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Hokkaido University Collection of Scholarly and Academic Papers (130.615 recursos)

HUSCAP (Hokkaido University Collection of Scholarly and Academic Papers) contains peer-reviewed journal articles, proceedings, educational resources and any kind of scholarly works of Hokkaido University.

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Mostrando recursos 1 - 20 de 178

  1. The ICDAS (International Caries Detection & Assessment System) : a new set of caries assessment criteria

    Kanehira, Takashi; Takehara, Junji; Nakamura, Kimiya; Hongo, Hirohisa; Miyake, Ryo; Takahashi, Dairo
    A dental examination is a service performed by dentists in daily clinical practice. This is also performed as part of a group of dental examinations, such as school dental examinations and community health examinations. The Japan Association of School Dentists (JASD) criteria has been used for assessing dental caries in these examinations. These criteria evaluate caries on a scale of C1-C4. In an era when dental caries are pervasive, these criteria are useful. The application of fluoride has become a widespread practice for preventing dental caries in developed countries. The decrease in the incidence of dental caries in younger patients and...

  2. Evaluation of recovery after intravenous sedation

    Shibuya, Makiko; Fujisawa, Toshiaki
    The Intravenous Sedation (IVS) Guideline Working Group of the Japanese Dental Society of Anesthesiology (JDSA) formulated guidelines for intravenous conscious sedation in dentistry. These guidelines were then published on the website of the JDSA in October 2009. These guidelines were developed in accordance with the “MINDS Handbook for Clinical Practice Guideline Development 2007” published by the Medical Information Network Distribution Service (MINDS), and were listed on the MINDS Website in February 2011. One of the authors participated in the planning of these guidelines and was responsible for the section on recovery period. The revised version has been published on the...

  3. Bruxism : Association to jaw-muscle pain

    Arima, Taro
    Jaw-muscle pain associated with temporomandibular disorders (TMD) has traditionally been linked to hyperactivity or abnormal contraction of masticatory muscles such as “bruxism”. A frequent clinical observation has been that many patients with TMD exhibit a tendency to clench or grind their teeth during sleep. It has been considered for a long time that unaccustomed or abnormal contractions of the muscles causes this pain, and once the pain had developed, it causes more muscle hyperactivity, setting up a vicious cycle. However, this theory has not been clarified scientifically and the relationship between various types of orofacial motor activity and TMD is...

  4. Current international consensus on burning mouth syndrome : systematic review of recent review articles

    Sato, Jun; Kitagawa, Yoshimasa; Asaka, Takuya; Ohga, Noritaka; Yamashita, Emi; Nakamura, Yusuke; Satoh, Chiharu
    Burning mouth syndrome (BMS) is a type of chronic orofacial pain, which is difficult to diagnose and treat. Patients suffer from BMS worldwide. The pathophysiology of this disorder is not fully understood. This study looked at recent review articles about the classifications, diagnosis and pathophysiology of BMS. PubMed/MEDLINE and WEB of SCIENCE® databases were reviewed to identify articles about BMS, written in English from 2010 to May 2017. Eighteen review articles about BMS were identified, including six systematic reviews, 11 narrative reviews, and one meta-analysis. The most frequently cited classification system for BMS was the International Classification of Headache Disorders...

  5. Therapeutic strategies for etiologies in the oral and maxillofacial regions

    Tei, Kanchu; Ohiro, Yoichi; Matsusita, Kazuhiro; Matsuzawa, Yusuke; Satoh, Kazuyo; Yamada, Tamaki
    In this paper we describe our strategies for treatment of oral cancer, jaw deformity, and odontogenic tumors. Details of the strategy for cleft palate is introduced in a separate report, by Professor Mikoya. Newly applied strategies for patients with post-surgical swallowing dysfunction and dentoalveolar surgery are also introduced. Oral cancer, jaw deformity, cleft, and odontogenic tumors are the main etiologies in the oral and maxillofacial region. Early stages of oral cancer (StageI and StageII) are mainly treated with surgery or radiotherapy alone, and the 5-year survival rate is 80 to 90%. With advanced oral cancer (StageIII and StageIV) a combination...

