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The KnowledgeBank at OSU (76.052 recursos)

Knowledge Bank contains collections of presentations, publications and reports related to Ohio State University.

9th Fall Undergraduate Research Student Poster Forum (2015)

Mostrando recursos 1 - 20 de 36

  1. Effect of Transmission Electron Microscopy Sample Preparation Methods on Nano Structure and Properties of Metallic Glasses

    Park, Gyuchul
    Metallic glasses (MGs) are new metallic alloys with excellent mechanical properties. However, practical applications of MGs are still limited due to the lack of understanding on their atomic structure. Since MGs have disordered atomic structure, it is difficult to obtain the structural information that directly connects to their important properties. Recently developed transmission electron microscopy (TEM) techniques, such as fluctuation microscopy, opened new possibility in understanding the structure-property relationships in disordered materials. However, it is important to understand the effect of the TEM sample preparation methods to the structure and the quality of the samples. In the present work, we...

  2. Effect of Transmission Electron Microscopy Sample Preparation Methods on Nano Structure and Properties of Metallic Glasses

    Park, Gyuchul
    Metallic glasses (MGs) are new metallic alloys with excellent mechanical properties. However, practical applications of MGs are still limited due to the lack of understanding on their atomic structure. Since MGs have disordered atomic structure, it is difficult to obtain the structural information that directly connects to their important properties. Recently developed transmission electron microscopy (TEM) techniques, such as fluctuation microscopy, opened new possibility in understanding the structure-property relationships in disordered materials. However, it is important to understand the effect of the TEM sample preparation methods to the structure and the quality of the samples. In the present work, we...

  3. Consequences of an NFU1 Mutation in the Fe-­S Cluster Biosynthetic Pathway

    Wesley, Nathaniel; Wachnowsky, Christine; Fidai, Insiya
    A three-year embargo was granted for this item.

  4. Consequences of an NFU1 Mutation in the Fe-­S Cluster Biosynthetic Pathway

    Wesley, Nathaniel; Wachnowsky, Christine; Fidai, Insiya
    A three-year embargo was granted for this item.

  5. Synthetic Approach to Realkyation of Aged Acetylcholinesterase Using Quinone Methide Precursors

    Rao, Harsha
    Organophosphorus (OP) nerve agents are a class of toxic compounds that inhibit acetylcholinesterase (AChE), an enzyme that catalyzes the conversion of acetylcholine to choline at neurosynaptic junctions. OP inhibits AChE by binding to the active site and this undergoes a subsequent irreversible process called aging, where the OP-AChE adduct is dealkylated. This results in the accumulation of excess acetylcholine in the central nervous system that causes significant nerve damage. Current oxime-based pharmaceutical agents, such as 2-PAM, used to treat inhibited AChE are ineffective on aged AChE. Previous studies have shown that quinone methides (QM) are alkylating agents and these could...

  6. Synthetic Approach to Realkyation of Aged Acetylcholinesterase Using Quinone Methide Precursors

    Rao, Harsha
    Organophosphorus (OP) nerve agents are a class of toxic compounds that inhibit acetylcholinesterase (AChE), an enzyme that catalyzes the conversion of acetylcholine to choline at neurosynaptic junctions. OP inhibits AChE by binding to the active site and this undergoes a subsequent irreversible process called aging, where the OP-AChE adduct is dealkylated. This results in the accumulation of excess acetylcholine in the central nervous system that causes significant nerve damage. Current oxime-based pharmaceutical agents, such as 2-PAM, used to treat inhibited AChE are ineffective on aged AChE. Previous studies have shown that quinone methides (QM) are alkylating agents and these could...

  7. Developing an in vitro myobundle model system for pathophysiological studies of human skeletal muscle

    Sherry, Aubrey
    Existing in vitro models for liver, lung, and cardiac tissue have made recent notable progress, however a predictive model of human skeletal muscle does not exist. While, two-dimensional cultures of myoblasts are well known, these cultures lack the organization and function of a native muscle. Therefore, the usefulness of these existing models in pharmacological studies and disease modeling is limited. The purpose of this study is to adapt a novel three-dimensional skeletal muscle model and confirm that it is usable in future studies. This will be done by creating custom silicone molds and teflon frames in which various myoblast cell...

