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Hokkaido University Collection of Scholarly and Academic Papers (53,929 recursos)
HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.

Mostrando recursos 41 - 60 de 108

41. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. - Yamamoto, Tetsuya; Sekine, Yuichi; Kashima, Keiichi; Kubota, Atsuko; Sato, Noriko; Aoki, Naohito; Matsuda, Tadashi
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway.

42. The immunomodulator FTY720 is phosphorylated and released from platelets - Anada, Yoshihiro; Igarashi, Yasuyuki; Kihara, Akio
The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues.

43. RNA interference induced by siRNAs modified with 4'-thioribonucleosides in cultured mammalian cells - Hoshika, Shuichi; Minakawa, Noriaki; Kamiya, Hiroyuki; Harashima, Hideyoshi; Matsuda, Akira
Short interfering RNAs (siRNAs) variously modified with 4'-thioribonucleosides against the Photinus luciferase gene were tested for their induction of the RNA interference (RNAi) activity in cultured NIH/3T3 cells.

44. Catalytic asymmetric hetero-Diels–Alder route to a key intermediate for the synthesis of calyxin L - Washio, Takuya; Nambu, Hisanori; Anada, Masahiro; Hashimoto, Shunichi
A catalytic asymmetric formal synthesis of diarylheptanoid natural product calyxin L has been achieved by incorporating an enantio- and diastereoselective hetero-Diels-Alder (HDA) reaction, a Suzuki-Miyaura coupling, and a stereocontrolled catalytic hydrogenation of 2,4,6-trisubstituted dihydropyran as the key steps.

45. Enantioselective amination of silylketene acetals with (N-arylsulfonylimino)phenyliodinanes catalyzed by chiral dirhodium(II) carboxylates: asymmetric synthesis of phenylglycine derivatives - Tanaka, Masahiko; Kurosaki, Yasunobu; Washio, Takuya; Anada, Masahiro; Hashimoto, Shunichi
The first catalytic enantioselective amination of silylketene acetals with (N-arylsulfonylimino) phenyliodinanes is described.

46. Asymmetric syntheses of diarylheptanoid natural products (?)-centrolobine and (?)-de-O-methylcentrolobine via hetero-Diels–Alder reaction catalyzed by dirhodium(II) tetrakis[(R)-3-(benzene-fused-phthalimido)-2-piperidinonate] - Washio, Takuya; Yamaguchi, Reika; Abe, Takumi; Nambu, Hisanori; Anada, Masahiro; Hashimoto, Shunichi
Catalytic asymmetric syntheses of (-)-centrolobine and (-)-de-O-methylcentrolobine have been achieved, incorporating a hetero-Diels-Alder (HDA) reaction between 4-aryl-2-silyloxy-1,3-butadienes and phenylpropargyl aldehyde derivatives as a key step.

47. UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides - Hori, Mika; Ishiguro, Chieko; Suzuki, Tetsuya; Nakagawa, Noriko; Nunoshiba, Tatsuo; Kuramitsu, Seiki; Yamarnoto, Kazuo; Kasai, Hiroshi; Harashima, Hideyoshi; Kamiya, Hiroyuki
in this study, to examine whether a nucleotide excision repair enzyme, Escherichia coli UvrABC, could suppress the mutations induced by oxidized deoxyribonucleotides in vivo, oxidized DNA precursors, 8-hydroxy-2'-deoxyguanosine 5'-triphosphate and 2-hydroxy-2'-deoxyadenosine 5'-triphosphate, were introduced into uvrA, uvrB, and uvrC E.

48. Base excision repair enzyme endonuclease III suppresses mutagenesis caused by 8-hydroxy-dGTP - Suzuki, Tetsuya; Yamamoto, Kazuo; Harashima, Hideyoshi; Kamiya, Hiroyuki
To examine whether base excision repair suppresses mutations induced by oxidized deoxyribonucleotide 5?-triphosphates in the nucleotide pool, 8-hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP were introduced into Escherichia coli strains deficient in endonucleases III (Nth) and VIII (Nei) and MutY, and mutations in the chromosomal rpoB gene were analyzed.

49. A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes - Kaneko, Masayuki; Yasui, Saori; Niinuma, Yoshifumi; Arai, Kiho; Omura, Tomohiro; Okuma, Yasunobu; Nomura, Yasuyuki
Human HRD1 and SEL1 are components of endoplasmic reticulum-associated degradation (ERAD), which is a retrograde transport mechanism from the ER to the cytosol for removing unfolded proteins.