  6. Development of a technical aid for occlusal adjustment during dental treatment under general anesthesia

    Kobayashi, Kunihiko; Okada, Kazutaka; Ozaki, Kimiya; Yamazaki, Yutaka; Notani, Kenji; Inoue, Nobuo
    General anesthesia can increase the volume of the tongue. A large tongue between the upper and lower teeth may be a serious obstacle, especially for tapping during occlusal adjustments in prosthetic treatment. We developed a tongue retractor to eliminate interference by the tongue. This study assesses the effect of the tongue retractor on occlusal adjustment time and describes two patients in which the tongue retractor was used. Methods The study involved five patients and two dentists. Measurements were performed during occlusal adjustment of the molars. The time from when the dentist took hold of the articulating paper to the first...

  7. Long term follow up of prosthetic treatment for cleft lip and palate patients in Hokkaido University Hospital

    Iida, Shunji
    Cleft lip and palate patients need various approaches and treatments. At Hokkaido University Hospital, medical, dental, para medical, and para dental specialists have a team approach, and worked with cleft lip and palate patients since 1990. Moreover, final treatment of cleft lip and palate are usually prosthetic which should be stable and function in their oral space for long periods of time. This is usually with good prognosis. This study investigated the past 23 years of prosthetic treatments and analyzed their effectiveness. This long term follow up revealed that the availability of metal retainers, or bridge work prevented post-orthodontic relapse.

  8. Lip incompetence and myofunctional therapy

    Iida, Junichiro; Kaneko, Tomoo; Nakanishi (Ohtsuka), Mai; Yoshizawa, Saori; Yamamoto, Takaaki; Sato, Yoshiaki
    Lip incompetence, which is a state in which the upper and lower lips are constantly apart, is thought to induce mouth breathing that may result in the development of gingivitis and periodontal disease. In the orthodontic field, lip incompetence has major problems for diagnosis, when determining the treatment goal and at the time of retention. We have been performing studies on lip incompetence and have obtained the following results : (1) it is possible to predict to some extent the state of lip closure during sleep by examination only in an awake state, (2) anterior teeth are positioned forward in...

  9. Root canal treatment of traumatized permanent teeth with external root resorption

    Yawaka, Yasutaka; Toyota, Yuki; Hisada, Akina; Maeda, Ayako; Inoue, Shohei; Yoshihara, Toshihiro
    External root resorption is an important challenge in the preservation of traumatized teeth. External root resorption is observed in cases of replanted teeth from dental trauma. Root canal dressing containing calcium hydroxide (Ca(OH)2) is one recommended clinical approach for external root resorption treatment. However, complete control of external resorption may not be possible due to certain factors, such as the smear layer, which is formed by reaming and filing during root canal treatments. The smear layer plugs dentinal tubules and inhibits the effects of Ca(OH)2 as a root canal dressing material. Our study showed that root canal irrigation with ethylenediaminetetraacetic...

  10. Application of poly CDME (PCDME) gel to the palatal plate

    Kaneko, Tomoo; Mikoya, Tadashi
    In some patients with cleft lip and palate, the palatal cleft is wide and three-dimensionally deformed at birth. This can result in difficulty in sucking, which subsequently causes poor weight and development. The resin-based palatal plate for patients is maintained in position with retentive components such as a ball clasp and Adams clasp. In this study, we report on our experience conducting research and developing a palatal plate that consists of PCDME [Poly-N-(carboxymethyl)-N,N-dimethyl-2-(methacryloyloxy) ethanaminium] gel adhered to a polycarbonate frame. The gel is viscous and adheres to the mucosa, thereby maintaining the plate. Moreover, there are no retentive components, such...

