A Novel Genetic Algorithm for Evolvable Hardware
- Emanuele Stomeo; Member Ieee; Tatiana Kalganova; Cyrille Lambert
Abstract—Evolutionary algorithms are used for solving search and optimization problems. A new field in which they are also applied is evolvable hardware, which refers to a self-configurable electronic system. However, evolvable hardware is not widely recognized as a tool for solving real-world applications, because of the scalability problem, which limits the size of the system that may be evolved. In this paper a new genetic algorithm, particularly designed for evolving logic circuits, is presented and tested for its scalability. The proposed algorithm designs and optimizes logic circuits based on a Programmable Logic Array (PLA) structure. Furthermore it allows the evolution...
A Guided Search Non-dominated Sorting Genetic Algorithm for the Multi-Objective University Course Timetabling Problem
- Sadaf Naseem Jat; Shengxiang Yang
Abstract. The university course timetabling problem is a typical combinatorial optimization problem. This paper tackles the multi-objective universitycoursetimetablingproblem(MOUCTP)andproposesaguided search non-dominated sorting genetic algorithm to solve the MOUCTP. The proposed algorithm integrates a guided search technique, which uses a memory to store useful information extracted from previous good solutions to guide the generation of new solutions, and two local search schemes to enhance its performance for the MOUCTP. The experimental results based on a set of test problems show that the proposed algorithm is efficient for solving the MOUCTP. 1
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of breast cancer in the Cypriot population
- Andreas Hadjisavvas; Æ Kyriacos Kyriacou; M. A. Loizidou; T. Michael; A. Hadjisavvas; K. Kyriacou; M. A. Cariolou; E. Bashiardes; S. L. Neuhausen; R. F. Newbold; Y. Marcou; M. Daniel; E. Kakouri; P. Papadopoulos; S. Malas
Genetic variation in genes interacting with BRCA1/2 and risk
GENETIC EPIDEMIOLOGY OF BREAST CANCER IN CYPRUS: A CASE-CONTROL STUDY OF DNA REPAIR GENES
- England U. K; Maria Loizidou
Genetic epidemiology of breast cancer in Cyprus: A case-control study of DNA repair genes Ph.D., 2009 The occurrence of early-onset breast cancer (EOBC) has been associated with germline mutations in the BRCA1 and BRCA2 genes. The first aim of this thesis was to evaluate the frequency and distribution of mutations in these genes, in a group of Cypriot women diagnosed with EOBC. Pathogenic mutations were identified in 6 of the 26 unrelated patients. This study supports a strong correlation between the early onset breast cancer phenotype and the presence of pathogenic BRCA1/2 mutations. It is of interest that pathogenic mutations...
Human Sex Chromosomes in Oral and Craniofacial Growth
- Lassi Alvesalo
This paper has been submitted for consideration for inclusion in a Supplement to Archives of Oral Biology. This Supplement arises from a series of papers given at an International Workshop on Oral Growth and Development held in Liverpool on November 26-28, 2007. The papers to be submitted consist of a series of review and new concept papers to be followed by papers outlining new work in each of the areas covered by the reviews.- 2-Human sex chromosomes in oral and craniofacial growth Studies on tooth crown size and structure in families and in individuals with various sex chromosome anomalies have...
School of Engineering and Design Electronic & Computer Engineering Intelligent Genetic Algorithms for Next-Generation Broadband Multi-Carrier CDMA Wireless Networks
- Yang Zhang; Co-supervisor Profyonghua Song
airport. She left us on June 14, 2006. This thesis is dedicated to the memory of my grandma. 11 Table of Contents Abstract....................................................................................... 1
Learning the Dominance in Diploid Genetic Algorithms for Changing Optimization Problems
- Shengxiang Yang
Abstract — Using diploid representation with dominance scheme is one of the approaches developed for genetic algorithms to address dynamic optimization problems. This paper proposes an adaptive dominance mechanism for diploid genetic algorithms in dynamic environments. In this scheme, the genotype to phenotype mapping in each gene locus is controlled by a dominance probability, which is learnt adaptively during the searching progress. The proposed dominance scheme is experimentally compared to two other schemes for diploid genetic algorithms. Experimental results validate the efficiency of the dominance learning scheme. I.
