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Enlighten (144.728 recursos)

Enlighten is the University of Glasgow's institutional repository service for published research material including peer-reviewed journal articles, published conference papers,books and book chapters

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Mostrando recursos 1 - 20 de 372

  1. Afterword

    Hammill, Faye
    No abstract available.

  2. Effect of the proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab on glycemia, body weight, and new-onset diabetes mellitus

    Sattar, Naveed; Toth, Peter P.; Blom, Dirk J.; Koren, Michael J.; Soran, Handrean; Uhart, Magdalena; Elliott, Mary; Cyrille, Marcoli; Somaratne, Ransi; Preiss, David
    Statin therapy modestly increases new-onset diabetes risk. The effect of proprotein convertase subtilisin/kexin type 9 inhibition on new-onset diabetes, glycemia, and weight remains unclear. We studied the effects of the proprotein convertase subtilisin/kexin type 9 inhibitor evolocumab on fasting plasma glucose, glycated hemoglobin, weight, and new-onset diabetes mellitus. We pooled 1-year (48-week) data for participants who had completed an evolocumab parent study before entering an open-label extension (OLE) trial. Data were available for 4,802 participants (1,602 on standard of care [SOC]; 3,200 on evolocumab plus SOC) in 2 OLE trials. Evolocumab lowered low-density lipoprotein cholesterol by approximately 60% compared with...

  3. The Amagugu intervention for disclosure of maternal HIV to uninfected primary school-aged children in South Africa: a randomised controlled trial

    Rochat, Tamsen J.; Stein, Alan; Cortina-Borja, Mario; Tanser, Frank; Bland, Ruth M.
    Background: Increasing populations of children who are HIV-exposed but uninfected will face the challenge of disclosure of parental HIV infection status. We aimed to test the efficacy of an intervention to increase maternal HIV-disclosure to primary school-aged HIV-uninfected children. Methods: This randomised controlled trial was done at the Africa Health Research Institute in KwaZulu-Natal, South Africa. Women who had tested HIV positive at least 6 months prior, had initiated HIV treatment or been enrolled in pretreatment HIV care, and had an HIV-uninfected child (aged 6–10 years) were randomly allocated to either the Amagugu intervention or enhanced standard of care, using a...

  4. Session types revisited

    Dardha, Ornela; Giachino, Elena; Sangiorgi, Davide
    Session types are a formalism used to model structured communication-based programming. A binary session type describes communication by specifying the type and direction of data exchanged between two parties. When session types and session processes are added to the syntax of standard π-calculus they give rise to additional separate syntactic categories. As a consequence, when new type features are added, there is duplication of effort in the theory: the proofs of properties must be checked both on standard types and on session types. We show that session types are encodable into standard π- types, relying on linear and variant types....

  5. Session types revisited

    Dardha, Ornela; Giachino, Elena; Sangiorgi, Davide
    Session types are a formalism used to model structured communication-based programming. A binary session type describes communication by specifying the type and direction of data exchanged between two parties. When session types and session processes are added to the syntax of standard π-calculus they give rise to additional separate syntactic categories. As a consequence, when new type features are added, there is duplication of effort in the theory: the proofs of properties must be checked both on standard types and on session types. We show that session types are encodable into standard π- types, relying on linear and variant types....

  6. Distributed Spacecraft Path Planning and Collision Avoidance via Reciprocal Velocity Obstacle Approach

    Channumsin, Sittiporn; Radice, Gianmarco; Ceriotti, Matteo
    No abstract available.

