Recursos de colección

ARCA - Access to Research and Communication Annals - IGC Repository (1.013 recursos)

The Institutional Repository of Instituto Gulbenkian de Ciência, developed under the project RCAAP, is intended to collect, preserve and promote open access to the intellectual production of their researchers.

Lymphocyte Physiology

Mostrando recursos 1 - 20 de 45

  1. Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses

    Hirota, Keiji; Turner, Jan-Eric; Villa, Matteo; Duarte, João H; Demengeot, Jocelyne; Steinmetz, Oliver M; Stockinger, Brigitta
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672955/

  2. 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice

    Ferreira, Gabriela B; Gysemans, Conny A; Demengeot, Jocelyne; da Cunha, João Paulo M C M; Vanherwegen, An-Sofie; Overbergh, Lut; Van Belle, Tom L; Pauwels, Femke; Verstuyf, Annemieke; Korf, Hannelie; Mathieu, Chantal
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: http://www.jimmunol.org/content/192/9/4210.long#ack-1

  3. Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model

    Gibson, V. B.; Nikolic, T.; Pearce, V. Q.; Demengeot, J.; Roep, B. O.; Peakman, M.
    TThis deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636887/

  4. IgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition

    Oruc, Zeliha; Oblet, Christelle; Boumediene, Ahmed; Druilhe, Anne; Pascal, Virginie; Le Rumeur, Elisabeth; Cuvillier, Armelle; El Hamel, Chahrazed; Lecardeur, Sandrine; Leanderson, Tomas; Morelle, Willy; Demengeot, Jocelyne; Aldigier, Jean-Claude; Cogné, Michel
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004660/

  5. Host and microbiota interactions are critical for development of murine Crohn’s-like ileitis

    Roulis, M; Bongers, G; Armaka, M; Salviano, T; He, Z; Singh, A; Seidler, U; Becker, C; Demengeot, J; Furtado, G C; Lira, S A; Kollias, G
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027991/

  6. Myocardial aging as a T-cell–mediated phenomenon

    Ramos, Gustavo Campos; van den Berg, Anne; Nunes-Silva, Vânia; Weirather, Johannes; Peters, Laura; Burkard, Matthias; Friedrich, Mike; Pinnecker, Jürgen; Abeßer, Marco; Heinze, Katrin G.; Schuh, Kai; Beyersdorf, Niklas; Kerkau, Thomas; Demengeot, Jocelyne; Frantz, Stefan; Hofmann, Ulrich
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373357/

  7. Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance

    Agua-Doce, Ana; Caridade, Marta; Oliveira, Vanessa G; Bergman, Lisa; Lafaille, Maria C; Lafaille, Juan J; Demengeot, Jocelyne; Graca, Luis
    This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: http://www.jimmunol.org/content/200/1/101.long#ack-1

  8. Escherichia coli adaptation to the gut environment: a constant fight for survival

    Gordo, Isabel; Demengeot, Jocelyne; Xavier, Karina
    LAO/ITQB, FCT.

  9. Adaptive immunity increases the pace and predictability of evolutionary change in commensal gut bacteria

    Barroso-Batista, João; Demengeot, Jocelyne; Gordo, Isabel
    Co-evolution between the mammalian immune system and the gut microbiota is believed to have shaped the microbiota's astonishing diversity. Here we test the corollary hypothesis that the adaptive immune system, directly or indirectly, influences the evolution of commensal species. We compare the evolution of Escherichia coli upon colonization of the gut of wild-type and Rag2(-/-) mice, which lack lymphocytes. We show that bacterial adaptation is slower in immune-compromised animals, a phenomenon explained by differences in the action of natural selection within each host. Emerging mutations exhibit strong beneficial effects in healthy hosts but substantial antagonistic pleiotropy in immune-deficient mice. This...

