Recursos de colección

IOE EPrints (18.097 recursos)

IOE EPrints is a repository that collects together the work of researchers and allows them to make their research outputs freely available over the web via a searchable "open access" database.

Mostrando recursos 1 - 20 de 81

  1. Cannabis Use and Hypomania in Young People: A Prospective Analysis

    Marwaha, S; Winsper, C; Bebbington, P; Smith, D
    BACKGROUND: Cannabis use in young people is common and associated with psychiatric disorders. However, the prospective link between cannabis use and bipolar disorder symptoms has rarely been investigated. The study hypothesis was that adolescent cannabis use is associated with hypomania in early adulthood via several potential etiological pathways. METHODS: Data were used from the Avon Longitudinal Study of Parents and Children, a UK birth cohort study. The prospective link between cannabis use at age 17 and hypomania at age 22–23 years was tested using regression analysis, adjusted for gender, early environmental risk factors, alcohol and drug use, and depression and psychotic...

  2. Internet-accessed sexually transmitted infection (e-STI) testing and results service: A randomised, single-blind, controlled trial

    Wilson, E; Free, C; Morris, TP; Syred, J; Ahamed, I; Menon-Johansson, AS; Palmer, MJ; Barnard, S; Rezel, E; Baraitser, P
    BACKGROUND: Internet-accessed sexually transmitted infection testing (e-STI testing) is increasingly available as an alternative to testing in clinics. Typically this testing modality enables users to order a test kit from a virtual service (via a website or app), collect their own samples, return test samples to a laboratory, and be notified of their results by short message service (SMS) or telephone. e-STI testing is assumed to increase access to testing in comparison with face-to-face services, but the evidence is unclear. We conducted a randomised controlled trial to assess the effectiveness of an e-STI testing and results service (chlamydia, gonorrhoea, HIV,...

  3. A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

    Bielecka, MK; Tezera, LB; Zmijan, R; Drobniewski, F; Zhang, X; Jayasinghe, S; Elkington, P
    Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined bioengineering, genetically modified bacteria, longitudinal readouts, and fluidics to develop a transformative platform to address the drug development bottleneck, utilizing Mycobacterium tuberculosis as the model organism. We generated microspheres incorporating virulent reporter bacilli, primary human cells, and an extracellular matrix by using bioelectrospray methodology. Granulomas form within the three-dimensional matrix, and mycobacterial stress genes are upregulated. Pyrazinamide, a vital first-line antibiotic for treating human tuberculosis, kills M. tuberculosis in a three-dimensional culture but not in a standard two-dimensional...

  4. Influence of feed/inoculum ratios and waste cooking oil content on the mesophilic anaerobic digestion of food waste

    Li, Y; Jin, Y; Borrion, A; Li, J
    Information on the anaerobic digestion (AD) of food waste (FW) with different waste cooking oil contents is limited in terms of the effect of the initial substrate concentrations. In this work, batch tests were performed to evaluate the combined effects of waste cooking oil content (33–53%) and feed/inoculum (F/I) ratios (0.5–1.2) on biogas/methane yield, process stability parameters and organics reduction during the FW AD. Both waste cooking oil and the inoculation ratios were found to affect digestion parameters during the AD process start-up and the F/I ratio was the predominant factor affecting AD after the start-up phase. The possible inhibition...

  5. Human trafficking for labour exploitation: the results of a two-phase systematic review mapping the European evidence base and synthesising key scientific research evidence

    Cockbain, EP; Bowers, K; Dimitrova, G

  6. Emerging personality dimensions during adolescence and young adulthood are underpinned by a latent trait indexing impairment in social functioning

    Polek, E; Jones, PB; Fearon, RMP; Brodbeck, J; Moutoussis, M; NSPN Consortium, .; Dolan, R; Fonagy, P; Bullmore, ET; Goodyer, IM

  7. Facilitating coproduction: the role of leadership in coproduction initiatives in the UK

    Bussu, S; Galanti, M
    The concept of coproduction primarily refers to direct user involvement in the production of services. This paper identifies the main dimensions of this broad and at times fuzzy concept and focuses on types and styles of leadership that can emerge from, and sustain, effective coproduction practice. We do so by carrying out a narrative review of cases of coproduction in the UK, with a focus on the role of citizens, bureaucrats and, specifically, local politicians, to unpick how the latter can facilitate or hinder coproductive processes. The analysis distances itself from a traditional understanding of leadership to examine relational dynamics...

