Infoscience
(66.951 recursos)
Repository of the publications, research reports, PhD Theses, Ms Theses, semester works, lectures, etc., of the Facultés, Laboratories and Researchers at the EPFL.
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An Internal Teacher - Floreano, D.
Contextual signals might supervise discovery of coherently varying information between cortical modules computing different functions of their receptive field input. This hypothesis is explored in two sets of computational experiments, one studying the effects on learning of long-range unidirectional contextual signals mediated by intervening processors, and the other showing contextually supervised discovery of a high-order variable in a multi-layer network.
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Glycosylation pathways as drug targets for cancer: glycosidase inhibitors - Juillerat-Jeanneret, L; Gerber-Lemaire, S
The combined and ordered sequential action of glycosidases and glycosyltransferases in mammalian cell compartments leads to the addition of defined glycans to proteins and lipids. Altered glycosylation patterns, neoexpression, underexpression or overexpression of glycans are a hallmark of cancer. These changes are either found in the core or the terminal structures of the carbohydrates of glycoproteins. Affected proteins can be either cellular, cell-surface or secreted proteins, and glycosylation modifications frequently result in a modified expression, metabolism, functions, properties, stability and/or cellular localization of glycoproteins in cancer cells, resulting in part in their uncontrolled growth and aggressive behavior. Therefore glycosylation pathways,...
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Machining of non-conducting materials using electrochemical discharge phenomenon An overview - Fascio, Valia; Wüthrich, Rolf
Machining with electrochemical discharges is an unconventional technology able to machine several electrically non-conductive materials like glass or some ceramics. After almost 40 years of its first mention in literature, this technology remains an academic application and was never applied in industrial context. The knowledge about machining of non-conducting materials using electrochemical discharge phenomenon is reviewed up to this date with some particular attention to the electrochemical point of view. Some main limiting factors are highlighted and possible solutions are discussed.
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ELECTROWETTING Shake, rattle and roll - Girault, HH
A comprehensive theoretical basis for understanding electrowetting is now available. It shows that it is possible to effect drastic shape changes in electrolyte droplets immersed in another (immiscible) electrolyte.
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Power and Reliability Management of SoCs - De Micheli, G; Simunic, T; Mihic, K
Today's embedded systems integrate multiple IP cores for processing, communication, and sensing on a single die as systems-on-chip (SoCs). Aggressive transistor scaling, decreased voltage margins and increased processor power and temperature have made reliability assessment a much more significant issue. Although reliability of devices and interconnect has been broadly studied, in this work, we study a tradeoff between reliability and power consumption for component-based SoC designs. We specifically focus on hard error rates as they cause a device to permanently stop operating. We also present a joint reliability and power management optimization problem whose solution is an optimal management policy....
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Simulation modelling of ecological hierarchies in constructive dynamical systems - Stoffel, Kilian; Müller, Jean-Pierre; Gillet, François; Ratzé, Cédric
Organized complexity is a characteristic feature of ecological systems with heterogeneous components interacting at several spatio-temporal scales. The hierarchy theory is a powerful epistemological framework to describe such systems by decomposing them vertically into levels and horizontally into holons. It was at first developed in a temporal and functional perspective and then, in the context of landscape ecology, extended to a spatial and structural approach. So far, most ecological applications of this theory were restricted to observational purposes, using multi-scale analysis to describe hierarchies. In spite of an increasing attention to dynamics of hierarchically structured ecological systems, current simulation models...
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From genes to brain: understanding brain development in neurogenetic disorders using neuroimaging techniques - Eliez, Stephan; Schaer, Marie
Since almost two decades, a considerable amount of work has been devoted to the accurate delineation of normal and abnormal brain development, using cerebral MRI. In the broad field of neuroimaging research, specific genetic conditions associated with impaired cognitive performances or with psychiatric symptoms have received increased attention, due to their potential for revealing insight on the biological correlates of behavior. First delineated by volumetric measurements of cerebral lobes or regions of interest, new image processing techniques are now defining cerebral phenotypes associated with neurogenetic disorders with increasing precision. We review here the contribution of structural brain imaging in advancing...
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