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Repositório Comum (27.436 recursos)

É um repositório para instituições de ensino e investigação produtoras de literatura científica cuja dimensão ainda não justifica a criação de um repositório próprio. Permite integrar instituições, grupos ou indivíduos na infra-estrutura do projecto, nomeadamente através das pesquisas do Portal RCAAP e da B-On.

Mostrando recursos 1 - 20 de 25

  1. Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial

    Al-Batran, SE; Homann, N; Pauligk, C; Illerhaus, G; Martens, UM; Stoehlmacher, J; Schmalenberg, H; Luley, KB; Prasnikar, N; Egger, M; Probst, S; Messmann, H; Moehler, M; Fischbach, W; Hartmann, JT; Mayer, F; Höffkes, HG; Koenigsmann, M; Arnold, D; Kraus, TW; Grimm, K; Berkhoff, S; Post, S; Jäger, E; Bechstein, W; Ronellenfitsch, U; Mönig, S; Hofheinz, RD
    IMPORTANCE: Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. OBJECTIVE: To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection. DESIGN, SETTING, AND PARTICIPANTS: The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is a prospective, phase 2 trial of 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Patients were enrolled from 52 cancer care centers in Germany between February 1, 2009, and January 31, 2010, and stratified to 1 of 3 groups: resectable (arm A), limited metastatic (arm B), or extensive metastatic (arm...

  2. Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial

    Al-Batran, SE; Homann, N; Pauligk, C; Illerhaus, G; Martens, UM; Stoehlmacher, J; Schmalenberg, H; Luley, KB; Prasnikar, N; Egger, M; Probst, S; Messmann, H; Moehler, M; Fischbach, W; Hartmann, JT; Mayer, F; Höffkes, HG; Koenigsmann, M; Arnold, D; Kraus, TW; Grimm, K; Berkhoff, S; Post, S; Jäger, E; Bechstein, W; Ronellenfitsch, U; Mönig, S; Hofheinz, RD
    IMPORTANCE: Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. OBJECTIVE: To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection. DESIGN, SETTING, AND PARTICIPANTS: The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is a prospective, phase 2 trial of 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Patients were enrolled from 52 cancer care centers in Germany between February 1, 2009, and January 31, 2010, and stratified to 1 of 3 groups: resectable (arm A), limited metastatic (arm B), or extensive metastatic (arm...

  3. Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial

    Al-Batran, SE; Homann, N; Pauligk, C; Illerhaus, G; Martens, UM; Stoehlmacher, J; Schmalenberg, H; Luley, KB; Prasnikar, N; Egger, M; Probst, S; Messmann, H; Moehler, M; Fischbach, W; Hartmann, JT; Mayer, F; Höffkes, HG; Koenigsmann, M; Arnold, D; Kraus, TW; Grimm, K; Berkhoff, S; Post, S; Jäger, E; Bechstein, W; Ronellenfitsch, U; Mönig, S; Hofheinz, RD
    IMPORTANCE: Surgical resection has a potential benefit for patients with metastatic adenocarcinoma of the stomach and gastroesophageal junction. OBJECTIVE: To evaluate outcome in patients with limited metastatic disease who receive chemotherapy first and proceed to surgical resection. DESIGN, SETTING, AND PARTICIPANTS: The AIO-FLOT3 (Arbeitsgemeinschaft Internistische Onkologie-fluorouracil, leucovorin, oxaliplatin, and docetaxel) trial is a prospective, phase 2 trial of 252 patients with resectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Patients were enrolled from 52 cancer care centers in Germany between February 1, 2009, and January 31, 2010, and stratified to 1 of 3 groups: resectable (arm A), limited metastatic (arm B), or extensive metastatic (arm...

  4. Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer

    Herbst, A; Vdovin, N; Gacesa, S; Philipp, A; Nagel, D; Holdt, LM; Op den Winkel, M; Heinemann, V; Stieber, P; Graeven, U; Reinacher-Schick, A; Arnold, D; Ricard, I; Mansmann, U; Hegewisch-Becker, S; Kolligs, F T
    Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimidine, oxaliplatin and bevacizumab to test whether HPP1 mfcDNA is a suitable prognostic and response biomarker. From 467 patients of the prospective clinical study AIO-KRK-0207, mfcDNA was isolated from plasma samples at different time points and bisulfite-treated mfcDNA was quantified using methylation specific PCR. About 337 of 467 patients had detectable levels for HPP1 mfcDNA...

