García Núñez, Carlos; Braña, Alejandro F.; López, Nair; García, Basilio J.
The successful synthesis of high crystalline quality and high aspect ratio GaAs nanowires (NWs) with a uniform diameter is needed to develop advanced applications beyond the limits established by thin film and bulk material properties. Vertically aligned GaAs NWs have been extensively grown by Ga-assisted vapor–liquid–solid (VLS) mechanism on Si(111) substrates, and they have been used as building blocks in photovoltaics, optoelectronics, electronics, and so forth. However, the nucleation of parasitic species such as traces and nanocrystals on the Si substrate surface during the NW growth could affect significantly the controlled nucleation of those NWs, and therefore the resulting performance...
Zhang, Limei; Duff, Aoife; Smith, Cindy J.
Terrestrial–marine boundaries are significant sites of biogeochemical activity with delineated gradients from land to sea. While niche differentiation of ammonia‐oxidizing archaea (AOA) and bacteria (AOB) driven by pH and nitrogen is well known, the patterns and environmental drivers of AOA and AOB community structure and activity across soil‐sediment boundaries have not yet been determined. In this study, nitrification potential rate, community composition and transcriptional activity of AOA and AOB in soil, soil/sediment interface and sediments of two coastal Bays were characterized using a combination of field investigations and microcosm incubations. At DNA level, amoA gene abundances of AOA were significantly...
Stark, H. Sophia; Altmann, Philipp J.; Sproules, Stephen; Hess, Corinna R.
A series of mono- and bimetallic copper-Mabiq complexes is described. One-electron reduction of the CuII and CuICuII complexes is ligand-centered, yielding the (Mabiq•) form of the macrocycle. Both bimetallic compounds are thus mixed-valent with respect to the metal ions. The influence of the outer copper ion on the redox, spectroscopic, and photochemical properties of the central ion was examined. The two metals ions interact weakly, such that the photoactivity of the central Cu-Mabiq unit is retained.
Ferguson, B.; Petridou, N.; Fracasso, A.; van Den Heuvel, M.P.; Brouwer, R.M.; Hulshoff Pol, H.E.; Kahn, R.S.; Mandl, R.C.W.
Studies into cortical thickness in psychiatric diseases based on T1-weighted MRI frequently report on aberrations in the cerebral cortex. Due to limitations in image resolution for studies conducted at conventional MRI field strengths (e.g. 3 Tesla (T)) this information cannot be used to establish which of the cortical layers may be implicated. Here we propose a new analysis method that computes one high-resolution average cortical profile per brain region extracting myeloarchitectural information from T1-weighted MRI scans that are routinely acquired at a conventional field strength. To assess this new method, we acquired standard T1-weighted scans at 3 T and compared...
Hazley, Barry; Wright, Valerie; Abrams, Lynn; Kearns, Ade
In recent years, the social research of Pearl Jephcott has been subject to scholarly reappraisal on the grounds that it displays an early commitment to the unmediated reporting of ‘the authentic voice of her participants’. This article investigates the extent to which this claim holds for Jephcott’s seminal 1971 study Homes in High Flats. It suggests that, although Homes in High Flats sought to investigate ‘people and their homes rather than housing in the usual sense’, the study’s ability to realise this aim was complicated by the social distance obtaining between researcher and researched. Based on re-analysis of the study’s...
Yurchenko, Andrey A.; Katolikova, Nataliia; Polev, Dmitrii; Shcherbakova, Irina; Strelkov, Petr
The Baltic clam Limecola balthica L. (Tellinidae) is broadly used in ecophysiological, toxicological, evolutionary and environmental monitoring studies. However, it is poorly studied in respect of genome and gene functions. We obtained a transcriptome of Limecola b. balthica from Kamchatka (Western Pacific) generated with the use of Illumina high-throughput sequencing. We annotated 11,374 proteins, including 53 from the oxidative phosphorylation pathway and a number of pollution-stress biomarkers, recovered 254,540 single nucleotide variants within two annotated transcriptomes including 25,330 scorable in the previously published European data. Our results confirmed the available allozyme data indicating that nuclear genomes of the clams from...
Daniels, Stephen J.
Recently, doubt has been cast on the ability of Scottish education to meet relevant Human Rights requirements relating to education. This article will outline both a means of clarification for international requirements for Human Rights Education, and an analysis of documentation outlining Scottish educational policy for compatibility with these requirements. In doing so, this article will outline the development, and application, of a tool for document analysis focused on international requirements for Human Rights Education. The findings of this analysis suggest a number of key limitations in the current approach favoured by the Scottish Government. This approach posits Global Citizenship...
