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University of Vienna Phaidra (215.751 recursos)

Is a publication service run by the University of Vienna. It is an institutional repository whose aim is to collect and present the research results of university staff. This includes journal articles and monographs as well as congress and working papers. In principle it is possible to use u:scholar to also archive research data.

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Mostrando recursos 1 - 20 de 147

  1. IMNGS: A comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies

    Lagkouvardos, Ilias; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München; Joseph, Divya; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München; Kapfhammer, Martin; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München; Giritli, Sabahattin; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München; Horn, Matthias; Department fur Mikrobiologie und Okosystemforschung, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Mikrobiologie und Okosystemforschung, Fakultat fur Lebenswissenschaften, University of Vienna; Haller, Dirk; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München; Clavel, Thomas; ZIEL Institute for Food and Health, Core Facility NGS/Microbiome, Technische Universität München
    The SRA (Sequence Read Archive) serves as primary depository for massive amounts of Next Generation Sequencing data, and currently host over 100,000 16S rRNA gene amplicon-based microbial profiles from various host habitats and environments. This number is increasing rapidly and there is a dire need for approaches to utilize this pool of knowledge. Here we created IMNGS (Integrated Microbial Next Generation Sequencing), an innovative platform that uniformly and systematically screens for and processes all prokaryotic 16S rRNA gene amplicon datasets available in SRA and uses them to build sample-specific sequence databases and OTU-based profiles. Via a web interface, this integrative...

  2. New potential binding determinant for hERG channel inhibitors

    Saxena, P.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Zangerl-Plessl, E.-M.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Linder, T.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Windisch, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Hohaus, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Timin, E.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Hering, S.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Stary-Weinzinger, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna
    Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K+ current (IKr) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants of hERG1 channel blockers include T623, S624 and V625 on the pore helix, and residues G648, Y652 and F656, located on segment S6. We and others have previously hypothesized that additional binding determinants may be located on helix S5, which is in close contact with the S6 segments. In order to test this hypothesis, we performed a detailed investigation...

  3. New potential binding determinant for hERG channel inhibitors

    Saxena, P.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Zangerl-Plessl, E.-M.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Linder, T.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Windisch, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Hohaus, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Timin, E.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Hering, S.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Stary-Weinzinger, A.; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Pharmakologie und Toxikologie, Fakultat fur Lebenswissenschaften, University of Vienna
    Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K+ current (IKr) and are essential for the repolarization of the cardiac action potential. hERG1 inhibition by structurally diverse drugs may lead to life threatening arrhythmia. Putative binding determinants of hERG1 channel blockers include T623, S624 and V625 on the pore helix, and residues G648, Y652 and F656, located on segment S6. We and others have previously hypothesized that additional binding determinants may be located on helix S5, which is in close contact with the S6 segments. In order to test this hypothesis, we performed a detailed investigation...

