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Enlighten (154.243 recursos)

Enlighten is the University of Glasgow's institutional repository service for published research material including peer-reviewed journal articles, published conference papers,books and book chapters

Status = In Press

Mostrando recursos 1 - 20 de 1.294

  1. Planning and Profits: The Military-Industrial Complex and British Naval Arms Manufacture, 1918-41

    Miller, Christopher
    In a time of great need for Britain, a small coterie of infl uential businessmen gained access to secret information on industrial mobilisation as advisers to the Principal Supply Offi cers Committee. They provided the state with priceless advice, but, as ‘insiders’ utilised their access to information to build a business empire at a fraction of the normal costs. Outsiders, in contrast, lacked infl uence and were forced together into a defensive ‘ring’ – or cartel – which eff ectively fi xed prices for British warships. By the 1930s, the cartel grew into one of the most sophisticated profiteering groups of its day. This book examines the relationship...

  2. Keeping it off: the challenge of weight-loss maintenance

    Lean, Michael; Hankey, Catherine
    No abstract available.

  3. Steroid regulation: an overlooked aspect of tolerance and chronic rejection in kidney transplantation

    Christakoudi, Sofia; Runglall, Manohursingh; Mobillo, Paula; Rebollo-Mesa, Irene; Tsui, Tjir-Li; Nova-Lamperti, Estefania; Norris, Sonia; Kamra, Yogesh; Hilton, Rachel; Bhandari, Sunil; Baker, Richard; Berglund, David; Carr, Sue; Game, David; Griffin, Sian; Kalra, Philip A.; Lewis, Robert; Mark, Patrick B.; Marks, Stephen D.; MacPhee, Iain; McKane, William; Mohaupt, Markus G.; Pararajasingam, Ravi; Kon, Sui Phin; Serón, Daniel; Sinha, Manish; Tucker, Beatriz; Viklický, Ondrej; Lechler, Robert I.; Lord, Graham M.; Stahl, Dabuek; Hernandez-Fuentes, Maria P.
    Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared. Healthy controls (n = 14) were used as reference. The anti-inflammatory glucocorticoid receptor (NR3C1) and the cortisol-activating HSD11B1 and H6PD genes were up-regulated in CR and were lowest in tolerant patients. The pro-inflammatory mineralocorticoid gene (NR3C2) was downregulated in stable and...

  4. LDL cholesterol: how low to go?

    Packard, Chris J.
    Epidemiology and the results of large-scale outcome trials indicate that the association of LDL with atherosclerotic cardiovascular disease is causal, and continuous not only across levels seen in the general population but also down to sub-physiological values. There is no scientific basis, therefore, to set a target or 'floor' for LDL cholesterol lowering, and this presents a clinical and conceptual dilemma for prescribers, patients, and payers. With the advent of powerful agents such as proprotein convertase/subtilisin kexin type 9 (PCSK9) inhibitors, LDL cholesterol can be lowered profoundly but health economic constraints mandate that this therapeutic approach needs to be selective....

  5. Using evolutionary algorithms and machine learning to explore sequence space for the discovery of antimicrobial peptides

    Yoshida, Mari; Hinkley, Trevor; Tsuda, Soichiro; Abul-Haija, Yousef; Mcburney, Roy T.; Kulikov, Vladislav; Mathieson, Jennifer; Galinanes Reyes, Sabrina; Castro Spencer, Maria D.; Cronin, Leroy
    We present a proof-of-concept methodology for efficiently optimizing a chemical trait by using an artificial evolutionary workflow. We demonstrate this by optimizing the efficacy of antimicrobial peptides (AMPs). In particular, we used a closed-loop approach that combines a genetic algorithm, machine learning, and in vitro evaluation to improve the antimicrobial activity of peptides against Escherichia coli. Starting with a 13-mer natural AMP, we identified 44 highly potent peptides, achieving up to a ca. 160-fold increase in antimicrobial activity within just three rounds of experiments. During these experiments, the conformation of the peptides selected was changed from a random coil to...

  6. Conclusion: CEE energy security - more than Russia

    Butler, Eamonn
    No abstract available.

  7. Hungary

    Butler, Eamonn
    No abstract available.

  8. Understanding Energy Security in Central and Eastern Europe: Russia, Transition and National Interest

    The purpose of this book is to move beyond the approach which views energy as a purely geopolitical tool of the Russian state and assumes a 'one size fits all' approach to energy security in Central and Eastern Europe (CEE). It argues that in order to fully understand Russian involvement in the regional energy complex, the CEE-Russian energy relationship should be analysed in the context of the political and economic transitions that Russia and the CEE states underwent. The chapters on individual countries in the book demonstrate that, although Russia has and will continue to play a substantial role in...

