Mostrando recursos 161 - 180 de 172,300

  1. Research Article The Laws of Natural Deduction in Inference by DNA Computer

    Aukasz Rogowski; Petr Sosík
    License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We present a DNA-based implementation of reaction system with molecules encoding elements of the propositional logic, that is, propositions and formulas.The protocol can perform inference steps using, for example,modus ponens andmodus tollens rules and de Morgan’s laws. The set of the implemented operations allows for inference of formulas using the laws of natural deduction. The system can also detect whether a certain proposition a can be deduced from the basic facts and given rules. The whole protocol is fully autonomous; that is,...

  2. The Logic of Fashion Cycles

    Alberto Acerbi; Stefano Ghirl; Magnus Enquist
    Many cultural traits exhibit volatile dynamics, commonly dubbed fashions or fads. Here we show that realistic fashion-like dynamics emerge spontaneously if individuals can copy others ’ preferences for cultural traits as well as traits themselves. We demonstrate this dynamics in simple mathematical models of the diffusion, and subsequent abandonment, of a single cultural trait which individuals may or may not prefer. We then simulate the coevolution between many cultural traits and the associated preferences, reproducing power-law frequency distributions of cultural traits (most traits are adopted by few individuals for a short time, and very few by many for a long...

  3. $rec.titulo


    Epithelial ovarian cancer is still the most lethal of all gyneco-logic malignancies, and it is the fourth most common cause of cancer-related death among women worldwide [1]. Because proper screening test for early detection is not available, most

  4. Research Article A Fuzzy Logic Enhanced Environmental Protection Education Model for Policies Decision Support in Green Community Development

    Sung-lin Hsueh
    Copyright © 2013 Sung-Lin Hsueh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study proposes the promotion of environmental protection education among communities as a solution to the serious problems of high energy consumption and carbon emissions around the world. Environmental protection education has direct and lasting influences on everyone in society; therefore, it is helpful in our fight against many serious problems caused by high energy consumption. In this study, the Delphi method and the fuzzy...

  5. Global Spine J 2014;4:263–268.

    Ignacio J. Barrenechea; Address Ignacio; J. Barrenechea; Servicio De
    A 64-year-old woman with no previous medical history sus-tained a motor vehicle accident (MVA) on January 23, 2012 (she crashed into a truck from behind). When examined in the field, the patient noted numbness and weakness in her arms and numbness inher lower limbs. Shewasput inaPhiladelphia collar and transferred to the nearest hospital, where head and spine images were obtained. The cervical spine X-rays and computed tomography scan showed a frank C5–C6 dislocation with jumped facets (►Figs. 1A, B, and C). Magnetic resonance imag-ing (MRI) showed a spared posterior longitudinal ligament with ruptured posterior elements (interspinous and supraspinous ligaments;►Fig. 1D)....

  6. Logic-based models for the analysis of cell signaling networks

    Melody K. Morris; Julio Saez-rodriguez; Peter K. Sorger; Douglas A. Lauffenburger
    ABSTRACT: Computational models are increasingly used to analyze the operation of complex biochemical networks, including those involved in cell signaling networks. Here we review recent advances in applying logic-based modeling to mammalian cell biology. Logic-based models represent biomolecular networks in a simple and intuitive manner without describing the detailed biochemistry of each interaction. A brief description of several logic-based modeling methods is followed by six case studies that demonstrate biological questions recently addressed using logic-based models and point to potential advances in model formalisms and training procedures that promise to enhance the utility of logic-based methods for studying the relationship...

  7. Association Between Bone Marrow Dosimetric Parameters and Acute Hematologic Toxicity in Cervical Cancer Patients Undergoing Concurrent Chemoradiotherapy Comparison of Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiation Therapy


    Objective: We compare different dosimetric parameters in cervical cancer patients receiv-ing concurrent chemotherapy and three-dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiation therapy (IMRT) and explore the incidence of hematological toxicity (HT) in these patients. Methods: Twenty patients receiving 3DCRT or IMRT and 4 weekly doses of cisplatin (25 mg/m2/w) were studied. The volumes of bone marrow receiving 10, 20, 30, 40 and 50 Gy or greater (V10, V20, V30, V40, and V50, respectively) were calculated. The HT was graded according to the guidelines of the Radiation Therapy Oncology Group system. The associations between dosimetric parameters and HT and chemotherapy delivery...

