Mostrando recursos 1 - 20 de 170.433

  1. Wireless Ultrasound-Guided Vacuum-Assisted Breast

    E-ryung Choi; Boo-kyung Han; Eun Sook Ko; Eun Young Ko; Ji Soo Choi; Yoon Cho; Seok Jin Nam
    Objective To determine the imaging characteristic of frequent target lesions of wireless ultrasound (US)-guided, vacuum-assisted breast biopsy (Wi-UVAB) and to evaluate diagnostic yield, accuracy and complication of the device in indeterminate breast lesions. Materials and Methods From March 2013 to October 2014, 114 women (age range, 29–76 years; mean age, 50.0 years) underwent Wi-UVAB using a 13-gauge needle (Mammotome Elite1; Devicor Medi-cal Products, Cincinnati, OH, USA). In 103 lesions of 96 women with surgical (n = 81) or fol-low-up (n = 22) data, complications, biopsy procedure, imaging findings of biopsy targets and histologic results were reviewed. Results Mean number of...

  2. Parallel and Multivalued Logic by the Two-Dimensional Photon-Echo Response of a Rhodamine−DNA Complex

    Barbara Fresch; Marco Cipolloni; Tian-min Yan; Elisabetta Collini; R. D. Levine; F. Remacle
    ABSTRACT: Implementing parallel and multivalued logic operations at the molecular scale has the potential to improve the miniaturization and efficiency of a new generation of nanoscale computing devices. Two-dimensional photon-echo spectroscopy is capable of resolving dynamical pathways on electronic and vibrational molecular states. We experimentally demonstrate the implementation of molecular decision trees, logic operations where all possible values of inputs are processed in parallel and the outputs are read simultaneously, by probing the laser-induced dynamics of populations and coherences in a rhodamine dye mounted on a short DNA duplex. The inputs are provided by the bilinear interactions between the molecule...

  3. Reviewed by:

    Wasima Dar; Stuart J. Knechtle; Stephen Paul Cobbold; Anne L. Fletcher; Dana-farber Cancer
    Since the concept of immunologic tolerance was discovered in the 1940s, the pursuit of tolerance induction in human transplantation has led to a rapid development of pharmaco-logic and biologic agents. Short-term graft survival remains an all-time high, but successful withdrawal of immunosuppression to achieve operational tolerance rarely occurs outside of liver transplantation. Collaborative efforts through the NIH sponsored Immune Toler-ance Network and the European Commission sponsored Reprogramming the Immune System for Establishment of Tolerance consortia have afforded researchers opportunity to evaluate the safety and efficacy of tolerogenic strategies, investigate mechanisms of toler-ance, and identify molecular and genetic markers that distinguish...

  4. Discriminating External and Internal Causes for Heading Changes in Freely Flying Drosophila. PLoS Comput Biol. 2013; 9: e1002891. doi

    Andrea Censi; Andrew D. Straw; Rosalyn W. Sayaman; Richard M. Murray; Michael H. Dickinson
    As animals move through the world in search of resources, they change course in reaction to both external sensory cues and internally-generated programs. Elucidating the functional logic of complex search algorithms is challenging because the observable actions of the animal cannot be unambiguously assigned to externally- or internally-triggered events. We present a technique that addresses this challenge by assessing quantitatively the contribution of external stimuli and internal processes. We apply this technique to the analysis of rapid turns (‘‘saccades’’) of freely flying Drosophila melanogaster. We show that a single scalar feature computed from the visual stimulus experienced by the animal...

  5. The Rockefeller University Press


    Systems cell biology: What it is and what it is not Systems cell biology is the study of the emergent properties of a cell and its component parts using comprehensive and quantita-tive experimental methods that are interpreted by predictive mathematical and statistical models. Emergent properties result from “the whole being greater than the sum of its parts. ” The pro-gression to studying the cell as a system is a natural one for cell biologists who have always sought to meld the biochemical pro-cesses of molecules and modules with the spatial and structural features of cells (Alberts, 1998; Hartwell et al.,...

  6. Systems biology Analyzing biological network parameters with CentiScaPe

    Giovanni Scardoni; Michele Petterlini; Carlo Laudanna
    Summary: The increasing availability of large network datasets along with the progresses in experimental high-throughput technologies have prompted the need for tools allowing easy integration of experimental data with data derived form network computational analysis. In order to enrich experimental data with network topological parameters, we have developed the Cytoscape plug-in CentiScaPe. The plug-in computes several network centrality parameters and allows the user to analyze existing relationships between experimental data provided by the users and node centrality values computed by the plug-in. CentiScaPe allows identifying network nodes that are relevant from both experimental and topological viewpoints. CentiScaPe also provides a...