  4. Diversity and carbon storage across the tropical forest biome

    Sullivan, Martin J. P.; School of Geography, University of Leeds; Talbot, Joey; School of Geography, University of Leeds; Miles, Lera; United Nations Environment Programme World Conservation Monitoring Centre; Silveira, Marcos; Museu Universitário, Universidade Federal do Acre; Slik, J. W. Ferry; Carboforexpert; Steel, Lisa; World Wildlife Fund; Taedoumg, Hermann; Plant Systematic and Ecology Laboratory, University of Yaounde I; Tan, Sylvester; CTFS-AA Asia Program, Harvard University; Terborgh, John W.; Nicholas School of the Environment, Duke University; Thomas, Sean C.; Faculty of Forestry, University of Toronto; Toledo, Marisol; Instituto Boliviano de Investigación Forestal; Umunay, Peter M.; Yale School of Forestry & Environmental Studies; Gamarra, Luis Valenzuela; Jardín Botánico de Missouri; Monteagudo-Mendoza, Abel; Jardín Botánico de Missouri; Vieira, Ima Célia Guimarães; Museu Paraense Emilio Goeldi; Vos, Vincent A.; Universidad Autónoma del Beni; Wang, Ophelia; School of Earth Sciences and Environmental Sustainability, Northern Arizona University; Willcock, Simon; Biological Sciences, University of Southampton; Zemagho, Lise; Plant Systematic and Ecology Laboratory, University of Yaounde I; Sonké, Bonaventure; Plant Systematic and Ecology Laboratory, University of Yaounde I; Sunderland, Terry; CIFOR; ter Steege, Hans; Naturalis Biodiversity Center; White, Lee J. T.; Agence Nationale des Parcs Nationaux, Gabon; Affum-Baffoe, Kofi; Mensuration Unit, Forestry Commission of Ghana; Aiba, Shin-ichiro; Graduate School of Science and Engineering, Kagoshima University; de Almeida, Everton Cristo; Instituto de Biodiversidade e Floresta, Universidade Federal do Oeste do Pará; de Oliveira, Edmar Almeida; Universidade do Estado de Mato Grosso; Lewis, Simon L.; School of Geography, University of Leeds; Alvarez-Loayza, Patricia; Center for Tropical Conservation, Duke University; Dávila, Esteban Álvarez; Red para la Mitigación y Adaptación al Cambio Climático de la UNAD; Andrade, Ana; Instituto Nacional de Pesquisas da Amazônia, Brazil; Aragão, Luiz E. O. C.; Geography, College of Life and Environmental Sciences, University of Exeter; Ashton, Peter; Department of Organismic and Evolutionary Biology, Harvard University; Aymard C., Gerardo A.; Programa de Ciencias del Agro y el Mar, Herbario Universitario; Baker, Timothy R.; School of Geography, University of Leeds; Balinga, Michael; CIFOR; Banin, Lindsay F.; Centre for Ecology and Hydrology, UK; Baraloto, Christopher; International Center for Tropical Botany, Department of Biological Sciences, Florida International University; Phillips, Oliver L.; School of Geography, University of Leeds; Bastin, Jean-Francois; UMR AMAP, IRD; Berry, Nicholas; School of GeoSciences, The University of Edinburgh; Bogaert, Jan; Biodiversity and Landscape Unit, Gembloux Agro-Bio Tech, Université de Liège; Bonal, Damien; INRA, UMR EEF; Bongers, Frans; Forest Ecology and Forest Management group, Wageningen University; Brienen, Roel; School of Geography, University of Leeds; Camargo, José Luís C.; Projeto Dinâmica Biológica de Fragmentos Florestais, Instituto Nacional de Pesquisas da Amazônia, Brazil; Cerón, Carlos; Herbario Alfredo Paredes, Universidad Central del Ecuador; Moscoso, Victor Chama; Universidad Nacional de San Antonio Abad del Cusco; Chezeaux, Eric; Rougier-Gabon; Qie, Lan; School of Geography, University of Leeds; Clark, Connie J.; Nicholas School of the Environment, Duke University; Pacheco, Álvaro Cogollo; Jardín Botánico Joaquín Antonio Uribe; Comiskey, James A.; Inventory & Monitoring Program, National Park Service, USA; Valverde, Fernando Cornejo; Andes to Amazon Biodiversity Program; Coronado, Eurídice N. Honorio; Instituto de Investigaciones de la Amazonia Perúana; Dargie, Greta; School of Geography, University of Leeds; Davies, Stuart J.; Smithsonian Tropical Research Institute; De Canniere, Charles; Landscape Ecology and Vegetal Production Systems Unit, Universite Libre de Bruxelles; Djuikouo K., Marie Noel; Department of Botany & Plant Physiology, Faculty