Mostrando recursos 1 - 15 de 15

  1. Characterization of Plasma Labile Heme in Hemolytic Conditions

    Gouveia, Zélia; Carlos, Ana Rita; Yuan, Xiaojing; Aires-da-Silva, Frederico; Stocker, Roland; J. Maghzal, Ghassan; Leal, Sónia S.; Gomes, Cláudio M.; Todorovic, Smilja; Iranzo, Olga; Ramos, Susana; Santos, Ana Catarina; Hamza, Iqbal; Gonçalves, João; Soares, Miguel P.
    The deposited article is the accepted manuscript (post-print version) posted online 7 August 2017 and provided by The Febs Journal. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. The deposited article version contains attached the supplementary materials within the pdf. This publication hasn't any creative commons license associated, although it is in open access.

  2. Involvement of the p62/NRF2 signal transduction pathway on erythrophagocytosis

    Santarino, Inês B.; Viegas, Michelle S.; Domingues, Neuza S.; Ribeiro, Ana M.; Soares, Miguel P.; Vieira, Otília V.
    This deposit is composed by the main article plus the supplementary materials of the publication.

  3. The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1viaNuclear Factor Erythroid-2-Related Factor 2

    Parada, Esther; Egea, Javier; Buendia, Izaskun; Negredo, Pilar; Cunha, Ana C.; Cardoso, Silvia; Soares, Miguel P.; López, Manuela G.
    The deposited article is a post-print version.

  4. Tissue damage control in disease tolerance

    Soares, Miguel P; Gozzelino, Raffaella; Weis, Sebastian
    The deposited article is a prost-print version.

  5. Macrophage and epithelial cell H-ferritin expression regulates renal inflammation

    Bolisetty, Subhashini; Zarjou, Abolfazl; Hull, Travis D.; Traylor, Amie M.; Perianayagam, Anjana; Joseph, Reny; Kamal, Ahmed I.; Arosio, Paolo; Soares, Miguel P.; Jeney, Viktoria; Balla, Jozsef; George, James F.; Agarwal, Anupam
    The deposited article is a post-print version (author's manuscript from PMC).

  6. Red alert: labile heme is an alarmin

    Soares, Miguel P; Bozza, Marcelo T
    This publication hasn't any creative commons license associated.

  7. Microbiota Control of Malaria Transmission

    Soares, Miguel P.; Yilmaz, Bahtiyar
    This publication hasn't any creative commons license associated.

  8. Disease tolerance and immunity in host protection against infection

    Soares, Miguel P.; Teixeira, Luis; Moita, Luis F.
    The deposited article is a pre-print version.

  9. IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections

    Sakamoto, Kei; Kim, Yun-Gi; Hara, Hideki; Kamada, Nobuhiko; Caballero-Flores, Gustavo; Tolosano, Emanuela; Soares, Miguel P.; Puente, José L.; Inohara, Naohiro; Núñez, Gabriel
    This publication hasn't any creative commons license associated.

  10. Beyond killing: Can we find new ways to manage infection?

    Vale, Pedro F.; McNally, Luke; Doeschl-Wilson, Andrea; King, Kayla C.; Popat, Roman; Domingo-Sananes, Maria R.; Allen, Judith E.; Soares, Miguel P.; Kümmerli, Rolf
    This deposit is composed by the main article, and hasn't not associated any supplementary materials of the publication.

  11. Specific expression of heme oxygenase-1 by myeloid cells modulates renal ischemia-reperfusion injury

    Rossi, Maxime; Thierry, Antoine; Delbauve, Sandrine; Preyat, Nicolas; Soares, Miguel P.; Roumeguère, Thierry; Leo, Oberdan; Flamand, Véronique; Le Moine, Alain; Hougardy, Jean-Michel
    This work was presented in abstract form at the 17th Congress of the European Society for Organ Transplantation (ESOT) in Brussels, Belgium (Brief Oral Presentation, BOS04 – Ischemia, Reperfusion, Metabolism and Aging, abstract N°BO33; 13–16 September 2015) and at the 16th Congress of the European Association of Urology (EAU) in Munich, Germany (Poster Session 48, Kidney Transplant: From Bench to clinical practice, abstract n°603; 11–15 March 2016).

  12. Identification of cyclins A1, E1 and vimentin as downstream targets of heme oxygenase-1 in vascular endothelial growth factor-mediated angiogenesis

    Bauer, Andrea; Mylroie, Hayley; Thornton, C. Clare; Calay, Damien; Birdsey, Graeme M.; Kiprianos, Allan P.; Wilson, Garrick K.; Soares, Miguel P.; Yin, Xiaoke; Mayr, Manuel; Randi, Anna M.; Mason, Justin C.
    Angiogenesis is an essential physiological process and an important factor in disease pathogenesis. However, its exploitation as a clinical target has achieved limited success and novel molecular targets are required. Although heme oxygenase-1 (HO-1) acts downstream of vascular endothelial growth factor (VEGF) to modulate angiogenesis, knowledge of the mechanisms involved remains limited. We set out identify novel HO-1 targets involved in angiogenesis. HO-1 depletion attenuated VEGF-induced human endothelial cell (EC) proliferation and tube formation. The latter response suggested a role for HO-1 in EC migration, and indeed HO-1 siRNA negatively affected directional migration of EC towards VEGF; a phenotype reversed...

  13. The importance of iron in pathophysiologic conditions

    Gozzelino, Raffaella; Arosio, Paolo
    Biological iron is necessary for vital functions and also potentially toxic to the organisms. This dual effect raised the interest of many investigators to study the mechanisms controlling its homeostasis that are altered in many pathologic conditions. Recently the understanding of iron metabolism significantly improved with the discovery of genes responsible for genetic disorders, such as hemochromatosis, the IRE/IRPs machinery and the hepcidin-ferroportin axis, which allowed to elucidate the basis of cellular and systemic iron homeostasis. In addition, these advances disclosed a causal link between deregulation of iron homeostasis, inflammation and oxidative stress, often induced by the iron accumulation that...

  14. Regulation of Nuclear Factor κB (NF-κB) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT)

    Pejanovic, Nadja; Hochrainer, Karin; Liu, Tao; Aerne, Birgit L.; Soares, Miguel P.; Anrather, Josef
    The NF-κB family member p65 is central to inflammation and immunity. The purpose of this study was to identify and characterize evolutionary conserved genes modulating p65 transcriptional activity. Using an RNAi screening approach, we identified chaperonin containing TCP1 subunit η (CCTη) as a regulator of Drosophila NF-κB proteins, Dorsal and Dorsal-related immunity factor (Dif). CCTη was also found to regulate NF-κB-driven transcription in mammalian cells, acting in a promoter-specific context, downstream of IκB kinase (IKK). CCTη knockdown repressed IκBα and CXCL2/MIP2 transcription during the early phase of NF-κB activation while impairing the termination of CCL5/RANTES and CXCL10/IP10 transcription. The latter...

  15. Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

    Larsen, Rasmus; Gouveia, Zélia; Soares, Miguel P.; Gozzelino, Raffaella
    Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of reactive oxygen species. Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, under pathologic conditions associated with oxidative stress, some hemoproteins can release their prosthetic heme groups. While this heme is not necessarily damaging per se, it becomes highly cytotoxic in the presence of a range of inflammatory mediators such as tumor...

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