Mostrando recursos 1 - 4 de 4

  1. Motor dysfunctions and neuropathology in mouse models of spinocerebellar ataxia type 2: A comprehensive review

    Alves-Cruzeiro, João M. da Conceição; Mendonça, Liliana; Almeida, Luís Pereira de; Nóbrega, Clévio
    Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of CAG repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. SCA2 is characterized by several symptoms including progressive gait ataxia and dysarthria, slow saccadic eye movements, sleep disturbances, cognitive impairments, and psychological dysfunctions such as insomnia and depression, among others. The available treatments rely on palliative care, which mitigate some of the major symptoms but ultimately fail to block the disease progression. This persistent lack of effective therapies led to the...
    - 10-feb-2018

  2. Dimensões da qualidade de vida e apoio social dos pacientes hospitalizados nas unidades de assistência à saúde do Algarve

    Duarte, António; Joaquim, Natércia; Nunes, Cristina
    This study assessed the relations between quality of life and social support network of patients in continuing care units in Algarve, using WHOQOL-BREF and ASSIS. Participants were 92 users of ages between 34-101 years: very elderly (40.2%), female (58.7%), widows (40.2%), upper-middle class (46.8%), cohabiting with spouse (43.2%), and partly dependent (72.5%). Emotional, tangible and informational support networks were mainly composed by family. We found significant associations between informative social support and physical domains, social relations and environment of quality of life (p< 0.05). The results suggest middle levels in self-perception and satisfaction with health, and lower levels in physical...
    - 07-feb-2018

  3. The role of hypoxia in glioblastoma invasion

    Monteiro, Ana; Hill, Richard; Pilkington, Geoffrey; Madureira, Patrícia
    Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 to 17 months. The current treatment for GBM involves tumor resection surgery based on MRI image analysis, followed by radiotherapy and treatment with temozolomide. However, the gradual development of tumor resistance to temozolomide is frequent in GBM patients leading to subsequent tumor regrowth/relapse. For this reason, the development of more effective therapeutic approaches for GBM is of critical importance. Low tumor oxygenation, also known as hypoxia, constitutes a major concern for GBM...
    - 03-feb-2018

  4. rdml: A Mathematica package for parsing and importing Real-Time qPCR data

    Magno, Ramiro; Duarte, Isabel; Andrade, Raquel P.; Palmeirim, Isabel
    Objective The purpose and objective of the research presented is to provide a package for easy importing of Real-Time PCR data markup language (RDML) data to Mathematica. Results Real-Time qPCR is the most widely used experimental method for the accurate quantification of gene expression. To enable the straightforward archiving and sharing of qPCR data and its associated experimental information, an XML-based data standard was developed—the Real-Time PCR data markup language (RDML)—devised by the RDML consortium. Here, we present rdml, a package to parse and import RDML data into Mathematica, allowing the quick loading and extraction of relevant data,...
    - 19-oct-2017

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