Mostrando recursos 1 - 20 de 246

  1. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms

    Rathore, Om Singh; Faustino, Alexandra; Prudêncio, Pedro; Van Damme, Petra; Cox, Cymon J.; Martinho, Rui Gonçalo
    Protein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we determined that NAT diversification did not occur in the eukaryotes, as all six major human NATs were most likely present in the Last Eukaryotic Common Ancestor (LECA). Furthermore, we also observed that some NATs were actually secondarily lost during evolution of major eukaryotic lineages; therefore,...

  2. Preserving Dignity in Later Life

    São José, José
    This article examines how elders who receive social care in the community experience loss of dignity and how they preserve their dignity. Qualitative research revealed that loss of dignity is a major concern for these elders and that they preserve their dignity differently, ranging from actively engaging with life to detaching themselves from life. We conclude that, in later life, preserving dignity while receiving social care differs from preserving dignity in the context of health care, especially health care provided in institutional settings. Furthermore, preserving dignity in later life, while receiving social care, is a complex process, depending not only...

  3. Monitoring tourism flows and destination management: Empirical evidence for Portugal

    Andraz, Jorge Miguel; Rodrigues, Paulo M. M.
    We propose the use of a tool recently introduced by Gayer (2010), known as the "economic climate tracer", to analyze and monitor the cyclical evolution of tourism source markets to Portugal. Considering the period 1987-2015, we evaluate how tourism to Portugal has been affected by economic cycles. This tool is useful as it clearly illustrates the evolutionary patterns of different markets, and allows us to identify close relationships with economic fluctuations. We found that German tourism plays a leading role, since its movements are followed with delays by tourism flows from other countries, and exhibits higher resilience to shocks. Also,...

  4. Do tourism spillovers matter in regional economic analysis? An application to Portugal

    Andraz, Jorge Miguel; Norte, Nélia; Gonçalves, Hugo S.
    This study estimates tourism's effects on economic performance at the national and regional levels, accounting explicitly for the existence of regional spillovers. The results suggest that there are important regional spillover effects on output, employment, and investment, respectively, and regions benefit differently from tourism located in the region and tourism located elsewhere in the country. The geographical pattern that emerges from the results is that the direct effects are more important in the central regions, while spillovers are more important in the northern and southern regions, the latter being one of the most important touristic regions in the country.

  5. Measuring active ageing: a Data Envelopment Analysis approach

    Amado, Carla; São José, José; Santos, Sérgio Pereira dos
    The 'Active Ageing Index' was created with the purpose of helping policy makers implement and monitor active ageing policies both at European and national levels. However, this index has not fully achieved this purpose. In this article we propose a methodological approach based on Data Envelopment Analysis to enhance the measurement of active ageing in the European Union countries. We use a model with 22 indicators grouped into four domains. By introducing different types of virtual weight restrictions, we combine normative judgements with an optimisation procedure, showing each country in the best possible light. Furthermore, we undertake a sensitivity analysis...

  6. On the relationship between soveregn bonds and credit default swaps in Portugal

    Andraz, Jorge Miguel; Viegas, Cristina; Norte, Nélia
    This paper aims at identifying the relationship between government bonds spreads and credit default swaps premiums in Portugal for long and short maturities, covering a period that includes the beginning of the 2008 international financial crisis. We estimate Autoregressive Distributed Lag error correction models for the sub periods prior and after the moment crisis started. Results reveal the absence of cointegration over the sample period, with important differences prior and after 2010 in both maturities. There is no evidence of long-run relationship between both markets in both maturities, as the 2007 crisis has interrupted the long run relationship that was...

  7. Comparing trade-off adjustments in credit risk analysis of mortgage loans using AHP, Delphi and MACBETH

    Ferreira, Fernando A. F.; Santos, Sérgio Pereira dos
    Due to the severe restrictions on access to credit resulting from the current economic climate, credit risk analysis of mortgage loans has been considered paramount for banking institutions and is currently accompanied by higher credit underwriting standards. In this paper, we present an empirical comparison of three decision support tools (i.e. Analytic Hierarchy Process (AHP), Delphi, and Measuring Attractiveness by a Categorical Based Evaluation Technique (MACBETH)) in the specific context of trade-off readjustments in credit risk analysis of mortgage loans. We conducted a panel study with credit analysts and focused on five lines of comparison: ease of use; time-consumption; ease...

