Recursos de colección

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É um repositório para instituições de ensino e investigação produtoras de literatura científica cuja dimensão ainda não justifica a criação de um repositório próprio. Permite integrar instituições, grupos ou indivíduos na infra-estrutura do projecto, nomeadamente através das pesquisas do Portal RCAAP e da B-On.

HB - Endocrinologia

Mostrando recursos 1 - 1 de 1

  1. Design of cationic lipid nanoparticles for ocular delivery: Development, characterization and cytotoxicity

    Fangueiro, JF; Andreani, T; Egea, MA; Garcia, ML; Souto, SB; Silva, AM; Souto, EB
    In the present study we have developed lipid nanoparticle (LN) dispersions based on a multiple emulsion technique for encapsulation of hydrophilic drugs or/and proteins by a full factorial design. In order to increase ocular retention time and mucoadhesion by electrostatic attraction, a cationic lipid, namely cetyltrimethylammonium bromide (CTAB), was added in the lipid matrix of the optimal LN dispersion obtained from the factorial design. There are a limited number of studies reporting the ideal concentration of cationic agents in LN for drug delivery. This paper suggests that the choice of the concentration of a cationic agent is critical when formulating...
    - 24-mar-2015

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