  8. Developing an in vitro myobundle model system for pathophysiological studies of human skeletal muscle

    Sherry, Aubrey
    Existing in vitro models for liver, lung, and cardiac tissue have made recent notable progress, however a predictive model of human skeletal muscle does not exist. While, two-dimensional cultures of myoblasts are well known, these cultures lack the organization and function of a native muscle. Therefore, the usefulness of these existing models in pharmacological studies and disease modeling is limited. The purpose of this study is to adapt a novel three-dimensional skeletal muscle model and confirm that it is usable in future studies. This will be done by creating custom silicone molds and teflon frames in which various myoblast cell...

  9. Eddy Current Microscopy for Detection of Solid Tumors

    Javor, Josh
    Optical microscopy is commonly used to investigate observable characteristics in biological tissue. A method will be presented to image electrical properties of tissue using known engineering techniques that will complement conventional histopathology. Eddy current detection involves measuring the electrical properties of a conductive sample in the presence of a time-varying magnetic field. Biological tissue has a small but nonzero conductivity and so a precise signal filter is needed to detect small changes in the shape and size of tiny current paths (eddy currents) in the sample. Characteristics of abnormal tissue such as morphology, macromolecule concentration and ion transport contribute to...

  10. Eddy Current Microscopy for Detection of Solid Tumors

    Javor, Josh
    Optical microscopy is commonly used to investigate observable characteristics in biological tissue. A method will be presented to image electrical properties of tissue using known engineering techniques that will complement conventional histopathology. Eddy current detection involves measuring the electrical properties of a conductive sample in the presence of a time-varying magnetic field. Biological tissue has a small but nonzero conductivity and so a precise signal filter is needed to detect small changes in the shape and size of tiny current paths (eddy currents) in the sample. Characteristics of abnormal tissue such as morphology, macromolecule concentration and ion transport contribute to...

  11. Probabilistic Evaluation of Carbonation Induced Deterioration in Prestressed Concrete Structures

    Loos, Sabine
    Reinforced concrete is one of the most universally used building materials, since it has a high capacity under compression, handles tensile stresses through steel reinforcement, and provides lasting durability. This durability, however, is reduced by a form of deterioration, called carbonation, caused by the reaction of carbon dioxide with the constituents inside concrete. This form of deterioration alters concrete’s material properties by increasing the compressive strength, but reducing its deformation ability. Moreover, when carbonation is coupled with chloride penetration, it destroys the natural concrete protection surrounding reinforcing steel. These alterations decrease the structural capacity of concrete members by increasing the...

  12. Probabilistic Evaluation of Carbonation Induced Deterioration in Prestressed Concrete Structures

    Loos, Sabine
    Reinforced concrete is one of the most universally used building materials, since it has a high capacity under compression, handles tensile stresses through steel reinforcement, and provides lasting durability. This durability, however, is reduced by a form of deterioration, called carbonation, caused by the reaction of carbon dioxide with the constituents inside concrete. This form of deterioration alters concrete’s material properties by increasing the compressive strength, but reducing its deformation ability. Moreover, when carbonation is coupled with chloride penetration, it destroys the natural concrete protection surrounding reinforcing steel. These alterations decrease the structural capacity of concrete members by increasing the...

  13. The Petrologist’s Guide to the Galaxy: A method for modeling terrestrial exoplanets using the MELTS algorithm

    Hull, Scott
    Recent technological advances in exoplanet detection have led to planetary findings on an unprecedented scale and opened the doors to a new area of geophysical inquiry. This inquiry includes both the hunt for Earth-like exoplanets and how planetary chemistry and physical properties vary from star to star. We are currently restricted to considering little more than the planet’s density and the distance from its star, which gives us only a vague insight into these new questions. This study has produced a method for creating a more detailed model of exoplanets using thermodynamic phase-equilibrium computer code and stellar compositions as representatives...

  14. The Petrologist’s Guide to the Galaxy: A method for modeling terrestrial exoplanets using the MELTS algorithm

    Hull, Scott
    Recent technological advances in exoplanet detection have led to planetary findings on an unprecedented scale and opened the doors to a new area of geophysical inquiry. This inquiry includes both the hunt for Earth-like exoplanets and how planetary chemistry and physical properties vary from star to star. We are currently restricted to considering little more than the planet’s density and the distance from its star, which gives us only a vague insight into these new questions. This study has produced a method for creating a more detailed model of exoplanets using thermodynamic phase-equilibrium computer code and stellar compositions as representatives...