  7. A polynuclear and two dinuclear copper(II) Schiff base complexes: Synthesis, characterization, self-assembly, magnetic property and DFT study

    Bhattacharyya, Anik; Bauzá, Antonio; Sproules, Stephen; Natrajan, Louise S.; Frontera, Antonio; Chattopadhyay, Shouvik
    Three elongated (4+1) square pyramidal copper(II) complexes, [Cu2(L)2(μ1,1-N3)2]⋅H2O (1), [Cu2(L)2(μ1,1-NCO)2] (2) and [Cu(L)(μ1,5-dca)]n (3) [HL = 1((2-(methylamino)ethylimino)methyl)naphthalen-2-ol and dca = dicyanamide], have been synthesized using a tridentate N2O donor Schiff base ligand (HL) and characterized. Complexes 1 and 2 are centrosymmetric dimers in which copper(II) centres are connected by asymmetric double end on pseudohalide bridges. Complex 3 features a 1D zigzag chain in which copper(II) centres are connected by end to end dca bridges. Variable temperature (2-300K) magnetic susceptibility measurements indicate the presence of antiferromagnetic exchange coupling between copper(II) centres in complexes 1 (J = -2.313 cm-1) and 3 (J...

  8. Sequencing Dafydd ap Gwliym

    Clancy, Thomas

  9. An integrative appraisal of the hormonal and metabolic changes induced by acute stress using king penguins as a model

    Viblanc, Vincent A.; Schull, Quentin; Cornioley, Tina; Stier, Antoine; Ménard, Jean-Jérôme; Groscolas, René; Robin, Jean-Patrice
    A large number of studies have focused on the reactivity of the hypothalamic-pituitary-adrenal (HPA) axis and the consequences of glucocorticoids (GC) in mediating life-history trade-offs. Although short-term increases in GCs are viewed as adaptive, mobilizing energy substrates allowing animals to deal with impending threats (e.g. stimulating hepatic gluconeogenesis, stimulating lipolysis, mobilizing amino acids), few studies have actually measured the exact time-course of substrate mobilisation in response to acute stress in natural conditions. We evaluated the hormonal and metabolic components of the stress response to acute stress in 32 free-living king penguins (Aptenodytes patagonicus). We monitored changes in blood GCs (corticosterone,...

  10. Disentangling the 1MLCT transition of [Ru(bpy)3]2+ by Stark absorption spectroscopy

    Kawamoto, Keisuke; Tamiya, Yudai; Storr, Tim; Cogdell, Richard J.; Kinoshita, Isamu; Hashimoto, Hideki
    The metal-to-ligand charge transfer (MLCT) transition of [Ru(bpy)3]2+ was investigated using Stark absorption spectroscopy, where bpy is the abbreviation of 2,2′-bipyridyl ligand. The magnitude and direction of the photoinduced intramolecular charge transfer were precisely determined for the 1MLCT transition of [Ru(bpy)3]2+. The 1MLCT absorption band of [Ru(bpy)3]2+, observed in the 18,000–30,000 cm−1 spectral region, is composed of several sub-bands that can be approximated with Gaussian profiles. In particular, three distinct major 1MLCT bands of [Ru(bpy)3]2+ (g4, 21272 cm−1; g5, 22026 cm−1; g7, 23448 cm−1) could be distinguished by the direction of the charge transfer of each transition. The experimentally determined...

  11. Disentangling the 1MLCT transition of [Ru(bpy)3]2+ by Stark absorption spectroscopy

    Kawamoto, Keisuke; Tamiya, Yudai; Storr, Tim; Cogdell, Richard J.; Kinoshita, Isamu; Hashimoto, Hideki
    The metal-to-ligand charge transfer (MLCT) transition of [Ru(bpy)3]2+ was investigated using Stark absorption spectroscopy, where bpy is the abbreviation of 2,2′-bipyridyl ligand. The magnitude and direction of the photoinduced intramolecular charge transfer were precisely determined for the 1MLCT transition of [Ru(bpy)3]2+. The 1MLCT absorption band of [Ru(bpy)3]2+, observed in the 18,000–30,000 cm−1 spectral region, is composed of several sub-bands that can be approximated with Gaussian profiles. In particular, three distinct major 1MLCT bands of [Ru(bpy)3]2+ (g4, 21272 cm−1; g5, 22026 cm−1; g7, 23448 cm−1) could be distinguished by the direction of the charge transfer of each transition. The experimentally determined...

