Recursos de colección

Universidad Nacional de La Plata (74.538 recursos)

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vol. 30, no. 07

Mostrando recursos 1 - 20 de 33

  1. Vibrational spectra of tris(maltolato)gallium(III): a new interesting antitumoral agent

    Wagner, Claudia C.; Parajón Costa, Beatriz S.; Barán, Enrique José
    The FTIR and FT-Raman spectra of the gallium(III) complex of 3-hydroxy-2-methyl-4-pyrone (maltol), tris(maltolato)gallium(III), a new very promising antitumoral drug, were recorded and briefly discussed by comparison with the spectra of uncoordinated maltol and with some related species.

  2. Preparation, crystal structure and prodrug studies of genistein benzensulfonate

    Peng, You; Gan, Li- Jun; Deng, Ze-yuan
    4'-ethyl-7-phenylsulfonylgenistein (EPG, 3), a potential prodrug for genistein (1), was synthesized in high yield and its crystal structure was reported firstly. It possesses better physical and chemical properties such as solubility, lipid/water partition coefficient, LogP, and hydrolysis kinetics than its original form. The LogP value (2.07) and the half-life of the hydrolysis value (13.4 h) show that its oral bioavailability is possibly improved evidently compared with that of genistein. These results indicate that EPG can be considered a potential prodrug for genistein.

  3. Enantiomeric separation and determination of stereospecific drug release from marketed racemic omeprazole products by chiral HPLC

    Somagoni, Jagan M.; Katakam, Vinay K.; Reddy, Sunil; Gande, Suresh; Manda, Sarangapani; Yamsani, Madhusudan R.
    The objective of carrying out this research work was to investigate the effect of chirality on stereospecific dissolution of omeprazole enantiomers from various marketed racemic omeprazole products. Omeprazole is used for the treatment of gastro-duodenal ulcers and symptomatic gastro-oesophageal reflux. Dissolution of various marketed products was performed using USP type I apparatus in 0.1 N HCl for 2 h and in pH 6.8 phosphate buffer for 1 h at 100 rpm. The separation of enantiomers was done using a chiral HPLC method on CHIRAL AGP column (100 x 4.6 mm i.d.). The wavelength for UV detection was set at 210...

  4. Electroanalytical characterization of 4-nerolidylcatechol and its derivatives

    Leal, Ana Flávia V. B.; Rezende, Kênnia R.; Gil, Éric S.
    4-Nerolidylcatechol (4-NRC) is the most abundant antioxidant product isolated from the roots of Pothomorphe umbellata (L) Miq. It displays important sunscreen protection and other pharmacological properties comprising analgesic, anti-inflammatory and antimicrobial activity. However, low water solubility and chemical instability has limited its use and analysis. Therefore, chemical modifications such as silylated derivatives and inclusion complexes have been proposed. Regarding antioxidants, electrochemical investigation techniques are important tools in comprehensive characterization of phenol molecules, showing higher selectivity than spectroscopic methods. In the present study, the 4-NRC and its derivatives are characterizated by voltammetric analysis in order to support physicochemical properties of 4-NRC...

  5. Quality control of radiopharmaceutical 99mTc-MAG3

    Guimarães, Tiago Teixeira; Bordim, Augusto; Souza Albernaz, Marta de; Santos Oliveira, Ralph
    The use of mercaptoacetyltriglycine (MAG3) as a radiopharmaceutical is well known. The MAG3 is formerly called Technetium-99m (99mTc) mercaptoacetyltriglycine and it is the standard radiopharmaceuticals for renal scintilography . In this study we propose three methodologies based on the use of a new stationary phase (paper Hahnemuhle) and a mobile phase. The results showed that all the three conditions were very close, and for this reason can be interchangeable.