Simonsen, Claus Z.; Thomalla, Götz; Boutitie, Florent; Andersen, Grethe; Berthezene, Yves; Cheng, Bastian; Cheripelli, Bharath; Cho, Tae-Hee; Fazekas, Franz; Fiehler, Jens; Ford, Ian FordIan; Galinovic, Ivana; Gellissen, Susanne; Golsari, Amir; Gregori, Johannes; Günther, Matthias; Guibernau, Jorge; Häusler, Karl Georg; Hennerici, Michael; Kemmling, André; Marstrand, Jacob; Modrau, Boris; Neeb, Lars; Perez de la Ossa, Natalia; Puig, Josep; Ringleb, Peter; Roy, Pascal; Scheel, Enno; Schonewille, Wouter; Serena, Joaquin; Sunaert, Stefan; Villringer, Kersten; Wouters, Anke; Thijs, Vincent; Ebinger, Martin; Endres, Matthias; Fiebach, Jochen B.; Lemmens, Robin; Muir, Keith W.; Nighoghossian, Norbert; Pedraza, Salvador; Gerloff, Christian
Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase.
In a multicenter trial, we randomly assigned patients who had an unknown time of onset of stroke to receive either intravenous alteplase or placebo. All the patients had an ischemic lesion that was visible on MRI...
McClurg, Urszula L.; Chit, Nay C.T.H.; Azizyan, Mahsa; Edwards, Joanne; Nabbi, Arash; Riabowol, Karl T.; Nakjang, Sirintra; McCracken, Stuart R.; Robson, Craig N.
The TP53-MDM2-AR-AKT signalling network plays a critical role in the development and progression of prostate cancer. However, the molecular mechanisms regulating this signalling network are not completely defined. By conducting transcriptome analysis, denaturing immunoprecipitations and immunopathology, we demonstrate that the TP53-MDM2-AR-AKT cross-talk is regulated by the deubiquitinating enzyme USP12 in prostate cancer. Our findings explain why USP12 is one of the 12 most commonly overexpressed cancer-associated genes located near an amplified super-enhancer. We find that USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer. Consequently, USP12 levels...
Sharma, Mukul; Hart, Robert G.; Mundl, Hardi; Kasner, Scott E.; Bangdiwala, Shrikant I.; Berkowitz, Scott D.; Swaminathan, Balakumar; Lavados, Pablo; Wang, Yongjun; Wang, Yilong; Davalos, Antonio; Shamalov, Nikolay; Mikulik, Robert; Cunha, Luis; Lindgren, Arne; Arauz, Antonio; Lang, Wilfried; Czlonkowska, Anna; Eckstein, Jens; Gagliardi, Rubens J.; Amarenco, Pierre; Ameriso, Sebastian F.; atlisumak, Turgut T.; Veltkamp, Roland; Hankey, Graeme J.; Toni, Danilo; Bereczki, Daniel; Uchiyama, Shinichiro; Ntaios, George; Yoon, Byung-Woo; Brouns, Raf; Endres, Matthias; Muir, Keith W.; Bornstein, Natan; Ozturk, Serefnur; O’Donnell, Martin J.; De Vries Basson, Matthys M.; Pare, Guillaume; Pater, Calin; Kirsch, Bodo; Sheridan, Patrick; Peters, Gary; Weitz, Jeffrey I.; Peacock, W. Frank; Shoamanesh, Ashkan; Benavente, Oscar R.; Joyner, Campbell; Themeles, Ellison; Connolly, Stuart J.
Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin.
We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for the prevention of recurrent stroke in patients with recent ischemic stroke that was presumed to be from cerebral embolism but without arterial stenosis, lacune, or an identified cardioembolic source. The primary efficacy outcome was the first recurrence...
Turk-MacLeod, Rebecca; Henson, Alon; Rodriguez-Garcia, Marc; Gibson, Graham M.; Aragon Camarasa, Gerardo; Caramelli, Dario; Padgett, Miles J.; Cronin, Leroy
The sorting of objects into groups is a fundamental operation, critical in the preparation and purification of populations of cells, crystals, beads, or droplets, necessary for research and applications in biology, chemistry, and materials science. Most of the efforts exploring such purification have focused on two areas: the degree of separation and the measurement precision required for effective separation. Conventionally, achieving good separation ultimately requires that the objects are considered one by one (which can be both slow and expensive), and the ability to measure the sorted objects by increasing sensitivity as well as reducing sorting errors. Here we present...
Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn O.; Bjøro, Trine; Vatten, Lars J.; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J.
Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups.
Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included. Thyroid hormone status was defined using clinical cut-off values. Estimated glomerular filtration rates (eGFR) were calculated by means of the four-variable Modification of Diet in Renal Disease (MDRD) formula....
