Recursos de colección

Repositório Comum (25.459 recursos)

É um repositório para instituições de ensino e investigação produtoras de literatura científica cuja dimensão ainda não justifica a criação de um repositório próprio. Permite integrar instituições, grupos ou indivíduos na infra-estrutura do projecto, nomeadamente através das pesquisas do Portal RCAAP e da B-On.

Mostrando recursos 1 - 20 de 723

  1. Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals

    Winand, Raf; Theys, Kristof; Eusébio, Mónica; Aerts, Jan; Camacho, Ricardo J.; Gomes, Perpétua; Suchard, Marc A.; Vandamme, Anne-Mieke; Abecasis, Ana B.; on behalf of the Portuguese HIV-1 Resistance Study Group
    OBJECTIVES: Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs. DESIGN: This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients. METHODS: The prevalence of SDRMs to protease inhibitors, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in drug-naive and treatment-failing patients was measured for 3554 HIV-1 subtype B patients. Transmission ratio (prevalence in drug-naive/prevalence in treatment-failing patients), average viral load and robust linear regression with outlier...

  2. Discordant predictions of residual activity could impact dolutegravir prescription upon raltegravir failure

    Theys, Kristof; Abecasis, Ana; Libina, Pieter; Gomes, Perpétua; Cabanas, Joaquim; Camacho, Ricardo J.; Van Laethem, Kristel
    BACKGROUND: Dolutegravir is approved for the treatment of HIV-1 patients exposed to other integrase inhibitors, but the decision to use dolutegravir in this setting should be informed by drug resistance testing. OBJECTIVES: This study determined the extent of disagreement in predicted residual dolutegravir activity after raltegravir use, and identified individual mutational patterns for which uncertainty exists among HIV-1 expert systems. STUDY DESIGN: Mutation patterns were classified in raltegravir signature pathways including positions 143, 148 and 155, and interpreted into clinically informative resistance levels using genotypic drug resistance interpretation systems ANRS v24, HIVdb v7.0 and Rega v9.1.0, and instructions of dolutegravir use as approved by the...

  3. Trisomy 15 mosaicism: challenges in prenatal diagnosis

    Silva, Marisa; Alves, Cristina; Pedro, Sónia; Marques, Bárbara; Ferreira, Cristina; Furtado, José; Martins, Ana Teresa; Fernandes, Rosário; Correia, Joaquim; Correia, Hildeberto
    "This is the peer reviewed version of the following article: Am J Med Genet A. 2015 Nov;167A(11):2847-50., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.37229/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."

  4. Caracterização da atividade antioxidante de sumos verdes comerciais e os seus equivalentes manufaturados, ao longo do tempo

    Cavaco, Joana Kouprianoff Damas
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  5. Perturbações de hiperatividade e défice de atenção e respetivas terapêuticas

    Leitão, Diogo André Gonçalves
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  6. Gastric outlet obstruction: an unusual adverse event of percutaneous endoscopic gastrostomy

    Barosa, Rita; Santos, Carla; Fonseca, Jorge
    Letter to the Editor

  7. Percutaneous endoscopic gastrostomy for nutritional support in dementia patients

    Nunes, Gonçalo; Santos, Carla Adriana; Santos, Carla; Fonseca, Jorge
    The final publication is available at link.springer.com

  8. Malnutrition and clinical outcome of 234 head and neck cancer patients who underwent percutaneous endoscopic gastrostomy

    Fonseca, Jorge; Santos, Carla Adriana; Brito, José
    This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 2016, available online: http://www.tandfonline.com/10.1080/01635581.2016.1158297.

  9. Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding

    Santos, Carla Adriana; Fonseca, Jorge; Carolino, Elisabete; Guerreiro, António
    Background & aims: Patients who underwent endoscopic gastrostomy (PEG) present protein-energy malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron (Fe), Chromium (Cr). Our aim was the evaluation of serum TE in patients who underwent PEG and its relationship with serum proteins, BMI and nature of underlying disorder. Methods: A prospective observational study was performed collecting: patient's age, gender, underlying disorder, NRS-2002, BMI, serum albumin, transferrin and TE concentration. We used ferrozine colorimetric method for Fe; Inductively Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace Atomic Absorption Spectroscopy for Se/Cr. The patients were divided into head and neck cancer (HNC) and neurological...

  10. Análise de águas residuais na monitorização de biomarcadores de consumo de substâncias psicoativas

    Figueiredo, Ana Luísa Bronze de
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  11. Rotulagem: a perspetiva do consumidor

    Gomes, Ana Rita Verdasca
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  12. Estado da arte em oncologia médica: tumores da cabeça e do pescoço

    Canelas, Inês Cravidão Prates
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  13. Farmacoterapia e prescrição médica em medicina dentária

    Madeira, Filipa Maria Moreia
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  14. Impacte dos estrogénios no ambiente

    Rento, Filipa Bento Soares
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  15. Desenvolvimento clínico de novas moléculas terapêuticas: tendências na IF

    Simões, Helena Nogueira da Silva
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  16. PHMB como desinfectante e anti-séptico

    Afonso, Francisco Ribeiro
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  17. Avaliação de riscos para a saúde resultantes de misturas de metais potencialmente presentes em medicamentos

    Silva, Milene Filipa de Jesus
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

  18. "Mens sana in corpore sano" : the concept of health and illness in colorectal cancer patients

    Dias, Maria do Rosário; Ferreira, Ana; Neves, Ana Cristina
    "Colorectal cancer is the most frequent cancer in Portugal. As such, the present research project studied colostomies patients, with temporary or definitive stoma so as to examine the internalized imago of ‘healthy person’ and ‘sick person’. A descriptive and exploratory study with a qualitative methodological strategy was carried out. Our sample comprised 46 ostomy individuals of both sexes, aged between 36 and 91 years. All participants answered to a brief socio-demographic and clinic survey and to a protocol that involved producing a pictorial representation of a healthy and sick person and provide a written answer on these concepts. The results...

  19. Genetic diversity, transmission dynamics and drug resistance of Mycobacterium tuberculosis in Angola

    Perdigão, João; Clemente, Sofia; Ramos, Jorge; Masakidi, Pedro; Machado, Diana; Silva, Carla; Couto, Isabel; Viveiros, Miguel; Taveira, Nuno; Portugal, Isabel
    This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

  20. O uso de própolis na cavidade oral: revisão bibliográfica

    Frazão, Maria Ana de Sousa Manuel Franco
    Dissertação para obtenção do grau de Mestre no Instituto Superior de Ciências da Saúde Egas Moniz

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