of Science, University of Buea; Doucet, Jean-Louis; Forest Ressources Management, Gembloux Agro-Bio Tech, University of Liege; Begne, Serge K.; School of Geography, University of Leeds; Erwin, Terry L.; Smithsonian Institution; Espejo, Javier Silva; Universidad Nacional de San Antonio Abad del Cusco; Ewango, Corneille E. N.; Wildlife Conservation Society-DR Congo; Fauset, Sophie; School of Geography, University of Leeds; Feldpausch, Ted R.; Geography, College of Life and Environmental Sciences, University of Exeter; Herrera, Rafael; Institut fur Geographie und Regionalforschung, Fakultat fur Geowissenschaften, Geographie und Astronomie, University of Vienna; Institut fur Geographie und Regionalforschung, Fakultat fur Geowissenschaften, Geographie und Astronomie, University of Vienna; Gilpin, Martin; School of Geography, University of Leeds; Gloor, Emanuel; School of Geography, University of Leeds; Hall, Jefferson S.; Smithsonian Tropical Research Institute; Harris, David J.; Royal Botanic Garden Edinburgh; Chave, Jerôme; Université Paul Sabatier CNRS; Hart, Terese B.; Lukuru Wildlife Research Foundation; Kartawinata, Kuswata; Herbarium Bogoriense, Indonesian Institute of Sciences; Kho, Lip Khoon; Tropical Peat Research Institute, Biological Research Division, Malaysian Palm Oil Board; Kitayama, Kanehiro; Kyoto University; Laurance, Susan G. W.; Centre for Tropical Environmental and Sustainability Sciences and College of Science and Engineering, James Cook University; Laurance, William F.; Centre for Tropical Environmental and Sustainability Sciences and College of Science and Engineering, James Cook University; Leal, Miguel E.; Wildlife Conservation Society; Lovejoy, Thomas; Department of Environmental Science and Policy, George Mason University; Lovett, Jon C.; School of Geography, University of Leeds; Lukasu, Faustin Mpanya; Faculté des Sciences Agronomiques, Université de Kisangani; Cuni-Sanchez, Aida; Department of Geography, University College London; Makana, Jean-Remy; Wildlife Conservation Society-DR Congo; Malhi, Yadvinder; School of Geography and the Environment, University of Oxford; Maracahipes, Leandro; Universidade Federal de Goiás; Marimon, Beatriz S.; Universidade do Estado de Mato Grosso; Junior, Ben Hur Marimon; Universidade do Estado de Mato Grosso; Marshall, Andrew R.; Flamingo Land Ltd; Morandi, Paulo S.; Universidade do Estado de Mato Grosso; Mukendi, John Tshibamba; Faculté des Sciences Agronomiques, Université de Kisangani; Mukinzi, Jaques; Wildlife Conservation Society-DR Congo; Nilus, Reuben; Sabah Forestry Department; Hubau, Wannes; School of Geography, University of Leeds; Vargas, Percy Núñez; Universidad Nacional de San Antonio Abad del Cusco; Camacho, Nadir C. Pallqui; Universidad Nacional de San Antonio Abad del Cusco; Pardo, Guido; Universidad Autónoma del Beni; Peña-Claros, Marielos; Forest Ecology and Forest Management group, Wageningen University; Pétronelli, Pascal; CIRAD, UMR Ecologie des Forêts de Guyane; Pickavance, Georgia C.; School of Geography, University of Leeds; Poulsen, Axel Dalberg; Natural History Museum, University of Oslo; Poulsen, John R.; Nicholas School of the Environment, Duke University; Primack, Richard B.; Department of Biology, Boston University; Priyadi, Hari; CIFOR; Lopez-Gonzalez, Gabriela; School of Geography, University of Leeds; Quesada, Carlos A.; Instituto Nacional de Pesquisas da Amazônia, Brazil; Reitsma, Jan; Bureau Waardenburg; Réjou-Méchain, Maxime; Université Paul Sabatier CNRS; Restrepo, Zorayda; Fundación Con Vida; Rutishauser, Ervan; Carboforexpert; Salim, Kamariah Abu; Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam; Salomão, Rafael P.; Museu Paraense Emilio Goeldi; Samsoedin, Ismayadi; FORDA, The Ministry of Forestry and Environment, Indonesia; Sheil, Douglas; CIFOR; Sierra, Rodrigo; GeoIS
    Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified. Here, we compile a unique pan-tropical dataset of 360 plots located in structurally intact old-growth closed-canopy forest, surveyed using standardised methods, allowing a multi-scale evaluation of diversity-carbon relationships in...

