Recursos de colección

ARCA - Access to Research and Communication Annals - IGC Repository (791 recursos)

The Institutional Repository of Instituto Gulbenkian de Ciência, developed under the project RCAAP, is intended to collect, preserve and promote open access to the intellectual production of their researchers.

Membrane Traffic

Mostrando recursos 1 - 6 de 6

  1. Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE

    Cavadas, Miguel; Oikonomidi, Ioanna; Gaspar, Catarina J.; Burbridge, Emma; Badenes, Marina; Félix, Inês; Bolado, Alfonso; Hu, Tianyi; Bileck, Andrea; Gerner, Christopher; Domingos, Pedro M.; von Kriegsheim, Alex; Adrain, Colin
    This deposit is composed by the main article plus the supplementary materials of the publication.

  2. Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis

    Johnson, Nicholas; Březinová, Jana; Stephens, Elaine; Burbridge, Emma; Freeman, Matthew; Adrain, Colin; Strisovsky, Kvido
    This deposit is composed by the main article plus the supplementary materials of the publication.

  3. Inactive rhomboid proteins: New mechanisms with implications in health and disease

    Lemberg, Marius K; Adrain, Colin
    This deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication. This publication hasn't any creative commons license associated.

  4. Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate

    Nguyen, Lan K; Cavadas, Miguel A S; Kholodenko, Boris N; Frank, Till D; Cheong, Alex
    There are no funders and sponsors indicated explicitly in the document. The upload is composed by two files: the main article and supplementary materials (both in pdf format).

  5. REST is a hypoxia-responsive transcriptional repressor

    Cavadas, Miguel A. S.; Mesnieres, Marion; Crifo, Bianca; Manresa, Mario C.; Selfridge, Andrew C.; Keogh, Ciara E.; Fabian, Zsolt; Scholz, Carsten C.; Nolan, Karen A.; Rocha, Liliane M. A.; Tambuwala, Murtaza M.; Brown, Stuart; Wdowicz, Anita; Corbett, Danielle; Murphy, Keith J.; Godson, Catherine; Cummins, Eoin P.; Taylor, Cormac T.; Cheong, Alex
    Cellular exposure to hypoxia results in altered gene expression in a range of physiologic and pathophysiologic states. Discrete cohorts of genes can be either up- or down-regulated in response to hypoxia. While the Hypoxia-Inducible Factor (HIF) is the primary driver of hypoxia-induced adaptive gene expression, less is known about the signalling mechanisms regulating hypoxia-dependent gene repression. Using RNA-seq, we demonstrate that equivalent numbers of genes are induced and repressed in human embryonic kidney (HEK293) cells. We demonstrate that nuclear localization of the Repressor Element 1-Silencing Transcription factor (REST) is induced in hypoxia and that REST is responsible for regulating approximately...

  6. Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFα

    Wunderle, Lina; Knopf, Julia D.; Kühnle, Nathalie; Morlé, Aymeric; Hehn, Beate; Adrain, Colin; Strisovsky, Kvido; Freeman, Matthew; Lemberg, Marius K.
    Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFα, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. Our data also demonstrate that RHBDL4-dependent trafficking control is regulated by G-protein coupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including EGFR signaling. We propose that RHBDL4...

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