  8. Transnational comparability of advanced pharmacy practice developmental frameworks: A country-level crossover mapping study

    Udoh, A; Bruno, A; Bates, I; Galbraith, K
    BACKGROUND: Previous work by the International Pharmaceutical Federation Education Initiative (FIPEd) demonstrates that even though some country-specific variations occur in pharmacy practice, there exists a set of practice-related competencies that are globally applicable. This study aimed to evaluate the transnational comparability of the Royal Pharmaceutical Society Advanced Pharmacy Framework (RPS-APF, Great Britain) and the Advanced Pharmacy Practice Framework for Australia (APPF). The objective was to obtain preliminary data on the transnational applicability of the developmental competencies contained in the two frameworks. METHOD: A crossover mapping study involving 42 advanced-level pharmacists from four countries was conducted. Qualitative interview (n = 17) was...

  9. Carers’ experiences of home enteral feeding: a survey exploring medicines administration challenges and strategies

    Alsaeed, D; Furniss, D; Blandford, A; Smith, F; Orlu, M

  10. A Topology of Shared Control Systems – Finding Common Ground in Diversity

    Abbink, DA; Carlson, T; Mulder, M; de Winter, JCF; Aminravan, F; Gibo, TL; Boer, ER
    Shared control is an increasingly popular approach to facilitate control and communication between humans and intelligent machines. However, there is little consensus in guidelines for design and evaluation of shared control, or even in a definition of what constitutes shared control. This lack of consensus complicates cross-fertilization of shared control research between different application domains. This paper provides 1) a definition for shared control in context with previous definitions, and 2) a set of general axioms for design and evaluation of shared control solutions. The utility of the definition and axioms are demonstrated by applying them to four application domains: automotive, robot-assisted surgery, brainmachine interfaces and learning. Literature is discussed for each of...

  11. Vanadium Compounds as PTP Inhibitors

    Irving, E; Stoker, AW
    Phosphotyrosine signaling is regulated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here we discuss the potential of vanadium derivatives as PTP enzyme inhibitors and metallotherapeutics. We describe how vanadate in the V oxidized state is thought to inhibit PTPs, thus acting as a pan-inhibitor of this enzyme superfamily. We discuss recent developments in the biological and biochemical actions of more complex vanadium derivatives, including decavanadate and in particular the growing number of oxidovanadium compounds with organic ligands. Pre-clinical studies involving these compounds are discussed in the anti-diabetic and anti-cancer contexts. Although in many...

  12. The public good created by higher education institutions in Russia

    Marginson, S
    The public/private distinction is central to higher education but there is no consensus on the meaning of 'public'. Two different meanings are in use. Economic theory distinguishes non market goods (public) that cannot be produced for profit, from market-based activity (private). This provides a basis for identifying the minimum necessary public expenditure, but does not effectively encompass collective goods. In political theory 'public' is often understood as state ownership and/ or control. This is more inclusive than the economic definition, and recognizes the scope for norms and policies, but lacks clear boundaries. The first part of the article synthesizes these...

  13. Higher education research in the Asia-Pacific

    Huang, F; Marginson, S

  14. Slave codes and penal laws in eighteenth-century Jamaica and Ireland: a comparative and historiographical survey

    Graham, AB
    During the long eighteenth century, a period stretching roughly between 1660 and 1840, the British elites of both Ireland and Jamaica faced very similar problems of social control. Both were small and embattled minorities within a society made up mainly of Catholic Irish in the one place and black slaves in the other, who were in general overwhelmingly hostile to elites and unwilling to accept their subordinate status. In Ireland between about 1695 and 1719, the Protestant Ascendancy in the Irish Parliament created a body of laws known as the ‘Penal Laws’ intended to regulate the behaviour of the Catholic...

