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DSpace at MIT (28.952 recursos)
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Mostrando recursos 1 - 20 de 106

1. Activation Ratios For Reconstruction Of Signal Transduction Networks - Femenia, F. Javier; Stephanopoulos, Gregory
This approach, termed activation ratio analysis, involves the ratio between active and inactive forms of signaling intermediates at steady state.

2. Association Behavior of Poly(methacrylic acid)-block-Poly(methyl methacrylate) in Aqueous Medium: Potentiometric and Laser Light Scattering Studies - Palaniswamy, R.; Wang, C; Tam, Michael K. C.; Gan, L.H.
A combination of static and dynamic light scattering (SLS, DLS) and potentiometric titration techniques were used to investigate the size and shape of the micelle at various degrees of neutralization.

3. Changes in the Overall Extent of Protein Glycosylation by Chinese Hamster Ovary Cells Over the Course of Batch Culture - Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.
Glycosylation of recombinant proteins can change during the culture of animal cells.

4. Computational Method for Drug Target Search and Application in Drug Discovery - Chen, Yuzong; Li, Zerong; Ung, C.Y.
Ligand-protein inverse docking has recently been introduced as a computer method for identification of potential protein targets of a drug.

5. Computer-Aided Drug Target Search - Chen, Yuzong; Li, Zerong; Ung, C.Y.
Identification of the unknown targets of drugs, investigative drugs and herbal ingredients is an important task in drug discovery.

6. Designer peptides to understand the mineralization of calcium salts - Ajikumar, Parayil Kumaran; Lakshminarayanan, Rajamani; Valiyaveettil, Suresh; Kini, R. Manjunatha
We designed two peptides using the unique features of the sequence of ansocalcin and the role of these peptides in CaCO₃ crystallization was investigated.

7. Electrochemical Insertion/extraction of Lithium in Multiwall Carbon Nanotube/Sb and SnSbâ??.â?? Nanocomposites - Chen, Wei Xiang; Lee, Jim Yang; Liu, Zhaolin
Multiwall carbon nanotubes (CNTs) were synthesized by catalytic chemical vapor deposition of acetylene and used as templates to prepare CNT-Sb and CNT-SnSbâ??.â.

8. Engineering Mammalian Cells for Improved Recombinant Protein Production - Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.
The production of recombinant glycoproteins from mammalian cell cultures requires robust processes that can achieve high protein yield while ensuring the efficacy of these proteins as human therapeutics.

9. Enhancing Production of Recombinant Proteins from Mammalian Cells - Wong, Victor V.T.; Wong, Niki S.C.; Tan, Hong-Kiat; Wang, Daniel I.C.; Yap, Miranda G.S.
The bio-manufacturing of recombinant proteins from mammalian cell cultures requires robust processes that can maximize protein yield while ensuring the efficacy of these proteins as human therapeutics.

10. Glucose-Sensitive Nanoparticles for Controlled Insulin Delivery - Zion, Todd C.; Tsang, Henry H.; Ying, Jackie Y.
Nanoparticles were constructed using a model system comprised of dextran, poly(α-1,6 glucose), physically crosslinked with the tetrafunctional glucose-binding protein, Con A.

11. Glycosylation by Chinese Hamster Ovary Cells in Dolichol Phosphate-Supplemented Cultures - Yuk, Inn Huam Yvonne.; Wang, Daniel I.C.
An essential step in this intracellular process is the transfer of oligosaccharide from dolichol monophosphate (Dol-P) to a potential glycosylation site.

12. Increasing The Odds Of Hit Iidentification By Screening Against Receptor Homologs - Chen, Yuzong; Cai, Congzhong; Li, Zerong; Han, Lianyi; Wang, Jifeng
The odds for finding a hit are closely related either to the diversity of libraries or to the availability of focused libraries.

13. A New Class of Photoresponsive Surfactants - Shang, Tiangang; Wang, Elizabeth A.; Smith, Kenneth A.; Hatton, T. Alan
Recently, surface tension has been shown to be important in emerging high technologies, such as in pumping and control of flow in microfluidic devices, in microchemical analysis of complex fluids, and in rapid DNA screening, etc.

14. NIR-Sensitive Au-Auâ??S Nanoparticles for Drug Delivery - Ren, L.; Chow, Gan-Moog
Near IR (NIR) sensitive Au-Auâ??S nanoparticles were prepared by mixing HAuClâ.

15. Quantitative linkage of physiology and gene expression through empirical model construction: an investigation of diabetes - Misra, J.; Alevizos, I.; Bullen, J.; Blueher, S.; Mantzoros, C.; Stephanopoulos, Gregory
A methodology for the construction of predictive empirical models of physiological characteristics from microarray data is presented.

16. Quantification and signaling of alternatively spliced GFRα2 isoforms - Too, Heng-Phon; Fung, Winnie Kar Yee
The GDNF family receptor alpha 2 (GFRα-2) is the preferred receptor for NTN.

17. Rheological and Thermodynamic Properties of PEO-PPE-PEO and PAA-g-PEO-PPO-PEO System - Tian, Y.; Dai, S.; Tam, Michael K. C.; Bromberg, Lev; Hatton, T. Alan
Rheological and thermodynamic properties of Pluronic F127 copolymer and Pluronic-g-PAA have been studied as a function of temperature and concentration.

18. Self-Assembled Coatings for Controlling Biomolecular Adsorption on Surfaces - Seong, Jiehyun; Lee, Seok-Won; Jun, Shinae; Choi, Hyun-Goo; Laibinis, Paul E.
These films incorporate oligo- or poly(ethylene glycol) moieties that are expressed in high density in the near-surface region.

19. Smart Microgel Studies. Interaction of Polyether-Modified Poly(Acrylic Acid) Microgels with Anticancer Drugs - Bromberg, Lev; Hatton, T. Alan
Studies of submillimeter gels composed of covalently cross-linked poly(acrylic acid)-g-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (Pluronic-PAA) networks are reviewed in light of potential applications of the microgels as drug carriers in oral delivery.

20. Stability of Granular Materials under Vertical Vibrations - Deng, Rensheng; Wang, Chi-Hwa
This includes two major steps, firstly, the base state at various values of mass holdup (Mt) and energy input (Qt) is calculated and secondly, small perturbations are introduced to verify the stability of the base state by solving the resultant eigenvalue problem derived from the linearized governing equations and corresponding boundary conditions.

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