Winand, Raf; Theys, Kristof; Eusébio, Mónica; Aerts, Jan; Camacho, Ricardo J.; Gomes, Perpétua; Suchard, Marc A.; Vandamme, Anne-Mieke; Abecasis, Ana B.; on behalf of the Portuguese HIV-1 Resistance Study Group
Surveillance drug resistance mutations (SDRMs) in drug-naive patients are typically used to survey HIV-1-transmitted drug resistance (TDR). We test here how SDRMs in patients failing treatment, the original source of TDR, contribute to assessing TDR, transmissibility and transmission source of SDRMs.
This is a retrospective observational study analyzing a Portuguese cohort of HIV-1-infected patients.
The prevalence of SDRMs to protease inhibitors, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) in drug-naive and treatment-failing patients was measured for 3554 HIV-1 subtype B patients. Transmission ratio (prevalence in drug-naive/prevalence in treatment-failing patients), average viral load and robust linear regression with outlier...
Theys, Kristof; Abecasis, Ana; Libina, Pieter; Gomes, Perpétua; Cabanas, Joaquim; Camacho, Ricardo J.; Van Laethem, Kristel
Dolutegravir is approved for the treatment of HIV-1 patients exposed to other integrase inhibitors, but the decision to use dolutegravir in this setting should be informed by drug resistance testing.
This study determined the extent of disagreement in predicted residual dolutegravir activity after raltegravir use, and identified individual mutational patterns for which uncertainty exists among HIV-1 expert systems.
Mutation patterns were classified in raltegravir signature pathways including positions 143, 148 and 155, and interpreted into clinically informative resistance levels using genotypic drug resistance interpretation systems ANRS v24, HIVdb v7.0 and Rega v9.1.0, and instructions of dolutegravir use as approved by the...
Silva, Marisa; Alves, Cristina; Pedro, Sónia; Marques, Bárbara; Ferreira, Cristina; Furtado, José; Martins, Ana Teresa; Fernandes, Rosário; Correia, Joaquim; Correia, Hildeberto
"This is the peer reviewed version of the following article: Am J Med Genet A. 2015 Nov;167A(11):2847-50., which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.37229/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
Barosa, Rita; Santos, Carla; Fonseca, Jorge
Letter to the Editor
Nunes, Gonçalo; Santos, Carla Adriana; Santos, Carla; Fonseca, Jorge
The final publication is available at link.springer.com
Fonseca, Jorge; Santos, Carla Adriana; Brito, José
This is an Accepted Manuscript of an article published by Taylor & Francis in Nutrition and Cancer on 2016, available online: http://www.tandfonline.com/10.1080/01635581.2016.1158297.
Santos, Carla Adriana; Fonseca, Jorge; Carolino, Elisabete; Guerreiro, António
Background & aims: Patients who underwent endoscopic gastrostomy (PEG) present protein-energy
malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron
(Fe), Chromium (Cr). Our aim was the evaluation of serum TE in patients who underwent PEG and its
relationship with serum proteins, BMI and nature of underlying disorder.
Methods: A prospective observational study was performed collecting: patient's age, gender, underlying
disorder, NRS-2002, BMI, serum albumin, transferrin and TE concentration. We used ferrozine colorimetric
method for Fe; Inductively Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace
Atomic Absorption Spectroscopy for Se/Cr. The patients were divided into head and neck cancer (HNC)
Dias, Maria do Rosário; Ferreira, Ana; Neves, Ana Cristina
"Colorectal cancer is the most frequent cancer in Portugal. As such, the present research project studied colostomies patients, with temporary or definitive stoma so as to examine the internalized imago of ‘healthy person’ and ‘sick person’. A descriptive and exploratory study with a qualitative methodological strategy was carried out. Our sample comprised 46 ostomy individuals of both sexes, aged between 36 and 91 years. All participants answered to a brief socio-demographic and clinic survey and to a protocol that involved producing a pictorial representation of a healthy and sick person and provide a written answer on these concepts. The results...
Perdigão, João; Clemente, Sofia; Ramos, Jorge; Masakidi, Pedro; Machado, Diana; Silva, Carla; Couto, Isabel; Viveiros, Miguel; Taveira, Nuno; Portugal, Isabel
This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third party material in this article are included in the article’s Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
Almeida, Sílvia M.; Furtado, José M.; Mascarenhas, Paulo; Ferraz, Maria E.; Silva, Luís R.; Ferreira, José C.; Monteiro, Mariana; Vilanova, Manuel; Ferraz, Fernando P.
"Objective: To develop and cross-validate predictive models for percentage body fat (%BF) from
anthropometric measurements [including BMI z-score (zBMI) and calf circumference
(CC)] excluding skinfold thickness.
Martins, Rui; Silva, Giovani L.; Andreozzi, Valeska
"Joint analysis of longitudinal and survival data has received increasing attention
in the recent years, especially for analyzing cancer and AIDS data. As both
repeated measurements (longitudinal) and time-to-event (survival) outcomes are
observed in an individual, a joint modeling is more appropriate because it takes
into account the dependence between the two types of responses, which are often
analyzed separately. We propose a Bayesian hierarchical model for jointly modeling
longitudinal and survival data considering functional time and spatial frailty effects,
respectively. That is, the proposed model deals with nonlinear longitudinal effects
and spatial survival effects accounting for the unobserved heterogeneity among individuals
living in the same region. This joint...
"The objective is to model longitudinal and survival data jointly taking into account
the dependence between the two responses in a real HIV/AIDS dataset using
a shared parameter approach inside a Bayesian framework. We propose a linear
mixed effects dispersion model to adjust the CD4 longitudinal biomarker data with
a between-individual heterogeneity in the mean and variance. In doing so we are relaxing
the usual assumption of a common variance for the longitudinal residuals. A
hazard regression model is considered in addition to model the time since HIV/AIDS
diagnostic until failure, being the coefficients, accounting for the linking between the
longitudinal and survival processes, time-varying. This flexibility is...