  5. Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer

    Herbst, A; Vdovin, N; Gacesa, S; Philipp, A; Nagel, D; Holdt, LM; Op den Winkel, M; Heinemann, V; Stieber, P; Graeven, U; Reinacher-Schick, A; Arnold, D; Ricard, I; Mansmann, U; Hegewisch-Becker, S; Kolligs, F T
    Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimidine, oxaliplatin and bevacizumab to test whether HPP1 mfcDNA is a suitable prognostic and response biomarker. From 467 patients of the prospective clinical study AIO-KRK-0207, mfcDNA was isolated from plasma samples at different time points and bisulfite-treated mfcDNA was quantified using methylation specific PCR. About 337 of 467 patients had detectable levels for HPP1 mfcDNA...

  6. Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer

    Herbst, A; Vdovin, N; Gacesa, S; Philipp, A; Nagel, D; Holdt, LM; Op den Winkel, M; Heinemann, V; Stieber, P; Graeven, U; Reinacher-Schick, A; Arnold, D; Ricard, I; Mansmann, U; Hegewisch-Becker, S; Kolligs, F T
    Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimidine, oxaliplatin and bevacizumab to test whether HPP1 mfcDNA is a suitable prognostic and response biomarker. From 467 patients of the prospective clinical study AIO-KRK-0207, mfcDNA was isolated from plasma samples at different time points and bisulfite-treated mfcDNA was quantified using methylation specific PCR. About 337 of 467 patients had detectable levels for HPP1 mfcDNA...

  7. Novel de novo FOXC1 nonsense mutation in an Axenfeld-Rieger syndrome patient

    Carmona, S; da Luz Freitas, MG; Froufe, H; Simões, MJ; Sampaio, MJ; Silva, ED; Egas, C
    info:eu-repo/semantics/publishedVersion

  8. Neuropathic pain after breast cancer treatment and its impact on sleep quality one year after cancer diagnosis

    Fontes, F; Gonçalves, M; Pereira, S; Lunet, N
    OBJECTIVES: Data regarding the impact of breast cancer treatment-related neuropathic pain (NP) on sleep quality are scarce. Therefore, we aimed to assess the impact of breast cancer treatment-related NP on patients' sleep quality, during the first year after cancer diagnosis. MATERIALS AND METHODS: A total of 501 breast cancer patients were followed prospectively. Incident NP was identified through systematic evaluations after treatments and one year after enrolment. NP severity was quantified using the Brief Pain Inventory severity subscale and sleep quality was evaluated through the Pittsburgh Sleep Quality Index (PSQI), at baseline and after one year. Adjusted regression coefficients (β) and 95% confidence...

  9. Sunbed use among Portuguese beach goers: a crave group while waiting sunbeds to be abolished

    Duarte, AF; Maia Silva, JN; Costa Pereira, A; Nagore, E; Picoto, A; Correia, O
    info:eu-repo/semantics/publishedVersion

  10. Endovascular Treatment of Symptomatic Renal Artery Aneurysm with Hostile Anatomy

    Sousa, J; Mansilha, A
    info:eu-repo/semantics/publishedVersion

  11. A dermatosis of pregnancy

    Brás, S; Oliveira, A; Mendes-Bastos, P; Amaro, C
    info:eu-repo/semantics/publishedVersion

  12. The Portuguese long version of the Copenhagen Psychosocial Questionnaire II (COPSOQ II) - a validation study

    Rosário, S; Azevedo, LF; Fonseca, JA; Nienhaus, A; Nübling, M; da Costa, JT
    BACKGROUND: Psychosocial risks are now widely recognised as one of the biggest challenges for occupational safety and health (OSH) and a major public health concern. The aim of this paper is to investigate the Portuguese long version of the Copenhagen Psychosocial Questionnaire II (COPSOQ II), in order to analyse the psychometric properties of the instrument and to validate it. METHODS: The Portuguese COPSOQ II was issued to a total of 745 Portuguese employees from both private and public organisations across several economic sectors at a baseline and then 2 weeks later. Methodological quality appraisal was based on COnsensus-based Standards for the selection of...

  13. Follicular Fluid redox involvement for ovarian follicle growth

    Freitas, C; Neto, AC; Matos, L; Silva, E; Ribeiro, Â; Silva-Carvalho, JL; Almeida, H
    As the human ovarian follicle enlarges in the course of a regular cycle or following controlled ovarian stimulation, the changes in its structure reveal the oocyte environment composed of cumulus oophorus cells and the follicular fluid (FF).In contrast to the dynamic nature of cells, the fluid compartment appears as a reservoir rich in biomolecules. In some aspects, it is similar to the plasma, but it also exhibits differences that likely relate to its specific localization around the oocyte. The chemical composition indicates that the follicular fluid is able to detect and buffer excessive amounts of reactive oxygen species, employing a...

