Recursos de colección

ARCA - Access to Research and Communication Annals - IGC Repository (1.013 recursos)

The Institutional Repository of Instituto Gulbenkian de Ciência, developed under the project RCAAP, is intended to collect, preserve and promote open access to the intellectual production of their researchers.

Disease Genetics

Mostrando recursos 1 - 20 de 42

  1. Contribution of PTPN22, CD28, CTLA-4 and ZAP-70 variants to the risk of type 1 diabetes in Tunisians

    Zouidi, Ferjeni; Stayoussef, Mouna; Bouzid, Dorra; Fourati, Hajer; Abida, Olfa; Ayed, M. Ben; Kammoun, Thouraya; Hachicha, Monjia; Penha-Gonçalves, Carlos; Masmoudi, Hatem
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0378111913013462?via%3Dihub#s0060

  2. Association of BANK1 and cytokine gene polymorphisms with type 1 diabetes in Tunisia

    Zouidi, Ferjani; Stayoussef, Mouna; Bouzid, Dorra; Fourati, Hajer; Abida, Olfa; João, Costa; Ayed, Mourad Ben; Fakhfakh, Raouia; Thouraya, Kammoun; Monjia, Hachicha; Carlos, Penha-Gonçalves; Masmoudi, Hatem
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0378111913016545?via%3Dihub#ac0005

  3. Autoimmune diseases association study with the KIAA1109–IL2–IL21 region in a Tunisian population

    Bouzid, Dorra; Fourati, Hajer; Amouri, Ali; Marques, Isabel; Abida, Olfa; Tahri, Nabil; Penha-Gonçalves, Carlos; Masmoudi, Hatem
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://link.springer.com/article/10.1007%2Fs11033-014-3596-5

  4. Association of TCR/CD3, PTPN22, CD28 and ZAP70 gene polymorphisms with type 1 diabetes risk in Tunisian population: Family based association study

    Ferjeni, Zouidi; Bouzid, D.; Fourati, H.; Stayoussef, M.; Abida, O.; Kammoun, T.; Hachicha, M.; Penha-Gonçalves, C.; Masmoudi, H.
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0165247814002594?via%3Dihub#sec0065

  5. Multiple enteropathogenic viruses in a gastroenteritis outbreak in a military exercise of the Portuguese Army

    Lopes-João, António; Costa, Inês; Mesquita, João R.; Oleastro, Mónica; Penha-Gonçalves, Carlos; Nascimento, Maria S.J.
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S1386653215001535?via%3Dihub#sec0040

  6. Serum Pantetheinase/Vanin Levels Regulate Erythrocyte Homeostasis and Severity of Malaria

    Rommelaere, Samuel; Millet, Virginie; Rihet, Pascal; Atwell, Scott; Helfer, Emmanuèle; Chasson, Lionel; Beaumont, Carole; Chimini, Giovanna; Sambo, Maria do Rosário; Viallat, Annie; Penha-Gonçalves, Carlos; Galland, Franck; Naquet, Philippe
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0002944015004393?via%3Dihub#ack0010

  7. CREM variant rs17583959 conferred susceptibility to T1D risk in the Tunisian families

    Zouidi, Ferjani; Bouzid, D.; Fourati, H.; Fakhfakh, R.; Kammoun, T.; Hachicha, M.; Penha-Gonçalves, C.; Masmoudi, H.
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S0165247816302711?via%3Dihub#sec0035

  8. Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

    Coll, Francesc; Phelan, Jody; Hill-Cawthorne, Grant A.; Nair, Mridul B.; Mallard, Kim; Ali, Shahjahan; Abdallah, Abdallah M.; Alghamdi, Saad; Alsomali, Mona; Ahmed, Abdallah O.; Portelli, Stephanie; Oppong, Yaa; Alves, Adriana; Bessa, Theolis Barbosa; Campino, Susana; Caws, Maxine; Chatterjee, Anirvan; Crampin, Amelia C.; Dheda, Keertan; Furnham, Nicholas; Glynn, Judith R.; Grandjean, Louis; Ha, Dang Minh; Hasan, Rumina; Hasan, Zahra; Hibberd, Martin L.; Joloba, Moses; Jones-López, Edward C.; Matsumoto, Tomoshige; Miranda, Anabela; Moore, David J.; Mocillo, Nora; Panaiotov, Stefan; Parkhill, Julian; Penha, Carlos; Perdigão, João; Portugal, Isabel; Rchiad, Zineb; Robledo, Jaime; Sheen, Patricia; Shesha, Nashwa Talaat; Sirgel, Frik A.; Sola, Christophe; Sousa, Erivelton Oliveira; Streicher, Elizabeth M.; Van Helden, Paul; Viveiros, Miguel; Warren, Robert M.; McNerney, Ruth; Pain, Arnab; Clark, Taane G.
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.nature.com/articles/s41588-018-0074-3

  9. A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil

    Duarte, Tonya Azevedo; Nery, Joilda Silva; Boechat, Neio; Pereira, Susan Martins; Simonsen, Vera; Oliveira, Martha; Gomes, Maria Gabriela Miranda; Penha-Gonçalves, Carlos; Barreto, Mauricio Lima; Barbosa, Theolis
    This deposit is composed by a publication in which the IGC's authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and can only be accessed by two ways: either by requesting a legal copy from the author (the email contact present in this deposit) or by visiting the following link: https://www.sciencedirect.com/science/article/pii/S1413867016305475?via%3Dihub

  10. Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

    do Sambo, Maria Rosário; Penha-Gonçalves, Carlos; Trovoada, Maria Jesus; Costa, João; Lardoeyt, Roberto; Coutinho, António
    This deposit is composed by the main article, and it hasn't any supplementary materials associated.

