Recursos de colección

E-Prints Complutense (97.547 recursos)

En este archivo los docentes e investigadores de la UCM depositan sus documentos en acceso abierto (open access)

Estado = En prensa

Mostrando recursos 1 - 20 de 196

  1. Tuning mesoporous silica dissolution in physiological environments: a review

    Paris, J.L.; Colilla, Montserrat; Izquierdo-Barba, Isabel; Manzano García, Miguel; Vallet Regí, María
    Matrix degradation has a major impact on the release kinetics of drug delivery systems. Regarding ordered mesoporous silica materials for biomedical applications, their dissolution is an important parameter that should be taken into consideration. In this paper, we review the main factors that govern the mesoporous silica dissolution in physiological environments. We also provide the necessary knowledge to researchers in the area for tuning the dissolution rate of those matrices, so the degradation could be controlled and the material behaviour optimised.

  2. Sostenibilidad humana de la vivienda mediante la rehabilitación cooperativa, el cohousing y la economía colaborativa

    Lambea Rueda, Ana
    • “Un hogar está destinado a ser un refugio seguro para las personas y familias, el cumplimiento de la necesidad básica de tener un techo sobre su cabeza” • Bien más preciado por el hombre. El hombre sin vivienda se deshumaniza, entra en la pobreza, es excluido de facto de la sociedad. • Bien esencial del ser humano, y debería ser accesible a todos, es una de las llaves que permite la inclusión social de las personas. • ¿Queremos seguir manteniendo sociedades de incluidos y excluidos, o favorecer la inclusión? • Encuentro de necesidades: necesidad del que la utiliza y de quien la promueve...

  3. Tecnologías de la conversación y la identidad digital: reflexiones en torno a la sociedad de la in-formación de los individuos

    Gordo López, Ángel Juan
    Este trabajo plantea que la amplia difusión de la mensajería instantánea (messenger) en el entorno Internet radica en su capacidad de incorporación, integración y redefinición de otras aplicaciones conversacionales. Tras una breve presentación de las aplicaciones conversacionales más utilizadas, consideramos el modo en que el messenger concede a los intercambios virtuales una dimensión autoreferencial, reflexiva y orientada al intra-grupo. También apuntamos el papel estratégico de estos programas a la hora de corporeizar nociones de identidad virtual en el intento de reducir las brechas existentes entre los usos informales-conversacionales y el administrativosgubernamentales de las aplicaciones y los recursos Internet. La última...

  4. Long-Term Impacts of Orthokeratology Treatment on Sub-Basal Nerve Plexus and Corneal Sensitivity Responses and Their Reversibility

    Nombela Palomo, María; Felipe Márquez, Gema; Teus, Miguel Ángel; Hernández Verdejo, José Luis; Nieto Bona, Amelia
    Purpose: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. Methods: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet-Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy. Results: In participants wearing OK lenses, significant reductions over the year were produced in SBNP...

  5. A netnographic study of P2P collaborative consumption platforms’ user interface and design

    Rivera, Javier de; Gordo López, Ángel Juan; Cassidy, Paul; Apesteguía, Amaya
    Although still embryonic, collaborative consumption and the sharing economy have become social and economic phenomena in just a few short years, yet there is little consensus on how to define them. The current classificatory schema or typologies of platforms have some weaknesses. Sectoral classifications, technological functionality, and discursive modes of understanding sharing and collaborative economies all provide valuable insights, but when taken individually important gaps are evident, not least in their inter-system isolation, but most particularly when technology, such as platform architecture and user interfaces, is disassociated from wider social and economic conditions of possibility. In order to build on...

  6. Working correlation structure selection in GEE analysis

    Pardo Llorente, María del Carmen; Alonso, R.
    The method of generalized estimating equations models the association between the repeated observations on a subject. It is important to select an appropriate working correlation structure for the repeated measures per subject in order to enhance efficiency of estimation of the regression parameter. Some existing selection criteria choose the structure for which the covariance matrix estimator and the specified working covariance matrix are closest. So, we define a new criterion based on this idea for selecting a working correlation structure. Also, we compare our criterion with some existing criteria to identify the true correlation structure via simulations for Poisson, binomial...

  7. Electron microscopy for inorganic-type drug delivery nanocarriers for antitumoral applications: What is possible to see?

    Baeza García, Alejandro; Castillo Romero, Rafael; Torres Pardo, Almudena; Gonzalez Calvet, J. M.; Vallet Regí, María
    The use of nanoparticles able to transport drugs, in a selective and controlable manner, directly to diseased tissues and cells have improved the therapeutic arsenal for addressing unmet clinical situations. In the recent years, a vast number of nanocarriers with inorganic, organic, hybrid and even biological nature have been developed, expecially for their application in oncology fied. The exponential growing in the nanomedicine field would not have been possible without the also rapid expansion of electron microscopy techniques, which allow a more precise observation of nanometric objects. The use of these techniques provides a better understanding of the key parameters...

  8. Double sequential encrypted targeting sequence: A new concept for bone cancer treatment.

    Villaverde Cantizano, Gonzalo; Nairi, Valentina; Baeza, Alejandro; Vallet Regí, María
    The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuliresponsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation which contains a high selective...

  9. Double sequential encrypted targeting sequence: A new concept for bone cancer treatment

    Villaverde Cantizano, Gonzalo; Nairi, Valentina; Baeza, Alejandro; Vallet Regí, María
    The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show selectivity lacks. Herein, double sequential encrypted targeting system is proposed as stimuliresponsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in first place, and once there, a hidden secondary targeting group is activated by the presence of an enzyme overproduced in the malignant tissue (cathepsin K), triggering the recognition of diseased cells. Transporting the cell targeting agent in a hidden conformation which contains...