  14. Hemolysis, Elevated Liver Enzymes, Low Platelets Syndrome Superimposed on Hemolytic Uremic Syndrome

    Martins, I; Conceição, MG; Gomes, PP; Clode, N
    A pregnancy complicated by typical hemolytic uremic syndrome (HUS) and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is reported. At 20 weeks of gestation, a case of HUS was diagnosed, with Shiga toxin-producing Escherichia coli identified. Plasmapheresis allowed continuation of the pregnancy for 5 weeks. Superimposed preeclampsia and HELLP syndrome were diagnosed after the establishment of nephrotic range proteinuria, hypertension and recurrence of hemolysis. This is a singular case, as it demonstrates that HELLP syndrome can superimpose upon HUS, a fact that can impact future research on reproductive immunology. It also reminds clinicians that the overlapping of clinical and...

  15. The current situation in hip arthroscopy

    Marin-Peña, O; Tey-Pons, M; Perez-Carro, L; Said, HG; Sierra, P; Dantas, P; Villar, RN
    Hip arthroscopy is an evolving surgical technique that has recently increased in popularity.Although femoroacetabular impingement was an important launch pad for this technique, extra-articular pathology has been described through hip endoscopy.Good clinical results in the medium term will allow improvements in this technique and increase its indications. Cite this article: EFORT Open Rev 2017;2:58-65. DOI: 10.1302/2058-5241.2.150041.

  16. Pathophysiology, Diagnosis and Treatment of Somatosensory Tinnitus: A Scoping Review

    Haider, HF; Hoare, DJ; Costa, RF; Potgieter, I; Kikidis, D; Lapira, A; Nikitas, C; Caria, H; Cunha, NT; Paço, JC
    Somatosensory tinnitus is a generally agreed subtype of tinnitus that is associated with activation of the somatosensory, somatomotor, and visual-motor systems. A key characteristic of somatosensory tinnitus is that is modulated by physical contact or movement. Although it seems common, its pathophysiology, assessment and treatment are not well defined. We present a scoping review on the pathophysiology, diagnosis, and treatment of somatosensory tinnitus, and identify priority directions for further research. Methods: Literature searches were conducted in Google Scholar, PubMed, and EMBASE databases. Additional broad hand searches were conducted with the additional terms etiology, diagnose, treatment. Results: Most evidence on the...

  17. Surgical Treatment of Rotator Cuff Tears After 65 Years of Age: A Systematic Review

    Silva, BM; Cartucho, A; Sarmento, M; Moura, N
    INTRODUCTION: The objective of this study was to analyze current evidence regarding surgical management of rotator cuff tears in patients of 65 years of age and above. Our hypothesis was that surgical repair of rotator cuff tears, in patients older than 65 years, conveys good outcome scores. We have not found a similar systematic review in current literature. MATERIAL AND METHODS: Medline®, PubMed, Scopus, and the Cochrane Register of Controlled Trials were searched from January 1999 unto December 2015 for studies, regardless of language, including the words 'rotator cuff' and '65 years' or '70 years'. Inclusion criteria were studies (level I to IV)...

  18. Pseudocholangiocarcinoma Sign: Management of Portal Cavernoma Biliopathy with Fully-Covered Self-Expandable Metal Stent

    Lourenço, LC; Horta, DV; Rodrigues, CG; Canena, J; Reis, J
    info:eu-repo/semantics/publishedVersion

  19. International core curriculum for capsule endoscopy training courses

    Fernandez-Urien, I; Panter, S; Carretero, C; Davison, C; Dray, X; Fedorov, E; Makins, R; Mascarenhas, M; McAlindon, M; McNamara, D; Palmer, H; Rey, JF; Saurin, JC; Seitz, U; Spada, C; Toth, E; Wiedbrauck, F; Keuchel, M
    Capsule endoscopy (CE) has become a first-line noninvasive tool for visualisation of the small bowel (SB) and is being increasingly used for investigation of the colon. The European Society of Gastrointestinal Endoscopy (ESGE) guidelines have specified requirements for the clinical applications of CE. However, there are no standardized recommendations yet for CE training courses in Europe. The following suggestions in this curriculum are based on the experience of European CE training courses directors. It is suggested that 12 hours be dedicated for either a small bowel capsule endoscopy (SBCE) or a colon capsule endoscopy (CCE) course with 4 hours for...

  20. Titration with automatic continuous positive airway pressure in obstructive sleep apnea

    Dias, C; Sousa, L; Batata, L; Reis, R; Teixeira, F; Moita, J; Moutinho Dos Santos, J
    Background and objective Autotitrating positive airway pressure (APAP) is an accepted titration method to determine the optimal positive airway pressure (PAP), for the treatment of obstructive sleep apnea (OSA). The required duration of APAP monitoring to determine a fixed continuous positive airway pressure level still remains to be established. We aimed to evaluate the variation in PAP level, delivered by APAP devices, at different periods of treatment, to determine the APAP treatment duration required to reach an effective and stable PAP level. Methods A cross-sectional study of 62 patients newly diagnosed with OSA were evaluated after 3 months of APAP therapy. APAP data...

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