Techniques: Deterministic Crowding Genetic Algorithms and Ant Colony Search Methods
- Munzer Chebbo; Hind Munzer Chebbo
The goal of transmission planning in electric power systems is a robust network which is economical, reliable, and in harmony with its environment taking into account the inherent uncertainties. For reasons of practicality, transmission planners have normally taken an incremental approach and tended to evaluate a relatively small number of expansion alternatives over a relatively short time horizon. In this thesis, two new planning methodologies namely the Deterministic Crowding Genetic Algorithm and the Ant Colony System are applied to solve the long term transmission planning problem. Both optimisation techniques consider a 'green field' approach, and are not constrained by the...
Genomic Imbalances Are Confined to Non-Proliferating Cells in Paediatric Patients with Acute Myeloid Leukaemia and a Normal or Incomplete Karyotype
- Erica Ballabio; Regina Regan; Elisa Garimberti; Jochen Harbott; Jutta Bradtke; Andrea Teigler; Andrea Biondi; Giovanni Cazzaniga; Giovanni Giudici; James S. Wainscoat; Joanna M. Bridger; Samantha J. L. Knight; Sabrina Tosi
Leukaemia is often associated with genetic alterations such as translocations, amplifications and deletions, and recurrent chromosome abnormalities are used as markers of diagnostic and prognostic relevance. However, a proportion of acute myeloid leukaemia (AML) cases have an apparently normal karyotype despite comprehensive cytogenetic analysis. Based on conventional cytogenetic analysis of banded chromosomes, we selected a series of 23 paediatric patients with acute myeloid leukaemia and performed whole genome array comparative genome hybridization (aCGH) using DNA samples derived from the same patients. Imbalances involving large chromosomal regions or entire chromosomes were detected by aCGH in seven of the patients studied. Results...
- Terry Knight; Julie Barnett; Terry Knight (corresponding; Se Nh; Julie Barnett
based on ideas of developing a more capable public and the assumed effects this may have for science. However, such a relationship is yet to be sufficiently explored and recent work indicates that a more involved public may have counterintuitive effects. Using nationally representative survey data for the UK and Northern Ireland, the effects of the publics own beliefs about involvement are explored. Developing the concept of „belief in public efficacy‟, findings suggest those who believe that the public might be able to affect the course of decision making have less approving attitudes towards future applications of genetic science, however,...
Heuristic Search Methods and Cellular Automata Modelling for Layout Design.
- Fadratul Hafinaz Hassan
Spatial layout design must consider not only ease of movement for pedestrians under normal conditions, but also their safety in panic situations, such as an emergency evacuation in a theatre, stadium or hospital. Using pedestrian simulation statistics, the movement of crowds can be used to study the consequences of different spatial layouts. Previous works either create an optimal spatial arrangement or an optimal pedestrian circulation. They do not automatically optimise both problems simultaneously. Thus, the idea behind the research in this thesis is to achieve a vital architectural design goal by automatically producing an optimal spatial layout that will enable...
ALCOHOL-RELATED EXPECTANCIES ARE ASSOCIATED WITH THE D2 DOPAMINE RECEPTOR AND GABAA RECEPTOR β3 SUBUNIT GENES.
- Ross Mcd Young A; Bruce R. Lawford C; Gerald F. X. Feeney B; Terry Ritchie D; Ernest P. Noble D
receptor and GABAA receptor beta3 subunit genes. Psychiatry Research 127(3):171-183. Copyright 2004 Elsevier Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor β3 subunit (GABRB3) genes. Whether such genetic risk manifests itself in stronger alcohol-related outcome expectancies, or in difficulty resisting alcohol, is unknown. In the present study, A1+ (A1A1 and A1A2 genotypes) and A1- (A2A2 genotype) alleles of the DRD2 and G1+ (G1G1 and G1 non-G1 genotypes) and G1- (non-G1 non-G1 genotype) alleles of the GABRB3 were determined in a group of 56 medically-ill patients diagnosed...
- Jianxiang Chi; Erica Ballabio; Xiao-he Chen; Rajko Kušec; Steve Taylor; Deborah Hay; Daniela Tramonti; Nigel J Saunders; Timothy Littlewood; Francesco Pezzella; Jacqueline Boultwood; James S Wainscoat; Christian Sr Hatton; Charles H Lawrie
MicroRNA expression in multiple myeloma is associated with genetic subtype, isotype and survival
Optimized multi-objective design of herringbone micromixers
- Cesar A. Cortes-quiroz; Mehrdad Zangeneh
Abstract A design method which systematically integrates Computational Fluids Dynamics (CFD) with an optimization scheme based on the use of the techniques Design of Experiments (DOE), Function Approximation technique (FA) and Multi-Objective Genetic Algorithm (MOGA), has been applied to the shape optimization of the staggered herringbone micromixer (SHM) at different Reynolds numbers. To quantify the mixing intensity in the mixer a Mixing index is defined on the basis of the intensity of segregation of the mass concentration on the outlet section. Four geometric parameters, i.e., aspect ratio of the mixing channel, ratio of groove depth to channel height, ratio of...
