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Rhodes eResearch Repository (2.360 recursos)
Repository of the academic and research output of the Rhodes University community.

Mostrando recursos 1 - 20 de 20

1. The human skin-blanching assay as an indicator of topical corticosteroid bioavailability and potency: an update - Smith, E.W.; Meyer, E.; Haigh, J.M.; Maibach, H.I.

2. In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation - Smith, E.W.; Haigh, J.M.

3. Assessing penetration enhances for topical corticosteroids - Smith, E.W.; Haigh, J.M.

4. New developments in the methodology available for the assessment of topical corticosteroid-induced skin blanching - Haigh, J.M.; Smith, E.W.; Maibach, H.I.
Since the publication of the previous edition of this book there have been considerable developments and controversy in the field of topical corticosteroid bioequivalence assessment.

5. Application of the Minolta chromameter to the assessment of corticosteroid-induced skin blanching - Walker, R.B.; Haigh, J.M.; Smith, E.W.

6. The effects of elevated and ambient temperature conditions on dilutions of fluocinolone acetonide ointment assessed using the human skin-blanching assay - Haigh, J.M.; Smith, E.W.
Topical application of corticosteroids produces a whitening (blanching) of the skin, the intensity of which is directly proportional to the clinical efficacy of the formulation.

7. Bioequivalence testing of topical dermatological formulations, the gap between science and legislation - Schwarb, F.P.; Smith, E.W.; Haigh, J.M.; Surber, C.
Bioavailability concerns for topical dermatological products are complex and it is especially difficult to determine the bioequivalence of similar topical formulations.

8. Precision of tristimulus chromameter results from corticosteroid-induced skin blanching - Smith, E.W.; Haigh, J.M.
The human skin blanching (vasoconstriction) assay has been in use for 3 decades as a tool for the assessment of the release of corticosteroids from topical dosage forms.

9. The use of supersaturated solutions for the percutaneous delivery of rooperol tetra-acetate - Pefile, S.C.; Haigh, J.M.; Smith, E.W.
Many of these systems attempt to alter the barrier potential by the use of enhancer technology.

10. Chromametry: measuring precision of diurnal and local variation of human forearm skin colour - Schwarb, F.P.; Smith, E.W.; Haigh, J.M.; Surber, C.
Chromameters are compact portable instruments used for the assessment of surface colour based on the tristimulus analysis of a reflected xenon light pulse, and have been used for the quantification of erythema in the study of irritant dermatitis, and corticosteroid-induced skin blanching in the vasoconstriction assay.

11. Comparison of visual CR-200 and CR-300 chromameter data obtained from the corticosteroid-induced skin-blanching assay - Schwarb, F.P.; Smith, E.W.; Haigh, J.M.; Surber, C.
In a recent Guidance document the American FDA recommended the use of a chromameterrather thanthe human eye for the assessment of the pharmacodynamic blanching response produced after topical application of corticosteroids.

12. Can shed snakeskin be considered to be a model membrane for human stratum corneum? - Haigh, J.M.; Beyssac, E.; Aiache, J.M.
Recently there has been some interest in the use of shed snake skin as a "model" membrane for in vitro diffusion studies.

13. Accuracy and reproducibility of the multiple-reading skin blanching assay - Smith, E.W.; Meyer, E.; Haigh, J.M.

14. In vivo/in vitro assessments of topical hydrocortisone availability: correlation between blanching assay and laboratory cell experiments - Smith, E.W.; Haigh, J.M.

15. Where have all the fathers gone? Media(ted) representations of fatherhood - Prinsloo, J.
While it is broadly accepted that the media do not reflect society, they do provide us with a repertoire of roles and images which we encounter and with which we engage." As the opening quote suggests, the media play a vital role in the circulation and mediation of ideas, attitudes and actions and their significance is commented on frequently.

16. Learning (dis)advantage in matriculation language classrooms - Prinsloo, J.
In this chapter the focus is on the language curriculum and the associated practices, or what I refer to as the literacy practices that have become naturalised over decades and persist in the present.

17. Late Pleistocene and Early Holocene foragers in southern Africa - Lewis, C.A.
Foragers occupied parts of southern Africa, including the mountains of the Drakensberg, during the Birnam Interstadial (c.

18. Ecological thinking: Schopenhauer, J.M. Coetzee and who we are in the world - Wright, L.S.
For the ecological agenda to make substantive progress, we will have to see powerful people and social agencies turning away from the ecological insanity that threatens us all, and for this to happen, people need to embrace voluntary renunciation, on the understanding that this is not self-sacrifice, but a different and more satisfying way of being in the world.

19. A research prospectus for the humanities - Wright, L.S.
The humanities in South Africa, as elsewhere, face a crisis of credibility.There is pressing need for the humanities to articulate their social and educational purpose more clearly, so that their academic value is recognised beyond the confines of academia.The aim of reshaping human character and society remains the foundational impulse of the humanities.

20. Disgrace as J.M.Coetzee's Tempest - Wright, L.S.
Amid the deluge of criticism and commentary evoked by Disgrace, quite remarkably nobody has noticed that the book re-engages exactly the energies Shakespeare deployed in The Tempest, a play which has become an icon, if not the icon, of colonial and post-colonial studies.