Mostrando recursos 1 - 20 de 23.262
Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues
Alvarez-Ginarte, Y. M.; Crespo-Otero, R.; Marrero-Ponce, Y.; Noheda Marín, Pedro; García de la Vega, J. M.; Montero-Cabrera, L. A.; Ruiz García, J. A.; Caldera-Luzardo, J. A.; Alvarado, Y. J.
Predictive quantitative structure-activity relationship (QSAR) models of anabolic and androgenic activities for the testosterone and dihydrotestosterone steroid analogues were obtained by means of multiple linear regression using quantum and physicochemical molecular descriptors (MD) as well as a genetic algorithm for the selection of the best subset of variables. Quantitative models found for describing the anabolic (androgenic) activity are significant from a statistical point of view: R2 of 0.84 (0.72 and 0.70). A leave-one-out cross-validation procedure revealed that the regression models had a fairly good predictability [q2 of 0.80 (0.60 and 0.59)]. In addition, other QSAR models were developed to predict...
Understanding connectivity over different spatial and temporal scales is fundamental for biodiversity conservation and management. The Amazonian rainforest, one of the most diverse biodiversity hotspots, has experienced dramatic range contractions and expansions due to Pleistocene climate oscillations, and its human-induced fragmentation has accelerated at an unparalleled pace in the course of the Anthropocene. In this context, epiphytes, with their relatively short life-cycles, offer an ideal model to investigate the impact of past and present fragmentation on patterns of genetic structure and diversity. Due to the necessity to switch from one host tree to another, or from one leaf to another,...
Genetic diversity among Korean Candida albicans bloodstream isolates: assessment by multilocus sequence typing and restriction endonuclease analysis of genomic DNA by use of BssHII.
Shin, Jong Hee; Bougnoux, Marie-Elisabeth; D'Enfert, Christophe; Kim, Soo Hyun; Moon, Chang-Jin; Joo, Min Young; Lee, Kyungwon; Kim, Mi-Na; Lee, Hye Soo; Shin, Myung Geun; Suh, Soon Pal; Ryang, Dong Wook
BONNET, Anna; Gassiat, Elisabeth; LEVY LEDUC, Céline
Motivated by applications in genetic fields, we propose to estimate the heritability in high-dimensional sparse linear mixed models. The heritability determines how the variance is shared between the different random components of a linear mixed model. The main novelty of our approach is to consider that the random effects can be sparse, that is may contain null components, but we do not know either their proportion or their positions. The estimator that we consider is strongly inspired by the one proposed by Pirinen, Donnelly and Spencer (2013), and is based on a maximum likelihood approach. We also study the theoretical...
Walden, Helen; Muqit, Miratul M.K.
Biochemical alterations found in the brains of Parkinson's disease (PD) patients indicate that cellular stress is a major driver of dopaminergic neuronal loss. Oxidative stress, mitochondrial dysfunction, and ER stress lead to impairment of the homeostatic regulation of protein quality control pathways with a consequent increase in protein misfolding and aggregation and failure of the protein degradation machinery. Ubiquitin signalling plays a central role in protein quality control; however, prior to genetic advances, the detailed mechanisms of how impairment in the ubiquitin system was linked to PD remained mysterious. The discovery of mutations in the α-synuclein gene, which encodes the...
Narayanaswami, Pushpa; Dubinsky, Richard; Wang, David; Gjorvad, Gina; David, William Samuel; Finder, Jonathan; Smith, Benn; Cheng, Jianguo; Shapiro, Frederic; Mellion, Michelle; Spurney, Christopher; Wolff, Jodi; England, John
The muscular dystrophies (MDs) are a heterogeneous group of genetically determined myopathies. Identification of underlying genetic defects has demonstrated that MDs exhibit significant phenotypic and genetic heterogeneity. One genetic mutation can lead to a variety of phenotypes while different genetic mutations can manifest similar phenotypes; therefore MDs are challenging to diagnose. A major goal of health care reform in the United States is to replace the traditional fee-for-service model with a value-based system, which incentivizes high-quality care. Quality measurement is an integral and necessary part of this process.1,2 While standardizing care of MDs can be challenging because of their heterogeneity, common...
Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine
Narayanaswami, Pushpa; Weiss, Michael; Selcen, Duygu; David, William Samuel; Raynor, Elizabeth M; Carter, Gregory; Wicklund, Matthew; Barohn, Richard J.; Ensrud, Erik; Griggs, R. C.; Gronseth, Gary; Amato, Anthony A.
Objective: To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs). Methods: Systematic review and practice recommendation development using the American Academy of Neurology guideline development process. Results: Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic background of the population studied. Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, extramuscular involvement, and muscle biopsy findings. The few published therapeutic trials were not designed to establish clinical efficacy of any...
Correlación entre los azúcares declarados en los rótulos de bebidas analcohólicas y los determinados experimentalmente
Olmedo, Luciana; Henning, María Florencia; García, Silvia; Papalardo, Brenda; Malpeli, Agustina; Bisceglia, María Gabriela; Pellón Maisón, Magalí
La obesidad es una enfermedad multifactorial con un importante componente genético, pero en la mayoría de los casos se produce como consecuencia de un desbalance energético entre calorías consumidas y calorías gastadas. El consumo excesivo de bebidas azucaradas contribuye de manera significativa al aumento del consumo calórico y por lo tanto, al desarrollo de la obesidad. Existe controversia sobre el impacto negativo diferencial que ejercen cada uno de los edulcorantes calóricos utilizados en la industria de bebidas, como el jarabe de maíz de alta fructosa (JMAF), la sacarosa o la glucosa. Pese al impacto negativo del consumo de altos niveles...