  9. Reply to: "Reply to: No effect of resistance-associated substitutions in patients with rare HCV subtypes following treatment with sofosbuvir-containing regimens"

    da Silva Filipe, Ana; Sreenu, Vattipally; Hughes, Joseph; Aranday-Cortes, Elihu; Irving, William L.; Foster, Graham R.; Agarwal, Kosh; Rosenberg, William; Macdonald, Douglas; Richardson, Paul; Aldersley, Mark A.; Wiselka, Martin; Ustianowski, Andrew; McLauchlan, John; Thomson, Emma C.
    No abstract available.

  10. Introduction

    Adams, Sean A.; Ehorn, Seth M.
    No abstract available.

  11. Composite citations in antiquity: a conclusion

    Adams, Sean A.; Ehorn, Seth M.
    No abstract available.

  12. Composite Citations in Antiquity. [Volume 2.]. New Testament Uses

    No abstract available.

  13. Jurisprudence. Themes and Concepts [3rd ed.]

    Veitch, Scott; Christodoulidis, Emilios; Goldoni, Marco

  14. Sensoryscapes: multisensory media art by Masaki Fujihata

    Sosnowska, Emilia
    No abstract available.

  15. Developing an online psychoeducation programme for adolescent depression

    Jones, Rhys Bevan; Thapar, Anita; Rice, Frances; Cichosz, Rachel; Mars, Becky; Smith, Danie; Merry, Sally; Stallard, Paul; Thapar, Ajay; Simpson, Sharon

  16. Balloon aortic valvuloplasty in the transcatheter valve era: single centre indications and early safety data in a high risk population

    Ford, Thomas; Nguyen, Katherine; Brassil, Joseph; Kushwaha, Virag; Friedman, Daniel; Allan, Roger; Pitney, Mark; Jepson, Nigel
    Background: The introduction of transcatheter aortic valve implantation (TAVI) has generated a renewed interest in the techniques available to treat high-risk patients with severe aortic stenosis (AS). We report our single centre experience with balloon aortic valvuloplasty (BAV) focussing on indications, procedural success and 30-day outcomes. Methods: We retrospectively reviewed all patients that underwent BAV procedures at our institution between August 2012 and August 2014. Procedural success and complications were adjudicated according to VARC-2 criteria. Results: Fifty-one consecutive adult patients with severe symptomatic AS underwent a total of 55 BAV procedures. The patients had a mean age of 88 ± 5.7 years...

  17. Alternation bias and sums of identically distributed monetary lotteries

    Robles-Zurita, José
    The alternation bias is the tendency of people to believe that random events alternate more often than statistical laws imply. This paper examines the theoretical effect of this psychological bias on preferences over repeated investments by using a model of the belief in the law of small numbers. An alternation bias agent (ABA) has a different perception to a rational agent (RA) about the outcome distribution of the sum of n realizations of a lottery. The results show that an ABA, that maximises expected utility, could reject a single realization of a lottery while accepting several repetitions in accordance with...

  18. “They were built to last”: anti-consumption and the materiality of waste in obsolete buildings

    Anderson, Stephanie; Hamilton, Kathy; Tonner, Andrea
    Previous consumer research on waste has prioritized disposable and low-involvement possessions. The authors extend scholarship into the context of obsolete buildings as a means to better engage with the complex materiality of waste and to explore the role anti consumption plays in consumers’ valuations of end-stage consumption. This study focuses on the phenomenon of urban exploration, a subculture who seek to discover and explore derelict buildings. Drawing on an ethnographic study including in-depth interviews, the authors reveal how anti-consumption manifests in the urban environment in terms of alternative understandings of value. In contrast to the economic valuations that often dominate public...

  19. Powder distribution on powder injection moulding of ceramic green compacts using thermogravimetric analysis and differential scanning calorimetry

    Poh, Leslie; Della, Christian; Ying, Shengjie; Goh, Cindy; Li, Yun
    Powder-binder separation during injection moulding causes defects such as cracking, warpage or anisotropic shrinkage during firing. In this paper, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) that were previously used to analyse powder distribution within the green body for metal injection moulding are used for ceramics. TGA and DSC are used to characterize the mass loss and heat of fusion of the binder system, silicon nitride feedstock and test-bars. TGA can measure the volume fraction of powder in green parts directly with 1.76 vol% difference from nominal volume fraction and variations up to 0.177 vol%. The DSC empirical model...

  20. Mobile technologies for managing non-communicable-diseases in the developing countries

    Latif, Siddique; Khan, Muhammad Yasir; Qayyum, Adnan; Qadir, Junaid; Usman, Muhammad; Ali, Syed Mustafa; Abbasi, Qammer Hussain; Imran, Muhammad
    Non-communicable diseases (NCDs) are the global leading cause of morbidity and mortality and disproportionately affecting more to the less developed countries. Mobile technologies are being used for a variety of purposes in healthcare. Most importantly, they are enabling new ways for NCDs management by providing powerful tools to both doctors and patients for effective prevention and treatment. As the common risk factors of NCDs are related to human behavior, therefore, mobile phone-based health solutions can be used to combat with rising burden of NCDs by focusing on behavioral change programs to promote a healthy lifestyle. This chapter discusses the common...

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