Mostrando recursos 1 - 20 de 26

  1. Pilocytic astrocytoma

    Lourenço, Eva Patrícia; Nzwalo, Hipólito; Sampaio, Mário Rui; Varela, Ana Verónica

  2. Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac MR imaging study

    Dawes, Timothy J. W.; Gandhi, Ajay; de Marvao, Antonio; Buzaco, Rui; Tokarczuk, Pawel; Quinlan, Marina; Durighel, Giuliana; Diamond, Tamara; Garcia, Laura Monje; de Cesare, Alain; Cook, Stuart A.; O'Regan, Declan P.
    Purpose: To determine the relationship between pulmonary artery (PA) stiffness and both right ventricular (RV) mass and function with cardiac magnetic resonance (MR) imaging.Materials and Methods: The study was approved by the local research ethics committee, and all participants gave written informed consent. Cardiac MR imaging was performed at 1.5 T in 156 healthy volunteers (63% women; age range, 19-61 years; mean age, 36.1 years). High-temporal-resolution phase-contrast imaging was performed in the main and right PAs. Pulmonary pulse wave velocity (PWV) was determined by the interval between arterial systolic upslopes. RV function was assessed with feature tracking to derive peak...

  3. Evaluation of medical devices in thoracic radiograms in intensive care unit - time to pay attention!

    Moreira, Ana Sofia Linhares; Afonso, Maria da Graça Alves; Dinis, Mónica Ribeiro dos Santos Alves; Santos, Maria Cristina Granja Teixeira dos
    OBJECTIVE: To identify and evaluate the correct positioning of the most commonly used medical devices as visualized in thoracic radiograms of patients in the intensive care unit of our center.METHODS: A literature search was conducted for the criteria used to evaluate the correct positioning of medical devices on thoracic radiograms. All the thoracic radiograms performed in the intensive care unit of our center over an 18-month period were analyzed. All admissions in which at least one thoracic radiogram was performed in the intensive care unit and in which at least one medical device was identifiable in the thoracic radiogram were...

  4. Lung caught in Nilutamide treatment

    Lourenço, Eva Patricia; Nzwalo, Hipólito; Sampaio, Mário Rui; Brito, Helena

  5. Liquid mixtures involving hydrogenated and fluorinated alcohols: thermodynamics, spectroscopy, and simulation

    Morgado, Pedro; Garcia, Ana Rosa; Ilharco, Laura M.; Marcos, João; Anastácio, Martim; Martins, Luís F. G.; Filipe, Eduardo J. M.
    This article reports a combined thermodynamic, spectroscopic, and Computational study on the interactions and structure of binary mixtures of hydrogenated and fluorinated substances that simultaneously interact through strong hydrogen bonding. Four binary mixtures of hydrogenated and fluorinated alcohols have been studied, namely, (ethanol + 2,2,2-trifluoroethanol (TFE)), (ethanol + 2,2,3,3,4,4,4-heptafluoro-1-butanol), (1-butanol (BuOH) + TFE), and (BuOH + 2,23,4,4,4-heptafluoto-1-butanol). Excess molar volumes and vibrational spectra of all four binary mixtures have been measured as a function of composition at 298 K, and molecular dynamics simulations have been performed. The systems display a complex behavior when compared with mixtures of hydrogenated alcohols and...

  6. IgG4: related disease presenting with headache and papilloedema

    Lourenço, Eva Patrícia; Nzwalo, Hipólito; Sampaio, Mário Rui; Afonso, Luís

  7. Honeycomb-like appearance in the brain of a former boxer with hyperhomocysteinemia, severe carotid disease and hemorrhagic stroke

    Felix, Ana C.; Fernandes, Nadia; Guilherme, Patricia; Nzwalo, Hipolito

  8. Transtornos mentais comuns nos Cuidados de Saúde Primários: Um estudo de revisão

    Murcho, Nuno; Pacheco, Eusébio; Jesus, Saul
    Os transtornos mentais comuns (TMC) são um conceito criado para designar um conjunto de sintomas não psicóticos que habitualmente estão relacionados com quadros subclínicos de ansiedade, depressão e stresse, os quais pela sua elevada prevalência nos Cuidados de Saúde Primários (CSP) são considerados como um dos maiores problemas de saúde pública mundial.

