Recursos de colección

Universidad Nacional de La Plata (75.687 recursos)

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vol. 30, no. 01

Mostrando recursos 1 - 20 de 33

  1. South American medicinal flora: a promising source of novel compounds with antiprotozoal activity

    Frank, Fernanda M.; Sülsen, Valeria P.; Cazorla, Silvia I.; Anesini, Claudia; Muschietti, Liliana V.; Martino, Virginia S.
    Native populations of South America have employed herb-based preparations for the treatment of parasite diseases. In this review, some examples of South American medicinal plants from which bioactive molecules have been isolated are presented. Results of our research related to the study of novel compounds with antiprotozoal activity are also presented herein. Peruvin and psilostachyin, two sesquiterpene lactones isolated from the Argentine medicinal species Ambrosia tenuifolia, presented significative in vitro activity on Trypanosoma cruzi epimastigotes and trypomastigotes. Psilostachyin also presented in vivo activity in T. cruzi infected mice. Both compounds were also active on Leishmania spp. The results obtained suggest that psilostachyin could be considered a potential...

  2. Validation of UV spectrophotometric method for telithromycin in pharmaceutical formulations and comparison with HPLC and microbiological assay

    Vaucher, Lauren C.; Paim, Clésio S.; Lange, Alini D.; Schapoval, Elfrides E. S.
    An ultraviolet (UV) spectrophotometric method was developed for the analysis of telithromycin, member of the ketolides, in drug substance and coated tablets. The method validation yielded good results, such as the range, linearity, intra and inter-day precision, accuracy, recovery specificity, and robustness. UV spectrophotometric determinations were performed at 258 nm. Good linearity was obtained between 10.0 and 70.0/ μg mL. A prospective validation showed that the method is linear (r = 1) with precise relative standard deviation (RSD) of 0.4 %. The intra and inter-day precision values were < 2 % for all samples analyzed. The comparison between UV spectrophotometric,...

  3. Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide

    Shirote, Pramodkumar J.; Bhatia, Manish S.
    A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were characterized by IR, 1H-NMR, HRMS-FAB and elemental analysis and evaluated for anti-inflammatory activity using carrageenin- induced rat paw oedema method. Compound PJS 5 showed significant activity exhibiting comparable reduction in edema.

  4. In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

    Sayeed, Mohammed Aktar; Hasan, Raquibul; Rana, Sohel
    The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement. Job’s analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon’s plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However,...

  5. Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

    Khan, Arif-ullah; Gilani, Anwarul-Hassan
    Valeriana wallichii D.C. (Valerianaceae) is widely used in folk medicine for the treatment of hypo-motility disorder of the gut. The aim of the present study was to scientifically rationalize its usefulness in the constipation. The V. wallichii leaves crude extract, which tested positive for the presence of anthraquinones, flavonoids, saponins, sterols, tannins and terpenes caused concentration-dependent (3-10 mg/mL) contractile effect in isolated guinea-pig ileum. Pretreatment of tissues with atropine (1 μM) completely abolished the stimulatory effect of V. wallichii leaves crude extract, similar to that of acetylcholine. These results indicate that the spasmogenic effect of V. wallichii is mediated possibly...

  6. Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting

    Cheng, Yan; Yan, Chengyun; Gu, Jiwei; Wang, Xi; Huang, Zhan; Chen, Dawei
    In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studies showed that all Suc-Chi-NPs displayed high affinity to k562 cells. After intravenous injection of Suc- Chi-NPs via the tail vein, a small amount of Suc-Chi-NPs was found in liver and spleen for 4 days, whereas a negligible quantity was detected in heart and lung. The distributed amount of Suc-Chi-NPs in blood was as a high level throughout...

  7. In vitro cytotoxicity of carbon nanoparticles against Hep G 32 cells

    Anreddy, Rama N. R.; Devarakonda, Krishna R.; Vurimindi, Himabindu; Yellu, Narsimha R.
    The aim of the present study was to evaluate the in vitro toxicity of two multi wall carbon nanotubes (MWCNT) on human hepatocytes (Hep G 32 cell lines). The toxic effects of carbon nanoparticles were analyzed after 48 h of incubation with Hep G 32 cells using MTT assay and also estimated the levels of LDH (that is leakage into the media). The results of the LDH estimation demonstrated that exposure of multi wall carbon nanotubes to hepatocytes (Hep G 32) for 48 h resulted in concentration-dependent increase in LDH leakage and exhibited a significant (p < 0.05) cytotoxicity at...