Bodde, Mathijs C.; Welsh, Paul; Bergheanu, Sandrin C.; Lijfering, Willem M.; Mertens, Bart; Liem, An-Ho; van der Laarse, Arnoud; Sattar, Naveed; Jukema, J.Wouter
Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high‐sensitivity troponin‐I (hs‐cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up‐titrated at 6‐week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs‐cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow‐up. Statin treatment resulted in a mean change of serum hs‐cTnI of –8.2% (P = 0.010) after 6 weeks and –12.3% (P = 0.001) after 18 weeks. After 18...
Fisk, Helena L.; Irvine, Michael; Miles, Elizabeth A.; Lietz, Georg; Mathers, John C.; Packard, Chris J.; Armah, Christopher K.; Kofler, Bettina M.; Curtis, Peter J.; Minihane, Anne M.; Calder, Philip C.
n-3 Fatty acids are associated with better cardiovascular and cognitive health. However, the concentration of EPA, DPA and DHA in different plasma lipid pools differs and factors influencing this heterogeneity are poorly understood. Our aim was to evaluate the association of oily fish intake, sex, age, BMI and APOE genotype with concentrations of EPA, DPA and DHA in plasma phosphatidylcholine (PC), NEFA, cholesteryl esters (CE) and TAG. Healthy adults (148 male, 158 female, age 20–71 years) were recruited according to APOE genotype, sex and age. The fatty acid composition was determined by GC. Oily fish intake was positively associated with...
Sumanapala, Dilini K.; Walbrin, Jon; Kirsch, Louise P.; Cross, Emily S.
Studies investigating human motor learning and movement perception have shown that similar sensorimotor brain regions are engaged when we observe or perform action sequences. However, the way these networks enable translation of complex observed actions into motor commands—such as in the context of dance—remains poorly understood. Emerging evidence suggests that the ability to encode specific visuospatial and kinematic movement properties encountered via different routes of sensorimotor experience may be an integral component of action learning throughout development. Using a video game-based dance training paradigm, we demonstrate that patterns of voxel activity in visual and sensorimotor brain regions when perceiving movements...
Kirsch, Louise P.; Cross, Emily S.
Understanding how action perception, embodiment, and emotion interact is essential for advancing knowledge about how we perceive and interact with each other in a social world. One tool that has proved particularly useful in the past decade for exploring the relationship between perception, action, and affect is dance. Dance is, in its essence, a rich and multisensory art form that can be used to help answer not only basic questions about social cognition but also questions concerning how aging shapes the relationship between action perception, and the role played by affect, emotion, and aesthetics in social perception. In the present...
Jing, Yi; Han, Thang S.; Alkhalaf, Majid M.; Lean, Michael E.J.
While weight gain and obesity are the dominant factors, dietary sugar and specifically sugar-sweetened beverages (SSB) has been implicated in causing type 2 diabetes (T2DM). We assessed how much of the apparent effect of SSB is explained by adiposity, but not captured by adjustment for BMI, which is a poor index of body fat.
We examined data from 5187 adults (mean age 50.8 years, SD = 16.4, 172 (3.3%) T2DM), from the Scottish Health Survey 2003 and 2008–2010 databases. Logistic regression was used to assess the association between SSB consumption and T2DM (non-insulin treated) and its attenuation (reduction in odds ratios, ORs), after...
Dickie, David Alexander; Valdés Hernández, Maria del C.; Makin, Stephen D.; Staals, Julie; Wiseman, Stewart J.; Bastin, Mark E.; Wardlaw, Joanna M.
A structural magnetic resonance imaging measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia.
We aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the brain health index.
Materials and methods:
We computed brain health index in N = 288 participants using voxel-based Gaussian mixture model cluster analysis of T1, T2, T2*, and FLAIR magnetic resonance imaging. We tested brain health index against a validated total small vessel disease visual score and white matter hyperintensity volumes in two patient...
Docherty, Kieran F.; Jhund, Pardeep S.
No abstract available.
Ferreira, João Pedro; Duarte, Kévin; Pitt, Bertram; Dickstein, Kenneth; McMurray, John J.V.; Zannad, Faiez; Rossignol, Patrick
Background: Visit-to-visit office blood pressure variation
(BPV) has prognostic implications independent from mean
BP across several populations in the cardiovascular field.
The association of BPV with outcomes in patients with
myocardial infarction (MI) with systolic dysfunction and/or
heart failure is yet to be determined.
Methods: Two independent cohorts were assessed: the
EPHESUS and the OPTIMAAL trials with a total of more
than 12 000 patients. The primary outcome was all-cause
death. BPV was calculated as a coefficient of variation,
that is, the ratio of the SD to the mean BP along the
postbaseline follow-up. Cox regression models were used
to determine the associations between BPV and events.
Results: Compared with the middle and...