  6. High-performance liquid chromatographic determination of fluconazole in plasma and its application to a bioequivalence study

    Sousa, Carlos E.M.; Bedor, Danilo C. G.; Sampaio Fhilo, L. C. A.; Silva, T. M.; Bonifácio, F. N.; Albuquerque, Miracy M.; Santana, Davi P.
    A sensitive and accurate HPLC-UV method for the quantification of fluconazole (FNZ) in human plasma has been developed. The sample was prepared by liquid–liquid extraction (LLE) of FNZ from plasma using ethyl acetate. Nevirapine (NVP) was used as internal standard. The chromatographic retention times of FNZ and NVP were 3.4 and 5.7 min, respectively. The lower limit of quantitation (LLOQ) was 0.5 μg/mL, and no interferences were detected in the chromatograms. The HPLC-UV method was validated by evaluating its intra-day and inter-day precisions and accuracies in a linear concentration range between 0.5 and 8.0 μg/mL. The method was developed, validated...

  7. Synthesis and in vitro antimicrobial activity of novel hydrazide-hydrazone derivatives of dodecanoic acid

    Kumar, Mahesh; Jain, Sandeep; Deep, Aakash; Phogat, Priyanka
    Six new dodecanoic acid hydrazide-hydrazones (compounds 4a–f), unsubstituted or carrying hydroxy, methoxy, nitro and chloro groups on the benzene ring, were synthesized and tested, in vitro, for their antimicrobial activity against two Gram negative bacteria strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive bacteria strains (Bacillus subtilis and Staphylococcus aureus) and two fungal strains (Candida albicans and Aspergillus niger). The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. These hydrazone derivatives were characterized by CHN analysis, IR, and 1H NMR spectral data. All newly synthesized compounds exhibited promising results.

  8. Administration of oral solid pharmaceutical forms through enteral feeding tubes at a university hospital in southern Brazil

    Santos, Luciana dos; Jacoby, Thalita; Martinbiancho, Jacqueline K.; Almeida, Silvia H. de; Ayres, Márcio V.; Santos, María Elisa
    Besides enteral tubes are used for administration of enteral feeding, they are also alternative ways to manage drugs in patients with impaired swallowing. When the drug is not available in the oral liquid form, the extemporaneous preparations from solid oral dosage forms (SODF) function as alternative means. This study aimed to analyze the standardized solid oral dosage forms at Hospital de Clínicas de Porto Alegre (HCPA) that are at risk of obstruction and pharmacokinetics alterations when administered via probe, and the feasibility of carrying out extemporaneous preparations. The SODF in the Selection of Medications were included. 222 medications - from...

  9. Preparation, characterization and in vitro evaluation of stable mucoadhesive intranasal microsphere of L-Dopa

    Ghodke, Dhananjay S.; Naikwade, Nilofar S.
    Novel stable mucoadhesive chitosan microspheres were developed to explore the possibility of nasal delivery of L-dopa to avoid first pass metabolism and to improve therapeutic efficiency in treating the symptoms of parkinsonism. The mucoadhesive microspheres were prepared by spray drying using 23 full factorial design with inlet temperature (A), liquid feed flow rate (B), and drug to polymer concentration (C) as independent variable. Then microspheres were characterized in terms of morphology (Scanning Electron Microscopy, SEM), drug content, production yield, particle size and thermal behavior (Differential Scanning Calorimetry (DSC) and mucoadhesion test. In vitro drug release studies were performed in simulated...

  10. Inhibition of fluconazole in vitro antifungal activity in formulations containing propylene glycol

    Salerno, Claudia; Carlucci, Adriana M.; Chiappetta, Diego A.; Bregni, Carlos
    Inhibition action of propylene glycol (PG) on the antifungal activity of fluconazole has been investigated. PG was used as cosolvent and penetration enhancer in different solutions and topical dosage forms. The interaction was analyzed by comparing with Transcutol P® (TCL), another cosolvent and penetration enhancer. Solubility of the drug was evaluated in aqueous solutions containing PG or TCL and the crystallized drug was studied by both DSC and FTIR. Solutions of the drug in the solvents were studied by FTIR and UV spectroscopy. Antifungal activity was determined for solutions with several concentrations of PG/TCL and in dosage forms with PG...

