VERBRUGGE, Frederik; GRIETEN, Lars; MULLENS, Wilfried
Background: The management of the cardiorenal syndrome (CRS) in decompensated heart failure (HF) is challenging, with high-quality evidence lacking. Summary: The pathophysiology of CRS in decompensated HF is complex, with glomerular filtration rate (GFR) and urine output representing different aspects of kidney function. GFR depends on structural factors (number of functional nephrons and integrity of the glomerular membrane) versus hemodynamic alterations (volume status, renal perfusion, arterial blood pressure, central venous pressure or intra-abdominal pressure) and neurohumoral activation. In contrast, urine output and volume homeostasis are mainly a function of the renal tubules. Treatment of CRS in decompensated HF patients should...
Duchenne, Jurgen; VERBRUGGE, Frederik; DUPONT, Matthias; Vercammen, Jan; Jacobs, Linda; GRIETEN, Lars; VANDERVOORT, Pieter; MULLENS, Wilfried
Objective The objective of this study was to assess the feasibility and impact on readmissions of transmural disease management across the borders of the cardiology department in patients with advanced heart failure (HF). Methods and results Consecutive patients, readmitted within one year for advanced HF by a dedicated specialist (n = 55), were followed for 22 10 months after implementation of a hospitalwide transmural disease management strategy. Participants received a tag in their electronic medical record, triggering a HF caregiver contact, with subsequent guideline-recommended, protocol-driven care on each cardiac or non-cardiac hospitalization as well as outpatient evaluation. Upon transition to...
Puttevils, Daisy; DE VUSSER, Philip; GEUSENS, Piet; DENS, Jo
Patients with established rheumatoid arthritis (RA) have a higher cardiovascular morbidity and mortality in comparison with the general population. It is considered to be an independent risk factor for cardiovascular disease. The purpose of this article is to describe the mechanisms responsible for accelerated atherogenesis in RA patients and to give an overview of the effects of different RA therapies (methotrexate, TNF antagonists and other biologicals).
Singh, Sally J.; SPRUIT, Martijn A.; Troosters, Thierry; Holland, Anne E.
RAVINDRAN NAIR, Ambily; SMEETS, Karen; KEUNEN, Els; Lee, Wing-Kee; Thévenod, Frank; VAN KERKHOVE, Emmy; CUYPERS, Ann
Cadmium (Cd) is a toxic metal with a long half-life in biological systems. This half-life is partly as a result of metallothioneins (MTs), metal-binding proteins with a high affinity for Cd. The high retention properties of the kidneys reside in proximal tubular cells that possess transport mechanisms for Cd-MT uptake, ultimately leading to more Cd accumulation. Researchers have studied MT–metal interactions using various techniques including quantitative real-time PCR (qPCR), an efficient tool for quantifying gene expression. Often a poor choice of reference genes, which is represented by their instability and condition dependency, leads to inefficient normalization of gene expression data...
Ravindran Nair, Ambily; Lee, Wing-Kee; Smeets, Karen; Swennen, Quirine; Sanchez, Amparo; Thévenod, Frank; Cuypers, Ann
Cadmium (Cd2+) induces oxidative stress that ultimately defines cell fate and pathology. Mitochondria are the main energy-producing organelles in mammalian cells, but they also have a central role in formation of reactive oxygen species, cell injury, and death signaling. As the kidney is the major target in Cd2+ toxicity, the roles of oxidative signature and mitochondrial function and biogenesis in Cd2+-related stress outcomes were investigated in vitro in cultured rat kidney proximal tubule cells (PTCs) (WKPT-0293 Cl.2) for acute Cd2+ toxicity (1–30 µM, 24 h) and in vivo in Fischer 344 rats for sub-chronic Cd2+ toxicity (1 mg/kg CdCl2 subcutaneously,...
Storms, Hannelore; Marquet, Kristel; Nelissen, Katherine; Hulshagen, Leen; Lenie, Jan; Remmen, Roy; Claes, Neree
Background: An accurate medication overview is essential to reduce medication errors. Therefore, it is essential to keep the medication overview up-to-date and to exchange healthcare information between healthcare professionals and patients. Digitally shared information yields possibilities to improve communication. However, implementing a digitally shared medication overview is challenging. This articles describes the development process of a secured, electronic platform designed for exchanging medication information as executed in a pilot study in Belgium, called “Vitalink”.
Findings: The goal of “Vitalink” is to improve the exchange of medication information between professionals working in healthcare and patients in order to achieve a more efficient...
