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Document Server@UHasselt (58.026 recursos)

Repository of the University of Hasselt containing publications in the fields of statistics, computer science, information strategies and material from the Institute for behavioural sciences.


Mostrando recursos 1 - 20 de 202

  1. Possible morphological substrates in the pathogenesis of arthritis

    van Zwieten, Koos Jaap; Lambrichts, Ivo; de Bakker, Bernadette S.; Kosten, Lauren; De Munter, Stephanie; Gervois, Pascal; Schmidt, Klaus P.; Helder, Paul; Lippens, Peter L.
    To gain more insight into the morphogenesis of synovial joints, as well as into pathogeneses of joint diseases like Rheumatoid Arthritis (RA) and possibly also Osteoarthritis (OA), we surveyed human finger joint ontogeny from early developmental stages. In adult interphalangeal joints, dorsal and palmar but also ulnar and radial synovial folds do persist. During adult life, synovial membranes as well as synovial folds (e.g., after micro-damage) may elicit chronic inflammatory processes that eventually lead to arthritis. In proximal interphalangeal (PIP) joint proper collateral ligaments (PCL), we found neurofilaments and oval-shaped lamellated corpuscles (?? ??? 120 ??). Supposedly acting as mechanoreceptors,...

  2. Alpha-Adrenoceptor Modulation in Central Nervous System Trauma: Pain, Spasms, and Paralysis - An Unlucky Triad.

    LEMMENS, Stefanie; Brône, Bert; Dooley, Dearbhaile; HENDRIX, Sven; Geurts, Nathalie
    Many researchers have attempted to pharmacologically modulate the adrenergic system to control locomotion, pain, and spasms after central nervous system (CNS) trauma, although such efforts have led to conflicting results. Despite this, multiple studies highlight that α-adrenoceptors (α-ARs) are promising therapeutic targets because in the CNS, they are involved in reactivity to stressors and regulation of locomotion, pain, and spasms. These functions can be activated by direct modulation of these receptors on neuronal networks in the brain and the spinal cord. In addition, these multifunctional receptors are also broadly expressed on immune cells. This suggests that they might play a...

  3. Mesenchymal stem cells overexpressing IL-13 decrease lesion size and demyelination after spinal cord injury

    DOOLEY, Dearbhaile; LEMMENS, Evi; VANGANSEWINKEL, Tim; LEMMENS, Stefanie; De Vocht, Nathalie; Le Blon, Debbie; Ponsaerts, Peter; HENDRIX, Sven

  4. Attachment Rate of the Inferior Alveolar Nerve to Buccal Plate During Bilateral Sagittal Split Osteotomy Influences Self-Reported Sensory Impairment

    POLITIS, Constantinus; LAMBRICHTS, Ivo; SUN, Yi; Vrielinck, Luc; Schepers, Serge; Agbaje, Jimoh Olubanwo
    This study was aimed to investigate a modified buccal osteotomy technique and whether the integrity of the lingual part of the lower border influences the attachment of the neurovascular bundle to the proximal segment of the mandible during a sagittal split osteotomy without increasing the number of bad splits. The presence of self-reported sensibility disturbance in the lower lip at the last follow-up visit was assessed. This study included 220 and 133 patients with bilateral sagittal split osteotomy undergoing the classical and the new modified buccal osteotomy techniques, respectively. In the new technique, the lower border is divided into a...

  5. Cerebral tissue saturation, the next step in cardiopulmonary resuscitation management?

    Genbrugge, Cornelia; BOER, Willem; Meex, Ingrid; Jans, Frank; Dens, Jo; De Deyne, Cathy
    The goal of cardiopulmonary resuscitation (CPR) is to preserve the pre-arrest neurological state by maintaining sufficient cerebral blood flow and oxygenation, but the predictors thereof remain largely unknown. Despite recent attempts to improve the quality of basic and advanced life support, no monitored link to the neurological and physiological response of these CPR efforts has been established. The difficult decision to end pre-hospital resuscitation efforts is currently based on the circumstances of cardiac arrest, length of resuscitation efforts (if available), knowledge of pre-morbid physiological reserves, and (if present) end-tidal carbon dioxide (ETCO2) measurement. ETCO2 is currently the only parameter proven...