  11. Treatment of infected root canals with 4-META/MMA-TBB resin

    Sugaya, Tsutomu; Tanaka, Saori; Miyaji, Hirofumi; Shimoji, Shinji; Kudo, Megumi; Takefu, Hiroe; Washizu, Taro
    This review paper describes the various applications of 4-methacryloxyethyl trimellitate anhydride/methyl methacrylate-tri-n-butyl borane (4-META/MMA-TBB) and reviews research studies on the treatment of infected root canals using 4-META/MMA-TBB resin. 4-META/MMA-TBB resin exhibits good biocompatibility, polymerisation, and adhesiveness to dentine. As a result, it has improved the previously low success rates of root-end sealing, root canal filling, and perforation sealing in difficult cases. Root-end sealing of resected surfaces using 4-META/MMA-TBB during apicoectomy and intentional replantation prevents leakage from root canal and root resorption. 4-META/MMA-TBB can offer sealing for root canals with opened root apex in which pressure could not be applied during...

  12. History of and current situation regarding dental CAD/CAM systems and future perspectives

    Ueda, Yasuo; Yamaguchi, Taihiko
    The Dental CAD/CAM system has been in use for more than 30 years, and has been an indispensable tool for dental workflow. Before this practical system was in operation, it was necessary to develop computer technology in the handling of 3-dimensional data freely and to advance new dental materials. This trend will continue to expand in the future. Recently, optical impressions are taken instead of using impression materials against the background of great progress in sensor technology. Likewise, dental workflows that do not need plaster working models have become mainstream. In this paper, we outline the history and current trends...

  13. Carbon nanomaterials for bone tissue regeneration

    Hirata, Eri
    Carbon nanomaterials (CNMs), including carbon nanotubes carbon nanohorns and graphene, have gained great attention in the scientific community due to their unique physico-chemical properties. These could also be promising in many biomedical-related fields. In particular, CNMs have been studied for bone tissue engineering, because of their low toxicity. In this review, the advantages of using carbon-based materials in bone tissue engineering are presented. In this study osteoblast cell culture scaffold was achieved using carbon nanotubes and functionalized carbon nanotubes for bone regeneration and is described. The biocompatibility of the CNMs for bone and mechanism of the bone formation by CNMs...

  14. Interfacial interactions of bioadhesive materials with human hard tissues

    Yoshida, Yasuhiro; Inoue, Satoshi; Tamai, Miho; Abe, Shigeaki; Akasaka, Tsukasa; Yoshihara, Kumiko; Meerbeek, Bart Van
    Recently, in dental practice, tooth reconstruction can be performed using dental adhesive technology following either a “glass-ionomer”, an “etch-and-rinse” or a “self-etch” approach. Glass-ionomer cements are well-known to possess an auto-adhesive capability without requiring any surface pre-treatment. The fundamental bonding mechanism of resin-based materials to enamel and dentin is essentially based on an exchange process, in which minerals removed from the dental hard tissues are replaced by resin monomers. These resin monomers, upon polymerization become micro-mechanically interlocked in the created porosities. Besides micro-mechanical interlocking through hybridization, an additional chemical interaction between functional monomers/polymers and tooth substrate components has been found...

  15. Vascular formation : in vitro differentiation of vascular endothelial cells from pluripotent stem cells

    Tsuji-Tamura, Kiyomi; Tamura, Masato; Tsuji-Tamura
    During early vascular development, vascular endothelial cells (ECs) differentiate, proliferate, migrate, and change morphologically, forming tube-like vascular structures. The ECs are then surrounded by vascular smooth muscle cells (SMCs), leading to the formation of stable vascular structures, or vascular maturation. The stages of cell or tissue development can be monitored and analyzed using in vitro differentiation systems of pluripotent stem cells. In this review, we present the molecular mechanisms that regulate the developmental processes of vasculature.

