ETD at Indian Institute of Science
Repository of Theses and Dissertations of Indian Institute of Science, Bangalore, India. The repository has been developed to capture, disseminate and preserve research theses of Indian Institute of Science.
Inorganic and Physical Chemistry (ipc)
Mostrando recursos 1 - 20 de 105
Studies On The Photocytotoxic Effect Of Ferrocene-Conjugated Copper(II) Complexes - Goswami, Tridib Kumar
The present thesis deals with different aspects of the chemistry and photo-biology of various ferrocene-conjugated metal complexes, their interaction with double helical DNA, DNA photocleavage and photo-enhanced cytotoxicity in visible light. Phenyl analogues of the active complexes have been synthesized and used for comparison in biological assays.
Chapter I provides an introduction to the potential of metal complexes as photochemotherapeutic agents with special reference to organometallic compounds. A brief overview of Photodynamic Therapy (PDT) as a new modality of cancer treatment has been given. Various modes of non-covalent interactions of small molecules with duplex DNA are mentioned. Recent reports on...
Ultrafast Raman Loss Spectroscopy (URLS) : Understanding Resonant Excitation Response And Linewidth Changes - Adithya Lakshmanna, Y
Raman spectroscopy involves change in the polarizability of the molecular system on excitation and is based on scattering process. Spontaneous Raman scattering is a two photon process, in which the input light initiates the excitation, which then leads to an emission of another photon due to scattering. It is extensively used to understand molecular properties. As spontaneous Raman scattering is a weak process, the detection of these weak Raman photons are rather difficult.
Alternatively, resonance Raman (RR) scattering is another technique where the excitation wavelength is chosen according to the material under study. The excitation wavelength is chosen to be...
Targeting Cancer Cells And Live Cell Imaging Using Bis(thiosemicarbazone) Complexes Of Copper And Zinc - Duraippandi, P
Transition metal bis(thiosemicarbazone) complexes have been of great interest in the last five decades. One of the most striking features of these complexes is that they possess a wide range of biological properties including antimalarial, antibacterial and anticancer activity. Zinc and copper bis(thiosemicarbazone) complexes have recently attracted attention due to their intracellular fluorescence and anticancer activity, respectively. The present work “Targeting Cancer Cells and Live Cell Imaging Using Bis(thiosemicarbazone) Complexes of Copper and Zinc” is an effort to target cancer cells using folic acid or biotin linked anticancer active copper bis(thiosemicarbazone) complexes. Interestingly, bis(thiosemicarbazone) ligands form zinc complexes that could...
Self-Assembly Of Functional Supramolecular Architectures via Metal-Ligand Coordination - Shanmugaraju, S
Over the past few decades, supramolecular self-assembly has become an alternative synthetic tool for constructing targeted discrete molecular architectures. Among various interactions, metal-ligand coordination has attracted great attention owing to high bond enthalpy (15−50 Kcal/mol) and predictable directionality. The basic principle of metal-ligand directed self-assembly relies on the proper designing of information encoded rigid complementary building units (a transition metal based acceptor and a multidentate organic donor) that self-recognize themselves in a chemically reasonable way (depends on their bite angle and symmetry) during self-assembly process. As far as acceptor units are concerned, Pd(II) and Pt(II) metal-based cis-blocked 90° acceptors have...
Ultrafast Raman Loss Spectroscopy (URLS) - Mallick, Babita
Contemporary laser research involves the development of spectroscopic techniques to understand the microscopic structural aspects of a simple molecular system in chemical and materials to more complex biological systems such as cells. In particular, Raman spectroscopy, which provides bond specific information, has attracted considerable attention. Further with the advent of femtosecond (fs) laser, the recent trend in the field of fs chemistry is to develop nonlinear Raman techniques that allow one to acquire vibrational structural information with both fs temporal resolution as well as good spectral resolution. Among many advanced nonlinear Raman techniques, the development of fs Stimulated Raman scattering...
Studies On Lanthanide Complexes Showing Photo-activated DNA Cleavage And Anticancer Activity - Hussain, Akhtar
This thesis work deals with different aspects of the chemistry of La(III) and Gd(III) complexes, their interaction with DNA and proteins, photo-induced cleavage of double-stranded DNA, photocytotoxic effect on cancer cells, cell death mechanism and cellular localization behaviour.