  6. Validating cone-beam computed tomography for peri-implant bone morphometric analysis

    HUANG, Yanru; Van Dessel, Jeroen; Depypere, Maarten; EzEldeen, Mostafa; Iliescu, Alexandru Andrei; Dos Santos, Emanuela; LAMBRICHTS, Ivo; LIANG, Xin; Jacobs, Reinhilde
    Cone-beam computed tomography (CBCT) has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional (3D) peri-implant trabecular bone morphometry by comparing it to two-dimensional (2D) histology, 36 alveolar bone samples (with implants n=27 vs. without implants n=9) from six mongrel dogs, were scanned ex vivo using a high-resolution (80 mu m) CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections (similar to 6 mu m) to obtain high contrast 2D images. By using CT An imaging software, bone morphometric parameters including trabecular number (Tb.N), thickness...

  7. Oncostatin M Reduces Lesion Size and Promotes Functional Recovery and Neurite Outgrowth After Spinal Cord Injury

    Slaets, Helena; NELISSEN, Sofie; JANSSENS, Kris; VIDAL VERA, Pia; LEMMENS, Evi; STINISSEN, Piet; HENDRIX, Sven; HELLINGS, Niels
    The family of interleukin (IL)-6 like cytokines plays an important role in the neuroinflammatory response to injury by regulating both neural as well as immune responses. Here, we show that expression of the IL-6 family member oncostatin M (OSM) and its receptor is upregulated after spinal cord injury (SCI). To reveal the relevance of increased OSM signaling in the pathophysiology of SCI, OSM was applied locally after spinal cord hemisection in mice. OSM treatment significantly improved locomotor recovery aftermild and severe SCI. Improved recovery in OSM treated mice was associated with a reduced lesion size. OSM significantly diminished astrogliosis and...


    Keupers, M.; VANDEVENNE, Jan; GIELEN, Ellen; HORVATH, Monique; PALMERS, Yvan; VANDERSTEEN, Marjan

  9. Presurgical CBCT assessment of maxillary neurovascularization in relation to maxillary sinus augmentation procedures and posterior implant placement

    Pinheiro Nicolielo, Laura Ferreira; Van Dessel, Jeroen; Jacobs, Reinhilde; MARTENS, Wendy; LAMBRICHTS, Ivo; Fischer Rubira-Bullen, Izabel Regina
    To provide more information to clinicians planning sinus grafting and maxillofacial surgical interventions, the present study evaluated the prevalence, diameter and location of the superior alveolar canals (SAC) using CBCT images. The maxillary sinus CBCT scans (i-CAT Classic(A (R)), ISI, USA) of 100 adult patients (67 women and 33 men) aged 20-79 years [mean (SD) 40 (15)] were examined. A dentomaxillofacial radiologist observed the SAC based on CBCT image data and more specifically the parasagittal views to assess SAC's diameter and location. The anterior and posterior SAC, double ASAC, intraosseous anastomoses and the extension of the anterior SAC to the...

  10. Controlling and Monitoring Stem Cell Safety In Vivo in an Experimental Rodent Model

    Leten, Cindy; Roobrouck, Valerie D.; STRUYS, Tom; Burns, Terry C.; Dresselaers, Tom; Vande Velde, G.; SANTERMANS, Jeanine; Lo Nigro, Antonio; Ibrahimi, Abdelilah; Gijsbers, Rik; Eggermont, Kristel; LAMBRICHTS, Ivo; Verfaillie, Catherine M.; Himmelreich, Uwe
    Adult stem cells have been investigated increasingly over the past years for multiple applications. Although they have a more favorable safety profile compared to pluripotent stem cells, they are still capable of self-renewal and differentiate into several cell types. We investigated the behavior of Oct4-positive (Oct4(+)) and Oct4-negative (Oct4(-)) murine or rat bone marrow (BM)-derived stem cells in the healthy brain of syngeneic mice and rats. Engraftment of mouse and rat Oct4-positive BM-derived hypoblast-like stem cells (m/rOct4(+) BM-HypoSCs) resulted in yolk-sac tumor formation in the healthy brain which was monitored longitudinally using magnetic resonance imaging (MRI) and bioluminescence imaging (BLI)....