  8. doi:10.5402/2012/419419 Research Article Hybrid-Controlled Neurofuzzy Networks Analysis Resulting in Genetic Regulatory Networks Reconstruction

    Isrn Bioinformatics; Roozbeh Manshaei; Pooya Sobhe Bidari; Mahdi Aliyari Shoorehdeli; Amir Feizi; Tahmineh Lohrasebi; Mohammad Ali Malboobi; Matthew Kyan; Javad Alirezaie
    Copyright © 2012 Roozbeh Manshaei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Reverse engineering of gene regulatory networks (GRNs) is the process of estimating genetic interactions of a cellular system from gene expression data. In this paper, we propose a novel hybrid systematic algorithm based on neurofuzzy network for recon-structing GRNs from observational gene expression data when only a medium-small number of measurements are available. The approach uses fuzzy logic to transform gene expression values...

  9. $rec.titulo


    To determine the epidemiology and trends of invasive fungal infections (IFIs) in France, we analyzed incidence, risk factors, and in-hospital death rates related to the most frequent IFIs registered in the national hospital discharge database during 2001–2010. The identified 35,876 IFI cases included candidemia (43.4%), Pneumocystis jirove-cii pneumonia (26.1%), invasive aspergillosis (IA, 23.9%), cryptococcosis (5.2%), and mucormycosis (1.5%). The overall incidence was 5.9/100,000 cases/year and the mortality rate was 27.6%; both increased over the period (+1.5%, +2.9%/year, respectively). Incidences substan-tially increased for candidemia, IA, and mucormycosis. Pneumocystis jirovecii pneumonia incidence decreased among AIDS patients (-14.3%/year) but increased in non-HIV–infected patients (+13.3%/year). Candidemia and IA incidence was increased among patients with hemato-logic...

  10. Research Article Fuzzy Temporal Logic Based Railway Passenger Flow Forecast Model

    Fei Dou; Limin Jia; Li Wang; Jie Xu; Yakun Huang
    permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Passenger flow forecast is of essential importance to the organization of railway transportation and is one of the most important basics for the decision-making on transportation pattern and train operation planning. Passenger flow of high-speed railway features the quasi-periodic variations in a short time and complex nonlinear fluctuation because of existence of many influencing factors. In this study, a fuzzy temporal logic based passenger flow forecast model (FTLPFFM) is presented based on fuzzy logic relationship recognition techniques that predicts the short-term passenger flow for...

  11. doi: 10.3389/fonc.2014.00243 Prostate cancer and new insights in angiogenesis

    Sanja Štifter
    Angiogenesis is considered one of the hallmarks of tumor initiation and pro-gression therefore it is also the widely accepted therapeutic target. It has been shown that angiogenesis blockers prolong patient’s survival for several months (1). In order to progress, cancer cells acquire several distinct morphological alterations increasing their capacity to proliferate and independently sustain growth, and at the same time, inhibit homeostatic, physio-logic signals from the microenvironment they are in, and under the control of which they should have remained. This is the main principle behind a tumor gaining the

  12. RESEARCH ARTICLE Open Access

    Jike Cui Todd F Deluca
    Phylogenetically informed logic relationships improve detection of biological network organization

  13. DERMATOLOGY PRACTICAL & CONCEPTUAL www.derm101.com

    Editorial Dermatol; Pract Concept
    Binary world/bivalent logic It cannot be denied that the change from analog to digi-tal technology had an enormous effect on how we com-municate in daily life. For somebody who grew up within the last 20 years it is difficult to imagine a world with-out cell phones, email, or online communities. The digital revolution has not only changed our daily life, it also had a significant impact on the way we share information in medicine. We can share a huge amount of data conveniently and rapidly across vast distances. Modern communication technologies eliminate distance barriers and permit the pro-viding of health...

  14. RESEARCH ARTICLE Hyaluronic Acid: Perspectives in Upper Aero- Digestive Tract. A Systematic Review

    Manuele Casale; Antonio Moffa; Lorenzo Sabatino; Annalisa Pace; Massimiliano Vitali; Peter Baptista; Fabrizio Salvinelli
    Background To date, topical therapies guarantee a better delivery of high concentrations of pharmaco-logic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT. Aims The aim of our work was to review the published literature regarding all the potential thera-peutic effects of SH in the chronic inflammatory disease of UADT. Methods Relevant published studies were searched in...

