Mostrando recursos 1 - 4 de 4

  1. Warfarin effects in the skeletal development of zebrafish (Danio rerio)

    Peres dos Santos, R.; Bensimon-Brito, A.; Gavaia, Paulo J.; Cancela, Leonor
    Vitamin K-dependent gamma carboxylation (VKGC) is crucial for posttranslational modification of glutamate residues to form α-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide (1). This modification has important implications, mainly physiological, like homeostasis, signal transduction and bone calcification. This mechanism ensures complete carboxylation of coagulation factors, and proteins like bone Gla protein (BGP) and matrix Gla protein (MGP), being essential for their biological activity. Warfarin is a known anticoagulant that inhibits the action of VKGC (2), inhibiting consequently the activity of the referred proteins.
    - 11-jul-2014

  2. Two isoforms of vasa maternal factor in Senegalese sole: Biotechnological applications

    Pacchiarini, T.; Cabrita, E.; Cross, I.; Ortiz-Delgado, J. B.; Leite, Ricardo B.; Gavaia, Paulo J.; Herráez, M. P.; Rebordinos, L.; Sarasquete, C.
    Primordial Germ Cells (PGCs) identification and manipulation present considerable potential for hatchery practice and surrogate broodstocks. To carry out the PGCs characterization a specific molecular marker is required. The vasa gene is a good candidate to identify PGCs and others germinal cells (Nagasawa et al., 2009). The aim of this study was the cloning of the Solea senegalensis vasa cDNA and its expression pattern during early development and adulthood.
    - 16-jul-2014

  3. Expression of Gla proteins during fish skeletal development

    Gavaia, Paulo J.
    Apear early in development: frequent in reared larva; reflect culture conditions. Leads to: decreased growth rate; increased mortality; increased prodution costs; decreased market price.
    - 23-jul-2014

  4. Skeletal development and bone-related gene expression in fish larvae

    Gavaia, Paulo J.; Cancela, Leonor
    Skeletogenesis in fish starts early in embrionic development. First calcified structures are normaly asociated tofeding and movement.
    - 23-jul-2014

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