  8. Low-technology industries and regional innovation systems: the salmon industry in Chile

    Rojo, Mauricio Maldonado; Noronha, Teresa de
    Results show that the worldwide competitiveness of the low-tech Salmon Industry in the Los Lagos region has not developed the principal factors permitting the consolidation of a Regional Innovation System (RIS). On the contrary we identify important gaps in terms of the regional conditions such as "networking", "knowledge creation and diffusion", among others, capable to stimulate the innovation behavior of salmon firms.

  9. The economic dimension of climate change impacts on tourism: the case of Portugal

    Pintassilgo, Pedro; Rossello, Jaume; Santana-Gallego, Maria; Valle, Elisabeth
    Climate variables such as temperature and precipitation play a crucial role on tourism flows worldwide. This places tourism at the forefront of the economic sectors to be affected by climate change. In this article, we address the impacts of climate change on the arrivals of inbound tourists to Portugal, a south European country where tourism is a core economic sector. The economic dimension of the impacts, in terms of gross domestic product (GDP) and employment, is then assessed. This is achieved by combining a world gravity model of tourism flows with an input-output model. The results show that under standard...

  10. International Fisheries Management and Recreational Benefits: The Case of Baltic Salmon

    Oinonen, Soile; Gronbaek, Lone; Laukkanen, Marita; Levontin, Polina; Lindroos, Marko; Nieminen, Emmi; Parkkila, Katja; Pintassilgo, Pedro; Pulkkinen, Henni; Romakkaniemi, Atso
    This article studies how accounting for the benefits of recreational fisheries affects the formation and stability of an international fisheries agreement (IFA) on the management of Baltic salmon stocks. The interaction between four countries is modelled through a partition function game, under two scenarios. In the first scenario, countries take their participation decision for the IFA based only on the net present value of profits from commercial fisheries. In the second scenario, the net present value of the recreational benefits from angling is also considered. The results show that accounting for recreational benefits leads to the formation of the grand...

  11. Para além da vida quotidiana. Amor e sexualidade em contexto turístico: resultados preliminares de uma pesquisa exploratória no Algarve (Portugal)

    Marques, João Filipe; Lança, Milene
    This artide explores the idea according to which the concept of liminality, concretely liminoides situations', can be used to analyse and explain the behaviours and attitudes towards romance and non-commercialino-mploratoly sexual relationships occurring in tourism context. In a broad sense, the research problem was: which are the patterns of romantic and sexual behaviour in 'sun and beach' destination? We intended to study behavioural patterns, the attitudes towards sexuality and expressions of intimacy in a contemporary (hyper) tourist setting: the Algarve southern (Portugal). The data were collected using a questionnaire in a sample (stratified by country of residence) of 1015 tourists...

  12. What are we talking about when we talk about care? A conceptual review of the literature

    José, José de São
    The primary aim of this article is to make a contribution to clarify the concept of ?care? in the field of care for older people, by reviewing and discussing the conceptual literature and, based on this, by proposing a new unified definition. The secondary aim of this article is to trace, in general terms, the evolution of the empirical research on care for older people, presenting at the same time, possible avenues for future research. It is expected that a new unified definition of the concept of care may contribute to a better operationalization of it, enhancing the reliability and...

  13. From the April revolution to times of austerity in Portugal: a portrait of poverty, social exclusion and inequalities

    Pinto, Hugo; Guerreiro, Jorge Andre
    In the last forty years Portugal was confronted with a series of transformations. The revolutionary process of April 1974 and the European integration drove the country towards the economic policy convergence of the most developed member-states of European Union. This approach was slowing since the beginning of the Millennium, reversed with the advent of the economic and financial crisis in 2007. The crisis generated a response on austerity policies, with deep impacts on public policy with consequences in different dimensions. Poverty, a persistent phenomenon in Portugal, affecting hundreds of thousands of families in the last decades, increased with the crisis....

  14. Tracing the flows of knowledge transfer: Latent dimensions and determinants of university-industry interactions in peripheral innovation systems

    Fernandez-Esquinas, Manuel; Pinto, Hugo; Perez Yruela, Manuel; Pereira, Tiago Santos
    Firms interact with universities through a variety of channels, ranging from collaborative research projects, patents, spin-off creation, consultancy and specialized training, to informal relationships. This article explores the combination of mechanisms used by firms in Andalusia, a peripheral region in Spain and Europe, when interacting with universities. Using information from a survey of 737 innovative firms, the empirical study found evidence that university-industry links can be grouped into five latent dimensions (knowledge generation and adaptation, involvement in new organisations, training and exchange of human resources, intellectual property rights, and facilities and equipment) which are mainly based on exploitation or exploration...