  15. Modeling and Simulation of Non-Isothermal Gas-Assisted Injection Molding For Non-Newtonian Fluids

    Kolliopoulos, Panayiotis K.
    Current gas-assisted injection molding simulations do not accurately predict coating thickness of the frozen layer created by the polymer melt in non-isothermal systems. This project will present a hybrid control-volume finite element/finite-difference method to obtain a numerical simulation of gas-assisted injection molding for non-isothermal systems. In previous studies, a number of simplifying assumptions were made in order to make the simulation model simpler, however, those assumptions contributed to a significant error in predicting the coating thickness. The previous models will be improved upon by taking into account the temperature gradient during the penetration and the effect of forced convection heat...

  16. Modeling and Simulation of Non-Isothermal Gas-Assisted Injection Molding For Non-Newtonian Fluids

    Kolliopoulos, Panayiotis K.
    Current gas-assisted injection molding simulations do not accurately predict coating thickness of the frozen layer created by the polymer melt in non-isothermal systems. This project will present a hybrid control-volume finite element/finite-difference method to obtain a numerical simulation of gas-assisted injection molding for non-isothermal systems. In previous studies, a number of simplifying assumptions were made in order to make the simulation model simpler, however, those assumptions contributed to a significant error in predicting the coating thickness. The previous models will be improved upon by taking into account the temperature gradient during the penetration and the effect of forced convection heat...

  17. Building a Framework for Professional Commitment: Stories of Professional Growth in an Undergraduate Introduction to Pharmacy Course

    Williams, Victoria
    With admissions to PharmD programs becoming increasingly competitive, sophisticated pre-pharmacy preparation is becoming increasingly important. Admissions committees are now looking at measures beyond academic merit to assess potential for success within a PharmD program and the profession. Factors such as motivation to become a pharmacist and attitudes regarding patient-centered care are being evaluated in application reviews and interviews of candidates. Applicants to PharmD programs are expected to exhibit commitment to the profession before entering pharmacy school. Little research has been done to analyze how students develop this commitment. This study attempts to determine how an undergraduate introductory course helps pre-professional...

  18. Building a Framework for Professional Commitment: Stories of Professional Growth in an Undergraduate Introduction to Pharmacy Course

    Williams, Victoria
    With admissions to PharmD programs becoming increasingly competitive, sophisticated pre-pharmacy preparation is becoming increasingly important. Admissions committees are now looking at measures beyond academic merit to assess potential for success within a PharmD program and the profession. Factors such as motivation to become a pharmacist and attitudes regarding patient-centered care are being evaluated in application reviews and interviews of candidates. Applicants to PharmD programs are expected to exhibit commitment to the profession before entering pharmacy school. Little research has been done to analyze how students develop this commitment. This study attempts to determine how an undergraduate introductory course helps pre-professional...

  19. Associations between teachers’ personality, psychological well-being, and the quality of their cocaring relationships

    Maras, Elly
    Recent research has explored the conceptual similarities between coparenting relationships and parent-teacher, or cocaring relationships, in infant and toddler classrooms (Lang, 2015). Cocaring is defined as the relationship between a parent and his or her child’s early childhood educator. Due to the novelty of this cocaring concept, this study aims to fill the gaps by including an observational understanding of how cocaring dimensions are enacted in daily exchanges between parents and teachers. This study will also examine how anxiety, depression, and personality traits impact the quality of the cocaring relationship. Parents and teachers of approximately 30 infants and toddlers, between...

  20. Associations between teachers’ personality, psychological well-being, and the quality of their cocaring relationships

    Maras, Elly
    Recent research has explored the conceptual similarities between coparenting relationships and parent-teacher, or cocaring relationships, in infant and toddler classrooms (Lang, 2015). Cocaring is defined as the relationship between a parent and his or her child’s early childhood educator. Due to the novelty of this cocaring concept, this study aims to fill the gaps by including an observational understanding of how cocaring dimensions are enacted in daily exchanges between parents and teachers. This study will also examine how anxiety, depression, and personality traits impact the quality of the cocaring relationship. Parents and teachers of approximately 30 infants and toddlers, between...

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