Modifying the Genetic Regulation of Bone and Cartilage Cells and Associated Tissue by EMF Stimulation Fields and Uses Thereof - Goodwin, Thomas J.; Shackelford, Linda C.
An apparatus and method to modify the genetic regulation of mammalian tissue, bone, or any combination. The method may be comprised of the steps of tuning at least one predetermined profile associated with at least one time-varying stimulation field thereby resulting in at least one tuned time-varying stimulation field comprised of at least one tuned predetermined profile, wherein said at least one tuned predetermined profile is comprised of a plurality of tuned predetermined figures of merit and is controllable through at least one of said plurality of tuned predetermined figures of merit, wherein said plurality of predetermined tuned figures of...
Phylogeography of a species complex of lowland Neotropical rain forest trees (Carapa, Meliaceae) - Scotti-Saintagne, Caroline; Dick, Christopher W.; Caron, Henri; Vendramin, Giovanni G.; Guichoux, Erwan; Buonamici, Anna; Duret, Caroline; Sire, Pierre; Valencia, Renato; Lemes, Maristerra R.; Gribel, Rogério; Scotti, Ivan
[b]Aim[/b][br/] Many tropical tree species have poorly delimited taxonomic boundaries and contain undescribed or cryptic species. We examined the genetic structure of a species complex in the tree genus Carapa in the Neotropics in order to evaluate age, geographic patterns of diversity and evolutionary relationships, and to quantify levels of introgression among currently recognized species.[br/] [br/] [b]Location[/b][br/] Lowland moist forests in the Guiana Shield, the Central and Western Amazon Basin, Chocó and Central America.[br/] [br/] [b]Methods[/b][br/] Genetic structure was analysed using seven nuclear simple sequence repeats (nuSSR), five chloroplast SSRs (cpSSR), and two chloroplast DNA (cpDNA) intergenic sequences (trnH-psbA and...
RaBoT: a rarefaction-by-bootstrap method to compare genome-wide levels of genetic diversity - Scotti, Ivan; Montaigne, William; Cseke, Klara; Traissac, Stephane
No efficient method is available to compare multi-locus estimates of diversity while taking into account inter-locus and inter-population stochastic variance. The advent of genome scan approaches makes the development of such tests absolutely necessary. We developed a method to compare genome-wide diversity estimates while taking into account-and factoring out-variation in census size and making use of inter-locus variance to assess significance of differences in diversity levels. An approach based on rarefaction with bootstrap re-sampling (RaBoT) was implemented into a test of multi-locus comparison of diversity coded in R. The properties of the test were studied by applying it to simulated...
Highly local environmental variability promotes intrapopulation divergence of quantitative traits: an example from tropical rain forest trees - Brousseau, Louise; Bonal, Damien; Cigna, Jérémy; Scotti, Ivan
In habitat mosaics, plant populations face environmental heterogeneity over short geographical distances. Such steep environmental gradients can induce ecological divergence. Lowland rainforests of the Guiana Shield are characterized by sharp, short-distance environmental variations related to topography and soil characteristics (from waterlogged bottomlands on hydromorphic soils to well-drained terra firme on ferralitic soils). Continuous plant populations distributed along such gradients are an interesting system to study intrapopulation divergence at highly local scales. This study tested (1) whether conspecific populations growing in different habitats diverge at functional traits, and (2) whether they diverge in the same way as congeneric species having different...