Este artigo procura contribuir para uma reflexão sobre o lugar que a gestão da performance ocupa nas culturas juvenis, focando em particular as percepções dos jovens sobre os consumos de performance, entendidos como o consumo de medicamentos e/ou produtos terapêuticos com finalidades de gestão do desempenho neuro/cognitivo e/ou físico/corporal. A análise tem como base material empírico resultante da componente extensiva de um projecto de pesquisa sobre consumos de performance na população jovem (18-29 anos) em Portugal, designadamente um inquérito por questionário a uma amostra (n =1483) que abrangeu estudantes do ensino superior e trabalhadores sem formação superior. Os resultados revelam...
Pegado, Elsa; Zózimo, Joana; Lopes, Noémia
Partindo da experiência de investigação num estudo sociológico sobre a psicofarmacologização da velhice, cuja metodologia incluiu a realização de histórias de vida, o presente artigo visa discutir alguns dilemas éticos e correspondentes desafios metodológicos inerentes a esta técnica e, em particular, as especificidades da sua aplicação junto da população idosa. O estudo, desenvolvido no concelho de Almada, contemplou a realização de 30 entrevistas de histórias de vida a idosos a viver sós, com idades compreendidas entre os 67 e os 90 anos, com autonomia física e cognitiva, inseridos em três diferentes contextos (Domicílio, Centros de Dia e Lares).
Gonçalves, Carla; Coelho, Mauro A.; Salema-Oom, Madalena; Gonçalves, Paula
This is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record Mol Biol Evol (2016) 33 (2): 352-366 is available online at: http://mbe.oxfordjournals.org/content/33/2/352 DOI 10.1093/molbev/msv220.
Costa, Filipa Alves da; Periquito, Catarina; Carneiro, Maria Clara; Oliveira, Pedro; Fernandes, Ana Isabel; Cavaco-Silva, Patrícia
"Background: Potentially inappropriate medications (PIMs) are often found in high proportion among the elderly population. The STOPP criteria have been suggested to detect more PIMs in European elderly than the Beers criteria. Objective: This study aimed to determine the prevalence of PIMs and potential prescribing omissions (PPOs) in a sample of Portuguese nursing homes residents. Setting: Four elderly facilities in mainland Portugal Method: A descriptive cross-sectional study was used. Elderly polypharmacy patients were included in the study and their medication (registered in patient clinical records) analysed using the Beers (2012 original version and 2008 version adapted to Portugal), STOPP (Screening...
Aguiar, João Pedro; Costa, Filipa Alves da
"Por ocasião da comemoração dos 5 anos de vida do Projeto Geração Saudável, lançado pela Secção Regional do Sul e Regiões Autónomas da Ordem dos Farmacêuticos, tivemos oportunidade de assistir a um interessante debate sobre intervenções em Saúde Pública realizadas noutros países. Foram dados exemplos interessantíssimos e partilhados com entusiasmo pela plateia. No entanto, foram poucos os relatos de iniciativas portuguesas, para além do emblemático projeto Geração Saudável. Há inquestionavelmente um viés de publicação em Portugal, que conduz a que iniciativas louváveis não sejam partilhadas com a comunidade científica. Assim, enquanto docentes da Unidade Curricular de Saúde Pública do Mestrado...
Costa, Filipa Alves da; Teixeira, Inês; Duarte-Ramos, Filipa; Proença, Luís; Pedro, Ana Rita; Furtado, Cristina; Silva, José Aranda da; Cabrita, José
"Background: In view of the current financial and demographic situation in Portugal, accessibility to health care may be affected, including the ability to adhere to medication. Objective: To evaluate the perceived effects of the crisis on elderly patient’s access to medicines and medical care, and its implications on medicine-taking behaviour. Setting Community pharmacy. Method: A cross-sectional study was undertaken during April 2013, where elderly patients answered a self-administered questionnaire based on their health-related experiences in the current and previous year. Binary logistic regression was used to ascertain the effects of potential predictors on the likelihood of adherence. Main outcome measures...
Miranda, D.; Cardoso, R.; Gomes, R.; Guimarães, I.; Abreu, D. de; Godinho, C.; Pereira, P.; Domingos, J.; Nona, N.; Ferreira, J. J.
"Objectives: To determine and compare the frequency of undernutrition in institutionalized elderly patients with neurological diseases at admission using different nutritional assessment tools. Design: Cross-sectional observational study. Setting: One long-term care institution specialized in neurodegenerative diseases. Participants: 92 Elderly people (aged ≥ 65 years) with at least one neurological condition. Measurements: Mini Nutritional Assessment (MNA), body mass index (BMI), mid-arm (MAC) and calf circumferences (CC) were used for nutritional status assessment. Presence and severity of dysphagia, polypharmacy and feeding difficulties were also assessed. Results: According to MNA, 77.1% of the participants were undernourished at admission. BMI identified 46.8%, MAC identified...
Espay, Alberto J., et al.; Movement Disorders Society Task Force on Technology, on behalf of the
"The miniaturization, sophistication, proliferation, and accessibility of technologies are enabling the capture of more and previously inaccessible phenomena in Parkinson's disease (PD). However, more information has not translated into a greater understanding of disease complexity to satisfy diagnostic and therapeutic needs. Challenges include noncompatible technology platforms, the need for wide-scale and long-term deployment of sensor technology (among vulnerable elderly patients in particular), and the gap between the “big data” acquired with sensitive measurement technologies and their limited clinical application. Major opportunities could be realized if new technologies are developed as part of open-source and/or open-hardware platforms that enable multichannel data...