  11. Factors associated with pharmaceutical expenditures by elderly people in Belo Horizonte, Brazil

    Lima, Marina G.; Ribeiro, Andréia; Rozenfeld, Suely; Klein, Carlos H.; Acurcio, Francisco de A.
    A study was carried out to analyze the factors associated with drug spending by the elderly population in Belo Horizonte, Brazil. Data were obtained using a household survey of 667 communitydwelling persons aged 60 years or older conducted in 2003. A Tobit multivariate model was used to analyze factors associated with pharmaceutical expenditures. Data from 590 respondents were used for the analysis. The mean out-of-pocket pharmaceutical expenditure was US$ 38.91. Better sociodemographic conditions, worse health conditions and greater use of health services were associated with out-of-pocket pharmaceutical expenditures by elderly people in Belo Horizonte. The out-of-pocket pharmaceutical expenditures by elderly...

  12. Effects of nonionic surfactant lauryl alcohol ethoxylated on stratum corneum alternative model biomembranes evaluated by biophysical techniques

    Baby, André R.; Lacerda, Áurea C. L.; Prestes, Paula S.; Velasco, María Valéria R.; Kawano, Yoshio; Kaneko, Telma Mary
    The influence of the nonionic surfactant lauryl alcohol ethoxylate with 12 moles ethylene oxide (LAE-12OE) was evaluated on the Stratum corneum model biomembrane (SCMM) of shed snake skin (Bothrops jararaca and Spilotes pullatus) through the biophysical techniques Fourier transform Raman spectroscopy (FT-Raman) and Fourier transform infrared photoacoustic spectroscopy (PAS-FTIR). The surfactant was used in aqueous solutions above and below the critical micelle concentration (cmc), 50.0 and 0.21 g/L, respectively. The SCMM samples were pre-treated for periods of 8 h (whole SCMM) and for 12 h (SCMM after tape stripping procedure). The LAE-12OE did not promote increase in the hydration of...

  13. Development of glutaraldehyde cross-linked metronidazole loaded chitosan microcapsules: analysis of dissolution data using DD-Solver

    Murtaza, Ghulam
    The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions with different pH nature i.e. chitosan solution in 5 % glacial acetic acid containing metronidazole and 2 M NaOH solution were employed for the induction of coacervation. Glutaraldehyde was used as cross-linking agent. Different MLCM formulations were fabricated by varying chitosan and glutaraldehyde concentrations. Dissolution data was evaluated using new software, DDSolver. Microcapsules were discrete, brown, spherical and porous. Microcapsule size range was 343.6 ± 8.9 μm – 401.9 ± 9.6 μm and...

  14. Preparation and characterization of spherical agglomerates of piroxicam

    Dixit, Mudit; Kulkarni, Parthasarathi K.
    The purpose of the present study was to prepare spherical agglomerates (SA) of piroxicam by solvent change method. Crystallization medium used for spherical agglomerates of piroxicam consisted of DMF:water and chloroform. The presence of solvents residual in SA was determined by gas chromatography and were particles were characterized by DSC, FT-IR, XRD and SEM. The respective solubility study and dissolution behavior studies were carried out. The samples were stored in stability chamber to investigate their physical stabilities. Solvents residuals in SA were found to be within the limits and exhibited decreased crystallinity of piroxicam in SA than pure piroxicam. The...

  15. Effect of total flavones of buckwheat flowers and leaves on protein tyrosine phosphatase 1B expression in type 2 diabetic rats

    Gou, Xiang- Bo; Han, Shu-Ying; Xu, Jing-Man; Yu, Hong; Chu, Jin-Xiu; Wang, Zhi- Lu; Bai, Jing; Cao, Fu-Yuan; Han, Ting
    The total flavone content was obtained from flowers and leaf of buckwheat (Fagopyrum esculentum Moench) by heating reflux method. The effects of the total flavone extract on the protein tyrosine phosphatase 1B (PTP1B) expression in type 2 diabetic rats were evaluated by immunofluorescence, western blotting and real-time quantitative PCR. The results suggested that the total flavone fraction from buckwheat flowers and leaves can significantly decrease the PTP1B expression in liver.