  11. Some Byzantine / Greek Influences on the Early Work of the Anatomist Andreas Vesalius (1514-1564)

    VAN ZWIETEN, Koos Jaap; SCHMIDT, Klaus; ZUBOVA, Irina A.; VARZIN, Sergey A.; ZINKOVSKY, Anatoly V.; PISKÙN, Oleg E.
    500 years after the birth of Andreas Vesalius (1514-1564) it is appropriate to commemorate this first modern anatomist, doctor, scholar, and author. Different from other Vesalius-commemorations, however, we like to examine what - until the 16th century - did happen to the knowledge of anatomy as described by Galen (130-210) whose apparent “faults” were so effectively corrected by Vesalius. The intention of Andreas Vesalius - possibly after the authoritative Iranian physician and writer Rhazes (854-925 CE) - to correct Galen’s mistakes, may have been helped greatly by his initial contacts with the original Byzantine / Greek texts of Galen that...

  12. Validation of 3D power Doppler and VOCAL software in the 1 sonographic assessment of hepatic venous flow

    Claeskens, J.; TOMSIN, Kathleen; MOLENBERGHS, Geert; Van Holsbeke, C.; Mesens, T.; MEYLAERTS, Liesbeth; GYSELAERS, Wilfried
    Aim: To evaluate the reproducibility of three-dimensional power Doppler ultrasonography (3D-PDU) and the ??repeatability of Virtual Organ Computer-aided AnaLysis (VOCAL) software in the assessment of hepatic venous flow in ten healthy non-pregnant individuals. Methods: Visualization of hepatic veins was performed using both intra- and subhepatic approaches; These ??examinations were repeated twice. Vascular indices were obtained for each examination in a reference point using both small and large volume samples (3 times per type of volume sample). Intraclass Correlation Coefficients and Pearson???s Product-Moment Correlation Coefficient were calculated to assess reproducibility and repeatability, respectively. Results: Intraclass Correlation Coefficients were more than 0.60...

  13. Peri-implant bone innervation: Histological findings in humans

    Corpas, Livia dos Santos; LAMBRICHTS, Ivo; Quirynen, Marc; Collaert, Bruno; POLITIS, Constantinus; Vrielinck, Luc; MARTENS, Wendy; STRUYS, Tom; Jacobs, Reinhilde
    Purpose: The aim of the present study was to describe nerve fibres around osseointegrated implants in humans. Materials and methods: Twelve mechanically failed implants, retrieved from 10 patients were collected from three dental centres over a period of 5 years. After implant removal, decalcified semi-thin sections (0.5 mu m) were stained with thionic methylene blue for light microscopic analysis. In addition, an ultrastructural analysis was performed on serial ultra-thin sections (0.06 mu m) using transmission electron microscopy. Results: Both myelinated and unmyelinated nerve fibres could be identified inside the Haversian canals of the osteonal bone near the implant threads. Myelinated...

  14. Canonical and non-canonical EcfG sigma factors control the general stress response in Rhizobium etli

    Jans, Ann; Vercruysse, Maarten; Gao, Shanjun; Engelen, Kristof; LAMBRICHTS, Ivo; Fauvart, Maarten; Michiels, Jan
    A core component of the ??-proteobacterial general stress response (GSR) is the extracytoplasmic function (ECF) sigma factor EcfG, exclusively present in this taxonomic class. Half of the completed ??-proteobacterial genome sequences contain two or more copies of genes encoding ??EcfG-like sigma factors, with the primary copy typically located adjacent to genes coding for a cognate anti-sigma factor (NepR) and two-component response regulator (PhyR). So far, the widespread occurrence of additional, non-canonical ??EcfG copies has not satisfactorily been explained. This study explores the hierarchical relation between Rhizobium etli ??EcfG1 and ??EcfG2, canonical and non-canonical ??EcfG proteins, respectively. Contrary to reports in...

  15. Morphological substrates in Rheumatoid Arthritis pathogenesis

    VAN ZWIETEN, Koos Jaap; LAMBRICHTS, Ivo; DE BAKKER, Bernadette; KOSTEN, Lauren; DE MUNTER, Stephanie
    In the PIP joint capsule of the finger, neurofilaments and lamellated corpuscules are observed, comparable with those present in human facet joints. Our study demonstrated these corpuscules in the PIP Proper Collateral Ligament for the first time. Supposedly acting as mechanoreceptors, they may also produce cytokines and substance P, a neuropeptide involved in pain. As the PIP joints of fingers in particular show symptoms of Rheumatoid Arthritis at very early stages, these organs may therefore play a role in the pathogenesis of Rheumatoid Arthritis.

