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Hokkaido University Collection of Scholarly and Academic Papers (54.204 recursos)
HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.

Mostrando recursos 1 - 14 de 14

1. A highly stereoselective construction of 1,2-trans-?-glycosidic linkages capitalizing on 2-azido-2-deoxy-D-glycosyl diphenyl phosphates as glycosyl donors - Tsuda, Toshifumi; Nakamura, Seiichi; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??
The scope of TMSOTf-promoted glycosidation of 2-azido-2-deoxyglycopyranosyl diphenyl phosphates is investigated.

2. Direct and stereoselective synthesis of ?-D-mannosides using 4,6-O-benzylidene-protected mannosyl diethyl phosphite as a donor - Tsuda, Toshifumi; Arihara, Ryoichi; Sato, Shinya; Koshiba, Miyuki; Nakamura, Seiichi; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??; ??, ???; ??, ??; ??, ??
A direct and practical method for the construction of ?-mannosidic linkages is described.

3. Total synthesis of zaragozic acid C by an aldol-based strategy - Nakamura, Seiichi; Sato, Hiroki; Hirata, Yuuki; Watanabe, Nobuhide; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??; ??, ??; ??, ??
A total synthesis of zaragozic acid C by a convergent strategy is described in which the key features include (1) the simultaneous creation of the C4 and C5 quaternary stereogenic centers by a Sn(OTf)2-promoted aldol coupling reaction between an ?-keto ester and a silyl ketene thioacetal derived from L- and D-tartaric acids, respectively, (2) the direct introduction of lithium acetylide as the C1 side chain equivalent onto the fully functionalized aldehyde, and (3) construction of the bicyclic core structure by acid-catalyzed internal ketalization under kinetically controlled conditions.

4. Highly Enantio- and Diastereoselective Construction of 1,2-Disubstituted Cyclopentane Compounds by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]-Catalyzed C–H Insertion Reactions of ?-Diazo Esters - Minami, Kazushi; Tsutsui, Hideyuki; Saito, Hiroaki; Nambu, Hisanori; Anada, Masahiro; Hashimoto, Shunichi; ??, ??
A highly enantio- and diastereoselective intramolecular C–H insertion reaction of ?-diazo esters has been achieved with the use of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] as a catalyst, providing exclusively cis-2-arylcyclopentane-1-carboxylates in up to 95% ee with no evidence of alkene formation.

5. Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines - Sato, Noriko; Kamada, Nobuyuki; Muromoto, Ryuta; Kawai, Taro; Sugiyama, Kenji; Watanabe, Tadashi; Imoto, Seiyu; Sekine, Yuichi; Ohbayashi, Norihiko; Ishida, Masato; Akira, Shizuo; Matsuda, Tadashi
Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site.

6. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury - Tsuruma, Kazuhiro; Nakagawa, Tadashi; Morimoto, Nobutaka; Minami, Masabumi; Hara, Hideaki; Uehara, Takashi; Nomura, Yasuyuki
Recently, we demonstrated that glucocorticoid modulatory element-binding protein 1( GMEB1) interacts with the prodomain of procaspase-2, thereby disrupting its autoactivation and the induction of apoptosis.

7. ???????????? - ??, ?; Ichikawa, Satoshi
Herbicidin B and fully protected tunicaminyluracil, which were undecose nucleoside antibiotics, were synthesized using a samarium diiodide (Sml2)mediated aldol reaction with the use of ?-phenylthioketones as enolate sources.

8. Amphidinolides B4 and B5, Potent Cytotoxic 26-Membered Macrolides from Dinoflagellate Amphidinium Species - Tsuda, Masashi; Kariya, Yuuko; Iwamoto, Rie; Fukushi, Eri; Kawabata, Jun; Kobayashi, Jun’ichi
(strain Y-100), and the structures were elucidated on the basis of detailed analyses of 2D NMRdata including 13C?13C correlations.

9. Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp. - Kubota, Takaaki; Takahashi, Ayako; Tsuda, Masashi; Kobayashi, Jun'ichi
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite,has been isolated from the cultured marine dinoflagellate Amphidinium sp., whichwas isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris.

10. Four hydrogen-bonding motifs in oligonucleotides - Minakawa, Noriaki; Kuramoto, Kazuyuki; Hikishima, Sadao; Matsuda, Akira
Part (vii): Special Issue Plenary and Invited Lectures ICHC-20.

11. Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA - Muromotoa, Ryuta; Okabea, Kanako; Fujimurob, Masahiro; Sugiyamac, Kenji; Yokosawab, Hideyoshi; Seyad, Tsukasa; Matsuda, Tadashi; ??, ?
The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associatednuclear antigen (LANA) is known to modulate viral and cellular gene expression.

12. MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains. - Fujimura, Yuiko; Iwashita, Misato; Matsuzaki, Fumio; Yamamoto, Tohru
We have identified a novel GPI-anchored IgSF molecule containing a MAM (meprin, A5 protein, PTP?) domain, named MDGA1, by screening for genes that are expressed by subpopulations of cells in the embryonic chick spinal cord.

13. Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration - Ishiyama, Haruaki; Nakamura, Yoichi; Kobayashi, Jun’ichi; ??, ??
An asymmetric synthesis of a diastereomer (2) of the structure (1) proposed for amphidinolide A, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished.

14. Dirhodium(II) tetrakis(perfluorobutyrate)-catalyzed 1,4-hydrosilylation of ?,?-unsaturated carbonyl compounds - Anada, Masahiro; Tanaka, Masahiko; Suzuki, Kanami; Nambu, Hisanori; Hashimoto, Shunichi
The use of dirhodium(II) catalysts in the 1,4-hydrosilylation of ?,?-unsaturthis process, providing the corresponding silyl enol ethers in high yields.ated ketones and aldehydes was explored.