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The KnowledgeBank at OSU (76.127 recursos)

Knowledge Bank contains collections of presentations, publications and reports related to Ohio State University.

19th Denman Undergraduate Research Forum (2014)

Mostrando recursos 1 - 20 de 74

  1. Investigation of Vaporizing Foil Actuator Welding Between Dissimilar Metals

    Benzing, Jake; He, Mei; Vivek, Anupam
    This work aims to study the effect of microstructure of the weld between aluminum alloy AA6061 and commercially pure copper, Cu 110, on its mechanical properties. AA6061-T6 and T4 aluminum sheets of 1 mm thickness were launched towards copper targets using the Vaporizing Foil Actuator (VFA) tool operating at 8 kJ input energy level. Flyer plate velocities, measured via photonic Doppler velocimetry (PDV), were observed to be approximately 800 m/s. All the welded samples were subjected to instrumented peel testing, microhardness testing, energy-dispersive x-ray spectroscopy (EDS), and SEM. The welded joints had cracks which ran through the continuous intermetallic layers...

  2. Investigation of Vaporizing Foil Actuator Welding Between Dissimilar Metals

    Benzing, Jake; He, Mei; Vivek, Anupam
    This work aims to study the effect of microstructure of the weld between aluminum alloy AA6061 and commercially pure copper, Cu 110, on its mechanical properties. AA6061-T6 and T4 aluminum sheets of 1 mm thickness were launched towards copper targets using the Vaporizing Foil Actuator (VFA) tool operating at 8 kJ input energy level. Flyer plate velocities, measured via photonic Doppler velocimetry (PDV), were observed to be approximately 800 m/s. All the welded samples were subjected to instrumented peel testing, microhardness testing, energy-dispersive x-ray spectroscopy (EDS), and SEM. The welded joints had cracks which ran through the continuous intermetallic layers...

  3. Analysis of Rotationally Excited States of Deuterated CH5+ Using Diffusion Monte Carlo

    Ford, Jason E.
    The chemistry that occurs in space is very different from that on Earth, but it is necessary to understand these differences in order to comprehend many astronomical processes. In order to study the astrochemistry that is taking place, radioastronomy can be used to observe transitions between rotational energy levels of the molecules and ions. The resulting information, the spectrum, acts as a molecular fingerprint and can be utilized to determine some of the properties of the molecules and ions that are present. Understanding and predicting spectra is quite difficult for floppy molecules, those that exhibit large amplitude vibrational motions in...

  4. Analysis of Rotationally Excited States of Deuterated CH5+ Using Diffusion Monte Carlo

    Ford, Jason E.
    The chemistry that occurs in space is very different from that on Earth, but it is necessary to understand these differences in order to comprehend many astronomical processes. In order to study the astrochemistry that is taking place, radioastronomy can be used to observe transitions between rotational energy levels of the molecules and ions. The resulting information, the spectrum, acts as a molecular fingerprint and can be utilized to determine some of the properties of the molecules and ions that are present. Understanding and predicting spectra is quite difficult for floppy molecules, those that exhibit large amplitude vibrational motions in...

  5. Examining the short term effects of restoration plantings on emerald ash borer infested flood plains

    Hefflinger, Rachel
    Emerald Ash Borer (Agrilus planipennis) has been identified as present in Ohio since 2003. Since then this small Asian beetle has been devastating to floodplain areas throughout Ohio, killing almost the entire population (99%) of ash trees. In many of these ecosystems, ash was the dominant species in the canopy. The question now remains as how to best repair these areas. In 2011, restoration plots were planted in Clinton Conservation Area (Clinton, Ohio), Oak Openings Metropark (Toledo, OH) and Sharon Woods Metropark (Columbus, OH), representing a gradient of infestation duration and ash mortality. Three different species were planted randomly throughout...

  6. Examining the short term effects of restoration plantings on emerald ash borer infested flood plains

    Hefflinger, Rachel
    Emerald Ash Borer (Agrilus planipennis) has been identified as present in Ohio since 2003. Since then this small Asian beetle has been devastating to floodplain areas throughout Ohio, killing almost the entire population (99%) of ash trees. In many of these ecosystems, ash was the dominant species in the canopy. The question now remains as how to best repair these areas. In 2011, restoration plots were planted in Clinton Conservation Area (Clinton, Ohio), Oak Openings Metropark (Toledo, OH) and Sharon Woods Metropark (Columbus, OH), representing a gradient of infestation duration and ash mortality. Three different species were planted randomly throughout...

