Mostrando recursos 1 - 9 de 9

  1. Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

    Koyama, Takashi; Rodrigues, Marisa A; Athanasiadis, Alekos; Shingleton, Alexander W; Mirth, Christen K
    Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent checkpoint, critical weight. Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that Forkhead Box class O (FoxO), a negative regulator of IIS/TOR, directly interacts with Ultraspiracle (Usp), part of the ecdysone receptor. While overexpressing FoxO in the...

  2. The sex-specific effects of diet quality versus quantity on morphology in Drosophila melanogaster

    Shingleton, Alexander W.; Masandika, Josephine R.; Thorsen, Lily S.; Zhu, Yuqing; Mirth, Christen K.
    This deposit is composed by the main article plus the supplementary materials of the publication.

  3. The sex-specific effects of diet quality versus quantity on morphology in Drosophila melanogaster

    Shingleton, Alexander W.; Masandika, Josephine R.; Thorsen, Lily S.; Zhu, Yuqing; Mirth, Christen K.
    This deposit is composed by the main article plus the supplementary materials of the publication.

  4. The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae.

    Almeida-Carvalho, Maria J.; Berh, Dimitri; Braun, Andreas; Chen, Yi-chun; Eichler, Katharina; Eschbach, Claire; Fritsch, Pauline M. J.; Gerber, Bertram; Hoyer, Nina; Jiang, Xiaoyi; Kleber, Jörg; Klämbt, Christian; König, Christian; Louis, Matthieu; Michels, Birgit; Miroschnikow, Anton; Mirth, Christen; Miura, Daisuke; Niewalda, Thomas; Otto, Nils; Paisios, Emmanouil; Pankratz, Michael J.; Petersen, Meike; Ramsperger, Noel; Randel, Nadine; Risse, Benjamin; Saumweber, Timo; Schlegel, Philipp; Schleyer, Michael; Soba, Peter; Sprecher, Simon G.; Tanimura, Teiichi; Thum, Andreas S.; Toshima, Naoko; Truman, Jim W.; Yarali, Ayse; Zlatic, Marta
    This publication hasn't any creative commons license associated. This article has a Company of Biologists User Licence 1.1. The deposited article version contains attached the supplementary materials within the pdf.

  5. Adaptation to new nutritional environments: larval performance, foraging decisions, and adult oviposition choices in Drosophila suzukii

    Silva-Soares, Nuno F.; Nogueira-Alves, A.; Beldade, P.; Mirth, Christen Kerry
    This deposit is composed by the main article plus the supplementary materials of the publication.

  6. Coordinating morphology with behavior during development: an integrative approach from a fly perspective

    Carvalho, Maria João A.; Mirth, Christen K.
    Animals in the wild live in highly variable and unpredictable environments. This variation in their habitat induces animals, at all stages of their development, to make decisions about what to eat, where to live, and with whom to associate. Additionally, animals like insects show dramatic restructuring of their morphology across life stages, which is accompanied by alterations in their behavior to match stage-specific functions. Finally, in a process called developmental plasticity, environmental conditions feed back onto developmental mechanisms producing animals with stage-specific variation in both morphological and behavioral traits. In this review, we use examples from insects to explore the...

  7. Stage-Specific Plasticity in Ovary Size Is Regulated by Insulin/Insulin-Like Growth Factor and Ecdysone Signaling in Drosophila

    Mendes, C. C.; Mirth, C. K.
    Animals from flies to humans adjust their development in response to environmental conditions through a series of developmental checkpoints, which alter the sensitivity of organs to environmental perturbation. Despite their importance, we know little about the molecular mechanisms through which this change in sensitivity occurs. Here we identify two phases of sensitivity to larval nutrition that contribute to plasticity in ovariole number, an important determinant of fecundity, in Drosophila melanogaster. These two phases of sensitivity are separated by the developmental checkpoint called "critical weight"; poor nutrition has greater effects on ovariole number in larvae before critical weight than after. We...

  8. Drosophila melanogaster larvae make nutritional choices that minimize developmental time

    Rodrigues, Marisa A.; Martins, Nelson E.; Balancé, Lara F.; Broom, Lara N.; Dias, António J.S.; Fernandes, Ana Sofia D.; Rodrigues, Fábio; Sucena, Élio; Mirth, Christen K.
    Organisms from slime moulds to humans carefully regulate their macronutrient intake to optimize a wide range of life history characters including survival, stress resistance, and reproductive success. However, life history characters often differ in their response to nutrition, forcing organisms to make foraging decisions while balancing the trade-offs between these effects. To date, we have a limited understanding of how the nutritional environment shapes the relationship between life history characters and foraging decisions. To gain insight into the problem, we used a geometric framework for nutrition to assess how the protein and carbohydrate content of the larval diet affected key...

  9. Growth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size Regulation

    Koyama, Takashi; Mirth, Christen K.
    In Drosophila, the fat body, functionally equivalent to the mammalian liver and adipocytes, plays a central role in regulating systemic growth in response to nutrition. The fat body senses intracellular amino acids through Target of Rapamycin (TOR) signaling, and produces an unidentified humoral factor(s) to regulate insulin-like peptide (ILP) synthesis and/or secretion in the insulin-producing cells. Here, we find that two peptides, Growth-Blocking Peptide (GBP1) and CG11395 (GBP2), are produced in the fat body in response to amino acids and TOR signaling. Reducing the expression of GBP1 and GBP2 (GBPs) specifically in the fat body results in smaller body size...

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