  5. Dilthey als Wissenschaftsphilosoph

    Damböck, Christian; Institut Wiener Kreis, Fakultat fur Philosophie und Bildungswissenschaft, University of Vienna; Institut Wiener Kreis, Fakultat fur Philosophie und Bildungswissenschaft, University of Vienna; Lessing, Hans-Ulrich; Ruhr-Universität Bochum
    Dieser Band vereinigt die Beiträge einer im Juni 2013 am Institut Wiener Kreis der Universität Wien stattgefundenen Tagung, deren Ziel es gewesen ist, die Rolle Diltheys als Wissenschaftsphilosoph zu beleuchten, vor dem Hintergrund der in den letzten Jahrzehnten in der Dilthey-Forschung erarbeiteten Befunde, die Dilthey tendenziell von dem Bild einer rein „kontinentalen“ Philosophie der Hermeneutik des Lebens weg gerückt haben.

  6. Dilthey als Wissenschaftsphilosoph

    Damböck, Christian; Institut Wiener Kreis, Fakultat fur Philosophie und Bildungswissenschaft, University of Vienna; Institut Wiener Kreis, Fakultat fur Philosophie und Bildungswissenschaft, University of Vienna; Lessing, Hans-Ulrich; Ruhr-Universität Bochum
    Dieser Band vereinigt die Beiträge einer im Juni 2013 am Institut Wiener Kreis der Universität Wien stattgefundenen Tagung, deren Ziel es gewesen ist, die Rolle Diltheys als Wissenschaftsphilosoph zu beleuchten, vor dem Hintergrund der in den letzten Jahrzehnten in der Dilthey-Forschung erarbeiteten Befunde, die Dilthey tendenziell von dem Bild einer rein „kontinentalen“ Philosophie der Hermeneutik des Lebens weg gerückt haben.

  7. Connectivity, dynamics, and structure in a tetrahedral network liquid

    Roldán-Vargas, S. (Sándalo); Rovigatti, L. (Lorenzo); Sciortino, F. (Francesco)
    We report a detailed computational study by Brownian dynamics simulations of the structure and dynamics of a liquid of patchy particles which forms an amorphous tetrahedral network upon decreasing the temperature. The highly directional particle interactions allow us to investigate the system connectivity by discriminating the total set of particles into different populations according to a penta-modal distribution of bonds per particle. With this methodology we show how the particle bonding process is not randomly independent but it manifests clear bond correlations at low temperatures. We further explore the dynamics of the system in real space and establish a clear...

  8. Hierarchical self-organization of soft patchy nanoparticles into morphologically diverse aggregates

    C. Gârlea, I. (Ioana); Bianchi, E. (Emanuela); Capone, B. (Barbara); Rovigatti, L. (Lorenzo); N. Likos, C. (Christos)
    We present a concise review of the large variety of self-assembly scenarios observed in solutions of diblock copolymer stars with a solvophilic inner block and a solvophobic outer block. A variety of modeling approaches and simulation techniques at different levels of detail reveals that individual molecules assume configurations akin to patchy colloids, but with a patchiness that depends on physical parameters and can adjust to external stimuli such as temperature and pH. These soft, patchy building blocks inter-associate at finite concentrations into micellar or gel-like solutions, including spherical and wormlike micelles, or they display macroscopic phase separation. The connections between...

  9. Limiting the valence: advancements and new perspectives on patchy colloids, soft functionalized nanoparticles and biomolecules

    Bianchi, Emanuela; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Capone, Barbara; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Coluzza, Ivan; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Rovigatti, Lorenzo; University of Oxford; van Oostrum, Peter D. J.; University of Natural Resources and Life Sciences, Vienna
    Limited bonding valence, usually accompanied by well-defined directional interactions and selective bonding mechanisms, is nowadays considered among the key ingredients to create complex structures with tailored properties: even though isotropically interacting units already guarantee access to a vast range of functional materials, anisotropic interactions can provide extra instructions to steer the assembly of specific architectures. The anisotropy of effective interactions gives rise to a wealth of self-assembled structures both in the realm of suitably synthesized nano- and micro-sized building blocks and in nature, where the isotropy of interactions is often a zero-th order description of the complicated reality. In this...

