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Hokkaido University Collection of Scholarly and Academic Papers (135.521 recursos)

HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.

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Mostrando recursos 1 - 20 de 45

  1. 室内環境中のハウスダストによる健康影響

    荒木, 敦子; アイツバマイ, ゆふ; ケテマ, ラヘル メスフィン; 岸, 玲子
    In this review, we examine house dust and its effect on inhabitants’ health. Residential house dust includes components from plants, pollens, microorganisms, insects, skin flakes, hairs and fibers. It also includes materials contaminated with chemicals from combustion, furniture, interior materials, electronics, cleaning agents, personal care products. Nowadays, most people spend their time indoors. Thus, dust is an important medium of exposure to pollutions. According to United States Environmental Protection Agency Exposure Factors Handbook, the estimated amount of dust ingestion is 30 mg/day for adults, and 60 mg/day for children over 1 year of age. Since 2003, we have been conducting...

  2. 科学的エビデンスに基づく『新シックハウス症候群に関する相談と対策マニュアル(改訂新版)』を作成して

    岸, 玲子; 吉野, 博; 荒木, 敦子; 西條, 泰明; 東, 賢一; 河合, 俊夫; 大和, 浩; 大澤, 元毅; 柴田, 英治; 田中, 正敏; 増地, あゆみ; 湊屋, 街子; アイツバマイ, ゆふ
    Recently, we have published a book containing evidence-based public health guidelines and a practical manual for the prevention of sick house syndrome. The manual is available through the homepage of the Ministry of Health, Labour and Welfare (http://www.mhlw.go.jp/file/06-Seisakujouhou-11130500-Shokuhinanzenbu/0000155147.pdf). It is an almost completely revised version of the 2009 version. The coauthors are 13 specialists in environmental epidemiology, exposure sciences, architecture, and risk communication. Since the 1970s, health problems caused by indoor chemicals, biological pollution, poor temperature control, humidity, and others in office buildings have been recognized as sick building syndrome (SBS) in Western countries, but in Japan it was not...

  3. 2万人規模の出生コーホートと,500人規模の小コーホートからなる北海道スタディが目指してきたもの : 環境と子どもの健康 : 先天異常・発達・アレルギーの15年におよぶ経験と成果

    岸, 玲子; 荒木, 敦子; 宮下, ちひろ; 伊藤, 佐智子; 湊屋, 街子; 小林, 澄貴; 山﨑, 圭子; アイツバマイ, ゆふ; 三浦, りゅう; 田村, 菜穂美
    Since "Our Stolen Future" by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, "The Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy" was launched in 2001. It was a model of Japan Environment and Children's Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido. We tracked the effects of endocrine disruptors on developmental disorders. In a small-scale...

  4. Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age : The Hokkaido Study on Environment and Children's Health

    Minatoya, Machiko; Itoh, Sachiko; Araki, Atsuko; Tamura, Naomi; Yamazaki, Keiko; Miyashita, Chihiro; Kishi, Reiko
    Studies have suggested associations between maternal obesity and mental health problems of their children. However, the underlying mechanism is largely unknown. A possible mechanism can be via inflammatory states and the other possible mechanism is metabolic hormone-induced programming. Cross-talk between adipokines, including inflammatory cytokines and metabolic hormones secreted from adipose tissue and the central nervous system needs to be further investigated to elucidate the mechanism. Thus, the aim of this study was to investigate the association between fetal adipokine levels and child behavioral problems at preschool age. Cord blood adiponectin, leptin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) levels...