Reproductive performance, retention rate, and age at the third parity according to growth rate and age at first mating in the gilts with a modern genotype
Faccin, Jamil Elias Ghiggi; Laskoski, Fernanda; Lesskiu, Paulo Emílio; Paschoal, Aline Fernanda Lopes; Mallmann, André Luis; Bernardi, Mari Lourdes; Mellagi, Ana Paula Gonçalves; Wentz, Ivo; Bortolozzo, Fernando Pandolfo
Background: Gilts represent the largest category (18-20%) of female pigs in a breeding herd. Under field conditions, the amplitude of growth rate and age at the first mating of gilts are remarkably higher than the recommendations made by the genetic companies. There are several studies that have considered the management of these animals starting from their introduction to the herd till the mating. It has been noted that the genetic selection constantly promotes evolution that may change certain traits of these animals. However, there is a lack of the studies that evaluate the management strategies suitable for the modern sows....
DePas, W.; Bergkessel, M.; Newman, D. K.
The incidence of nontuberculous mycobacterial (NTM) infections in cystic fibrosis (CF) patients is increasing, with some CF clinics in the US reporting NTM prevalence upwards of 25%. In addition, the current treatment regimen for NTM involves long courses of antibiotic cocktails that demonstrate limited efficacy and cause frequent and serious side effects. Mycobacterium abscessus, in particular, is difficult to treat and correlates with a more rapid decline in lung function compared to Mycobacterium avium complex. Studies with zebrafish and human cell cultures have demonstrated that M. abscessus is more virulent when aggregated into cord-like biofilms, in part because of the decreased ability...
Genetic and Molecular Analysis of Phosphorus Homeostasis Regulatory Genes. A Key Nutrient for Aquaculture Sustainability
Suarez-Bregua, P.; Torres-Nunez, E.; Prober, D.; Cerda-Reverter, J. M.; Guerreiro, P. M.; Du, S. J.; Canestro, C.; Rotllant, J.
Grassi, Flávio; Schimit, Pedro; Pereira, Fabio,
Part 3: Knowledge-Based PLM
Combining Genetic Algorithm with Constructive and Refinement Heuristics for Solving the Capacitated Vehicle Routing Problem
Lima, Stanley; Santos, Renato; Araujo, Sidnei,; Schimit, Pedro
Part 3: Knowledge-Based PLM
Hypsipyla grandella (Zeller 1848) (Lepidoptera: Pyralidae: Phycitinae) en plantaciones de Cedrela odorata en Colombia
Gómez Piñerez, Luz Miryam
Hypsipyla grandella (Lepidoptera: Pyralidae), es uno de los principales limitantes de plantaciones comerciales de Cedrela odorata En la presente investigación se analizaron aspectos biológicos, de distribución geográfica, y genéticos (identidad molecular, flujo de genes y distribución de haplotipos) de este insecto asociados a plantaciones de C. odorata en Colombia, con el fin de conocer y entender el insecto como limitante en estos plantíos y aportar información básica que sirva para planear y ejecutar actividades de vigilancia y manejo de este insecto. Los especímenes se recolectaron en plantaciones C. odorata distribuidas en 6 localidades, ubicadas en los departamentos de Antioquia, Choco,...
Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
Padmanabhan, Sandosh; Joe, Bina
Compelling evidence for the inherited nature of essential hypertension has led to extensive research in rats and humans. Rats have served as the primary model for research on the genetics of hypertension resulting in identification of genomic regions that are causally associated with hypertension. In more recent times, genome-wide studies in humans have also begun to improve our understanding of the inheritance of polygenic forms of hypertension. Based on the chronological progression of research into the genetics of hypertension as the "structural backbone," this review catalogs and discusses the rat and human genetic elements mapped and implicated in blood pressure...
Evaluation of Alternate DNA Structures at c-MYC Fragile Region Associated with t(8;14) Translocation And Role of GNG Motifs During G-quadruplex Formation
Watson-Crick paired B-form DNA is the genetic material in most of the biological systems. Integrity of DNA is of utmost importance for the normal functioning of any organism. Various environmental factors, chemicals and endogenous agents constantly challenge integrity of the genome resulting in mutagenesis. Over the past few decades multiple reports suggest that DNA can adopt alternative conformations other than the right handed double helix. Such structures occur within the context of B-DNA as sequence dependent structural variations and are facilitated by free energy derived from negative supercoiling, which may be generated during physiological processes like transcription, replication, etc. or...
Leroy, Grégoire; Hedan, Benoit; Andre,, C.
Leroy, Grégoire; Baloche, Guillaume,; Danchin-Burge, Coralie; Raoul, J.; François, Liesbeth
Polyploidy and interspecific hybridization: partners for adaptation, speciation and evolution in plants
ALIX, Karine; GERARD, PIERRE; Schwarzacher, Trude; Heslop-Harrison, J. S. (Pat)
Background Polyploidy or whole-genome duplication is now recognized as being present in almost all lineages of higher plants, with multiple rounds of polyploidy occurring in most extant species. The ancient evolutionary events have been identified through genome sequence analysis, while recent hybridization events are found in about half of the world’s crops and wild species. Building from this new paradigm for understanding plant evolution, the papers in this Special Issue address questions about polyploidy in ecology, adaptation, reproduction and speciation of wild and cultivated plants from diverse ecosystems. Other papers, including this review, consider genomic aspects of polyploidy. Approaches Discovery...
Milios, Dimitrios; Stamelos, Ioannis; Chatzibagias, Christos
Part 14: Computational Intelligence in Software Engineering (CISE) Workshop