  10. The role of directional interactions in the designability of generalized heteropolymers

    Cardelli, Chiara; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Bianco, Valentino; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Rovigatti, Lorenzo; University of Oxford; Nerattini, Francesca; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Tubiana, Luca; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Dellago, Christoph; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Coluzza, Ivan; Computergestutzte Physik, Fakultat fur Physik, University of Vienna; Computergestutzte Physik, Fakultat fur Physik, University of Vienna
    Heteropolymers are important examples of self-assembling systems. However, in the design of artificial heteropolymers the control over the single chain self-assembling properties does not reach that of the natural bio-polymers, and in particular proteins. Here, we introduce a sufficiency criterion to identify polymers that can be designed to adopt a predetermined structure and show that it is fulfilled by polymers made of monomers interacting through directional (anisotropic) interactions. The criterion is based on the appearance of a particular peak in the radial distribution function, that we show being a universal feature of all designable heteropolymers, as it is present also...

  11. Strategie der Streuung. Das multimediale Geschäftsmodell des Reisefilmers Colin Ross in den Protokollen des Brockhaus-Verlags

    Schätz, Joachim; Ludwig Boltzmann Institut für Geschichte und Gesellschaft
    The short article investigates the genuinely multi-media business model of Vienna-born travel writer, filmmaker and lecturer Colin Ross (1885-1945). It stresses the ample insight gained through one source: the minutes produced by Ross's main publishing house Brockhaus about Ross's frequent visits.

  12. Strategie der Streuung. Das multimediale Geschäftsmodell des Reisefilmers Colin Ross in den Protokollen des Brockhaus-Verlags

    Schätz, J. (Joachim)
    The short article investigates the genuinely multi-media business model of Vienna-born travel writer, filmmaker and lecturer Colin Ross (1885-1945). It stresses the ample insight gained through one source: the minutes produced by Ross's main publishing house Brockhaus about Ross's frequent visits.

  13. “Think positively”: Parkinson’s disease, biomedicine, and hope in contemporary Germany

    Metzler, Ingrid; Fakultat fur Sozialwissenschaften, University of Vienna; Fakultat fur Sozialwissenschaften, University of Vienna; Just, Paul; Fakultat fur Sozialwissenschaften, University of Vienna; Fakultat fur Sozialwissenschaften, University of Vienna
    Narratives of hope shape contemporary engagements with Parkinson’s disease. On the one hand, a “biomedical narrative of hope” promises that biomedical research will help to transform this treatable but incurable disease into a curable one in the future. On the other hand, a more individual “illness narrative of hope” encourages patients to influence the course of Parkinson’s disease by practicing self-care and positive thinking. This article asks how these two narratives of hope interact. It bases its argument on an analysis of data from 13 focus groups conducted in Germany in 2012 and 2014 with patients with Parkinson’s disease and...

  14. Circumstellar disks of the most vigorously accreting young stars

    Liu, Hauyu Baobab; Academia Sinica Institute of Astronomy and Astrophysics; Takami, Michihiro; Academia Sinica Institute of Astronomy and Astrophysics; Dunham, Michael M.; Harvard-Smithsonian Center for Astrophysics; Karr, Jennifer L.; Academia Sinica Institute of Astronomy and Astrophysics; Kusakabe, Nobuhiko; National Astronomical Observatory of Japan; Tsuribe, Toru; College of Science, Ibaraki University; Kudo, Tomoyuki; National Astronomical Observatory of Japan; Hashimoto, Jun; National Astronomical Observatory of Japan; Dong, Ruobing; Academia Sinica Institute of Astronomy and Astrophysics; Vorobyov, Eduard I.; Institut fur Astrophysik, Fakultat fur Geowissenschaften, Geographie und Astronomie, University of Vienna; Institut fur Astrophysik, Fakultat fur Geowissenschaften, Geographie und Astronomie, University of Vienna; Pyo, Tae-Soo; National Astronomical Observatory of Japan; Fukagawa, Misato; National Astronomical Observatory of Japan; Tamura, Motohide; National Astronomical Observatory of Japan; Henning, Thomas; Max-Planck-Institut für Astronomie
    Stars may not accumulate their mass steadily, as was previously thought, but in a series of violent events manifesting themselves as sharp stellar brightening. These events can be caused by fragmentation due to gravitational instabilities in massive gaseous disks surrounding young stars, followed by migration of dense gaseous clumps onto the star. Our high-resolution near-infrared imaging has verified the presence of the key associated features, large-scale arms and arcs surrounding four young stellar objects undergoing luminous outbursts. Our hydrodynamics simulations and radiative transfer models show that these observed structures can indeed be explained by strong gravitational instabilities occurring at the...