  7. Using Biosensors to Measure Behavioral and Milk Compositional Changes During Bovine Mastitis

    Kester, Hannah
    Automated bio-sensors were used to compare milk constituents and physical activity measures of cows experimentally infected with Streptococcus uberis mastitis with those of uninfected cows. Twelve late lactation Holsteins cows were placed into 6 pairs based upon milk production and parity. One cow in each pair was experimentally infected into the right front mammary gland with Steptococcus uberis, while the remaining cow in each pair served as an uninfected control. The automated bio-sensor system provided real-time analysis of milk fat, protein, and lactose at each milking. Pedometers were placed on the left front leg of all cows and activity was...

  8. Using Biosensors to Measure Behavioral and Milk Compositional Changes During Bovine Mastitis

    Kester, Hannah
    Automated bio-sensors were used to compare milk constituents and physical activity measures of cows experimentally infected with Streptococcus uberis mastitis with those of uninfected cows. Twelve late lactation Holsteins cows were placed into 6 pairs based upon milk production and parity. One cow in each pair was experimentally infected into the right front mammary gland with Steptococcus uberis, while the remaining cow in each pair served as an uninfected control. The automated bio-sensor system provided real-time analysis of milk fat, protein, and lactose at each milking. Pedometers were placed on the left front leg of all cows and activity was...

  9. Overexpression of miR-3151 leads to direct deregulation of the TP53 pathway and is associated with BRAF mutations in malignant melanoma

    Lankenau, Malori
    The BRAF gene is the most frequently mutated gene in malignant melanoma (MM). When mutated, it is associated with a more aggressive disease phenotype. MicroRNAs are small non-coding RNAs that downregulate the expression of their target genes by binding to their 3′-UTR. Recently, microRNA miR-3151 was identified in intron 1 of BAALC, the most upregulated gene in BRAF mutated melanoma. In acute myeloid leukemia, both high miR-3151 and high BAALC are associated with poor survival. In addition, miR-3151 has leukemogenic activity via direct deregulation of TP53. To begin to decipher miR-3151’s role in MM carcinogenesis, miR-3151 and TP53 expression levels...

  10. Overexpression of miR-3151 leads to direct deregulation of the TP53 pathway and is associated with BRAF mutations in malignant melanoma

    Lankenau, Malori
    The BRAF gene is the most frequently mutated gene in malignant melanoma (MM). When mutated, it is associated with a more aggressive disease phenotype. MicroRNAs are small non-coding RNAs that downregulate the expression of their target genes by binding to their 3′-UTR. Recently, microRNA miR-3151 was identified in intron 1 of BAALC, the most upregulated gene in BRAF mutated melanoma. In acute myeloid leukemia, both high miR-3151 and high BAALC are associated with poor survival. In addition, miR-3151 has leukemogenic activity via direct deregulation of TP53. To begin to decipher miR-3151’s role in MM carcinogenesis, miR-3151 and TP53 expression levels...

  11. Dance, Design, and Neuroscience: Interdisciplinary Strategies to Promote Sustainability and Vitality in the Creative Sector

    Bedal, Lauren
    With the oversaturation of marketing and advertising in today’s world, the biggest challenge in the performing arts industry lies in encouraging consumers to leave the comfort of their homes to engage in a live cultural experience. Marketing and advertising for these organizations has called for innovative brand direction shifting from traditional market research to explore the psychological and neurological implications behind brand perception. In this study, I investigated how design theory and neuroscience, when included in branding and marketing strategies, can increase brand awareness and loyalty for the performing arts, specifically focusing on dance organizations. Today, the concept of branding...

  12. Dance, Design, and Neuroscience: Interdisciplinary Strategies to Promote Sustainability and Vitality in the Creative Sector

    Bedal, Lauren
    With the oversaturation of marketing and advertising in today’s world, the biggest challenge in the performing arts industry lies in encouraging consumers to leave the comfort of their homes to engage in a live cultural experience. Marketing and advertising for these organizations has called for innovative brand direction shifting from traditional market research to explore the psychological and neurological implications behind brand perception. In this study, I investigated how design theory and neuroscience, when included in branding and marketing strategies, can increase brand awareness and loyalty for the performing arts, specifically focusing on dance organizations. Today, the concept of branding...

  13. Oncolytic HSV-mediated Regulation of the Host Hypoxia Response

    Hurwitz, Brian; Yoo, Ji Young
    Glioblastoma (GBM) is the most common and deadly primary brain tumor, accounting for over 10,000 new cancer diagnoses in the United States each year. The poor prognosis for GBM patients necessitates novel biological treatments. One such approach is the use of oncolytic herpes simplex virus 1 (oHSV). Like many novel treatments, oHSV therapy causes side effects that are not yet well understood. Our lab has demonstrated that oHSV treatment increases the vascularity of brain tumors. The goal of this study is to determine the mechanism by which oHSV treatment increases the vascularity of brain tumors. We have determined that the...