  11. NOS2 Variants Reveal a Dual Genetic Control of Nitric Oxide Levels, Susceptibility to Plasmodium Infection, and Cerebral Malaria

    Trovoada, M. d. J.; Martins, M.; Ben Mansour, R.; Sambo, M. d. R.; Fernandes, A. B.; Antunes Goncalves, L.; Borja, A.; Moya, R.; Almeida, P.; Costa, J.; Marques, I.; Macedo, M. P.; Coutinho, A.; Narum, D. L.; Penha-Goncalves, C.
    This deposit is composed by the main article plus the supplementary materials of the publication.

  12. inTB - a data integration platform for molecular and clinical epidemiological analysis of tuberculosis

    Soares, Patrícia; Alves, Renato J; Abecasis, Ana B; Penha-Gonçalves, Carlos; Gomes, M Gabriela M; Pereira-Leal, José B
    This deposit is composed by the main article plus the supplementary materials of the publication.

  13. Iron overload in Plasmodium berghei-infected placenta as a pathogenesis mechanism of fetal death

    Penha-Gonçalves, Carlos; Gozzelino, Raffaella; de Moraes, Luciana V.
    This deposit is composed by the main article, and it hasn't any supplementary materials associated.

  14. Modeling Malaria Infection and Immunity against Variant Surface Antigens in Príncipe Island, West Africa

    Trovoada, Maria Jesus; Gonçalves, Lígia A.; Marinho, Cláudio R. F.; Turner, Louise; Hviid, Lars; Penha-Gonçalves, Carlos; Gomes, M. Gabriela M.
    This deposit is composed by the main article plus the supplementary materials of the publication.

  15. HGF Secreted by Activated Kupffer Cells Induces Apoptosis of Plasmodium-Infected Hepatocytes

    Gonçalves, Lígia Antunes; Rodo, Joana; Rodrigues-Duarte, Lurdes; de Moraes, Luciana Vieira; Penha-Gonçalves, Carlos
    Malaria liver stage infection is an obligatory parasite development step and represents a population bottleneck in Plasmodium infections, providing an advantageous target for blocking parasite cycle progression. Parasite development inside hepatocytes implies a gross cellular insult evoking innate host responses to counteract intra-hepatocytic infection. Using primary hepatocyte cultures, we investigated the role of Kupffer cell-derived hepatocyte growth factor (HGF) in malaria liver stage infection. We found that Kupffer cells from Plasmodium-infected livers produced high levels of HGF, which trigger apoptosis of infected hepatocytes through a mitochondrial-independent apoptosis pathway. HGF action in infected hepatocyte primary cultures results in a potent reduction...

  16. HGF Secreted by Activated Kupffer Cells Induces Apoptosis of Plasmodium-Infected Hepatocytes

    Gonçalves, Lígia Antunes; Rodo, Joana; Rodrigues-Duarte, Lurdes; de Moraes, Luciana Vieira; Penha-Gonçalves, Carlos
    This deposit is composed by the main article plus the supplementary materials of the publication

  17. A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis

    Fransén-Pettersson, Nina; Duarte, Nadia; Nilsson, Julia; Lundholm, Marie; Mayans, Sofia; Larefalk, Åsa; Hannibal, Tine D; Hansen, Lisbeth; Schmidt-Christensen, Anja; Ivars, Fredrik; Cardell, Susanna; Palmqvist, Richard; Rozell, Björn; Holmberg, Dan
    Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background. The disease is transferrable to immunodeficient recipients, while polyclonal T cells from...

  18. A New Mouse Model That Spontaneously Develops Chronic Liver Inflammation and Fibrosis

    Fransén-Pettersson, Nina; Duarte, Nadia; Nilsson, Julia; Lundholm, Marie; Mayans, Sofia; Larefalk, Åsa; Hannibal, Tine D; Hansen, Lisbeth; Schmidt-Christensen, Anja; Ivars, Fredrik; Cardell, Susanna; Palmqvist, Richard; Rozell, Björn; Holmberg, Dan
    This deposit is composed by the main article plus the supplementary materials of the publication.

  19. Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

    Martins, M; Boavida, J M; Raposo, J F; Froes, F; Nunes, B; Ribeiro, R T; Macedo, M P; Penha-Gonçalves, C
    This study aimed to estimate the prevalence of diabetes mellitus (DM) in hospitalized patients with community-acquired pneumonia (CAP) and its impact on hospital length of stay and in-hospital mortality.

  20. Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

    Martins, M; Boavida, J M; Raposo, J F; Froes, F; Nunes, B; Ribeiro, R T; Macedo, M P; Penha-Gonçalves, C
    This deposit is composed by the main article, and it hasn't any supplementary materials associated.

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