  15. Monkey vocal tracts are speech-ready

    Fitch, W. T.; Department fur Kognitionsbiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Kognitionsbiologie, Fakultat fur Lebenswissenschaften, University of Vienna; de Boer, B.; Artificial Intelligence Laboratory, Vrije Universiteit Brussel; Mathur, N.; Princeton Neuroscience Institute, Princeton University; Ghazanfar, A. A.; Princeton Neuroscience Institute, Princeton University
    For four decades, the inability of nonhuman primates to produce human speech sounds has been claimed to stem from limitations in their vocal tract anatomy, a conclusion based on plaster casts made from the vocal tract of a monkey cadaver. We used x-ray videos to quantify vocal tract dynamics in living macaques during vocalization, facial displays, and feeding. We demonstrate that the macaque vocal tract could easily produce an adequate range of speech sounds to support spoken language, showing that previous techniques based on postmortem samples drastically underestimated primate vocal capabilities. Our findings imply that the evolution of human speech...

  16. Who Believes in the Giant Skeleton Myth? An Examination of Individual Difference Correlates

    Swami, Viren; Anglia Ruskin University; Tran, Ulrich S.; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna; Stieger, Stefan; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna; Pietschnig, Jakob; Institut fur Angewandte Psychologie: Gesundheit, Entwicklung und Forderung , Fakultat fur Psychologie, University of Vienna; Institut fur Angewandte Psychologie: Gesundheit, Entwicklung und Forderung , Fakultat fur Psychologie, University of Vienna; Nader, Ingo W.; Fakultat fur Psychologie, University of Vienna; Fakultat fur Psychologie, University of Vienna; Voracek, Martin; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna; Institut fur Psychologische Grundlagenforschung und Forschungsmethoden , Fakultat fur Psychologie, University of Vienna
    This study examined individual difference correlates of belief in a narrative about the discovery of giant skeletal remains that contravenes mainstream scientific explanations. A total of 364 participants from Central Europe completed a survey that asked them to rate their agreement with a short excerpt describing the giant skeleton myth. Participants also completed measures of the Big Five personality factors, New Age orientation, anti-scientific attitudes, superstitious beliefs, and religiosity. Results showed that women, as compared with men, and respondents with lower educational qualifications were significantly more likely to believe in the giant skeleton myth, although effect sizes were small. Correlational...

  17. Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation

    Nukarinen, Ella; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Nägele, Thomas; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Dröge-Laser, Wolfgang; Julius-von-Sachs-Institut, Julius-Maximilians-Universität Würzburg; Weckwerth, Wolfram; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Pedrotti, Lorenzo; Julius-von-Sachs-Institut, Julius-Maximilians-Universität Würzburg; Wurzinger, Bernhard; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Mair, Andrea; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Landgraf, Ramona; Plant Health, Plant Metabolism Group, Leibniz-Institute of Vegetable and Ornamental Crops; Börnke, Frederik; Plant Health, Plant Metabolism Group, Leibniz-Institute of Vegetable and Ornamental Crops; Hanson, Johannes; Department of Plant Physiology, Umeå University; Teige, Markus; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Department fur Okogenomik und Systembiologie, Fakultat fur Lebenswissenschaften, University of Vienna; Baena-Gonzalez, Elena; Instituto Gulbenkian de Ciência
    Since years, research on SnRK1, the major cellular energy sensor in plants, has tried to define its role in energy signalling. However, these attempts were notoriously hampered by the lethality of a complete knockout of SnRK1. Therefore, we generated an inducible amiRNA::SnRK1α2 in a snrk1α1 knock out background (snrk1α1/α2) to abolish SnRK1 activity to understand major systemic functions of SnRK1 signalling under energy deprivation triggered by extended night treatment. We analysed the in vivo phosphoproteome, proteome and metabolome and found that activation of SnRK1 is essential for repression of high energy demanding cell processes such as protein synthesis. The most...