  9. Do patients value nutritional therapy? A quantitative study in type- 2 diabetes patients

    Pinto, Ezequiel; Braz, Nídia; Nascimento, Tânia; Gomes, Eurico
    Type 2 diabetes patients’ adherence to pharmacotherapy is higher than adherence to nutritional therapy or lifestyle change behaviours, and patients do not value nutritional therapy in the same level as they value other types of interventions. This study aimed to analyse the value that T2DM patients place on nutritional therapy and to identify perceived barriers to nutritional therapy adherence. Methods: A non-random sample of 62 patients receiving health care in a Diabetes Clinic in the municipality of Faro, in the Portuguese region of the Algarve, was interviewed with a semi-structured protocol regarding sociodemographic characteristics, lifestyle, physical activity, and dietary habits. Additional data were collected from the patient’s clinical files and by conducting anthropometric...

  10. Analysis of opo cis-regulatory landscape uncovers Vsx2 requirement in early eye morphogenesis

    Gago-Rodrigues, Inês; Fernández-Miñán, Ana; Letelier, Joaquin; Naranjo, Silvia; Tena, Juan J.; Gómez-Skarmeta, José L.; Martinez-Morales, Juan R.
    The self-organized morphogenesis of the vertebrate optic cup entails coupling the activation of the retinal gene regulatory network to the constriction-driven infolding of the retinal epithelium. Yet the genetic mechanisms underlying this coordination remain largely unexplored. Through phylogenetic footprinting and transgenesis in zebrafish, here we examine the cis-regulatory landscape of opo, an endocytosis regulator essential for eye morphogenesis. Among the different conserved enhancers identified, we isolate a single retina-specific element (H6_10137) and show that its activity depends on binding sites for the retinal determinant Vsx2. Gain- and loss-of-function experiments and ChIP analyses reveal that Vsx2 regulates opo expression through direct...

  11. Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis

    Bogdanović, Ozren; Delfino-Machín, Mariana; Nicolás-Pérez, María; Gavilán, María P.; Gago-Rodrigues, Inês; Fernández-Miñán, Ana; Lillo, Concepción; Ríos, Rosa M.; Wittbrodt, Joachim; Martínez-Morales, Juan R.
    Polarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known about the contribution of integrin trafficking to epithelial tissue morphogenesis. Here we show how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this process. Through interaction with the PTB domain of the clathrin adaptors Numb and Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin endocytosis in...

  12. AB1258­HPR pilot study: does a mediterranean diet­based weight loss programme improve health outcomes in overweight older women with knee osteoarthritis?

    Caixinha, Mónica; Mateus, Maria Palma; Pais, Sandra; Pinto, Ezequiel
    Osteoarthritis (OA) is one of the leading causes of pain and disability among older adults, particularly women. Pain and mobility disability are major consequences of knee OA which and can interfere with the functional autonomy of elderly and thus, making it difficult to perform activities of daily living. Evidence suggests that obesity is strongly linked to knee OA and that non­pharmacological therapy should be based on physical activity and weight loss in case of overweight and obesity. A positive relationship between adherence to the Mediterranean diet and health outcomes has been widely discussed in scientific literature, including its potential benefits in weight loss.

  13. Avaliação da dose em recém-nascidos numa unidade neonatal

    Ribeiro, Luís; Rodrigues, Sónia; Sousa, Patrick; Abrantes, António; Sousa, Liliana; Almeida, Rui; Azevedo, Kevin; Pinheiro, João
    Objetivo: Avaliar a dose a que estão sujeitos os recém-nascidos internados numa Unidade de Cuidados Intensivos Neonatais (UCIN) durante a realização de radiografias em incidência AP ao tórax e comparar os valores obtidos da Dose à Entrada da Pele (DEP), tanto com os recomendados internacionalmente para os recém-nascidos como com os resultados de estudos anteriores. Pretende-se também verificar se as doses utilizadas se encontram abaixo dos valores recomendados e se os pacientes se apresentam ou não em risco face às radiações ionizantes a que foram submetidos. Metodologia: Foi utilizado um equipamento de radiologia convencional móvel Siemens Mobilett XP Hybrid, uma...

  14. Radiographers perceptions of magnetic resonance imaging: a study of the causes that lead to the exams repetition

    Filipe, Tiago; Ribeiro, Luís; Almeida, Rui; Rodrigues, Sónia; Azevedo, Kevin; Silva, Carlos; Abrantes, António
    Purpose: To know how often occur the repetitions of MRI exams and sequences in radiology departments. Methods and Materials: A self applied-questionnaire was used as instrument and assigned to 57 radiographers who performed MRI exams to determine which were the causes that lead to the repetition. The questionnaires were interpreted and statistically analyzed through descriptive statistics and Spearman’s rho correlations. Results: At a 95% confidence interval, the major results suggest that the patient’s movement during de MRI exams is the main cause to repeat this exams (mean of 3.88 on a 5 points likert scale). However, there are causes related to the...