  10. Despido colectivo y unidad de referencia. La trasposición de la Directiva 98/59/CE y el margen de apreciación de los derechos nacionales

    Sánchez-Urán Azaña, Mª Yolanda; Fuentes García-Romero de Tejada, Carlos
    Sobre el modelo legal español de despido colectivo se plantean varias cuestiones relacionadas con su adecuación al Derecho de la UE. Entre ellas destaca la determinación legal de la unidad de referencia a efectos de configuración del despido colectivo según dispone la norma comunitaria y el margen que deja a los Estados Miembros. El estudio describe las varias opciones legislativas nacionales y, en concreto, la del legislador español para posteriormente fijar las reglas que, conforme a la interpretación por el TJUE, definen el despido colectivo en su dimensión cuantitativa y, en particular, la opción por el centro de trabajo como...

  11. Non-Lipschitz differentiable functions on slit domains

    Bernal-González, L.; Jimenez Rodriguez, G. A.; Muñoz-Fernández, Gustavo A.; Seoane-Sepúlveda, Juan B.
    It is proved the existence of large algebraic structures—including large vector subspaces or infinitely generated free algebras—inside the family of non-Lipschitz differentiable real functions with bounded gradient defined on special non-convex plane domains. In particular, this yields that there are many differentiable functions on plane domains that do not satisfy the mean value theorem.

  12. Bifurcations and Attractor-Repeller Splittings of Non-Saddle Sets

    Barge, Héctor; Rodríguez Sanjurjo, José Manuel
    This paper is devoted to the study of some aspects of the stability theory of flows. In particular, we study Morse decompositions induced by non-saddle sets, including their corresponding Morse equations, attractor-repeller splittings of non-saddle sets and bifurcations originated by implosions of the basin of attraction of asymptotically stable fixed points. We also characterize the non-saddle sets of the plane in terms of the Euler characteristic of their region of influence.

  13. Los intermediarios fiscales y su impacto en la concienciación cívico-tributaria: gestión y recaudación tributaria

    Bonell Colmenero, Ramón
    El problema creciente de falta de recaudación suficiente ante el endeudamiento de las Administraciones Públicas, es el reflejo de una defectuosa concepción del modelo de desarrollo y también del procedimiento de gestión y recaudación tributaria llevados a cabo. Es por ello que en el presente trabajo ofrecemos la solución idónea.

  14. Análisis de discursos y epistemología de las mediaciones en las prácticas sociales de la comunicación. Propuesta metodológica de un modelo

    Piñuel Raigada, José Luis; Gaitán Moya, Juan Antonio; Lozano Ascencio, Carlos
    A partir de una propuesta para la definición de DISCURSO y sus clases, se aborda la revisión epistemológica de las teorías del conocimiento y de las teorías sociales de las cuales derivan los diversos modelos que han sido formulados en Teoría de la Comunicación cuando se aspira a describir, explicar, evaluar y/o intervenir en las prácticas sociales de comunicación. Este objetivo implica el diseño de modelos capaces de tomar en cuenta las mediaciones que la comunicación experimenta y produce respecto al dominio de las interacciones sociales y de las condiciones existenciales de las conductas. En consecuencia se expone un modelo...

  15. On SIR epidemic models with generally distributed infectious periods: Number of secondary cases and probability of infection

    Gómez-Corral, Antonio; López García, M.
    Recently, Clancy [SIR epidemic models with general infectious period distribution, Statist. Prob. Lett. 85 (2014) 1–5] has shown how SIR epidemics in which individuals’ infection periods are not necessarily exponentially distributed may be modeled in terms of a piecewise-deterministic Markov process (PDMP). In this paper, we present a more detailed description of the underlying PDMP, from which we analyze the population transmission number and the infection probability of a certain susceptible individual.

  16. The Heat Equaton with General Periodic Boundary Conditions

    Rodríguez Bernal, Aníbal
    In this paper we address the well posedness of the linear heat equation under general periodic boundary conditions in several settings depending on the properties of the initial data. We develop an Lq theory not based on separation of variables and use techniques based on uniform spaces. We also allow less directions of periodicity than the dimension of the problem. We obtain smoothing estimates on the solutions. Also, based on symmetry arguments, we handle Dirichlet or Neumann boundary conditions in some faces of the unit cell.

  17. Retrial queues and related models

    Gómez-Corral, Antonio; Phung-Duc, Tuan

  18. Recent applications on the combination of Mesoporous Silica Nanoparticles with Nucleic Acids: Development of Bioresponsive Devices, Carriers and Sensors

    Castillo Romero, Rafael; Baeza, Alejandro; Vallet Regí, María
    The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples which report the use in combination of nanoparticles with nucleic acids, which demands boundedness. Following this premise, this revision will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials...

  19. Self-Immolative Polymers as novel pH-responsive gate keepers for drug delivery

    Gisbert Garzarán, Miguel; Lozano Borregón, Daniel; Vallet Regí, María; Manzano García, Miguel
    A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.

  20. 3D scaffold with effective multidrug sequential release against bacteria biofilm

    García-Álvarez, Rafaela; Izquierdo-Barba, Isabel; Vallet Regí, María
    Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared side effects. Herein, hierarchical 3D multidrug scaffolds based on nanocomposite bioceramic and polyvinyl alcohol (PVA) prepared by rapid prototyping with an external coating of gelatin-glutaraldehyde (Gel-Glu) have been fabricated. These 3D scaffolds contain three antimicrobial agents (rifampin, levofloxacin and vancomycin), which have been...

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