Recursos de colección

Caltech Authors (167.915 recursos)

Repository of works by Caltech published authors.

Group = WormBase

Mostrando recursos 1 - 2 de 2

  1. Genome-wide discovery of active regulatory elements and transcription factor footprints in Caenorhabditis elegans using DNase-seq

    Ho, Margaret C. W.; Quintero-Cadena, Porfirio; Sternberg, Paul W.
    Deep sequencing of size-selected DNase I–treated chromatin (DNase-seq) allows high-resolution measurement of chromatin accessibility to DNase I cleavage, permitting identification of de novo active cis-regulatory modules (CRMs) and individual transcription factor (TF) binding sites. We adapted DNase-seq to nuclei isolated from C. elegans embryos and L1 arrest larvae to generate high-resolution maps of TF binding. Over half of embryonic DNase I hypersensitive sites (DHSs) were annotated as noncoding, with 24% in intergenic, 12% in promoters, and 28% in introns, with similar statistics observed in L1 arrest larvae. Noncoding DHSs are highly conserved and enriched in marks of enhancer activity and...
    (application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/msword; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf; application/pdf) - 03-abr-2018

  2. WormBase 2017: molting into a new stage

    Lee, Raymond Y. N.; Arnaboldi, Valerio; Chan, Juancarlos; Chen, Wen J.; Grove, Christian; Kishore, Ranjana; Müller, Hans-Michael; Nakamura, Cecilia; Raciti, Daniela; Schindelman, Gary; Tuli, Mary Ann; Van Auken, Kimberly; Wang, Qinghua; Yook, Karen; Sternberg, Paul W.
    WormBase (http://www.wormbase.org) is an important knowledge resource for biomedical researchers worldwide. To accommodate the ever increasing amount and complexity of research data, WormBase continues to advance its practices on data acquisition, curation and retrieval to most effectively deliver comprehensive knowledge about Caenorhabditis elegans, and genomic information about other nematodes and parasitic flatworms. Recent notable enhancements include user-directed submission of data, such as micropublication; genomic data curation and presentation, including additional genomes and JBrowse, respectively; new query tools, such as SimpleMine, Gene Enrichment Analysis; new data displays, such as the Person Lineage browser and the Summary of Ontology-based Annotations. Anticipating more...
    (application/pdf; application/pdf) - 09-ene-2018

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