  7. The Largest Reported Dissecting Aneurysm of Ascending Aorta Following Aortic Valve Replacement Accompanied by Superior Vena Cava Syndrome

    Feridoun Sabzi; Donya Khosravi; Maryamosadat Hosseini; Reza Faraji
    BACKGROUND: Ascending aortic dissection (AAD) is a rare and serious complication of aortic valve replacement. Multiple risk factors such as connective tissue disease, aortic wall thinning, aortic diameter, calcification of wall, structural features of aortic wall and associated diseases have been considered as a predisposing factor for the occurrences of AAD. Preoperative recognition of these variables with proper intra intra operative logic judgment may decrease tehe incidence of this complication. CASE DETAILS: We herein present a huge ascending aorta with dissecting aneurysm (AAD) with a largeintra-operative diameter (15cm) that has not been recorded in the medical literature so far. He...

  8. Association of Polymyalgia Rheumatica With Socioeconomic Status in Primary Care: A Cross-Sectional Observational

    Richard A. Hayward; Trishna Rathod; Sara Muller; Samantha L. Hider; Edward Roddy; Christian; D. Mallen
    Objective. Polymyalgia rheumatica (PMR) is an inflammatory musculoskeletal condition predominantly diagnosed and managed in the community. Socioeconomic status (SES) is known to be associated with many inflammatory rheumato-logic conditions, but has not been investigated in relation to PMR. This study aimed to investigate the association between PMR and SES at both the area and individual levels. Methods. Patients ages>50 years registered with 8 general practices in North Staffordshire were sent a questionnaire requesting details of their general health, SES, and lifestyle. Individual SES was measured using occupation, educational level, and perceived adequacy of income. Area-level SES was measured using the...

  9. NEVESIM: event-driven neural simulation framework with a Python interface

    Dejan Pecevski; Zeno Jonke; Dan F. M. Goodman; Jesus A. Garrido; Dejan Pecevski
    NEVESIM is a software package for event-driven simulation of networks of spiking neurons with a fast simulation core in C++, and a scripting user interface in the Python programming language. It supports simulation of heterogeneous networks with different types of neurons and synapses, and can be easily extended by the user with new neuron and synapse types. To enable heterogeneous networks and extensibility, NEVESIM is designed to decouple the simulation logic of communicating events (spikes) between the neurons at a network level from the implementation of the internal dynamics of individual neurons. In this paper we will present the simulation...

  10. $rec.titulo


    Noninvasive ventilation has been utilized successfully in the pre- and out-of-hospital set-tings for a variety of disorders, including respi-ratory distress syndrome in neonates, neuro-logic and pulmonary diseases in infants and children, and heart failure as well as chronic obstructive pulmonary disease in adults. A variety of interfaces as well as mechanical pos-itive pressure devices have been used: simple continuous positive airway pressure devices are available which do not require sophisticat-ed equipment, while a broad spectrum of ven-tilators have been used to provide bilevel posi-tive airway pressure. Extensive training of transport teams may be important, particularly when utilizing bilevel positive airway...

  11. The logic of EGFR/ErbB signaling: Theoretical properties and analysis of high-throughput data

    Regina Samaga; Julio Saez-rodriguez; Leonidas G. Alexopoulos; Peter K. Sorger
    The epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied receptor system in mammalian cells, and it also has become a popular example for employing mathematical modeling to cellular signaling networks. Dynamic models have the highest explanatory and predictive potential; however, the lack of kinetic information restricts current models of EGFR signaling to smaller sub-networks. This work aims to provide a large-scale qualitative model that comprises the main and also the side routes of EGFR/ErbB signaling and that still enables one to derive important functional properties and predictions. Using a recently introduced logical modeling framework, we first examined...

  12. knowledge authoring and management

    Catherine J Staes; Eun Gyoung Han; Susan Mottice Phd; Richard Bradshaw
    To control disease, laboratories and providers are required to report conditions to public health authorities. Reporting logic is defined in a variety of resources, but there is no single resource available for reporters to access the list of reportable events and computable reporting logic for any jurisdiction. In order to develop evidence-based requirements for authoring such knowledge, we evaluated reporting logic in the Council of State and Territorial Epidemiologist (CSTE) position statements to assess its readiness for automated systems and identify features that should be considered when designing an authoring interface; we evaluated codes in the Reportable Condition Mapping Tables...

  13. Multi-Input Regulation and Logic with T7 Promoters in Cells and Cell-Free Systems

    Sukanya Iyer; David K. Karig; S. Elizabeth Norred; Michael L. Simpson; Mitchel J. Doktycz
    Engineered gene circuits offer an opportunity to harness biological systems for biotechnological and biomedical applications. However, reliance on native host promoters for the construction of circuit elements, such as logic gates, can make the implementation of predictable, independently functioning circuits difficult. In contrast, T7 promoters offer a simple orthogonal expression system for use in a variety of cellular backgrounds and even in cell-free systems. Here we develop a T7 promoter system that can be regulated by two different transcriptional repressors for the construction of a logic gate that functions in cells and in cell-free systems. We first present LacI repressible...

