of the anti-inflammatory and synergistic activities of bulbus Fritillariae ussuriensis and xuehua pear using acute inflammatory models

    Huang, Lijing; Gao, Wenyuan; Li, Xia; Man, Shuli; Zhang, Yanjun; Huang, Luqi; Liu, Changxiao
    The combination of the bulb of Fritillaria ussuriensis Maxim. (Bulbus Fritillariae ussuriensis, BFU) and the fruit of Pyrus bretschneideri Rehd. (Xuehua pear, PBR), as folk medicine, is widely used in treatment with respiratory disease. In this study, three acute inflammatory models were used to estimate the anti-inflammatory activities and cooperative interactions of them. The data were dealt with the Tallarida's improved contouring method and the Q value method to evaluate the cooperative interactions of BFU and PBR more directly. All the treated groups showed well preventive effects on xylene-induced mouse auricular edema, acetic acid-induced mouse vascular permeation and carrageenin-induced rat paw edema...

  19. Evaluation of oral fast disintegrating tablet of taste masked famotidine in rat

    Puri, Dinesh; Bhalekar, Mangesh R.; Sethi, Sunny S.
    The purpose of this research was to formulate fast-disintegrating tablets of famotidine by using tasteless complex of famotidine. Famotidine is a commonly used antiulcer drug but major disadvantage is its bitterness and low bioavailability. A fast-disintegrating dosage form has been developed as a user- friendly formulation that disintegrates in the mouth immediately. In this study the bitter taste of famotidine was masked by making complex with ion exchange resin Indion 214. The drug-resin complexes were characterized by infrared spectroscopy and thermal analysis. Famotidine oral fast disintegrating tablets were prepared by direct compression method by using different superdisintegrants. The prepared tablets were found to comply with various official...

  20. Óleo essencial de Thymus vulgaris: elaboração de enxaguatório bucal e avaliação do efeito in vitro na formação da placa bacteriana

    Santos, Rodolfo I.; Pereira, Daniel F. A.; Teodoro, Guilherme R.; Del Ciampo, Jose Orestes; Ogasawara, Mario S.; Canettieri, Antonio C.V.; Khouri, Sonia; Salvador, Marcos J.
    O objetivo deste estudo foi avaliar in vitro o efeito do óleo essencial de Thymus vulgaris (tomilho) puro ou incorporado em uma formulação farmacêutica de uso oral (enxaguatório bucal), frente ao Streptococcus mutans (ATCC 25175), determinando-se sua concentração inibitoria minima (CIM) e o efeito na formação da placa bacteriana. A CIM obtida para o óleo essencial de tomilho foi de 100 μg/mL (1 %). Procedeu-se o desenvolvimento de enxaguatório bucal com efeito antiplaca contendo o óleo essencial comercial de tomilho. As análises da formação da placa bacteriana (ensaios microbiológicos, análise macroscópica de aderência e análises por MEV) confirmaram a eficácia destas novas formulações de enxaguatórios, sem álcool,...

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