ETD at Indian Institute of Science
Repository of Theses and Dissertations of Indian Institute of Science, Bangalore, India. The repository has been developed to capture, disseminate and preserve research theses of Indian Institute of Science.
Chemical Engineering (chemeng)
Mostrando recursos 1 - 20 de 56
Modeling The Population Dynamics Of Erythrocytes To Identify Optimal Drug Dosages For The Treatment Of Hepatitis C Virus Infection - Krishnan, Sheeja M
The current treatment for hepatitis C virus (HCV) infection – combination therapy
with pegylated interferon and ribavirin – elicits sustained responses in only ~50% of
the patients treated. Greater cumulative exposure to ribavirin increases response to
interferon-ribavirin combination therapy. A key limitation, however, is the toxic sideeffect of ribavirin, hemolytic anemia, which often necessitates a reduction of ribavirin dosage and compromises treatment response. Maximizing treatment response thus
requires striking a balance between the antiviral and hemolytic activities of ribavirin.
Current models of viral kinetics describe the enhancement of treatment response due
to ribavirin. Ribavirin-induced anemia, however, remains poorly understood and
precludes rational optimization of combination therapy.
Experimental Determination And New Correlations For Multi-Component Solid Solubilities In Supercritical Carbon Dioxide - Reddy, N Siva Mohan
The fluids that are operated above their critical temperature and pressure are
known as supercritical fluids (SCFs). SCFs replaces the conventional organic solvents
in the chemical processes due to their attractive properties such as liquid like
densities, gas like diffusivities, negligible surface tension, lower viscosity and high compressibility. Carbon dioxide, being non-toxic, non-flammable with ambient
critical temperature and moderate critical pressure, is the most widely used SCF in
many chemical processes. Supercritical carbon dioxide (SCCO2) finds applications in
industrial processes such as extraction and separation processes. The feasibility of a
supercritical process can be determined from the solubility of solute in SCF. For the
efficient design of a...
Modeling Lysis Dynamcis Of Pore Forming Toxins And Determination Of Mechanical Properties Of Soft Materials - Vaidyanathan, M S
Pore forming toxins are known for their ability to efficiently form transmembrane pores which eventually leads to cell lysis. PFTs have potential applications in devel-oping novel drug and gene delivery strategies. Although structural aspects of many pore forming toxins have been studied, very little is known about the dynamics and subsequent rupture mechanisms. In the first part of the thesis, a combined experimental and modeling study to understand the lytic action of Cytolysin A (ClyA) toxins on red blood cells (RBCs) has been presented. Lysis experiments are carried out on a 1% suspension of RBCs for different initial toxin concentrations...
Understanding Structure And Growth Of Physisorbed Films : A Combined Atomic Force Microscopy And Modeling Study - Patil Kalyan, G
Surface modification has wide ranging implications in lubrication, microelectromechanical systems (MEMS), colloidal systems and biological membranes. Surface modification plays an important role in stabilizing gold nanoparticles, which have applications in targeted drug delivery and catalysis. A variety of surface modification techniques are used for controlling corrosion and wettability, as well as used extensively to understand the nature of interactions between surfaces. This thesis is mainly focused on understanding the kinetics, film growth and surface modification by long chain molecules physisorbed on a surface.
The time evolution of film growth and domain formation of octadecylamine on a mica surface is studied...
Defluoridation Of Drinking Water Using Activated Alumina - Kanwar, Lalita
Excess fluoride (F-) in drinking water poses a health threat to millions of people around the world. In the present work, activated alumina (AA) has been used as an adsorbent. Data obtained from batch experiments were fitted to the (i) pseudo-first order, (ii) pseudo-second order, and (iii) Langmuir kinetic model. Model (ii) performed better than model (i), and fitted the data well. However, the rate constant for adsorption ka had to be varied as a function of the initial concentration of F- in the liquid phase c0. A more satisfactory approach is provided by Langmuir model, which fitted the data...
Development Of Ionic Catalysts For The Water-gas Shift Reaction And Exhaust Gas Purification - Deshpande, Parag Arvind
Treatment of fuel cell feed H2 for the removal of CO is important owing to the poisoning of the catalysts, thereby affecting the performance of the fuel cell. Strong and preferential adsorption of CO over the catalyst takes place resulting in a reduction of the power output of the cell. Therefore, it is important to treat the fuel cell feed H2 to reduce its CO content below the tolerable limit. Development of efficient catalysts for the treatment of synthesis gas for the removal of CO and and H2 enrichment of the gas to make it suitable for fuel cells is...