  14. Theory on the Dynamics of Oscillatory Loops in the Transcription Factor Networks

    Rajamanickam Murugan
    We develop a detailed theoretical framework for various types of transcription factor gene oscillators. We further demonstrate that one can build genetic-oscillators which are tunable and robust against perturbations in the critical control parameters by coupling two or more independent Goodwin-Griffith oscillators through either-OR- or-AND- type logic. Most of the coupled oscillators constructed in the literature so far seem to be of-OR- type. When there are transient perturbations in one of the-OR- type coupled-oscillators, then the overall period of the system remains constant (period-buffering) whereas in case of-AND- type coupling the overall period of the system moves towards the perturbed...

  15. Type-1 pericytes accumula and produce collagen in a e


    entire organism. Cells tightly associated with the vasculature, called pericytes [1], stabilize the blood vessels in the micro-In tissue fibrosis, an integral component of most patho-logic conditions, extracellular matrix synthesis is deregu-

  16. RESEARCH ARTICLE Handling Permutation in Sequence Comparison: Genome-Wide Enhancer Prediction in Vertebrates by a Novel Non- Linear Alignment Scoring Principle

    Dirk Dolle; Juan L. Mateo; Michael P. Eichenlaub; Rebecca Sinn; Robert Reinhardt; Burkhard Höckendorf; Daigo Inoue; Lazaro Centanin; Laurence Ettwiller¤b Joachimwittbrodt
    heidelberg.de (JW) Enhancers have been described to evolve by permutation without changing function. This has posed the problem of how to predict enhancer elements that are hidden from align-ment-based approaches due to the loss of co-linearity. Alignment-free algorithms have been proposed as one possible solution. However, this approach is hampered by several problems inherent to its underlying working principle. Here we present a new approach, which combines the power of alignment and alignment-free techniques into one algorithm. It allows the prediction of enhancers based on the query and target sequence only, no matter whether the regulatory logic is co-linear or...

  17. RESEARCH ARTICLE On the Computing Potential of

    Intracellular Vesicles; Richard Mayne; Andrew Adamatzky
    Collision-based computing (CBC) is a form of unconventional computing in which travelling localisations represent data and conditional routing of signals determines the output state; collisions between localisations represent logical operations. We investigated patterns of Ca2+-containing vesicle distribution within a live organism, slime mould Physarum polyce-phalum, with confocal microscopy and observed them colliding regularly. Vesicles travel down cytoskeletal ‘circuitry ’ and their collisions may result in reflection, fusion or annihila-tion. We demonstrate through experimental observations that naturally-occurring vesicle dynamics may be characterised as a computationally-universal set of Boolean logical oper-ations and present a ‘vesicle modification ’ of the archetypal CBC ‘billiard...

  18. RESEARCH ARTICLE Role of the YAP Oncoprotein in Priming Ras- Driven Rhabdomyosarcoma

    Katherine K. Slemmons; Lisa E. S. Crose; Erin Rudzinski; Rex C. Bentley; M. Linardic
    Rhabdomyosarcoma (RMS), a cancer characterized by features of skeletal muscle histogen-esis, is the most common soft tissue sarcoma of childhood and adolescence. Survival for high-risk groups is less than 30 % at 5 years. RMS also occurs during adulthood, with a lower incidence but higher mortality. Recently, mutational profiling has revealed a correlation between activating Ras mutations in the embryonal (eRMS) and pleomorphic (pRMS) histo-logic variants of RMS, and a poorer outcome for those patients. Independently, the YAP tran-scriptional coactivator, an oncoprotein kept in check by the Hippo tumor suppressor pathway, is upregulated in eRMS. Here we show that YAP...

  19. ORI GIN AL ARTICLE What do we transfer in case discussions? The hidden curriculum in medicine…

    Yolande Witman; Y. Witman
    The Author(s) 2013. This article is published with open access at Springerlink.com Medical students and junior doctors learn according to the formal curriculum, but they also learn unwritten rules, the specific logic of the medical world, through a socialization process called ‘the hidden curriculum’. The result of the process seems to be an exclusive professional identity, the medical habitus. This article underlines the importance of the hidden curriculum in medicine, especially in meetings where patients are discussed. These case discussions, common daily rituals in medical practice, demonstrate the dynamic interaction of learning and practice within the medical world. The article...

  20. ral ssBioMed CentBMC Bioinformatics Open AcceSoftware SSWAP: A Simple Semantic Web Architecture and Protocol for semantic web services

    Damian Dg Gessler; Gary S Schiltz; Greg D May; Shulamit Avraham; Christopher D Town; David Grant; Rex T Nelson; Rex T Nelson
    Background: SSWAP (Simple Semantic Web Architecture and Protocol; pronounced "swap") is an architecture, protocol, and platform for using reasoning to semantically integrate heterogeneous disparate data and services on the web. SSWAP was developed as a hybrid semantic web services technology to overcome limitations found in both pure web service technologies and pure semantic web technologies. Results: There are currently over 2400 resources published in SSWAP. Approximately two dozen are custom-written services for QTL (Quantitative Trait Loci) and mapping data for legumes and grasses (grains). The remaining are wrappers to Nucleic Acids Research Database and Web Server entries. As an architecture,...

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