  15. Global geriatric evaluation of the Algarve population

    Braz, Nídia; Pais, Sandra; Cordeiro, Clara; Oliveira, Giovanna; Conde, Monserrat
    The ageing of population challenges communities to adapt and evolve to accommodate the needs of people that live longer (mostly out of work, either healthy, fragile or with chronic disease). Population ageing in the Algarve is higher than in overall Portugal. Studies on health conditions, frailty risk factors and elderly specific needs are undeveloped in Portugal and unknown in the Algarve. Objective To prepare a tool for Global Geriatric Evaluation, to be used in the “Survey of Health and Ageing in the Region of Algarve - SHARA”, a commitment to “European Innovation Partnership on Active and Healthy Ageing”. Methods A preliminary version of the screening...

  16. Isolation and characterization of piscine osteonectin and downregulation of Its expression by PTH-related protein

    Redruello, Begoña; Estêvão, M. Dulce; Rotllant, J.; Guerreiro, P. M.; Anjos, Liliana; Canario, Adelino V. M.; Power, Deborah
    The skeleton is the main source of osteonectin mRNA in adults of the seawater teleost sea bream Sparus auratus. It is expressed by cells forming the basement membrane of calcifying tissue indicating that, as in mammals, it may play a role in osteoblast differentiation. PTHrP induced downregulation of osteonectin mRNA in vitro in scales, a mineralizing tissue with bone-like metabolism. This indicates a means to redirect calcium to activities such as vitellogenesis when this ion is in high demand.

  17. Immunohistochemical detection of estrogen receptors in fish scales

    Pinto, Patricia; Estêvão, M. Dulce; Redruello, Begoña; Socorro, S.; Canario, Adelino V. M.; Power, Deborah
    Calcium mobilization from internal stores, such as scales, induced by 17b-estradiol during sexual maturation in salmonids is well documented. This calcium mobilization from scales is proposed to be mediated by the estrogen receptor (ER). However, the ER subtypes involved and signaling mechanisms responsible for this effect remain to be fully characterized. In the present study, we have localized ERa, ERba and ERbb proteins in juvenile and adult sea bream (Sparus auratus) and Mozambique tilapia (Oreochromis mossambicus) scales by immunohistochemistry with sea bream ER subtype specific antibodies. The three ERs were detected in isolated or small groups of round cells, in the basal layer...

  18. Cellular morphology and markers of cartilage and bone in the marine teleost Sparus auratus

    Estêvão, M. Dulce; Silva, Nadia; Redruello, Begoña; Costa, Rita; Gregório, Sílvia F.; Canario, Adelino V. M.; Power, Deborah
    Modifications have been characterised in terms of cellular organisation and the extracellular matrix (ECM) during bone ontogeny in the sea bream (Sparus auratus). During endochondral development, the agglomeration of matrix-secreting cells gives rise to chondrones; these chondrones frequently contain proliferating-cell-nuclearantigen-positive cells, which subsequently become large collagen-II-positive cells with the characteristics of chondrocytes. Moreover, the matrix:cell ratio within the perichondrium increases, accompanied by a modification in ECM composition. Mineralisation of cartilage ECM is marked by a rapid fall in cell number, the switching off of collagen II transcription and the switching on of collagen X transcription, followed by collagen I transcription and...

  19. Manual da qualidade e abordagem por processos: o caso de uma sala de mamografia

    Almeida, Rui; Silva, Carlos; Fernandes, Ana; Abrantes, António; Ribeiro, Luís; Azevedo, Kevin
    Publicação integrada na produção editorial do Centro de Investigação UNIDE (Unidade de Investigação em Desenvolvimento Empresarial), ISCTE business School do Instituto Universitário de Lisboa.

  20. The evaluation of patient’s anxiety levels undergoing magnetic resonance imaging examination

    Medeiros, Filipa; Azevedo, Kevin; Ribeiro, Luís; Abrantes, António; Rodrigues, Sónia; Silva, Carlos; Almeida, Rui
    Purpose: To analyse possible differences between the anxiety levels of patients who receive additional information about the MRI scan, and patients who receive only basic instructions from the hospital, and to verify if there is variation in anxiety levels of patients before and after the examination, and relate them to gender, age, education level, and previous MRI examinations. Methods and Materials: The total sample of 60 patients was divided into a control group and an experimental group, and each one divided into two subgroups before and after the exam, and then it was applied STAI form Y-1 to both, after the sociodemographic questions. Results: At...

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