Direct communication between different nervous systems has been recently reported through Brain-to-Brain-Interfaces and brainet. Closed loops systems between the brain and the spinal cord from the same individual have also been demonstrated. However, the connection between different nervous systems through the spinal cord has not yet been considered. This paper raises the hypothesis that connecting two spinal cords (spinal cord – spinal cord connection) is an indirect mean for communication of two brains and a direct way of communication between two nervous systems. A concept of electrical fingerprint of a drug is introduced. The notion of connection between two parts...
INTRODUCTION: There is substantial evidence of the association between mental disorders and low folic acid levels.
The aim of this study was to evaluate the prevalence of folic acid deficiency in a sample of Portuguese psychiatric outpatients.
METHODS: The study was retrospective and included 428 psychiatric outpatients with a diagnosis of depression or non-affective psychosis, for whom folic acid levels had been measured as part of routine blood tests. Folic acid levels from other hospital patients from the same time period were also registered.
RESULTS AND DISCUSSION: The prevalence of folic acid deficiency in this sample is 18%. Non-psychiatric hospital patients with risk...
Rodrigues, D; Pires, E; Gomes, V; Araújo, I
A intubação endotraqueal (IET), no pré-hospitalar, é considerada o “gold standard” na manutenção da via
aérea de modo a fornecer a ventilação e oxigenação à pessoa em situação crítica, no entanto, está associada a várias complicações e riscos. Com este trabalho de revisão sistemática da literatura pretendeu-se compreender a relação entre a IET em emergência pré-hospitalar e o prognóstico da pessoa em situação crítica, colocando a seguinte questão: “Qual o impacto da intubação endotraqueal, em emergência pré-hospitalar, no prognóstico clínico do doente?”. Este trabalho de investigação iniciou-se com uma pesquisa da literatura de língua inglesa e portuguesa, nas bases de dados...
Pais-Vieira, M; Yadav, AP; Moreira, D; Guggenmos, D; Silva-dos-Santos, A; Lebedev, M; Nicolelis, ML
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased...
Moura, M; Silva-dos-Santos, A; Afonso, J; Talina, M
Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ages.
Here, we present a case of a 15 year-old female adolescent with first-episode psychosis with anti-NMDA receptor encephalitis not related to tumor, which manifested with delusion, hallucinations, panic attacks, agitation, and neurological symptoms, and later with autonomic instability....
Coentre, R; Silva-dos-Santos, A; Cotrim-Talina, M
We report a case of a 61-year-old woman who presented with acute psychosis as a major manifestation of Legionnaires’ disease in the absence of other neuropsychiatric symptoms. Clinical history revealed dry cough and nausea. Observation showed fever and auscultation crackles in the lower lobe of the right lung. Laboratory testing demonstrated elevated C-reactive protein and lung chest radiograph showed patchy peribronchial and right lower lobe consolidation. Soon after admission, she started producing purulent
sputum. Epidemiological data suggested Legionella pneumophila as possible cause of the clinical picture that was confirmed by urinary antigen detection and polymerase chain reaction of the sputum. She...
Coentre, R; Silva-dos-Santos, A; Talina, MC
Background. No consensus between guidelines exists regarding neuroimaging in firstepisode
psychosis. The purpose of this study is to assess anomalies found in structural
neuroimaging exams (brain computed tomography (CT) and magnetic resonance
imaging (MRI)) in the initial medical work-up of patients presenting first-episode
Methods. The study subjects were 32 patients aged 18–48 years (mean age: 29.6 years),
consecutively admitted with first-episode psychosis diagnosis. Socio-demographic and
clinical data and neuroimaging exams (CT and MRI) were retrospectively studied.
Diagnostic assessments were made using the Operational Criteria Checklist +. Neuroimaging
images (CT and MRI) and respective reports were analysed by an experienced
Results. None of the patients had abnormalities in neuroimaging...