50. Uptake of 3,4-methylenedioxymethamphetamine and its related compounds by a proton-coupled transport system in Caco-2 cells - Kuwayama, Kenji; Inoue, Hiroyuki; Kanamori, Tatsuyuki; Tsujikawa, Kenji; Miyaguchi, Hajime; Iwata, Yuko; Miyauchi, Seiji; Kamo, Naoki; Kishi, Tohru
3,4-Methylenedioxymethamphetamine (MDMA) is an illegal amphetamine-type stimulant (ATS) that is abused orally in the form of tablets for recreational purposes.

51. Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats - Itagaki, Shirou; Chiba, Makoto; Kobayashi, Masaki; Sugawara, Mitsuru; Kobayashi, Michlya; Hirano, Takeshi; Iseki, Ken
It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats.

52. DUSP22/LMW-DSP2 regulates estrogen receptor-?-mediated signaling through dephosphorylation of Ser-118 - Sekine, Yuichi; Ikeda, Osamu; Hayakawa, Yoshihiro; Tsuji, Satoshi; Imoto, Seiyu; Aoki, Naohito; Sugiyama, Kenji; Matsuda, Tadashi
(ER?)-positive breast cancer cells, while E2-induced phosphorylation and activation of ER.

53. Catalytic Enantioselective Aziridination of Alkenes Using Chiral Dirhodium(II) Carboxylates - Yamawaki, Minoru; Tanaka, Masahiko; Abe, Takumi; Anada, Masahiro; Hashimoto, Shunichi
The enantioselective aziridination of alkenes with [N-(4-nitrophenylsulfonyl)imino]phenyliodinane catalyzed by dirhodium(II) tetrakis[N-tetrachlorophthaloyl-(S)-tert-leucinate], Rh2(S-TCPTTL)4, is described.

54. Enantioselective Synthesis of 3-Arylindan-1-ones via Intramolecular C-H Insertion Reactions of ?-Diazo-?-Ketoesters Catalyzed by Chiral Dirhodium(II) Carboxylates - Natori, Yoshihiro; Anada, Masahiro; Nakamura, Seiichi; Nambu, Hisanori; Hashimoto, Shunichi
A new, catalytic enantioselective route to 3-arylindan-1-ones, versatile intermediates for the synthesis of a number of bioactive and pharmaceutically interesting molecules, was developed by exploiting the chiral dirhodium(II) complex-catalyzed intramolecular C-H insertion reaction of ?-diazo-?-ketoesters as a key step.

55. Enantioselective Intramolecular C-H Amidation of Sulfamate Esters Catalyzed by Chiral Dirhodium(II) Carboxylates - Yamawaki, Minoru; Kitagaki, Shinji; Anada, Masahiro; Hashimoto, Shunichi
The chiral dirhodium(II) carboxylate-catalyzed enantioselective intramolecular C-H amidation reaction of sulfamate esters via in situ generated iminoiodinanes is described.

56. Dirhodium(II) Tetrakis[N-benzene-fused Phthaloyl-(S)-piperidinonate] as a Chiral Lewis Acid: Catalytic Enantioselective Aldol Reactions of Acetate-derived Silylketene Acetals and Aldehydes - Washio, Takuya; Nakamura, Seiichi; Anada, Masahiro; Hashimoto, Shunichi
A first example of chiral dirhodium(II) complex-catalyzed enantioselective Mukaiyama aldol reactions is described.

57. MITO-Porter : a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion - Yamada, Yuma; Akita, Hidetaka; Kamiya, Hiroyuki; Kogure, Kentaro; Yamamoto, Takenori; Shinohara, Yasuo; Yamashita, Kikuji; Kobayashi, Hideo; Kikuchi, Hiroshi; Harashima, Hideyoshi
Mitochondrial dysfunction is implicated in a variety of human diseases, including cancer and neurodegenerative disorders.

58. The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction - Ohbayashi, Norihiko; Kawakami, Shiho; Muromoto, Ryuta; Togi, Sumihito; Ikeda, Osamu; Kamitani, Shinya; Sekine, Yuichi; Honjoh, Tsutomu; Matsuda, Tadashi
Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML.

59. KAP1 regulates type I interferon/STAT1-mediated IRF-1 gene expression - Kamitani, Shinya; Ohbayashi, Norihiko; Ikeda, Osamu; Togi, Sumihito; Muromoto, Ryuta; Sekine, Yuichi; Ohta, Kazuhide; Ishiyama, Hironobu; Matsuda, Tadashi
Recently, we showed that KAP1 is a novel STAT-binding partner that regulates STAT3-mediated transactivation.

60. Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-? signaling - Imoto, Seiyu; Ohbayashi, Norihiko; Ikeda, Osamu; Kamitani, Shinya; Muromoto, Ryuta; Sekine, Yuichi; Matsuda, Tadashi
Sma- and MAD-related protein 3 (Smad3) plays crucial roles in the transforming growth factor-.

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