  8. In vitro cytotoxicity and antibacterial activities of cephalosporin tin(II) complexes

    Anacona, Juan R.; Brito, Liangel
    Cytotoxicity and antibacterial activities of three novel tin(II) complexes containing cephalosporins: [Sn(cephalothin)Cl], [Sn(cephradine)Cl].H2O and [Sn(cefotaxime)Cl].H2O were investigated against Artemia salina (brine shrimp) and four bacterial strains. The results were compared with the activity of free cephalosporins. The coordination of cephalothin and cephradine to tin(II) ion showed an enhancement of the antibacterial activity

  9. Immunomodulating activity of Celosia argentea Linn aerial parts

    Nirmal, Sunil A.; Rub, Ruksana A.; Zaware, Bharti B.; Mandal, Subhash C.; Devhare, Subhashree V.; Dhasade, Vipul V.
    Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol and water to produce respective extracts. These extracts were screened for delayed type hypersensitivity (DTH), neutrophil adhesion test and cyclophosphamide-induced myelosuppression to assess the effect on immunity in Swiss albino mice at the dose of 50 and 100 mg/kg, i.p. Results showed significant immunomodulating activity of aqueous extract.

  10. Formulation design and evaluation of metronidazole microspheres in a bioadhesive gel for local therapy of vaginal candidiasis

    Hani, Umme; Bhat, Sudeendra R.; Shivakumar, Hosakote G.
    The purpose of this study was to design a novel vaginal delivery system composed of metronidazole microspheres dispersed within a bioadhesive gel. Microspheres were prepared by solvent evaporation method using Eudragit RS-100 and RL-100 polymers with different drug/polymer ratios. Microspheres were characterized by SEM, DSC, FT-IR and particle size analysis and evaluated for morphology, drug loading and in vitro drug release in simulated vaginal fluid. The % yield, actual drug loading and encapsulation were found to range between 79 ± 0.5 to 94 ± 0.6%, 19.6 ± 0.27 to 35.91 ± 0.66 %, 69.3 ± 0.78 to 81.2 ± 0.36 %, respectively. The FT-IR and DSC...

  11. Development and evaluation of a pharmaceutical care program to reduce modifiable risk of chronic complications in brazilian type 2 diabetic patients

    Silva, Gisleine E. C. da; Bazotte, Roberto B.
    In this study we developed and evaluated a pharmaceutical care program (PCP) to reduce modifiable risk factors of chronic complications of type 2 diabetes. Patients who acquired their anti-diabetic drugs from a Brazilian community pharmacies chain were invited to participate in the PCP. The recruited patients were monthly interviewed and information about pharmacotherapy, comorbidities, diet, physical activity, body mass index (BMI), blood pressure (BP), and waist circumference (WC) were obtained. Evaluation of glycemia, glycated hemoglobin A1c (HbA1c), and lipid profile analyses was done after the first interview and repeated every four months until finish the PCP. The 51 (91.1 %) patients who completed the PCP (12 months)...

  12. Antimicrobial activity of Alternanthera brasiliana Kuntze (Amaranthaceae): a biomonitored study

    Silva, Luciane C. da; Pegoraro, Karem A.; Pereira, Airton V.; Esmerino, Luiz A.; Cass, Quezia B.; Barison, Anderson; Beltrame, Flávio L.
    In an attempt to identify new antimicrobial compounds with potential to be used as a bactericidal/ fungicidal agent, a biomonitored study of extracts of Alternanthera brasiliana, which is used in Brazilian folk medicine as bactericidal, analgesic and anti-inflammatory, was developed. Different techniques of evaluation have been used in the partitioned extracts of the antimicrobial activity associated with chromatographic methodologies. The work led to the isolation of two substances in the ethyl acetate extract, identified as quercetin and sitosterol glycoside and the antibacterial evaluation of these substances demonstrated that the flavonoid presented antibacterial action against S. aureus. Further studies intend to identify new substances with antibacterial activity in...

  13. Evaluation of pharmaceutical services in eight cities of the Brazilian Northeast

    Souza, Leila S.; Balisa Rocha, Blicie J.; Cerqueira, Karine S.; Aguiar, Patrícia M.; Barros da Silva, Wellington; Lyra Jr., Divaldo
    This article intended to assess the Pharmaceutical Services in eight cities of the Brazilian Northeast. It was a descriptive and transversal study done between July and September of 2007. Data was gathered from the sectors of the Pharmaceutical Services Bureau, medicines delivery, and pharmacies of the Municipal Secretaries of Health-care. The assessment was based on a study instrument developed by the researchers following the indicators elaborated by the Brazilian Health Ministry. The development levels for each Pharmaceutical Services stage were measured from 1 to 3, with 3 representing the Best quality of PS. The programming and acquisition stages showed the best results. On the other hand,...

  14. Method development and validation for the determination of cabergoline in tablets by capillary zone electrophoresis

    Dogan, Aysegul; Pehlivan, Ismail; Basci, Nursabah E.
    A capillary zone electrophoresis (CZE) method has been developed for the analysis of cabergoline in its pharmaceutical preparations. Optimized analysis conditions for cabergoline analysis were performed using 110 mM pH 5.0 phosphate buffer containing 30 % acetonitrile as an electrolyte solution. Separation was performed through a fused silica capillary (50 μm i.d., total length 64.5 cm, 50.0 cm effective length) at 30 ºC with an applied voltage of 30 kV and hydrodynamic injection for 4 s. Cabergoline and internal standard verapamil were detected at a wavelength of 220 nm. The calibration was liner from 5.0 to 90.0 μg mL–1 and...

