Recursos de colección

ARCA - Access to Research and Communication Annals - IGC Repository (649 recursos)

The Institutional Repository of Instituto Gulbenkian de Ciência, developed under the project RCAAP, is intended to collect, preserve and promote open access to the intellectual production of their researchers.

Systems Neuroscience

Mostrando recursos 1 - 4 de 4

  1. Towards an image of a memory trace

    Vicente, MI; Mainen, ZF
    Learning and memory lead to functional and structural changes in the brain, ultimately providing a basis for adaptive behavior. The honeybee is an elegant model for the study of learning and memory formation as it permits both the visualization of neural activity related to the events occurring in olfactory learning and the behavioral assessment of olfactory learning (Galizia and Menzel, 2000 ). The formation of odor memories in the honeybee is thought to involve the two primary processing centers of the olfactory system, the antennal lobe (AL) and the mushroom body (MB). The intrinsic neurons of the MB – the...
    - 08-jul-2016

  2. A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration

    Quirk, MC; Sosulski, DL; Feierstein, CE; Uchida, N; Mainen, ZF
    Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral...
    - 07-jul-2016

  3. Neural representation of behavioral outcomes in the orbitofrontal cortex

    Mainen, ZF; Kepecs, A
    The orbitofrontal cortex (OFC) is important in processing rewards and other behavioral outcomes. Here, we review from a computational perspective recent progress in understanding this complex function. OFC neurons appear to represent abstract outcome values, which may facilitate the comparison of options, as well as concrete outcome attributes, such as flavor or location, which may enable predictive cues to access current outcome values in the face of dynamic modulation by internal state, context and learning. OFC can use reinforcement learning to generate outcome predictions; it can also generate outcome predictions using other mechanisms, including the evaluation of decision confidence or...
    - 08-jul-2016

  4. Transient firing of dorsal raphe neurons encodes diverse and specific sensory, motor, and reward events

    Ranade, SP; Mainen, ZF
    Serotonin (5-hydroxytryptamine [5-HT]) is known to influence a wide range of behaviors and physiological processes, but relatively little is known about events that trigger 5-HT release. To address this issue, we recorded from neurons in the dorsal raphe nucleus (DRN) in rats performing an odor-guided spatial decision task. A large fraction of DRN neurons showed transient firing time locked to behavioral events on timescales as little as 20 ms. DRN transients were sometimes correlated with reward parameters, but also encoded specific sensorimotor events, including stimulus identity and response direction. These behavioral correlates were diverse but showed no apparent relationship with...
    - 07-jul-2016

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