  18. High-yield fabrication and properties of 1.4 nm nanodiamonds with narrow size distribution

    Stehlik, Stepan; Institute of Physics ASCR; Varga, Marian; Institute of Physics ASCR; Rezek, Bohuslav; Institute of Physics ASCR; Ledinsky, Martin; Institute of Physics ASCR; Miliaieva, Daria; Institute of Physics ASCR; Kozak, Halyna; Institute of Physics ASCR; Skakalova, Viera; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Mangler, Clemens; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Pennycook, Timothy J.; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Meyer, Jannik C.; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Physik Nanostrukturierter Materialien, Fakultat fur Physik, University of Vienna; Kromka, Alexander; Institute of Physics ASCR
    Detonation nanodiamonds (DNDs) with a typical size of 5 nm have attracted broad interest in science and technology. Further size reduction of DNDs would bring these nanoparticles to the molecular-size level and open new prospects for research and applications in various fields, ranging from quantum physics to biomedicine. Here we show a controllable size reduction of the DND mean size down to 1.4 nm without significant particle loss and with additional disintegration of DND core agglutinates by air annealing, leading to a significantly narrowed size distribution (±0.7 nm). This process is scalable to large quantities. Such molecular-sized DNDs keep their diamond structure and...

  19. Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

    Bernhart, Stephan H.; Chair of Bioinformatics, Leipzig University; Kretzmer, Helene; Chair of Bioinformatics, Leipzig University; Hoffmann, Steve; Chair of Bioinformatics, Leipzig University; Holdt, Lesca M.; Institute of Laboratory Medicine, Ludwig-Maximilians-University; Jühling, Frank; Chair of Bioinformatics, Leipzig University; Ammerpohl, Ole; Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel; Bergmann, Anke K.; Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel; Northoff, Bernd H.; Institute of Laboratory Medicine, Ludwig-Maximilians-University; Doose, Gero; Chair of Bioinformatics, Leipzig University; Siebert, Reiner; Institute of Human Genetics, Christian Albrechts University & University Hospital Schleswig-Holstein - Campus Kiel; Stadler, Peter F.; Institut fur Theoretische Chemie, Fakultat fur Chemie, University of Vienna; Institut fur Theoretische Chemie, Fakultat fur Chemie, University of Vienna
    Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated in normal cells, but frequently shows elevated methylation levels in cancer samples. Here, we developed a universal classifier built from chromatin data that can identify cancer samples solely from hypermethylation of bivalent chromatin. Tested on over 7,000 DNA methylation data sets from several cancer types, it reaches an AUC of 0.92. Although higher levels of...

  20. Role of Polar Phonons in the Photo Excited State of Metal Halide Perovskites

    Bokdam, Menno; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Sander, Tobias; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Stroppa, Alessandro; Consiglio Nazionale delle Ricerche - CNR-SPIN; Picozzi, Silvia; Consiglio Nazionale delle Ricerche - CNR-SPIN; Sarma, D. D.; Solid State and Structural Chemistry Unit, Indian Institute of Science; Franchini, Cesare; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Kresse, Georg; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna; Computergestutzte Materialphysik, Fakultat fur Physik, University of Vienna
    The development of high efficiency perovskite solar cells has sparked a multitude of measurements on the optical properties of these materials. For the most studied methylammonium(MA)PbI3 perovskite, a large range (6–55 meV) of exciton binding energies has been reported by various experiments. The existence of excitons at room temperature is unclear. For the MAPbX3 perovskites we report on relativistic Bethe-Salpeter Equation calculations (GW-BSE). This method is capable to directly calculate excitonic properties from first-principles. At low temperatures it predicts exciton binding energies in agreement with the reported ‘large’ values. For MAPbI3, phonon modes present in this frequency range have a negligible...

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