  15. Physicochemical characterization of La2(CO3)3.4H3O, a new and promising agent for the treatment of hyperphosphatemia

    Barán, Enrique José
    The synthesis of La2(CO3)3.4H2O was carefully investigated, on the basis of the thermal behavior (TG and DTA measurements) of the corresponding octahydrate, used as the precursor. The analysis of the X-ray powder diagrams of La2(CO3)3.4H2O showed that this hydrate crystallizes in the tetragonal crystal system with Z = 8. The FTIR and FT-Raman spectra of La2(CO3)3.4H2O and of La2(CO3)3.4H2O were recorded and assigned. The usefulness of the tetrahydrate for the treatment of hyperphosphatemia is briefly discussed.

  16. Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules

    Khan, Shujaat A.; Ahmad, Mahmood; Murtaza, Ghulam; Aamir, Muhammad N.; Rasool, Fatima; Raees, Muhammad A.
    Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis, morphology, micromeritics, drug content, encapsulation efficiency and drug release characteristics. All microcapsules obtained were discrete, large, free flowing and spherical in shape. The maximum encapsulation efficiency of nimesulide was up to 81.02 ± 2.10 %. Nimesulide release from microcapsules followed Higuchi model. Slow release of nimesulide from PLGA microcapsules over 12 h was observed.

  17. In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice

    Xuming, Deng; Wenhui, Qian; Xue, Shen; Na, Guo; Jingbo, Liu; Shuang, Guan; Jing, Lu
    Extracts from Ledum palustre (LP) have shown many benefit activities, while, the toxicity of extracts from LP was seldom reported. In the present study, we evaluated the genotoxicity of crude extract from LP. Our results demonstrated that the maximal tolerance dose (MTD) of LP extract was more than 30 g/kg BW in mice (oral). LP extract at doses of 2.5, 5.0 and 10.0 g/kg BW had no genotoxicity in mice and could inhibit cyclophosphamide (CP), a well known anti-tumor drug, induced genotoxicity in mice. LP extract at concentrations of 0.05 g/mL, 0.005 g/mL, and 0.0005 g/ mL had scavenging activity on O2-·in a dose-related way. It...

  18. Evaluation of pharmaceutical counseling after hospital discharge of post-surgery patients

    Lyra Jr., Divaldo; Chen, Timothy F.; Oliveira Filho, Alfredo D.; Jabbur Lopes, Monique O.; Andrade, Tâmara N. G.
    The aim of this study was to evaluate pharmaceutical counseling following hospital discharge. All subjects received pharmacist counseling before discharge in a private hospital in Aracaju-SE, Brazil, from October 2007 to February 2008. Medication adherence was measured by Haynes-Sacket and Morisky-Green-Levine scales at the end of post-discharge treatment. Post-surgery patients (n = 243) received counseling on the day of hospital discharge, while adherence was observed in 186 (76.5 %) of these patients. During the four months, the increase in adherence was observed in those patients that received the counseling: 68.7 %, 73.6 %, 82.9 % and 85.7 %, respectively. The patients were distributed according to the variables...

  19. Data identification of drug use in medical prescriptions of a private hospital at Campo Grande, Mato Grosso Do Sul, Brazil

    Ferreira, Maria B. C.; Yasunaka, Daniele S.; Queiroz, Dayane P.S.; Matos, Vanessa T.G. de; Toffoli Kadri, Mônica C.
    Rational prescription occurs when patients receive the appropriate drug in adequate dose for the necessary period of time and it represents the safest and cheaper pharmacotherapy. The aim of this study was to identify the information about drug use in medical prescriptions at a private hospital. It was prescribed 2100 medicines between March 2006 and February 2007 and 44.48 % of these were prescribed by Generic medication name. The average number of drugs per prescription was 7.42. Prescriptions of at least one injectable drug or antibiotic were found in 58,00 % and 80,20 % of prescriptions, respectively. Half of prescribed drugs were part of the National...

  20. Evaluation of hypoglycemic potential and pre-clinical toxicology of Morus nigra L. (Moraceae)

    Quintans Júnior, Lucindo José; Sá, Pedro G. S. de; Oliveira, Roniere A. de; Neves, Leonardo F.; Silva, Fabrício S.; Araújo, Edigênia C. da C.; Oliveira, Ana P. de; Guimarães, Amanda L.; Silva Almeida, Jackson R. G. da
    The hypoglycemic potential of crude ethanolic extract of leaves (CEE-Mn) of the Morus nigra L. (Moraceae) was evaluated in normoglycemic rats. CEE-Mn (200 and 400 mg/kg) and metformin (500 mg/kg) were tested on the glucose tolerance oral test. The acute toxicity of CEE-Mn was performed 2.0 g/kg intraperitoneally and 5.0 g/kg orally in Swiss mice. Blood was removed after seven days for laboratory analysis of hematological and biochemical parameters. In the glucose tolerance oral test, only metformin was able to reduce the glucose-induced hyperglycemia. Regarding acute toxicity no mortality and no toxicity signs were observed, indicating low toxicity of the extract. In the evaluation of hematological and...

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