EVOLUTIONARY COMPUTING FOR METALS PROPERTIES MODELLING
- M. F. Abbod; M. Mahfouf; D. A. Linkens
Abstract: During the last decade Genetic Programming (GP) has emerged as an efficient methodology for teaching computers how to program themselves. This paper presents research work which utilises GP for developing mathematical equations for the response surfaces that have been generated using hybrid modelling techniques for predicting the properties of hot deformation of materials. Collected data from the literature and experimental work on aluminium are utilised as the initial training data for the GP to develop the mathematical models under different deformation conditions and compositions.
HYBRID MODELLING METHODOLOGY APPLIED TO MICROSTRUCTURAL EVOLUTION DURING HOT DEFORMATION OF ALUMINIUM ALLOYS
- C. M. Sellars; M. F. Abbod; Q. Zhu; D. A. Linkens
Abstract. This paper considers how data based neurofuzzy modelling techniques for the poorly understood relationships between changing process histories and the evolution of the internal state variables of dislocation density, subgrain size and subgrain boundary misorientation can be combined with physically-based models to investigate the effects of the internal state variables on the flow stress and recrystallisation behaviour. The model uses genetic algorithms to optimise the constants and is validated for data on a range of aluminium-magnesium alloys of both high and commercial purity. It is shown that this hybrid modelling methodology supported by a knowledge base offers a flexible...
Enhanced Cold Tolerance in Transgenic Tobacco Expressing a Chloroplast Omega-3 Fatty Acid Desaturase Gene under the Control of a Coldinducible Promoter
- Plant Science Articles; Mariya Khodakovskaya; Richard Mcavoy; Jeanne Peters; Hao Wu; Yi Li; Yi Li
Enhanced cold tolerance in transgenic tobacco expressing a chloroplast ω-3 fatty acid desaturase gene under the control of a cold inducible promoter. Abstract A new cold-inducible genetic construct was cloned using a chloroplastspecific omega-3-fatty acid desaturase gene (FAD7) under the control of a cold-inducible promoter (cor15a) from Arabidopsis thaliana. RT-PCR confirmed a marked increase in FAD7 expression, in young Nicotiana tabacum (cv. Havana) plants harboring cor15a-FAD7, after a short-term exposure to cold. When young, cold-induced tobacco seedlings were exposed to low-temperature (0.5, 2 or 3.5 o C) for up to 44 days, survival within independent cor15a-FAD7 transgenic lines (40.2 to...
- Ammar Sami Al-dallal
ii Due to rapid growth of the number of Web pages, web users encounter two main problems, namely: many of the retrieved documents are not related to the user query which is called low precision, and many of relevant documents have not been retrieved yet which is called low recall. Information Retrieval (IR) is an essential and useful technique for Web search; thus, different approaches and techniques are developed. Because of its parallel mechanism with high-dimensional space, Genetic Algorithm (GA) has been adopted to solve many of optimization problems where IR is one of them. This thesis proposes searching model...
ACCEPTED FOR PUBLICATION 1 Robust H ∞ Feedback Control for Uncertain Stochastic Delayed Genetic Regulatory Networks with Additive and Multiplicative Noise
- Wei Pan; Zidong Wang; Huijun Gao; Yurong Li; Min Du
Noises are ubiquitous in genetic regulatory networks (GRNs). Gene regulation is inherently a stochastic process because of intrinsic and extrinsic noises that cause kinetic parameter variations and basal rate disturbance. Time-delays are usually inevitable due to different biochemical reactions in such GRNs. In this paper, a delayed stochastic model with additive and multiplicative noises is utilized to describe stochastic GRNs. A feedback gene controller design scheme is proposed to guarantee that the GRN is mean-square asymptotically stable with noise attenuation, where the structure of the controllers can be specified according to engineering requirements. By applying control theory and mathematical tools,...