  15. Efficient universal computing architectures for decoding neural activity. PLoS One 2012

    Benjamin I. Rapoport; Lorenzo Turicchia; Woradorn Wattanapanitch; Thomas J. Davidson; Rahul Sarpeshkar
    The ability to decode neural activity into meaningful control signals for prosthetic devices is critical to the development of clinically useful brain – machine interfaces (BMIs). Such systems require input from tens to hundreds of brain-implanted recording electrodes in order to deliver robust and accurate performance; in serving that primary function they should also minimize power dissipation in order to avoid damaging neural tissue; and they should transmit data wirelessly in order to minimize the risk of infection associated with chronic, transcutaneous implants. Electronic architectures for brain – machine interfaces must therefore minimize size and power consumption, while maximizing the...

  16. RESEARCH Open Access Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients

    Davide Cangelosi; Marco Muselli; Stefano Parodi; Fabiola Blengio; Pamela Becherini; Rogier Versteeg; Massimo Conte; Luigi Varesio
    Background: Cancer patient’s outcome is written, in part, in the gene expression profile of the tumor. We previously identified a 62-probe sets signature (NB-hypo) to identify tissue hypoxia in neuroblastoma tumors and showed that NB-hypo stratified neuroblastoma patients in good and poor outcome [1]. It was important to develop a prognostic classifier to cluster patients into risk groups benefiting of defined therapeutic approaches. Novel classification and data discretization approaches can be instrumental for the generation of accurate predictors and robust tools for clinical decision support. We explored the application to gene expression data of Rulex, a novel software suite including...

  17. Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals. Nucleic Acids Res

    Lei Qi; Julius B. Lucks; Chang C. Liu; Vivek K. Mutalik; Adam P. Arkin
    Non-coding RNAs (ncRNAs) are versatile regulators in cellular networks. While most trans-acting ncRNAs possess well-defined mechanisms that can regulate transcription or translation, they gen-erally lack the ability to directly sense cellular signals. In this work, we describe a set of design principles for fusing ncRNAs to RNA aptamers to engineer allosteric RNA fusion molecules that modulate the activity of ncRNAs in a ligand-inducible way in Escherichia coli. We apply these principles to ncRNA regulators that can regulate translation (IS10 ncRNA) and transcription (pT181 ncRNA), and demonstrate that our design strategy exhibits high modularity between the aptamer ligand-sensing motif and the...

  18. Basic conditional reasoning”: How children mimic counterfactual reasoning. Studia Logica. 2013 Advance online publication

    Brian Leahy; Eva Rafetseder; Josef Perner
    Children approach counterfactual questions about stories with a reasoning strategy that falls short of adults ’ Counterfactual Reasoning (CFR). It was dubbed “Basic Conditional Reasoning ” (BCR) in Rafetseder et al. (Child Dev 81(1):376-389, 2010). In this paper we provide a characterisation of the differences between BCR and CFR using a distinction between permanent and nonpermanent features of stories and Lewis/Stalnaker counterfactual logic. The critical difference pertains to how consistency between a story and a conditional antecedent incompatible with a nonpermanent feature of the story is achieved. Basic conditional reasoners simply drop all nonpermanent features of the story. Counterfactual reasoners...

  19. Edited by:

    Amir Goldental; Shoshana Guberman; Roni Vardi; Ido Kanter; Gabriel A. Silva; Yasuhiro Tsubo Ritsumeikan; Ido Kanter; Gonda Interdisciplinary
    doi: 10.3389/fncom.2014.00052 A computational paradigm for dynamic logic-gates in neuronal activity

  20. Correlation between spin structure oscillations and domain wall velocities

    Jakoba Heidler; Matthias Noske; Markus Weig; Stefan Eisebitt; Tolek Tyliszczak; Bartel Van Waeyenberge; Hermann Stoll
    Magnetic sensing and logic devices based on the motion of magnetic domain walls rely on the precise and deterministic control of the position and the velocity of individual magnetic domain walls in curved nanowires. Varying domain wall velocities have been predicted to result from intrinsic effects such as oscillating domain wall spin structure transformations and extrinsic pinning due to imperfections. Here we use direct dynamic imaging of the nanoscale spin structure that allows us for the first time to directly check these predictions. We find a new regime of oscillating domain wall motion even below the Walker breakdown correlated with...

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