  16. Accuracy of continuous thermodilution cardiac output monitoring by pulmonary artery catheter during therapeutic hypothermia in post-cardiac arrest patients

    Ameloot, Koen; MEEX, Ingrid; GENBRUGGE, Cornelia; JANS, Frank; Malbrain, Manu L. N.; MULLENS, Wilfried; DENS, Jo; DE DEYNE, Cathy; Dupont, M.
    Purpose: Thermodilution continuous cardiac output measurements (TDCCO) by pulmonary artery catheter (PAC) have not been validated during therapeutic hypothermia in post-cardiac arrest patients. The calculated cardiac output based on the indirect Fick principle (FCO) using pulmonary artery blood gas mixed venous oxygen saturation (FCO-BG-SvO2) is considered as the gold standard. Continuous SvO2 by PAC (PAC-SvO2) has also not been validated previously during hypothermia. The aims of this study were (1) to compare FCO-BG-SvO2 with TDCCO, (2) to compare PAC-SvO2 with BG-SvO2 and finally (3) to compare FCO with SvO2 obtained via PAC or blood gas. Methods: We analyzed 102 paired...

  17. Technology-supported client centered rehabilitation: Do patients use technologies and which skills do patients with neck pain prefer to train on?

    TIMMERMANS, Annick; HAESEN, Mieke; WILLEMS, Kim; CLAES, Guido; Olivieri, Enzo; Cuyvers, Bert; Verbrugghe, Jonas; CONINX, Karin
    Aim: The aim of this investigation is to inventorize training preferences and motives for motor rehabilitation of patients with neck pain. This knowledge is paramount in order to develop client-centered training for technology supported rehabilitation. Technology supported rehabilitation offers opportunities for increasing exercise variability during rehabilitation and may support patients to be compliant with home exercise regimes. The second aim of this study is to evaluate to which extent patients with neck pain are familiar with the use of technologies. Methods: Semi-structured interviews were conducted based on the Neck Disability Index (NDI) according to a method by Timmermans et al (Disability and...

  18. Possible morphological substrates in the pathogenesis of rheumatoid arthritis in human finger joints

    VAN ZWIETEN, Koos Jaap; LAMBRICHTS, Ivo; DE BAKKER, Bernadette; KOSTEN, Lauren; DE MUNTER, Stephanie; GERVOIS, Pascal; ADRIAENSENS, Peter; SCHMIDT, Klaus; HELDER, Paul; LIPPENS, Peter
    In conclusion, we state that curiosity-driven research after normal synovial folds within the PIP-joint of the finger confirms their actual location. Neurovascular bundles in the normal PIP-joint???s capsule, and neurons in lamellated corpuscles within the Proper Collateral Ligament, may shed new light on the pathogenesis of rheumatoid arthritis in human finger joints.

  19. Pro-angiogenic impact of dental stem cells in vitro and in vivo

    HILKENS, Petra; FANTON, Yanick; MARTENS, Wendy; GERVOIS, Pascal; STRUYS, Tom; POLITIS, Constantinus; LAMBRICHTS, Ivo; BRONCKAERS, Annelies
    Within the field of dental tissue engineering, the establishment of adequate tissue vascularization is one of the most important burdens to overcome. As vascular access within the tooth is restricted by the apical foramen, it is of major importance to implement effective vascularization strategies in order to recreate viable components of teeth and periodontal tissues. However, while the current regenerative approaches focus on the use of dental stem cells (DSCs), little is known about these cells and their ability to promote angiogenesis. Therefore, the present study aimed to elucidate the paracrine angiogenic properties of postnatal DSCs, in particular dental pulp...

  20. Oral presentation: Risicomanagement door retrospectieve risicoanalyse

    MARQUET, Kristel; CLAES, Neree; DE TROY, Elke; KOX, Gaby; DROOGMANS, Martijn; SCHROOTEN, Ward; WEEKERS; VLAYEN, Annemie; VANDERSTEEN, Marjan; VLEUGELS, Arthur

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