  12. Processes underlying rabies virus incursions across US–Canada Border as revealed by whole-genome phylogeography

    Trewby, Hannah; Nadin-Davis, Susan A.; Real, Leslie A.; Biek, Roman
    Disease control programs aim to constrain and reduce the spread of infection. Human disease interventions such as wildlife vaccination play a major role in determining the limits of a pathogen’s spatial distribution. Over the past few decades, a raccoon-specific variant of rabies virus (RRV) has invaded large areas of eastern North America. Although expansion into Canada has been largely prevented through vaccination along the US border, several outbreaks have occurred in Canada. Applying phylogeographic approaches to 289 RRV whole-genome sequences derived from isolates collected in Canada and adjacent US states, we examined the processes underlying these outbreaks. RRV incursions were...

  13. Processes underlying rabies virus incursions across US–Canada Border as revealed by whole-genome phylogeography

    Trewby, Hannah; Nadin-Davis, Susan A.; Real, Leslie A.; Biek, Roman
    Disease control programs aim to constrain and reduce the spread of infection. Human disease interventions such as wildlife vaccination play a major role in determining the limits of a pathogen’s spatial distribution. Over the past few decades, a raccoon-specific variant of rabies virus (RRV) has invaded large areas of eastern North America. Although expansion into Canada has been largely prevented through vaccination along the US border, several outbreaks have occurred in Canada. Applying phylogeographic approaches to 289 RRV whole-genome sequences derived from isolates collected in Canada and adjacent US states, we examined the processes underlying these outbreaks. RRV incursions were...

  14. Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems

    da Silva, Marcelo S.; Pavani, Raphael S.; Damasceno, Jeziel D.; Marques, Catarina A.; McCulloch, Richard; Tosi, Luiz Ricardo Orsini; Elias, Maria Carolina
    In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be...

  15. Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems

    da Silva, Marcelo S.; Pavani, Raphael S.; Damasceno, Jeziel D.; Marques, Catarina A.; McCulloch, Richard; Tosi, Luiz Ricardo Orsini; Elias, Maria Carolina
    In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be...

  16. Nuclear DNA replication in trypanosomatids: there are no easy methods for solving difficult problems

    da Silva, Marcelo S.; Pavani, Raphael S.; Damasceno, Jeziel D.; Marques, Catarina A.; McCulloch, Richard; Tosi, Luiz Ricardo Orsini; Elias, Maria Carolina
    In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be...

  17. Book Review: Sociological Theory Beyond the Canon by Syed Farid Alatas and Vineeta Sinha

    Dawson, Matt
    No abstract available.

  18. Book review: Syed Farid Alatas and Vineeta Sinha, Sociological Theory Beyond the Canon

    Dawson, Matt
    No abstract available.

  19. Access and use of clinical services and disease-modifying therapies by people with progressive multiple sclerosis in the United Kingdom

    Campbell, Evan; Coulter, Elaine; Mattison, Paul; McFadyen, Angus; Miller, Linda; Paul, Lorna
    Background: According to current UK guidelines everyone with progressive MS should have access to an MS Specialist but levels of access and use of clinical services is unknown. Our objective was to investigate access to MS Specialists, use of clinical services and disease-modifying therapies (DMTs) by people with progressive MS in the United Kingdom. Methods: A UK wide, online survey was conducted via the UK MS Register. Inclusion criteria: age over 18 years, primary or secondary progressive MS and a member of the UK MS Register. Participants were asked about access to MS Specialists; recent clinical service use; receipt of regular...

  20. Access and use of clinical services and disease-modifying therapies by people with progressive multiple sclerosis in the United Kingdom

    Campbell, Evan; Coulter, Elaine; Mattison, Paul; McFadyen, Angus; Miller, Linda; Paul, Lorna
    Background: According to current UK guidelines everyone with progressive MS should have access to an MS Specialist but levels of access and use of clinical services is unknown. Our objective was to investigate access to MS Specialists, use of clinical services and disease-modifying therapies (DMTs) by people with progressive MS in the United Kingdom. Methods: A UK wide, online survey was conducted via the UK MS Register. Inclusion criteria: age over 18 years, primary or secondary progressive MS and a member of the UK MS Register. Participants were asked about access to MS Specialists; recent clinical service use; receipt of regular...

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