Hokkaido University Collection of Scholarly and Academic Papers
(70.741 recursos)
HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.
Mostrando recursos 1 - 6 de 6
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Examination of the Lunatic fringe and Uncx4.1 expression by whole-mount in situ hybridization in the embryo of the CKH-Jsr（jumbled spine and ribs）mouse - OKANO, Shinya; ASANO, Atsushi; SASAKI, Nobuya; KON, Yasuhiro; WATANABE, Tomomasa; AGUI, Takashi
The CKH-Jsr (jumbled spine and ribs) mouse was found as a spontaneous mutant with malformation of vertebrae, that is, a short trunk and kinky tail.We examined Lunatic Fringe (Lfng) and Uncx4.1 expression in the presomitic mesoderm (PSM) and somites of Jsr-mutant (CKH-Jsr/+) embryos to elucidate pathogenesis of the Jsr mutation. Expression pattern of Lfng in the PSM of Jsr-mutant embryos was similar to that of the normal (C57BL/6) embryos. However, expression pattern of Uncx4.1 in the somites of Jsrmutant embryos was impaired to be irregular and mosaic, suggesting that the anterior-posterior (A-P) polarity is disordered in the Jsr mutant. These...
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Viral and bacterial diseases in livestock in Mongolia - ODONTSETSEG, Namsraijav; MWEENE, Aaron S.; KIDA, Hiroshi
This review focuses on the status of infectious diseases that are serious for animal health and have adverse economic effects in Mongolia. Data presented here are limited due to the lack of published or other easily available documents. Foot-and-mouth disease continues to cause substantial economic losses as exemplified by the outbreak of infection with serotype O PanAsia lineage virus. In the case of the 2001 outbreak, a 65% reduction in export revenues was recorded. In order to ascertain the free status of Mongolia from rinderpest, sero-epidemiological surveillance has been carried out since 2001.
In 2004, Mongolia was certified free from...
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Effect of components of green tea extracts, caffeine and catechins on hepatic drug metabolizing enzyme activities and mutagenic transformation of carcinogens - NIKAIDOU, Satoshi; ISHIZUKA, Mayumi; MAEDA, Yutaka; HARA, Yukihiko; KAZUSAKA, Akio; FUJITA, Shoichi
Green tea contains catechins and caffeine as major constituents. Treatment of rats with green tea (2.5% w/v) significantly increased 7-ethoxycoumarin O-deethylase (7-ECOD), caffeine N-1demethylase (CN1D) and UDP-glucuronyltransferase (UGT) activities. Treatment with caffeine similarly activated CYP1A2 and related monooxygenases as well as UGT, while treatment with catechins induced UGT activity but not 7-ECOD or CN1D activity. Numbers of benzo［a］pyrene(BP)-induced revertant colonies in an Ames test (mutation assay) with S. typhimurium TA98 as the test strain were markedly larger when BP was preincubated with the liver S-9 (9000×g supernatant of liver homogenate) from green tea-treated rats than when preincubated with that from...
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Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA 98 elicited by benzo［a］pyrene and oxidative DNA lesions in V 79 hamster lung cells - El. Bohi, Khlood M.; Sabik, Laila; Muzandu, Kaampwe; Shaban, Zein; Soliman, Mohamed; Ishizuka, Mayumi; Kazusaka, Akio; Fujita, Shoichi
Pleurotus cornucopiae (PC) mushroom with a brilliant yellow pileus is found in the field and known in Japan as Tamogi dake mushroom. The purpose of this paper is to investigate the mechanism of the antimutagenic effect of PC mushroom using both the Ames test and Comet assay. We have found a strong inhibitory effect of both aqueous and organic PC extracts on the mutagenicity elicited by benzo［a］pyrene (B［a］P), This inhibition was dosedependent in reaction mixtures containing cytosolic and microsomal fractions (S-9) from untreated rat liver as well as in those containing S-9 from aryl hydrocarbon receptor (Ah) ligand of Sudan...
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Lycopene and beta-carotene ameliorate catechol estrogen-mediated DNA damage - Muzandu, Kaampwe; El. Bohi, Khlood; Shaban, Zein; Ishizuka, Mayumi; Kazusaka, Akio; Fujita, Shoichi
The consumption of fruits and vegetables is associated with a reduced risk of various ailments, including cancer and cardiovascular diseases. Carotenoids, such as lycopene and beta-carotene, are natural constituents of edible plants and may protect against disease. In this study, the influence of lycopene and beta-carotene on DNA damage caused by catechol-estrogens in vitro is examined. One possible mechanism by which catechol estrogens such as 4-hydroxyestradiol (4-OHE2) and 2-hydroxyestradiol, which cause DNA damage in naked plasmid DNA as well as in cells, contributing to the process of carcinogenesis, is through the generation of reactive oxygen species. It was found that...
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