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Hokkaido University Collection of Scholarly and Academic Papers (54,094 recursos)
HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.

Mostrando recursos 61 - 80 de 112

61. An RNA biding protein, Y14 interacts with and modulates STAT3 activation - Ohbayashi, Norihiko; Taira, Naohisa; Kawakami, Shiho; Togi, Sumihito; Sato, Noriko; Ikeda, Osamu; Kamitani, Shinya; Muromoto, Ryuta; Sekine, Yuichi; Matsuda, Tadashi
Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors via specific tyrosine phosphorylation, dimerization and nuclear translocation.

62. Physical and functional interactions between ZIP kinase and UbcH5 - Ohbayashi, Norihiko; Okada, Katsuya; Kawakami, Shiho; Togi, Sumihito; Sato, Noriko; Ikeda, Osamu; Kamitani, Shinya; Muromoto, Ryuta; Sekine, Yuichi; Kawai, Taro; Akira, Shizuo; Matsuda, Tadashi
Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown.

63. Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+ binding protein Csg2 - Uemura, Satoshi; Kihara, Akio; Iwaki, Soichiro; Inokuchi, Jin-ichi; Igarashi, Yasuyuki
One of the yeast complex sphingolipids, mannosylinositol phosphorylceramide (MIPC), is produced by the redundant inositol phosphorylceramide (IPC) mannosyltransferases Csg1 and Csh1.

64. Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes - Ito, Kiyoharu; Anada, Yoshihiro; Tani, Motohiro; Ikeda, Mika; Sano, Takamitsu; Kihara, Akio; Igarashi, Yasuyuki
Platelets are known to store a large amount of the bioactive lipid molecule sphingosine 1-phosphate (S1P) and to release it into the plasma in a stimuli-dependent manner.

65. STAP-2 Negatively Regulates both Canonical and Noncanonical NF-?B Activation Induced by Epstein-Barr Virus-Derived Latent Membrane Protein 1 - Ikeda, Osamu; Sekine, Yuichi; Yasui, Teruhito; Oritani, Kenji; Sugiyma, Kenji; Muromoto, Ryuta; Ohbayashi, Norihiko; Yoshimura, Akihiko; Matsuda, Tadashi
The signal-transducing adaptor protein 2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH) and Src homology 2 (SH2)-like domains, as well as a proline-rich domain in its C-terminal region.

66. Mutations Induced by Oxidized DNA Precursors and Their Prevention by Nucleotide Pool Sanitization Enzymes - Kamiya, Hiroyuki
8-Hydroxy-dGTP (8-OH-dGTP) and 2-hydroxy-dATP (2-OH-dATP) have been identified as the major products of in vitro oxidation reactions with Fe2+.

67. Transient activation of transgene expression by hydrodynamics-based injection may cause rapid decrease in plasmid DNA expression - Ochiai, Hiroshi; Fujimuro, Masahiro; Yokosawa, Hideyoshi; Harashima, Hideyoshi; Kamiya, Hiroyuki
The intranuclear disposition of exogenous DNA is quite important for the therapeutic effects of the administered DNA.

68. Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice - Ikeda, Osamu; Sekine, Yuichi; Muromoto, Ryuta; Ohbayashi, Norihiko; Yoshimura, Akihiko; Matsuda, Tadashi
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein as a c-Fms/M-CSF receptor-interacting protein and constitutively expressed in macrophages.

69. A highly stereoselective construction of 1,2-trans-?-glycosidic linkages capitalizing on 2-azido-2-deoxy-D-glycosyl diphenyl phosphates as glycosyl donors - Tsuda, Toshifumi; Nakamura, Seiichi; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??
The scope of TMSOTf-promoted glycosidation of 2-azido-2-deoxyglycopyranosyl diphenyl phosphates is investigated.

70. Direct and stereoselective synthesis of ?-D-mannosides using 4,6-O-benzylidene-protected mannosyl diethyl phosphite as a donor - Tsuda, Toshifumi; Arihara, Ryoichi; Sato, Shinya; Koshiba, Miyuki; Nakamura, Seiichi; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??; ??, ???; ??, ??; ??, ??
A direct and practical method for the construction of ?-mannosidic linkages is described.