  5. Different Risk Factors for Very Low Birth Weight, Term-Small-for-Gestational-Age, or Preterm Birth in Japan

    Tamura, Naomi; Hanaoka, Tomoyuki; Ito, Kumiko; Araki, Atsuko; Miyashita, Chihiro; Ito, Sachiko; Minakami, Hisanori; Cho, Kazutoshi; Endo, Toshiaki; Sengoku, Kazuo; Ogasawara, Katsuhiko; Kishi, Reiko
    From 1985 to 2013, the mean birth weight of infants in Japan decreased from 3120 g to 3000 g, and the low-birth-weight rate among live births increased from 6.3% to 9.6%. No prospective study has elucidated the risk factors for poor fetal growth and preterm birth in recent Japanese parents, such as increased parental age, maternal body figure, assisted reproductive technology (ART), and socioeconomic status. Participants were mother-infant pairs (n = 18,059) enrolled in a prospective birth cohort in Hokkaido, Japan from 2002 to 2013. Parental characteristics were obtained via self-reported questionnaires during pregnancy. Medical records helped identify very-low-birth-weight (VLBW;...

  6. Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size : The Hokkaido study

    Kobayashi, Sumitaka; Sata, Fumihiro; Miyashita, Chihiro; Sasaki, Seiko; Ban, Susumu; Araki, Atsuko; Goudarzi, Houman; Kajiwara, Jumboku; Todaka, Takashi; Kishi, Reiko
    Objectives: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. Methods: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G >A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu I (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. Results: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g...

  7. Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

    Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko; Braimoh, Titilola Serifat; Araki, Atsuko; Miyashita, Chihiro; Goudarzi, Houman; Kobayashi, Sachiko; Kishi, Reiko
    Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off = 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed,...

  8. Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

    Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko; Braimoh, Titilola Serifat; Araki, Atsuko; Miyashita, Chihiro; Goudarzi, Houman; Kobayashi, Sachiko; Kishi, Reiko
    Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off = 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed,...

  9. Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size : Biomarker assessment in the Hokkaido Study

    Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko; Braimoh, Titilola Serifat; Araki, Atsuko; Miyashita, Chihiro; Goudarzi, Houman; Kobayashi, Sachiko; Kishi, Reiko
    Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off = 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed,...

  10. The Hokkaido Birth Cohort Study on Environment and Children's Health : cohort profile -- updated 2017

    Kishi, Reiko; Araki, Atsuko; Minatoya, Machiko; Hanaoka, Tomoyuki; Miyashita, Chihiro; Itoh, Sachiko; Kobayashi, Sumitaka; Bamai, Yu Ait; Yamazaki, Keiko; Miura, Ryu; Tamura, Naomi; Ito, Kumiko; Goudarzi, Houman; Members of The Hokkaido Study on Environment and Children’s Health
    The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose...

  11. Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren : A Cross-Sectional Study in Sapporo, Japan

    Cong, Shi; Araki, Atsuko; Ukawa, Shigekazu; Ait Bamai, Yu; Tajima, Shuji; Kanazawa, Ayako; Yuasa, Motoyuki; Tamakoshi, Akiko; Kishi, Reiko
    Background: Use of fuel heaters is associated with childhood asthma. However, no studies have evaluated the associations of flue use and mechanical ventilation (ventilation) with asthma symptoms in schoolchildren. Methods: This cross-sectional study investigated schoolchildren in grades 1 through 6 (age 6-12 years) in Sapporo, Japan. From November 2008 through January 2009, parents completed questionnaires regarding their home environment and their children's asthma symptoms. Results: In total, 4445 (69.5%) parents of 6393 children returned the questionnaire. After excluding incomplete responses, data on 3874 children (60.6%) were analyzed. The prevalence of current asthma symptoms and ever asthma symptoms were 12.8% and...