Chapter I gives an introduction to the metal-based anticancer agents with special emphasis on clinically used drugs and the growing field of lanthanide therapeutics. An overview of the current strategies of cancer treatment, especially photodynamic therapy (PDT), is presented. Mode of small molecule-DNA interactions and the mechanistic aspects associated with DNA photodamage reactions and PDT effect are discussed with selected examples of...
Rotational Specroscopic And Theoretical Investigations Of Non-conventional Hydrogen Bonds - Aiswarya Lakshmi, P
The nature of interactions within a molecule, i.e. chemical bonding, is well understood today. However, our understanding about intermolecular interactions, which has great relevance in nature, is still evolving. Historically there are two types of intermolecular interactions, van der Waals interaction and hydrogen bonding. However, there has been an upsurge of interest in the halogen bonding and lithium bonding during the last decade. The main emphasis of our research is to understand these interactions in detail, in particular non-conventional hydrogen bond acceptors. In this work, weakly bound complexes are studied using Pulsed Nozzle Fourier Transform Microwave Spectrometer, which has been...
Probing The Equilibrium Geometry Of Weakly Interacting Systems In Solution By Hyper-Rayleigh Scattering - Pandey, Ravindra
Under the electric dipole approximation, second harmonic of the incident light is scattered by a collection of randomly oriented molecular dipoles in solution due to instantaneous orientational fluctuation which is directional. If two such dipoles are correlated in space through intermolecular or other interactions, the intensity of the second harmonic scattered light (SHSL) will be related to the extent of such interactions. If two dipoles are arranged in a particular geometry by design, the geometry will determine the intensity of the SHSL. If a molecule has no dipole moment, the intensity of the SHSL will be less and is only...
Understanding Solvent Effect On Triplet State Structure Of Thioxanthone And Its Derivatives Using Time-Resolved Resonance Raman Spectroscopy - Pandey, Rishikesh
It has long been recognized that course and efficiency of a chemical reaction is largely mediated by the short-lived transient species (excited state or radicals) which are formed as reactive intermediates during a chemical reaction. Subtle changes not only in the bonding and electronic distributions but also in the conformations and geometries of these intermediates have a dramatic influence on the reactivity. A detailed understanding of the structural and dynamical aspects of electronic excited states is therefore essential towards unraveling photoinduced natural processes and for designing novel photonic materials. Time-resolved techniques have been widely used to study the transient species...
Conformational Reorganization Of Hyperbranched And Linear Polymers And Functionalized Porous Polymer Films - Samuel, Ashok Zachariah
The main focus of the research work presented in the thesis is the understanding of structural and conformational reorganizations in hyperbranched and linear polymers. The thesis includes three different investigations: a) the design, synthesis, conformational reorganizations and self-assembly of hyperbranched polymers (HBPs), b) the Raman spectroscopic studies of the melting of polyethylene glycol (PEG), and c) the preparation of functionalized porous polymer films.
HBPs are structurally imperfect analogues of the defect-free branched polymers called dendrimers. Dendrimers prepared using a stepwise polymerization methodology will carry all the unreacted B groups at the periphery and therefore modification of these peripheral units with...
Theoretical Studies Of Electronic Excitation Energy Transfer Involving Some Nanomaterials - Swathi, R S
Electronic Excitation Energy Transfer is an important intermolecular photophysical process that can affect the excited state lifetime of a chromophore. A molecule in an electronically excited state can return to the ground state by radiative as well as non-radiative processes. During the excited state lifetime, if the chromophore (energy donor) finds a suitable species (energy acceptor) nearby with resonant energy levels, it can transfer the excitation energy to that species and return to the ground state. This process is called Electronic Excitation Energy Transfer. When the energy donor is fluorescent, the process is called Fluorescence Resonance Energy Transfer (FRET) ....
Titanium Nitride-Based Electrode Materials For Oxidation Of Small Molecules : Applications In Electrochemical Energy Systems - Musthafa, O T Muhammed
Synopsis of the thesis entitled “Titanium Nitride-Based Electrode Materials for Oxidation of Small Molecules: Applications in Electrochemical Energy Systems” submitted by Muhammed Musthafa O. T under the supervision of Prof. S. Sampath at the Department of Inorganic and Physical Chemistry of the Indian Institute of Science for the Ph.D degree in the faculty of science.
Fuel cells have been the focus of interest for many decades because of the ever increasing demands in energy. Towards this direction, there have been considerable efforts to find efficient electrocatalysts to oxidize small organic molecules (SOMs) such as methanol, ethanol, glycerol, hydrazine and borohydride...