  15. Social network enterprise behaviors and patterns in SMEs: Lessons from a Portuguese local community centered around the tourism industry

    Fernandes, Silvia Brito; Belo, Ana; Castela, Guilherme
    This study analyzes uses of social networks by small and medium-sized enterprises (SMEs) at the Algarve region in Portugal. Results suggest that some firms have integrated their business strategies with social networks, and have groups of professionals responsible for these platforms. Most managers perceive that social networks enhance business performance, but few measure the results. Firms that most frequently use social networks have managers with higher qualifications. This study identified two types of socialnetwork use: a) producteclient interaction and knowledge/(re) search, and b) marketing potential. A complementary analysis (cluster analysis) identified three behavioral patterns with varying involvement with social networks....

  16. Innovation accelerators as entrepreneurial and interdisciplinary engines: the portuguese case

    Fernandes, Sílvia Brito
    Today's competition is tough, due especially to emergent information systems (IS) and information technology (IT) support. Managers must continuously cope with challenges to keep their businesses innovative and sustainable. They take most of their decisions based on considerable amounts of data. An important step is to employ strategies based on open innovation: partnerships with people who know the technology better, or how to conceive or run a certain activity, product or process. All these issues and potentials have been explored and supported in the so-called innovation accelerators or 'boot camps', either for launching new businesses or supporting their IT/IS platforms....

  17. Social networks as enablers of enterprise creativity: evidence from portuguese firms and users

    Fernandes, Sílvia Brito; Belo, Ana
    The present work analyzes the profiles of social networks' users, individuais and enterprises in Algarve (Portugal), having accomplished online questionnaires. Samples of 230 users and 70 firms were collected. According to data obtained there are different behaviors. Users' results highlight the need of harnessing the potential of recruitment and business projects through social networks, as searching for knowledge, communication and professional relations are expressive. Firms' results reveal two types of social networks' use: 1) knowledge search, interact with customers, launch new products; and 2) potential for marketing. Users' desire of expressing own ideas and being creative had low importance. In...

  18. Avaliação da qualidade dos serviços bancários online: proposta de integração dos modelos SERVQUAL, Kano e QFD

    Santos, Ariana Heleno Marques; Cândido, Carlos
    Este artigo centra-se no desenvolvimento teórico de um modelo integrado para a avaliação e a melhoria da qualidade dos serviços de Internet Banking (IB). Após uma revisão da literatura e uma análise crítica dos estudos já elaborados sobre o uso integrado dos modelos de Kano, SERVQUAL e Quality Function Deployment (QFD), propõe-se um modelo integrado significativamente distinto daquele que tem vindo a ser utilizado na literatura. O modelo que se apresenta visa superar as desvantagens inerentes ao modelo integrador existente, contribuindo para um melhor entendimento da “voz do cliente” e para uma melhoria da qualidade dos serviços de IB. O...

  19. Modos de apropriação local do programa de políticas públicas Iniciativa Novas Oportunidades: uma análise a partir de baixo

    Martins, João Eduardo
    Esta comunicação tem como objectivo a apresentação dos resultados de investigação no âmbito de uma tese de doutoramento em sociologia realizada na Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa cujo objecto de estudo esteve centrado nos modos de apropriação local do programa de políticas publicas denominado Iniciativa Novas Oportunidades. Procurou-se com esta pesquisa compreender a acção pública de educar adultos pouco escolarizados no contexto da sociedade portuguesa a partir da perspectiva dos técnicos que no terreno estão encarregues da implementação da medida. Do ponto de vista conceptual o enquadramento teórico produziu-se a partir da articulação entre...

  20. O Estado social ativo: um novo paradigma legitimador das políticas públicas em Portugal

    Martins, João Eduardo
    Elabora‑se neste artigo uma reflexão crítica sobre as políticas de ativação estatal a partir da análise dos resultados empíricos de uma investigação sociológica sobre a implementação das políticas públicas de educação de adultos no âmbito da Iniciativa Novas Oportunidades. O novo paradigma de políticas públicas centrado na ideia de Estado social ativo é aqui questionado a partir das representações dos técnicos responsáveis pela implementação desta medida, uma vez que é possível constatar que nem todos os beneficiários são perspetivados como dispondo das características necessárias para ir ao encontro da ideologia estatal da ativação. A partir de um estudo qualitativo que...

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