  12. The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long-Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of Their Offspring : The Hokkaido Study

    Kishi, Reiko; Nakajima, Tamie; Goudarzi, Houman; Kobayashi, Sachiko; Sasaki, Seiko; Okada, Emiko; Miyashita, Chihiro; Itoh, Sachiko; Araki, Atsuko; Ikeno, Tamiko; Iwasaki, Yusuke; Nakazawa, Hiroyuki
    Background: Fatty acids (FAs) are essential for fetal growth. Exposure to perfluorinated chemicals (PFCs) may disrupt FA homeostasis, but there are no epidemiological data regarding associations of PFCs and FA concentrations. Objectives: We estimated associations between perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) concentrations and maternal levels of FAs and triglyceride (TG) and birth size of the offspring. Methods: We analyzed 306 mother-child pairs in this birth cohort between 2002 and 2005 in Japan. The prenatal PFOS and PFOA levels were measured in maternal serum samples by liquid chromatography-tandem mass spectrometry. Maternal blood levels of nine FAs and TG were measured by gas...

  13. The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy : An Adjunct Study of the Japan Environment and Children's Study

    Kawanishi, Yasuyuki; Saijo, Yasuaki; Yoshioka, Eiji; Nakagi, Yoshihiko; Yoshida, Takahiko; Miyamoto, Toshinobu; Sengoku, Kazuo; Ito, Yoshiya; Miyashita, Chihiro; Araki, Atsuko; Kishi, Reiko
    Introduction: While the beneficial effects of prenatal yoga have been reported in recent years, little is known about its effectiveness in pregnant Japanese women. Despite several adverse effects, ritodrine hydrochloride is frequently prescribed to suppress preterm labor in Japan, and its usage may therefore indicate cases of preterm labor. This study aimed to clarify the association between prenatal yoga and ritodrine hydrochloride use during pregnancy. Methods: An observational study was conducted as an adjunct study by the Hokkaido unit of the Japan Environment and Children's Study. Information on prenatal yoga practice was collected using a self-questionnaire between March 21, 2012,...

  14. Predictors of folate status among pregnant Japanese women : the Hokkaido Study on Environment and Children's Health, 2002-2012

    Yila, Thamar A.; Araki, Atsuko; Sasaki, Seiko; Miyashita, Chihiro; Itoh, Kumiko; Ikeno, Tamiko; Yoshioka, Eiji; Kobayashi, Sumitaka; Goudarzi, Houman; Baba, Toshiaki; Braimoh, Titilola; Minakami, Hisanori; Endo, Toshiaki; Sengoku, Kazuo; Kishi, Reiko
    The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida in Japan. We determined first-trimester folate status of Hokkaido women and identified potential predictors. Participants were 15 266 pregnant women of the Hokkaido Study on Environment and Children’s Health Cohort. Data were extracted from self-reported questionnaires and biochemical assay results. Demographic determinants of low folate status were younger maternal age (adjusted OR (AOR) 1·48; 95 % CI 1·32, 1·66), lower educational level (AOR 1·27; 95 % CI 1·17, 1·39) and lower annual income (AOR 1·11; 95 % CI 1·01, 1·22). Plasma...

  15. Validation of diffusive mini-samplers for aldehyde and VOC and its feasibility for measuring the exposure levels of elementary school children

    Araki, Atsuko; Tsuboi, Tazuru; Kawai, Toshio; Ait Bamai, Yu; Takeda, Tomoya; Yoshioka, Eiji; Kishi, Reiko
    Exposure to various chemicals can cause adverse effects to health, such as asthma and allergies, especially in children. Data on personal exposure levels in children are scarce, thus small lightweight diffusive mini-samplers for aldehydes and volatile organic compounds (VOCs) were designed to measure the exposure level of children to these chemicals. The aim of the study was to validate and examine the applicability of these mini-samplers for measuring daily chemical exposure. The diffusive mini-samplers are 20 mm in length, 11 mm in diameter, and 1.67 g in weight. The devices are cylindrically shaped with polytetrafluoroethylene membrane filters placed at each...