  16. Na+/K+-ATPase as a target for cardiotonic steroids and cisplatin

    Suzuki, Kuniaki; Deyama, Yoshiaki; Minamikawa, Hajime; Yoshimura, Yoshitaka
    The sodium (Na+)/potassium (K+)-ATPase is an ion pump located on the surface of all animal cells. It pumps three sodium ions out of the cell while pumping two potassium ions into the cell, hydrolyzing one ATP molecule as the driving force for the reaction. Na+/K+-ATPase forms and maintains the electrochemical gradient in cells, which provides the basis for the excitability of nerve and muscle tissues and contributes to the osmotic regulation of cell volume. In addition, the electrochemical Na+ gradient is the driving force for the secondary transport of nutrients such as amino acids, sugars, and drugs. Recently, the Na+/K+-ATPase...

  17. Clinical application of MEG for the evaluation of sensory disturbances of the lip and tongue in patients with mandibular nerve injury

    Maezawa, Hitoshi
    This paper reviews the clinical applications of MEG in patients with sensory disturbances of the lip and tongue due to unilateral injury of the mandibular nerve. Multiple non-invasive approaches are available for the evaluation of human brain function. Some of these approaches are electroencephalography (EEG), magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), and positron emission tomography (PET). MEG is particularly advantageous due to its high spatiotemporal resolution. Mandibular nerve injury during orofacial surgery may result in sensory deficits of the lower lip and tongue, which often lead to speech disorders, eating difficulties, and significant reductions in patients quality of life....

  18. Electrophysiological analysis of neurons in the area postrema

    Funahashi, Makoto
    This mini-review highlights electrophysiological studies of neurons in the area postrema, including studies using anesthetized animals, neurons in the brain slices, and cultured cells. Electrophysiological studies have demonstrated chemosensitivities, intrinsic membrane properties, synaptic responses and the receptive mechanism of several peptides. For seven decades, electrophysiological research has produced much of what we know about the behavior of postrema neurons. This and other issues are presented and discussed in this paper.

  19. Cellular function of osteocytes in normal and αklotho-deficient mice

    Amizuka, Norio; Hasegawa, Tomoka; Yamamoto, Tomomaya; Mae, Takahito; Zixuan, Qiu; Abe, Miki; Shen, Zhao; Nagai, Tomoya; Yokoyama, Ayako; Naznin, Khadiza; Haraguchi, Mai; Yamamoto, Tsuneyuki; Freitas, Paulo Henrique Luiz de; Li, Minqi
    During the last decade, osteocyte-derived factors i.e., sclerostin, dentin matrix protein-1, fibroblast growth factor 23 (FGF23) that reduces serum phosphate concentration by mediating FGF receptor 1c/αklotho in the kidney, have been highlighted for osteocytes’ fine-turned regulation on bone remodeling and phosphate homeostasis. Osteocytes are interconnected through gap junctions between their cytoplasmic processes, and thereby, build upon the functional syncytia, referred to as the osteocytic lacunar-canalicular system (OLCS). Osteocytes appear to communicate surrounding osteocytes and osteoblasts by means of two possible pathways of molecular transport throughout the OLCS : One is a passageway of their cytoplasmic processes, and the other is...

  20. Matrix vesicle-mediated mineralization in bone

    Hasegawa, Tomoka
    Matrix vesicle-mediated mineralization is orchestrated by ultrastructural and biochemical events that lead to crystal nucleation and growth. Osteoblasts secrete extracellular matrix vesicles equipped with a variety of membrane transporters and enzymes, which are necessary for the initial nucleation and subsequent growth of calcium phosphate crystals. The influx of phosphate ions into the matrix vesicle is a complex process mediated by several enzymes and transporters, such as tissue nonspecific alkaline phosphatase (TNAP), ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), sodium/phosphate co-transporter type III (Pit1). The catalytic activity of ENPP1 generates pyrophosphate (PPi) using extracellular ATPs as a substrate, and the resultant PPi binds to...

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