Storms, Hannelore; Claes, Neree; Hulshagen, Leen; Conings, Stefanie; Nelissen, Katherine
Medicatiemanagement vereist een goede communicatie tussen zorgverleners intra- en transmuraal.
In deze studie wordt nagegaan of een papieren medicatieschema de communicatie tussen zorgverleners van de eerste en tweede lijn in Zuidoost-Limburg verbetert.
In deze regio werd een papieren medicatieschema geïmplementeerd.
Via een voor- en na-bevraging bij deelnemende zorgverleners werd het potentieel van het papieren medicatieschema nagegaan. De verwachtingen, de bevindingen en het gebruik van dit schema werden bevraagd.
Als belangrijkste valkuilen worden tijdsinvestering van zorgverleners en de medewerking van patiënten genoteerd.
Een papieren medicatieschema blijkt voornamelijk te worden gebruikt om medicatiefouten te reduceren.
Daarnaast zien slechts enkele zorgverleners het potentieel van een papieren medicatieschema als instrument...
Teuns, Greet B. A.; Geys, Helena; Geuens, Sonja M. A.; STINISSEN, Piet; Meert, Theo F.
Objectives: Preclinical abuse liability assessment of novel clinical CNS-active candidates involves several tests, addressing different aspects characteristic for abuse potential, which are considered predictive for substance abuse of these candidates, thus ensuring an appropriate translational approach. To demonstrate how such a strategy could work, a known drug of abuse, methylphenidate was evaluated in a full rodent test battery, comprising four test models, and in accordance with the requirements of the FDA, ICH and EMA guidelines. Methods: Methylphenidate was tested orally at 2.5, 5 or 10 mg/kg for its physical dependence potential in a repeated dose non-precipitated withdrawal test, for its...
ARAIN, Amber; ROBAEYS, Geert; St??ver, Heino
Globally, over 10 million people are held in prisons and other places of detention at any given time. People who inject drugs (PWID) comprise 10-48% of male and 30-60% of female prisoners. The spread of hepatitis C in prisons is clearly driven by injection drug use, with many infected prisoners unaware of their infection status. Risk behaviour for acquisition of hepatitis C via common use of injecting equipment is widespread in many prison settings. In custodial settings, effective and efficient prevention models applied in the community are very rarely implemented. Only approximately 60 out of more than 10,000 prisons worldwide...
WENS, Inez; Dalgas, Ulrik; VANDENABEELE, Frank; Krekels, Maartje; Grevendonk, Lotte; EIJNDE, OP 'T Bert
Background: The impact of multiple sclerosis (MS) on skeletal muscle characteristics, such as muscle fiber cross sectional
area (CSA), fiber type proportion, muscle strength and whole muscle mass, remains conflicting.
Methods: In this cross sectional study, body composition and muscle strength of the quadriceps were assessed in 34 MS
(EDSS: 2.560.19) patients and 18 matched healthy controls (HC). Hereafter a muscle biopsy (m.vastus lateralis) was taken.
Results: Compared to HC, mean muscle fiber CSA of all fibers, as well as CSA of type I, II and IIa fibers were smaller and
muscle strength of the quadriceps was lower in MS patients. Whole body composition was...
van Zwieten, Koos Jaap; Lambrichts, Ivo; de Bakker, Bernadette S.; Kosten, Lauren; De Munter, Stephanie; Gervois, Pascal; Schmidt, Klaus P.; Helder, Paul; Lippens, Peter L.
To gain more insight into the morphogenesis of synovial joints, as well as into pathogeneses of joint diseases like Rheumatoid Arthritis (RA) and possibly also Osteoarthritis (OA), we surveyed human finger joint ontogeny from early developmental stages. In adult interphalangeal joints, dorsal and palmar but also ulnar and radial synovial folds do persist. During adult life, synovial membranes as well as synovial folds (e.g., after micro-damage) may elicit chronic inflammatory processes that eventually lead to arthritis. In proximal interphalangeal (PIP) joint proper collateral ligaments (PCL), we found neurofilaments and oval-shaped lamellated corpuscles (?? ??? 120 ??). Supposedly acting as mechanoreceptors,...