Resonance Energy Transfer Using ZnO Nanocrystals And Magnetism In The Mixed Metal Layered Thiophosphates, Mn1-xFexPS3(0≤x≥1) - Rakshit, Sabyasachi
This thesis consists of two parts. The first part deals with the visible emission of ZnO Nanocrystals and its possible application in Resonance Energy Transfer (RET) studies. The second part of the thesis is on the magnetic properties of the layered transition metal Thiophosphates MPS3 (M = Mn, Fe), their solid solutions and intercalation compounds.
Recent advances in semiconductor nanocrystals or quantum dots (QDs) as inorganic fluorophores have pioneered a new direction in the fluorescent based techniques to investigate fundamental processes in lifesciences. Their broad absorption spectra with narrow, Size-tunable emissions with high quantum e±ciency and stability under relative harsh environments...
Graphite Oxide And Graphite Oxide-Based Composites : Physicochemical And Electrochemical Studies - Ramesha, G K
One of the major directions of research in the area of materials science is to impart multifunctionalities to materials. Carbon stands on the top of the list to provide various multifunctional materials. It exists in all dimensions, zero (fullerene), one (carbon nanotube, CNT), two (graphene) and three (graphite) dimensions are very well-known for their versatility in various studies. They are also used in various applications in nanoelectronics, polymer composites, hydrogen production and storage, intercalation materials, drug delivery, sensing, catalysis, photovoltaics etc. Electrical conductivity of carbon can be tuned from insulator (diamond) to semiconductor (graphene) to conductor (graphite) with varying band...
Self-Assembly Of Discrete Molecular Architectures : Design, Synthesis And Characterization - Ghosh, Sushobhan
Stepwise covalent synthesis of large molecules is often time consuming and laborious and thus generally ends in a low yield of the target product. It is also difficult to achieve a large desired product where the controlling force is a non-directional weak interaction. Instead, by utilizing stronger metal-ligand directional coordination bonding approach, one can easily prepare the desired large molecules using appropriate molecular units. Further attractive feature of this approach is the incorporation of functional groups into final structures to make the assemblies functional. It is found that symmetrical polypyridyl and rigid linkers have been used widely in the construction...
Thermal Decomposition Of Haloethanols And Ignition Of JP-10 - Chakravarty, Harish Kumar
In this thesis, the thermal decomposition investigation of haloethanols namely 2-chloroethanol and 2-bromoethanol are reported both experimental and theoretical. Computational calculation of enthalpy of formation haloethanols using isodesmic and atomization reactions has also been reported. Finally, the chemistry of JP-10 ignition has also been investigated using shock tube.
Chapter 1 gives a brief introduction to the experimental shock tube technique. Brief surveys of literature pertinent to haloethanols and JP-10 have also been discussed. The importance of thermal rate coefficient and detection techniques in shock tube chemistry is presented. Details of the theoretical methods used in the determination of thermal rate...
Chemistry Of Ferrocene Conjugates Showing DNA Cleavage And Photocytotoxic Activity - Maity, Basudev
Ferrocene is an important molecule in the field of chemical biology due to its stability, unique redox property and significant lipophilicity for better cellular delivery. The medicinal importance of ferrocene is well recognized after its successful incorporation into breast cancer drug tamoxifen and antimalarial drug chloroquin. Designing ferrocene conjugated transition metal complexes is an interesting area of research in the field of photodynamic therapy, a new modality of light activated cancer treatment. The objective of the present thesis work is to develop photoactive ferrocene conjugates showing DNA photocleavage and photocytotoxic activity.
We have synthesized the ferrocene conjugated imidazophenanthroline derivative which...
Controlling Conformation Of Macromolecules Using Non-Covalent Interaction And Micellization Behaviour Of Isomeric Phenyl Bearing Cationic Surfactants - De, Swati
This thesis contains investigations in two different areas, described under six chapters. Chapter 1 contains a broad introduction to the area of foldamers, while Chapters 2, 3, 4, and 5 deal with various novel classes of synthetic polymers which can form folded structures in solution utilizing different non-covalent interactions. Chapter 6 deals with a distinctly different topic, where the objective was to study the effect of phenyl ring location on the micellization properties of a series of isomeric cationic surfactants.
Synthetic polymers typically adopt a random coil conformation in solution, which is primarily an entropy driven process. So the generation...