  16. Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index : The Hokkaido Study

    Kobayashi, Sachiko; Azumi, Kaoru; Goudarzi, Houman; Araki, Atsuko; Miyashita, Chihiro; Kobayashi, Sumitaka; Itoh, Sachiko; Sasaki, Seiko; Ishizuka, Mayumi; Nakazawa, Hiroyuki; Ikeno, Tamiko; Kishi, Reiko
    Prenatal exposure to perfluoroalkyl acids (PFAAs) influences fetal growth and long-term health. However, whether PFAAs affect offspring DNA methylation patterns to influence health outcomes is yet to be evaluated. Here, we assessed effect of prenatal PFAA exposure on cord blood insulin-like growth factor 2 (IGF2), H19, and long interspersed element 1 (LINE1) methylation and its associations with birth size. Mother-child pairs (N=177) from the Hokkaido Study on Environment and Children's Health were included in the study. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels in maternal serum were measured by liquid chromatography-tandem mass spectrometry. IGF2, H19, and LINE1 methylation in...

  17. 児の出生時体格に妊婦の喫煙とAHR, CYP1A1, XRCC1遺伝子型の組合せが影響する : 北海道スタディ

    小林, 澄貴; 佐田, 文宏; 佐々木, 成子; ブライモー, チチローラ・セリファト; 荒木, 敦子; 宮下, ちひろ; ゴウダルジ, ホウマヌ; 小林, 祥子; 岸, 玲子
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  18. 環境化学物質の胎児期曝露による児の神経発達への影響に関する疫学文献レビュー : 注意欠如・多動性障害(AD/HD)・自閉症スペクトラム(ASD)を含めて

    小林, 澄貴; 池野, 多美子; 荒木, 敦子; 山﨑, 圭子; 西原, 進吉; 岸, 玲子

  19. Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families

    Bamai, Yu Ait; Araki, Atsuko; Kawai, Toshio; Tsuboi, Tazuru; Yoshioka, Eiji; Kanazawa, Ayako; Cong, Shi; Kishi, Reiko
    We measured urinary phthalate metabolites, including di-n-butyl phthalate (DnBP), di-isobutyl phthalate, benzyl butyl phthalate (BBzP), and di(2-ethylhexyl) phthalate (DEHP), from 178 school-aged children and their 284 family members using gas chromatography-mass spectrometry, and we calculated daily phthalate intakes. The highest median levels of phthalate metabolites were for mono-isobutyl phthalate in all participants except schoolchildren, where the highest levels were for mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP). Comparing the schoolchildren with their parents, the schoolchildren had significantly higher urinary metabolites for MEOHP, mono-(2-ethyl-5-carboxypentyl) phthalate, and EDEHP. Regarding daily intakes, the schoolchildren had significantly higher daily intakes of DnBP, BBzP, and EDEHP. All phthalate metabolite...

  20. 胎児期の母の受動喫煙と児の出生体重に関する最近の研究動向

    小林, 澄貴; 荒木, 敦子; 佐々木, 成子; 池野, 多美子; 宮下, ちひろ; 伊藤, 佐智子; 岸, 玲子
    妊娠中の受動喫煙曝露が児の出生体重に及ぼす影響について、この影響を修飾する遺伝的感受性の関与も含めて現在までの知見をまとめ、今後の研究の課題を探ることを本総説の目的とした。検索開始年は絞らずに2014年12月までに発表された論文について、(1)"Secondhand smoke"、(2)"Passive smoking"、あるいは(3)"Environmental tabacco smoke"と"Birth weight"をそれぞれキーワードとし、and条件としてPubMedで文献検索をおこなったところ37編となった。妊娠初期後半以降における母の受動喫煙が出生体重を減少させ、低出生体重やSGA(Small-for-gestational-age)のリスクを2倍まで上げることがわかった。今後の研究課題は、胎児期の曝露時期別による受動喫煙が出生体重に及ぼす影響についての検討をさらに進めるのと同時に、そのタバコ煙中の化学物質の代謝に関与する遺伝子多型についても解析し、明らかにすることである。出生体重に影響を受けやすい時期と遺伝的にリスクが高い群がいることを考慮した上で、妊婦の受動喫煙を避ける環境整備が重要である。

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