Permanent Genetic Resources added to Molecular Ecology Resources Database 1 June 2010 - 31 July 2010 - ANDRIS, MALVINA; ARADOTTIR, GUDBJORG I.; ARNAU, G.; AUDZIJONYTE, ASTA; BESS, EMILIE C.; Bonadonna, Francesco; Bourdel, G.; Bried, Joël; BUGBEE, GREGORY J.; Burger, P. A.; CHAIR, H.; CHARRUAU, P. C.; CIAMPI, A. Y.; COSTET, L.; DeBARRO, PAUL J.; Delatte, H.; Dubois, Marie-Pierre; ELDRIDGE, MARK D. B.; ENGLAND, PHILLIP R.; ENKHBILEG, D.; FARTEK, B.; GARDNER, MICHAEL G.; GRAY, KAREN-ANN; GUNASEKERA, RASANTHI M.; HANLEY, STEVEN J.; HAVIL, NATHAN; HEREWARD, JAMES P.; HIRASE, SHOTARO; HONG, YAN; Jarne, Philippe; JIANFEI, QI; JOHNSON, REBECCA N.; KANNO, MANAMI; KIJIMA, AKIHIRO; KIM, HYUN C.; KIM, KWAN S.; Kim, Woo-Jin; LaRUE, ELIZABETH; LEE, JANG W.; LEE, JEONG-HO; LI, CHUNHONG; LIAO, MINGHUI; LO, NATHAN; LOWE, ANDREW J.; Malausa, Thibaut; Malé, Pierre-Jean G.; MARKO, MICHELLE D.; Martin, Jean-François; MESSING, RUSSELL; MILLER, KAREN J.; MIN, BYEONG-WHA; MYEONG, JEONG-IN; NIBOUCHE, S.; NOACK, ANN E.; NOH, JAE K.; Orivel, Jérôme; PARK, CHOUL-JI; PETRO, D.; PRAPAYOTIN-RIVEROS, KITTIPATH; Quilichini, Angélique; Reynaud, B.; RIGINOS, CYNTHIA; RISTERUCCI, A. M.; ROSE, HARLEY A.; SAMPAIO, I.; SILBERMAYR, K.; SILVA, M. B.; TERO, N.; THUM, RYAN A.; VINSON, C. C.; VORSINO, ADAM; VOSSBRINCK, CHARLES R.; Walzer, C.; WHITE, JASON C.; WIECZOREK, ANIA; WRIGHT, MARK
$rec.titulo - Bernauer, Julie
The biological function of macromolecules, such as proteins and nucleic acids, relies heavily on their interactions with their partners. The prediction of how molecules interact and how they can create large assemblies acting as nanomachines is essential for our understanding of biology but also for therapeutics and nanotechnology design.
Blind challenges in biology, such as the CAPRI worldwide experiment for docking, have shown that in silico studies and simulations, mainly using physics-based potentials and techniques, could give structural insights in atomic detail. They might however be of very limited accuracy, particularly in predicting the native molecular structure of proteins, RNAs and...
Eliminación de contaminantes emergentes del agua mediante ozonación solar fotocatalítica - Quiñones Murillo, Diego Hernán
La detección de contaminantes emergentes, refractarios a las técnicas biológicas y fisicoquímicas de tratamiento que convencionalmente se aplican en las estaciones depuradoras de aguas residuales, representa un riesgo potencial que amenaza la salud de las especies que se benefician del agua. Especialmente, los productos farmacéuticos y de uso agrícola centran mayor atención, puesto que son consumidos en grandes cantidades a nivel mundial y se detectan con mayor frecuencia en el agua. A la mayoría de estos compuestos se les atribuyen efectos de mutación genética, carcinogénesis, defectos congénitos y disrupción del sistema endocrino. En esta Tesis Doctoral se ha estudiado la...
Antifungal Susceptibility In Vitro Determined by the Etest(r) for Candida Obtained from the Oral Cavity of Irradiated and Elderly Individuals - Freitas,Edimilson Martins de; Monteiro,Larissa Cavalcanti; Fernandes,Michelle Bonfim da Silva; Martelli Junior,Hercílio; Bonan,Paulo Rogério Ferreti; Nobre,Sergio Avelino Mota
This study aimed to evaluate the in vitro antifungal susceptibility of Candida species of head-and-neck-irradiated patients (Group 1), non-institutionalized (Group 2) and institutionalized elders (Group 3) using Etest(r) methodology. Candida was isolated from saliva and presumptively identified by CHROMagar Candida(r), confirmed by morphological criteria, carbohydrate assimilation (API 20C AUX(r)) and genetic typing (OPE 18). The collection was made from 29, 34 and 29 individuals (Groups 1, 2 and 3, respectively) with 67 isolates. Etest(r) strips (ketoconazole, itraconazole, fluconazole, amphotericin B and flucytosine) on RPMI (Roswell Park Memorial Institute) agar, on duplicate, were used to evaluate susceptibility. ATTC (American Type Culture...