  15. The British Financial Revolution and the Empire of Credit in St Kitts and Nevis, 1706-21

    Graham, AB
    The British ‘financial revolution’ was a colonial as well as metropolitan phenomenon. Yet the structures used by colonists to participate have rarely been studied as anything more than a subset of commercial developments. A close examination of the islands of St Kitts and Nevis, who received almost £100,000 in government debentures between 1706 and 1721, confirms that they used the same types of networks as their counterparts in Britain and Ireland to overcome the problems of distance and to manage their investment. In functional terms the new ‘empire of credit’ was therefore merely an extension of the British financial revolution.

  16. Privileged Mobilities: Locating the Expatriate in Migration Scholarship

    Kunz, S
    Migrants who are privileged by citizenship, class or ‘race’ are largely still absent from mainstream migra-tion research and theory; until recently, they were generally assumed to be adaptable and acceptablecosmopolites, positive drivers of cross-border transfers of knowledge and skills. This has been addressedby an emerging scholarship on ‘expatriates’. This article offers a review and critical reading of that litera-ture; it considers the instabilities and ambiguities of the term ‘expatriate’ and situates expatriate migrantswithin the global economy, before examining the gendered nature of expatriation and attending tomigrants’ incorporation in host contexts and expatriate negotiations of identity. The literature suggeststhat at the...

  17. Never Let A Good Crisis Go To Waste: Agenda Setting and Legislative Voting in Response to the EU Crisis

    Blumenau, JE; Lauderdale, BE
    The European Union's policy response to the recent global economic crisis transferred significant powers from the national to the European level. When exogenous shocks make status quo policies less attractive, legislators become more tolerant to proposed alternatives, and the policy discretion of legislative agenda-setters increases. Given control of the EU agenda-setting process by pro-integration actors, we argue that this dynamic explains changes in voting patterns of the European Parliament during the crisis period. We observe voting coalitions increasingly dividing legislators along the pro-anti integration, rather than the left-right, dimension of disagreement, but only in policy areas related to the crisis....

  18. Open/Closed List and Party Choice: Experimental Evidence from the UK

    Blumenau, J; Eggers, AC; Hangartner, D; Hix, S
    Which parties benefit from open-list (as opposed to closed-list) proportional representation elections? This article shows that a move from closed-list to open-list competition is likely to be more favorable to parties with more internal disagreement on salient issues; this is because voters who might have voted for a unified party under closed lists may be drawn to specific candidates within internally divided parties under open lists. The study provides experimental evidence of this phenomenon in a hypothetical European Parliament election in the UK, in which using an open-list ballot would shift support from UKIP (the Eurosceptic party) to Eurosceptic candidates...

  19. Two-years Postradiotherapy Biopsies: Lessons from MRC RT01 Trial

    Kass-Iliyya, A; Jovic, G; Murphy, C; Fisher, C; Syndikus, I; Jose, C; Scrase, CD; Graham, JD; Nicol, D; Sydes, MR; Dearnaley, D
    Background: The importance of 2-yr postradiotherapy prostate biopsy status remains uncertain. Objective: To assess the value of 2 year post treatment biopsies in a randomised trial of radiotherapy dose escalation. Design, setting, and participants: Between 1998 and 2001, 843 men with localised prostate cancer were randomised to receive either control-64 Gy or escalated-74 Gy conformal radiotherapy (CFRT) in the MRC RT01 trial in combination with 3–6-mo neoadjuvant androgen deprivation therapy. Prostate biopsies were planned at 2 yr from start of CFRT in suitable men. Outcome measurements and statistical analysis: Prostate biopsy results and prostate-specific antigen (PSA) levels performed at 2 yr post-CFRT were evaluated with long-term...

  20. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

    Thompson, AJ; Banwell, BL; Barkhof, F; Carroll, WM; Coetzee, T; Comi, G; Correale, J; Fazekas, F; Filippi, M; Freedman, MS; Fujihara, K; Galetta, SL; Hartung, HP; Kappos, L; Lublin, FD; Marrie, RA; Miller, AE; Miller, DH; Montalban, X; Mowry, EM; Sorensen, PS; Tintoré, M; Traboulsee, AL; Trojano, M; Uitdehaag, BMJ; Vukusic, S; Waubant, E; Weinshenker, BG; Reingold, SC; Cohen, JA
    The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation. The...

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