LEMMENS, Stefanie; Brône, Bert; Dooley, Dearbhaile; HENDRIX, Sven; Geurts, Nathalie
Many researchers have attempted to pharmacologically modulate the adrenergic system to control locomotion, pain, and spasms after central nervous system (CNS) trauma, although such efforts have led to conflicting results. Despite this, multiple studies highlight that α-adrenoceptors (α-ARs) are promising therapeutic targets because in the CNS, they are involved in reactivity to stressors and regulation of locomotion, pain, and spasms. These functions can be activated by direct modulation of these receptors on neuronal networks in the brain and the spinal cord. In addition, these multifunctional receptors are also broadly expressed on immune cells. This suggests that they might play a...
DOOLEY, Dearbhaile; LEMMENS, Evi; VANGANSEWINKEL, Tim; LEMMENS, Stefanie; De Vocht, Nathalie; Le Blon, Debbie; Ponsaerts, Peter; HENDRIX, Sven
THEWISSEN, Kristof; HENDRIKS, Jerome; STINISSEN, Piet; Slaets, Leen; HELLINGS, Niels
DE BOCK, Laura; SOMERS, Klaartje; FRAUSSEN, Judith; Hendriks, Jerome J. A.; VAN HORSSEN, Jack; ROUWETTE, Myrthe; HELLINGS, Niels; Villar, Luisa M.; Alvarez-Cermeno, Jose C.; Hupperts, Raymond; Jongen, Peter; Damoiseaux, Jan; Verbeek, Marcel M.; De Deyn, Peter P.; D'hooghe, Marie; Van Wijmeersch, Bart; Stinissen, Piet; Somers, Veerle
JANSSENS, Kris; Van den Haute, Chris; Baekelandt, Veerle; VAN HORSSEN, Jack; VAN WIJMEERSCH, Bart; STINISSEN, Piet; Hendriks, Jerome J. A.; Slaets, Leen; HELLINGS, Niels
Heesen, Christoph; Bruce, Jared; FEYS, Peter; Sastre-Garriga, Jaume; Solari, Alessandra; Eliasson, Lina; Matthews, Vicki; Hausmann, Bettina; Ross, Amy Perrin; Asano, Miho; Imonen-Charalambous, Kaisa; K??pke, Sascha; Clyne, Wendy; Bissell, Paul
Background: Adherence to medical interventions is a global problem. With an increasing amount of partially effective but expensive drug treatments adherence is increasingly relevant in multiple sclerosis (MS). Perceived lack of efficacy and side effects as well as neuropsychiatric factors such as forgetfulness, fatigue and depression are major determinants. However, research on adherence to behavioural interventions as part of rehabilitative interventions has only rarely been studied. Methods: In a one-day meeting health researchers as well as patient representatives and other stakeholders discussed adherence issues in MS and developed a general draft research agenda within a focus group session. Results: The...
POLITIS, Constantinus; LAMBRICHTS, Ivo; SUN, Yi; Vrielinck, Luc; Schepers, Serge; Agbaje, Jimoh Olubanwo
This study was aimed to investigate a modified buccal osteotomy technique and whether the integrity of the lingual part of the lower border influences the attachment of the neurovascular bundle to the proximal segment of the mandible during a sagittal split osteotomy without increasing the number of bad splits. The presence of self-reported sensibility disturbance in the lower lip at the last follow-up visit was assessed. This study included 220 and 133 patients with bilateral sagittal split osteotomy undergoing the classical and the new modified buccal osteotomy techniques, respectively. In the new technique, the lower border is divided into a...
THIJS, Sofie; Van Dillewijn, Pieter; SILLEN, Wouter; TRUYENS, Sascha; HOLTAPPELS, Michelle; D'HAEN, Jan; CARLEER, Robert; WEYENS, Nele; AMELOOT, Marcel; Ramos, Juan-Luis; VANGRONSVELD, Jaco
Background and aims Numerous microorganisms have been isolated from trinitrotoluene (TNT)-contaminated soils, however TNT tends to persist, indicating that the microbial biomass or activity is insufficient for degradation. Deep-rooting trees at military sites have been found to take-up contaminants from groundwater, and the extensive root and endosphere provide ideal niches for microbial TNT-transformations. Methods We characterised the rhizosphere, root endosphere and endo-phyllosphere bacteria of Acer pseudoplatanus growing at a historically TNT-contaminated location, using 16S rRNA gene fingerprinting, bacteria isolation, oxidoreductase gene-cloning, in planta growth-promotion (PGP) tests, inoculation, plant physiology measurements and microscopy. Results Based on terminal-restriction-fragment-length-polymorphism analysis, bulk soil and...