  10. A Novel Quantitative Fluorescent Reporter Assay for RAG Targets and RAG Activity

    Trancoso, Inês; Bonnet, Marie; Gardner, Rui; Carneiro, Jorge; Barreto, Vasco M.; Demengeot, Jocelyne; Sarmento, Leonor M.
    Recombination-Activating Genes (RAG) 1 and 2 form the site specific recombinase that mediates V(D)J recombination, a process of DNA editing required for lymphocyte development and responsible for their diverse repertoire of antigen receptors. Mistargeted RAG activity associates with genome alteration and is responsible for various lymphoid tumors. Moreover several non-lymphoid tumors express RAG ectopically. A practical and powerful tool to perform quantitative assessment of RAG activity and to score putative RAG-Recognition signal sequences (RSS) is required in the fields of immunology, oncology, gene therapy, and development. Here we report the detailed characterization of a novel fluorescence-based reporter of RAG activity,...

  11. INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

    Meehan, T.F.; Demengeot, Jocelyne; 44 colaborators, Infrafrontier Consortium
    The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of...

  12. INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

    Meehan, T.F.; Demengeot, Jocelyne; 44 colaborators, Infrafrontier Consortium
    The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of...

  13. INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community

    Meehan, T.F.; Demengeot, Jocelyne; 44 colaborators, Infrafrontier Consortium
    This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383977/

  14. The first steps of adaptation of Escherichia coli to the gut are dominated by soft sweeps

    João Barroso-Batista; Ana Sousa; Marta Lourenço; Marie-Louise Bergman; Jocelyne Demengeot; Karina B. Xavier; Isabel Gordo
    The accumulation of adaptive mutations is essential for survival in novel environments. However, in clonal populations with a high mutational supply, the power of natural selection is expected to be limited. This is due to clonal interference - the competition of clones carrying different beneficial mutations - which leads to the loss of many small effect mutations and fixation of large effect ones. If interference is abundant, then mechanisms for horizontal transfer of genes, which allow the immediate combination of beneficial alleles in a single background, are expected to evolve. However, the relevance of interference in natural complex environments, such as the gut, is poorly known. To address this...

  15. Tolerogenic insulin peptide therapy precipitates type 1 diabetes

    Bergman, Marie-Louise; Lopes-Carvalho, Thiago; Martins, Ana-Catarina; Grieco, Fabio A.; Eizirik, Décio L.; Demengeot, Jocelyne
    The deposited article version contains attached the supplementary materials within the pdf.

  16. Tolerogenic insulin peptide therapy precipitates type 1 diabetes

    Bergman, Marie-Louise; Lopes-Carvalho, Thiago; Martins, Ana-Catarina; Grieco, Fabio A.; Eizirik, Décio L.; Demengeot, Jocelyne
    This deposit is composed by the main article plus the supplementary materials of the publication.

  17. Fatal CTLA-4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation

    Moraes-Fontes, Maria Francisca; Hsu, Amy P.; Caramalho, Iris; Martins, Catarina; Araújo, Ana Carolina; Lourenço, Filipa; Taulaigo, Anna V.; Lladó, Ana; Holland, Steven M.; Uzel, Gulbu
    Further funders are not indicated in the document. There is no public supplementary material available for this publication. This deposit is composed by the main article, and it hasn't any supplementary materials associated.

  18. Fatal CTLA-4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation

    Moraes-Fontes, Maria Francisca; Hsu, Amy P.; Caramalho, Iris; Martins, Catarina; Araújo, Ana Carolina; Lourenço, Filipa; Taulaigo, Anna V.; Lladó, Ana; Holland, Steven M.; Uzel, Gulbu
    Further funders are not indicated in the document. There is no public supplementary material available for this publication. This deposit is composed by the main article, and it hasn't any supplementary materials associated.

  19. iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

    Bonnet, Marie; Sarmento, Leonor Morais; Martins, Ana C.; Sobral, Daniel; Silva, Joana; Demengeot, Jocelyne
    This deposit is composed by the main article plus the supplementary materials of the publication.

  20. iRAGu: A Novel Inducible and Reversible Mouse Model for Ubiquitous Recombinase Activity

    Bonnet, Marie; Sarmento, Leonor Morais; Martins, Ana C.; Sobral, Daniel; Silva, Joana; Demengeot, Jocelyne
    This deposit is composed by the main article plus the supplementary materials of the publication.

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