71. Total synthesis of zaragozic acid C by an aldol-based strategy - Nakamura, Seiichi; Sato, Hiroki; Hirata, Yuuki; Watanabe, Nobuhide; Hashimoto, Shunichi; ??, ??; ??, ??; ??, ??; ??, ??; ??, ??
A total synthesis of zaragozic acid C by a convergent strategy is described in which the key features include (1) the simultaneous creation of the C4 and C5 quaternary stereogenic centers by a Sn(OTf)2-promoted aldol coupling reaction between an ?-keto ester and a silyl ketene thioacetal derived from L- and D-tartaric acids, respectively, (2) the direct introduction of lithium acetylide as the C1 side chain equivalent onto the fully functionalized aldehyde, and (3) construction of the bicyclic core structure by acid-catalyzed internal ketalization under kinetically controlled conditions.

72. Highly Enantio- and Diastereoselective Construction of 1,2-Disubstituted Cyclopentane Compounds by Dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate]-Catalyzed C–H Insertion Reactions of ?-Diazo Esters - Minami, Kazushi; Tsutsui, Hideyuki; Saito, Hiroaki; Nambu, Hisanori; Anada, Masahiro; Hashimoto, Shunichi; ??, ??
A highly enantio- and diastereoselective intramolecular C–H insertion reaction of ?-diazo esters has been achieved with the use of dirhodium(II) tetrakis[N-phthaloyl-(S)-tert-leucinate] as a catalyst, providing exclusively cis-2-arylcyclopentane-1-carboxylates in up to 95% ee with no evidence of alkene formation.

73. PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells - Hyoda, Kanae; Hosoi, Toru; Horie, Naohiro; Okuma, Yasunobu; Ozawa, Koichiro; Nomura, Yasuyuki; ??, ??
Stress signals that impair the function of the endoplasmic reticulum (ER) can lead to an accumulation of unfolded proteins in the ER causing cell death.

74. Non-linear pharmacodynamics in a non-viral gene delivery system: Positive non-linear relationship between dose and transfection efficiency - Moriguchi, Rumiko; Kogure, Kentaro; Iwasa, Akitada; Akita, Hidetaka; Hideyoshi, Harashima; ??, ??
http://www.elsevier.com/wps/find/journaldescription.cws_home/502690/description.

75. Ascidian sperm receptor attached to the vitelline coat during oocyte maturation - Sawada, H.; Tanaka, E.; Abe, Y.; Takizawa, S.; Takahashi, Y.; Fujino, J.; Yokosawa, H.; ??, ?
Supplement : Copyright © (2000) Cambridge University Press.

76. ?????????? : ????(II)???????????? - ??, ??; ??, ??; ??, ??
????????????????????????????????????????????????????????????????????????????????????????????????????????3-?????-3-???????????A (HMG-CoA) ??????????????????????????????????????????????????????????????????????????????????????????(3).

77. Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines - Sato, Noriko; Kamada, Nobuyuki; Muromoto, Ryuta; Kawai, Taro; Sugiyama, Kenji; Watanabe, Tadashi; Imoto, Seiyu; Sekine, Yuichi; Ohbayashi, Norihiko; Ishida, Masato; Akira, Shizuo; Matsuda, Tadashi
Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site.

78. Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the ?-subunit of coatomer complex, ?-COP - Hata, Shoji; Koyama, Suguru; Kawahara, Hiroyuki; Doi, Naoko; Maeda, Tatsuya; Toyama-Sorimachi, Noriko; Abe, Keiko; Suzuki, Koichi; Sorimachi, Hiroyuki
nCL-2/calpain-8a was identified as a stomach-specific calpain, whose physiological functions are unclear.

79. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury - Tsuruma, Kazuhiro; Nakagawa, Tadashi; Morimoto, Nobutaka; Minami, Masabumi; Hara, Hideaki; Uehara, Takashi; Nomura, Yasuyuki
Recently, we demonstrated that glucocorticoid modulatory element-binding protein 1( GMEB1) interacts with the prodomain of procaspase-2, thereby disrupting its autoactivation and the induction of apoptosis.

80. Significant and prolonged antisense effect of a multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide - Nakamura, Yoshio; Kogure, Kentaro; Yamada, Yuma; Futaki, Shiroh; Harashima, Hideyoshi; ??, ???
Three types of R8-MENDs were prepared, co-encapsulating luciferase-encoding pDNA and antiluciferase oligodeoxynucleotide (ODN) condensed by three polycations, stearyl octaarginine (STR-R8), poly-L-lysine (PLL) and protamine, and the antisense effects of the ODN-encapsulated R8-MENDs (ODN-MEND) were analysed in-vitro.

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