  14. Oncolytic HSV-mediated Regulation of the Host Hypoxia Response

    Hurwitz, Brian; Yoo, Ji Young
    Glioblastoma (GBM) is the most common and deadly primary brain tumor, accounting for over 10,000 new cancer diagnoses in the United States each year. The poor prognosis for GBM patients necessitates novel biological treatments. One such approach is the use of oncolytic herpes simplex virus 1 (oHSV). Like many novel treatments, oHSV therapy causes side effects that are not yet well understood. Our lab has demonstrated that oHSV treatment increases the vascularity of brain tumors. The goal of this study is to determine the mechanism by which oHSV treatment increases the vascularity of brain tumors. We have determined that the...

  15. The Identification of New Genes Critical for Proper Epidermal Cell Division through Comparative Genetics of Caenorhabditis elegans and Caenorhabditis briggsae

    Fillis, Cambree; Chamberlin, Helen
    The evolutionary conservation of genes within the EGF/Ras signaling pathway among biological systems exemplifies the pathway’s significance in proper organismal development. Even slight deviation from the normal function of oncogenes and tumor suppressor genes within the pathway commonly results in abnormal cell proliferation and the formation of malignant growths. In order to identify and better understand these genes, we are continuing to investigate the role of genetic differences within the EGF/Ras signaling pathway and their influence on epidermal cell division by studying the relationship of vulva development between the nematode worm species, C. elegans and C. briggsae. A genetic screen...

  16. The Identification of New Genes Critical for Proper Epidermal Cell Division through Comparative Genetics of Caenorhabditis elegans and Caenorhabditis briggsae

    Fillis, Cambree; Chamberlin, Helen
    The evolutionary conservation of genes within the EGF/Ras signaling pathway among biological systems exemplifies the pathway’s significance in proper organismal development. Even slight deviation from the normal function of oncogenes and tumor suppressor genes within the pathway commonly results in abnormal cell proliferation and the formation of malignant growths. In order to identify and better understand these genes, we are continuing to investigate the role of genetic differences within the EGF/Ras signaling pathway and their influence on epidermal cell division by studying the relationship of vulva development between the nematode worm species, C. elegans and C. briggsae. A genetic screen...

  17. Effects of Regional Dialect on Word-Final Consonant Voicing

    Royer, Adam
    In English word-final consonants, the voicing feature is signaled by temporal cues, including the duration of the preceding vowel and the consonant itself (House, 1961; Klatt, 1976) and by non-temporal cues, including voicing during the consonant (Fowler, 1991). Purnell et al.'s (2012) research found that regional dialects of English vary in how they signal word-final consonant voicing. The goal of this study is to examine the use of temporal and non-temporal cues to phonological voicing as a function of regional American English dialect and consonant type. Monosyllabic words ending in either a stop (e.g. p, t, k, b, d, g)...

  18. Effects of Regional Dialect on Word-Final Consonant Voicing

    Royer, Adam
    In English word-final consonants, the voicing feature is signaled by temporal cues, including the duration of the preceding vowel and the consonant itself (House, 1961; Klatt, 1976) and by non-temporal cues, including voicing during the consonant (Fowler, 1991). Purnell et al.'s (2012) research found that regional dialects of English vary in how they signal word-final consonant voicing. The goal of this study is to examine the use of temporal and non-temporal cues to phonological voicing as a function of regional American English dialect and consonant type. Monosyllabic words ending in either a stop (e.g. p, t, k, b, d, g)...

  19. Health Information in the Digital Age: Online Federal Resources for Secondary Health Conditions Common in Adults with Developmental Disabilities

    Monteleone, Rebecca
    According to the Surgeon General’s Call to Action to Improve the Health and Wellness of Persons with Disabilities (2007), there is a public health crisis occurring among Americans who identify as disabled. In particular, the intellectually and developmentally disabled population (I/DD)—which currently accounts for nearly 4 million Americans—has both a significantly increased risk of secondary health conditions such as heart disease, oral health issues and obesity, and decreased access to health promotion and education programs. Currently, there are many resources available online for preventable health conditions, often produced and distributed by national non-profit networks. The accessibility of these resources for...

  20. Health Information in the Digital Age: Online Federal Resources for Secondary Health Conditions Common in Adults with Developmental Disabilities

    Monteleone, Rebecca
    According to the Surgeon General’s Call to Action to Improve the Health and Wellness of Persons with Disabilities (2007), there is a public health crisis occurring among Americans who identify as disabled. In particular, the intellectually and developmentally disabled population (I/DD)—which currently accounts for nearly 4 million Americans—has both a significantly increased risk of secondary health conditions such as heart disease, oral health issues and obesity, and decreased access to health promotion and education programs. Currently, there are many resources available online for preventable health conditions, often produced and distributed by national non-profit networks. The accessibility of these resources for...

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