  16. Determination of diphenhydramine hydrochloride in rabbit plasma by LC-MS/MS and its application to a pharmacokinetic study

    Ma Jianshe; Zhang, Meiling; Shentu, Yangping; Zhang, Yuqing; Fan, Xiaofang; Gong, Yongsheng
    A sensitive and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method for determination of diphenhydramine hydrochloride in rabbit plasma was developed and validated. After addition of triazolam as internal standard (IS), protein precipitation by acetonitrile was used as sample preparation. Chromatographic separation was achieved on a Zorbax SB-C18 (2.1 mm × 50 mm, 3.5 μm) column with acetonitrile-0.1 % formic acid as mobile phase with gradient elution. Electrospray ionization (ESI) source was applied and operated in positive ion mode; multiple reaction monitoring (MRM) mode was used to quantification using target fragment ions m/z 255.8 → 166.6 for diphenhydramine hydrochloride and...

  17. Accumulation and distribution of diterpenic acids in leaves of Montanoa tomentosa

    Robles Zepeda, Ramón E.; Lozoya Gloria, Edmundo; López, Mercedes G.; Molina Torres, Jorge
    Montanoa tomentosa has been used for at least last five centuries in traditional medicine in Mexico as a remedy for reproductive impairments. The accumulation of diterpenic acids in M. tomentosa leaves was determined. Using Scanning Electron Microscopy, the type and distribution of glandular trichomes (GTs) was observed on the abaxial and adaxial sides of leaves. GTs and non-glandular trichomes (NGTs) were observed on leaf surface, but the latter are confined to the leaves abaxial side. On the adaxial surface, only non-glandular trichomes were observed. Accumulation in GTs and leaf lamina of kaurenoic (KA) and grandiflorenic (GFA) acids was determined by...

  18. Optimization and validation of the quantitative assay of flavonoids in Achyrocline satureioides and A. flaccida

    Retta, Daiana; López, Paula G.; Gattuso, Martha; Gattuso, Susana; Filip, Rosana; Ferraro, Graciela Ester; Bandoni, Arnaldo L.
    Several populations of Achyrocline satureioides and Achyrocline flaccida from Argentina, two aromatic herbal species widely used in traditional medicine in South America and both known as marcela, were analyzed. The aims of this work were to evaluate the amounts of flavonoids that characterize these species in this country and provide a quantitative assay to be included in the monograph of marcela for future Argentine Pharmacopoeia editions. The extraction method and analysis by HPLC of the main flavonoids, quercetin and 3-O-methylquercetin, were optimized. The validation parameters of the method were determined. The analysis of the different parts of these plants was...

  19. Synthesis and biological activities of novel danshensu amide derivatives as anti-myocardial ischemia agents

    Wang, Tingfang; Shu, Jingjing; Zheng, Liping; Xiong, Liyan; Wang, Jing; Jin, Lei; Wu, Qiuye; Zou, Hao; Zhang, Chuan
    A series of novel danshensu amide derivatives were synthesized, and the protective effects of all the compounds on rat myocardial cell lines H9C2 by hypoxia were investigated. The results showed that all the seven compounds could significantly increased cell viability compared with hypoxia group. Among these compounds, 3-(3,4-dimethoxyphenyl)-2-hydroxy-N-propylpropanamide (6) exhibited good activities, with cell viability reached 94.2 % compared to the normal. The novel danshensu amide derivatives, possessing an additional lipophilic alkyl chain showed a good lipophilicity.

  20. Association between the morisky medication adherence scale and medication complexity and patient prescription knowledge in primary health care

    Fröhlich, Samanta E.; Vigo, Alvaro; Mengue, Sotero Serrate
    The aim of the study was to check the association of the Morisky Medication Adherence Scale with the prescription complexity and with the patient’s level of knowledge about the prescription. A cross-sectional study was conducted by means of an interview and analysis of the prescription received by patients selected at Family Health Strategy Units. A Poisson regression model with robust variance was used to describe the association between the variables. Low adherence was significantly associated with highly complex prescriptions: Prevalence Ratio (PR) = 1.53; 95 % Confidence Interval (CI) = 1.28-1.82, in comparison with low and moderate complexity. Low adherence...

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