Mostrando recursos 1 - 20 de 385.315
Vibrio cholerae putative ecotypes as revealed by genetic diversity and virulence genes in the aquatic environment.
Baron, Sandrine; Vandenkoornhuyse, Philippe; Chevallier, S.; Lesné, Jean
Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele.
Smagulova, Fatima; Brick, Kevin; Pu, Yongmei; Sengupta, Uttara; Camerini-Otero, Daniel,; Petukhova, Galina
Cérou, Frédéric; Del Moral, Pierre; Le Gland, François; Lezaud, Pascal
Negative genetic correlations between production traits and head or bony tissues in large all-female rainbow trout (Oncorhynchus mykiss)
Haffray, Pierrick; Bugeon, Jérôme; Pincent, Cédric; Chapuis, Herve; Mazeiraud, Emmanuel; Rossignol, Marie-Noelle; Chatain, Béatrice; Vandeputte, Marc; Dupont-Nivet, Mathilde
Chantier qualité GA
Genetic resistance and innate response to VHSV : a transcriptome analysis in rainbow trout homozygous clones.
Mativet, S.; Prunet, Patrick; Le Guillou, Sandrine; Tiquet, Franck; Letellier, Eric; Boudinot, Pierre; Quillet, Edwige
Genetic parameters for growth and flesh quality traits in large freshwater-reared rainbow trout[i] (Oncorhynchus mykiss[/i]) groups, mass selected or not for growth
Haffray, Pierrick; Pincent, Cédric; Chapuis, Hervé; Petit, Vincent; Bugeon, Jérôme; Choubert, Georges; Chatain, Béatrice; Vandeputte, Marc; Dupont-Nivet, Mathilde
Estudo dos marcadores genéticos dos sistemas CODIS e ESS numa população de indivíduos provenientes de Cabo Verde residente em Lisboa
Resende, Ana; Amorim, António; Silva, Cláudia Vieira da; Ribeiro, Teresa; Porto, Maria João; Santos, Jorge Costa; Costa, Heloísa Afonso
Poster apresentado na II Conferência Nacional do Instituto Nacional de Medicina legal e Ciências Forenses (INMLCF). Universidade de Coimbra, 29-30 Outubro 2015
Posterior parietal cortex lesions severely disrupt spatial learning in DBA mice characterized by a genetic hippocampal dysfunction
Ammassari-Teule, M; Save, E; Marsanich, B,; Thinus-Blanc, C
McDermott, James; Castelli, Mauro; Manzoni, Luca; Kronberger, Gabriel; Jaśkowski, Wojciech; Luke, Sean; White, David R.; Goldman, Brian W.; O'Reilly, Una-May
We present the results of a community survey regarding genetic programming benchmark practices. Analysis shows broad consensus that improvement is needed in problem selection and experimental rigor. While views expressed in the survey dissuade us from proposing a large-scale benchmark suite, we find community support for creating a “blacklist” of problems which are in common use but have important flaws, and whose use should therefore be discouraged. We propose a set of possible replacement problems.
Knowledge mining sensory evaluation data: genetic programming, statistical techniques, and swarm optimization
Vladislavleva, Ekaterina; O'Reilly, Una-May; Veeramachaneni, Kalyan
Knowledge mining sensory evaluation data is a challenging process due to extreme sparsity of the data, and a large variation in responses from different members (called assessors) of the panel. The main goals of knowledge mining in sensory sciences are understanding the dependency of the perceived liking score on the concentration levels of flavors’ ingredients, identifying ingredients that drive liking, segmenting the panel into groups with similar liking preferences and optimizing flavors to maximize liking per group. Our approach employs (1) Genetic programming (symbolic regression) and ensemble methods to generate multiple diverse explanations of assessor liking preferences with confidence information;...
Iliescu, Ciprian; Xu, Guolin; Yu, Fang; Tresset, Guillaume; Tong, Wen Hao; Bălan, Cătălin Mihai; Yu, Hanry
The paper presents a dielectrophoretic method for cell patterning using dielectrophoretic–hydrodynamic trap. A distinctive characteristic of the device is that the dielectrophoretic (DEP) force is generated using a structure that combines conventional electrode-based DEP (eDEP) with insulator-based DEP method (iDEP). The conventional eDEP force is generated across the microfluidic channel between a top plate indium tin oxide electrode and a thin CrAu electrode. Meantime, an isolating cage built from SU8 photoresist around the thin electrode modifies the electric field generating an iDEP force. The cells that are flowing through a microfluidic channel are trapped in the SU8 cage by the...
Abdel-Kafy, E.M.; Darwish, S.F.; ElKhishin, D.
The Myostatin (MSTN), or Growth and Differentiation Factor 8 (GDF8), gene has been implicated in the double muscling phenomenon, in which a series of mutations render the gene inactive and unable to properly regulate muscle fibre deposition. Single nucleotide polymorphisms (SNPs) in the MSTN gene have been correlated to production traits, making it a candidate target gene to enhance livestock and fowl productivity. This study aimed to assess any association of three SNPs in the rabbit MSTN gene (c.713T>A in exon 2, c.747+34C>T in intron 2, and c.*194A>G in 3’-untranslated region) and their combinations, with carcass, production and reproductive traits....
Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression
Malki, K; Tosto, MG; Mouriño-Talín, H; Rodríguez-Lorenzo, S; Pain, O; Jumhaboy, I; Liu, T; Parpas, P; Newman, S; Malykh, A; Carboni, L; Uher, R; McGuffin, P; Schalkwyk, LC; Bryson, K; Herbster, M
Response to antidepressant (AD) treatment may be a more polygenic trait than previously hypothesized, with many genetic variants interacting in yet unclear ways. In this study we used methods that can automatically learn to detect patterns of statistical regularity from a sparsely distributed signal across hippocampal transcriptome measurements in a large-scale animal pharmacogenomic study to uncover genomic variations associated with AD. The study used four inbred mouse strains of both sexes, two drug treatments, and a control group (escitalopram, nortriptyline, and saline). Multi-class and binary classification using Machine Learning (ML) and regularization algorithms using iterative and univariate feature selection methods,...
Using next-generation sequencing to understand the aetiology of dystonia and other neurological diseases
This thesis presents my work using both next-generation and traditional genetic techniques aimed at further clarifying the aetiology of hereditary neurological disorders, with a particular focus on dystonia. A large part of this was focused on the identification, clinical phenotyping, and genetic analysis of kindreds with neurological disease inherited in a Mendelian fashion but for which no causal mutation had yet been identified. My work led directly to the discovery of two new dystonia genes, ANO3 and HPCA, and the identification of two novel phenotypes for the known disease-associated genes, ATM and NUBPL. Mutations in a third novel gene, SLC25A46,...
O magmatismo de Arco Continental Pré-Colisional (790 Ma) e a reconstituição espaço-temporal do regime transpressivo (650 Ma) no Complexo Várzea do Capivarita, Sul da Província Mantiqueira
Martil, Mariana Maturano Dias
Este estudo foca no Complexo Várzea do Capivarita (CVC), localizado no sul da Província da Mantiqueira (PM), Brasil. A fim de investigar a evolução geológica do CVC, uma abordagem multi-disciplinar foi utilizada, incluindo geologia de campo, geologia estrutural, petrografia, geoquímica de elementos maiores e traços, isótopos de Sr-Nd e geocronologia U-Pb em zircão (LA-MC-ICP-MS e SHRIMP). O complexo compreende uma variedade de orto- e paragnaisses de composição e idade diversa. Volumes subordinados de sienitos sintectônicos também perfazem o CVC. A deformação é particionada em zonas de cisalhamento do tipo thrust (D1) e transcorrentes (D2), o que sugere tectônica transpressiva. O...
Isolation and molecular characterization of Mycobacterium bovis causing pulmonary tuberculosis and epistaxis in a Thoroughbred horse
Hlokwe, Tiny Motlatso; Sutton, David; Page, Patrick; Michel, Anita Luise
Background: Tuberculosis caused by Mycobacterium bovis (M. bovis) is very uncommon in horses worldwide. Case presentation: In the current study, an eight-year-old male Thoroughbred in good body condition was admitted to the Equine Clinic at the Onderstepoort Veterinary Academic Hospital in 2005 due to bilateral epistaxis accompanied by coughing. Routine examinations were conducted to determine the cause of the condition. Endoscopic examination revealed the major source of the epistaxis as the trachea, whereas thoracic radiography indicated the presence of a primary pulmonary mass. M. bovis was isolated from a broncho-alveolar lavage (BAL) sample collected. The pulmonary mass reduced in size three...
Sarata, Aman K
[Excerpt] This report explains when an employer may request genetic information from an employee as part of a wellness program with an inducement attached to participation and the requirements the employer must follow when doing so. It also discusses the EEOC’s proposed rule whereby a spouse may be incentivized to provide his or her own medical information, which is also the employee’s genetic information, as part of a wellness program.
Estudio de las praderas de fanerógamas marinas en Baja California Sur (México): ciclo de vida y estrategias reproductivas de Zostera marina, Halodule wrightii y Halophila decipiens
Santa-María Gallegos, Noé Abraham
Se analizó el comportamiento de la biomasa, densidad de haces, morfología y floración de tres especies de fanerógamas marinas Zostera marina L., Halodule wrightii Ascherson y Halophila decipiens Ostenfeld, en la península de Baja California Sur, una región en la que enfrentan condiciones ambientales cercanas a sus límites de tolerancia. El trabajo se compone de dos partes, la primera consiste de cuatro estudios sobre Zostera marina L., especie de afinidad templado-fría, que es dominante en la costa del Pacífico norte, y la segunda que se enfoca al estudio de Halodule wrightii y Halophila decipiens, especies de afinidad tropical que se...
Sarata, Amanda K
[Excerpt] Congress has considered, at various points in time, numerous pieces of legislation that relate to genetic and genomic technology and testing. These include bills addressing genetic discrimination in health insurance and employment; precision medicine; the patenting of genetic material; and the oversight of clinical laboratory tests (in vitro diagnostics), including genetic tests. The focus on these issues signals the growing importance of public policy issues surrounding the clinical and public health implications of new genetic technology. As genetic technologies proliferate and are increasingly used to guide clinical treatment, these public policy issues are likely to continue to garner attention....
Maternity and Paternity Leave: A Guided Approach for Employers With Employees Utilizing Surrogate Births and Other Reproductive Methods
[Excerpt] Forty-one-year-old mother Ms. Kara Krill (“Krill”) filed suit in the United States District Court for the District of Massachusetts on August 26, 2011 against her former employer, Cubist Pharmaceuticals, Inc. (Cubist), for refusing to provide Krill with certain fringe employment benefits, including “thirteen weeks of paid maternity leave for the birth and care of a child.” These employment benefits were originally stipulated in Krill’s employment contract with Cubist. Krill has suffered from Asherman’s syndrome since the birth of her first child in June 2007. According to Krill’s complaint, Asherman’s syndrome is a “reproductive disability that substantially and prematurely limits...