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Nomenclatura Unesco > (24) Ciencias de la Vida > (2409) Genética
(2409.01) Embriología (2409.02) Ingeniería genética
(2409.03) Genética de poblaciones (2409.90) Citogenética animal
(2409.91) Genética del desarrollo (2409.92) Genética molecular de plantas
(2409.93) Genética molecular (2409.94) Genética molecular de levaduras
(2409.99) Otras (especificar)

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(3201.02) Genética clínica (2410.07) Genética humana
(2407.02) Citogenética

Mostrando recursos 1 - 20 de 217,346

1. Investigación biomédica, tratamiento de muestras genéticas humanas y biobancos - Navarro Caballero, Teresa María

2. ¿Es necesario un acuerdo internacional en torno al diagnóstico genético preimplantacional (DGP)? - Jiménez González, Joaquín

3. Internet, genética y bioderecho. Una aproximación a las pruebas genéticas por internet: su proliferación, cese y regulación - Cárcar Benito, Jesús Esteban

4. Cálculo dimensional óptimo de una plata forma paralela tipo Stewart –Gough para aplicaciones pedagógicas usando algoritmos genéticos - Peña Cortés, César Augusto; Yime Rodríguez, Eugenio; Banfield, Ilka
En este artículo se propone el diseño óptimo de una plataforma paralela tipo Stewart-Gough que cubre un espacio de trabajo esférico. El cálculo de las dimensiones del robot se realizó por medio de técnicas de algoritmos genéticos. Ilustra los cálculos de cinemática inversa y del espacio de trabajo. Esta plataforma esta diseñada para aplicaciones pedagógicas en las áreas de teleoperación, control, visión y automatización usando robótica paralela. La plataforma experimental puede ser operada remotamente por usuarios de diversas universidades utilizando un lenguaje de programación bastante intuitivo y común.

5. Spatial heterogeneity in the Mediterranean Biodiversity Hotspot affects barcoding accuracy of its freshwater fishes - Geiger, Matthias F.; Herder, Fabian; Monaghan, Michael T.; Almada, Vítor Carvalho; Barbieri, Roberta; Bariche, Michel; Berrebi, Patrick; Bohlen, Jörg; Casal-Lopez, Miriam; Delmastro, Giovanni B.; Denys, Gäel P. J.; Dettai, Agnès; Doadrio, Ignacio; Kalogianni, Elena; Kärst, Heiko; Kottelat, Maurice; Kovacic, Marcelo; Laporte, Martin; Lorenzoni, Massimo; Marcic, Zoran; Özulug, Müfit; Perdices, Anabel; Perea, Silvia; Persat, Henri; Porcellotti, Stefano; Puzzi, Cesare; Robalo, Joana Isabel; Sanda, Radek; Schneider, Michael; Slechtova, Vendula; Stumboudi, Maria; Walter, Simon; Freyhof, Jörg
Incomplete knowledge of biodiversity remains a stumbling block for conservation planning and even occurs within globally important Biodiversity Hotspots (BH). Although technical advances have boosted the power of molecular biodiversity assessments, the link between DNA sequences and species and the analytics to discriminate entities remain crucial. Here, we present an analysis of the first DNA barcode library for the freshwater fish fauna of the Mediterranean BH (526 spp.), with virtually complete species coverage (498 spp., 98% extant species). In order to build an identification system supporting conservation, we compared species determination by taxonomists to multiple clustering analyses of DNA barcodes for 3165 specimens. The congruence of...

6. Genetic status, source and establishment risk of the giant tiger shrimp (penaeidae: penaeus monodon), an invasive species in colombian caribbean waters - AGUIRRE-PABÓN, J.C.; OROZCO BERDUGO, G. Jr.; NARVÁEZ BARANDICA, J.C.

7. Copper is required for oncogenic BRAF signaling and tumorigenesis - Brady, Donita C.; Crowe, Matthew S.; Turski, Michelle L.; Hobbs, G. Aaron; Yao, Xiaojie; Chaikuad, Apirat; Knapp, Stefan; Xiao, Kunhong; Campbell, Sharon L.; Thiele, Dennis J.; Counter, Christopher M.
The BRAF kinase is mutated, typically V600E, to induce an active oncogenic state in a large fraction of melanoma, thyroid, hairy cell leukemia, and to a lesser extent, a wide spectrum of other cancers1,2. BRAFV600E phosphorylates and activates the kinases MEK1 and MEK2, which in turn phosphorylate and activate the kinases ERK1 and ERK2, stimulating the MAPK pathway to promote cancer3. Targeting MEK1/2 is proving to be an important therapeutic strategy, as a MEK1/2 inhibitor provides a survival advantage in metastatic melanoma4, which is increased when co-administered with a BRAFV600E inhibitor5. In this regard, we previously found that copper (Cu)...

8. Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons - Chung, Chee Yeun; Khurana, Vikram; Auluck, Pavan K.; Tardiff, Daniel F.; Mazzulli, Joseph R.; Soldner, Frank; Baru, Valeriya; Lou, Yali; Freyzon, Yelena; Cho, Sukhee; Mungenast, Alison E.; Muffat, Julien; Mitalipova, Maisam; Pluth, Michael D; Jui, Nathan T.; Schüle, Birgitt; Lippard, Stephen J.; Tsai, Li-Huei; Krainc, Dimitri; Buchwald, Stephen L.; Jaenisch, Rudolf; Lindquist, Susan
The induced pluripotent stem (iPS) cell field promises a new era for in vitro disease modeling. However, identifying innate cellular pathologies, particularly for age-related neurodegenerative diseases, has been challenging. Here, we exploited mutation correction of iPS cells and conserved proteotoxic mechanisms from yeast to human to discover and reverse phenotypic responses to α-Synuclein (αSyn), a key protein involved in Parkinson’s disease (PD). We generated cortical neurons from iPS cells of patients harboring αSyn mutations, who are at high risk of developing PD dementia. Genetic modifiers from unbiased screens in a yeast model of αSyn toxicity led to identification of early...

9. Yeast reveal a “druggable” Rsp5/Nedd4 Network that Ameliorates α–Synuclein Toxicity in Neurons - Tardiff, Daniel F.; Jui, Nathan T.; Khurana, Vikram; Tambe, Mitali A.; Thompson, Michelle L.; Chung, Chee Yeun; Kamadurai, Hari B.; Kim, Hyoung Tae; Lancaster, Alex K.; Caldwell, Kim A.; Caldwell, Guy A.; Rochet, Jean-Christophe; Buchwald, Stephen L.; Lindquist, Susan
α–synuclein (α-syn) is a small lipid binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerative disease. Using unbiased phenotypic screens as an alternative to target-based approaches, we discovered an N-aryl benzimidazole (NAB) that strongly and selectively protected diverse cell-types from α-syn toxicity. Three chemical genetic screens in wild-type yeast cells established that NAB promoted endosomal transport events dependent on the E3 ubiquitin ligase, Rsp5/Nedd4. These same steps were perturbed by α–syn itself. Thus, NAB identifies...

10. Genetic composition of social groups influences male aggressive behaviour and fitness in natural genotypes of Drosophila melanogaster - Saltz, Julia B.

11. A heuristic model on the role of plasticity in adaptive evolution: plasticity increases adaptation, population viability and genetic variation - Gomez-Mestre, Ivan; Jovani, Roger

12. Estudio genético de la maduración del fruto en melón en la línea isogénica SC3-5-1 - Vegas Renedo, Juan
La maduración de los frutos es un proceso fisiológico complejo y altamente regulado en el que se producen una serie de cambios bioquímiccos en el fruto: color, aroma, estructura del mismo; hasta el completo desarrollo del fruto maduro. Este proceso es regulado principalmente por el etileno en frutos climatéricos, mientras que en el caso de los frutos no climatéricos se desconoce el mecanismo de regulación aunque se ha demostrado el papel de otras hormonas como las auxinas, los brasinoesteroides y el ácido abcísico. La coexistencia en melón de variedades climatéricas y no climatéricas junto con disponibilidad de un gran número...

13. Preliminary genetic structure of the endemic Montseny brook newt, Calotriton arnoldi inferred from mtDNA and nDNA - Valbuena-Ureña, E.; Amat, F.; Carranza, Salvador
The Montseny brook newt Calotriton arnoli, endemic to the Montseny massif (NE Iberian Peninsula), is catalogued as critically endangered by the IUCN. This rare and threatened species inhabits oligotrophic, cold (below 15°C) fast running brooks. Given its small population size and small distribution area, management measures should be considered. Genetic studies are a very useful tool and therefore are widely implemented in many conservation programs. Two mitochondrial (ND4 and Cyt b) and one nuclear (RAG-1) marker from 105 individuals were used to infer the population genetic structure and phylogeography of this species, covering its total distribution range. Both mitochondrial and nuclear markers confirm the differentiation between C. asper and...

14. Phylogeography of the geckos of the genus Haemodracon (Bauer, Good and Branch, 1997) endemic to the Socotra Archipelago (NW Indian Ocean) - Simón, Marc; Gómez-Díaz, Elena; Mora, Elisa; Fasola, Mauro; Pupin, Fabio; Sindaco, Roberto; Carranza, Salvador
Despite the biogeographical and evolutionary interest of Socotra Archipelago as a part of the Gondwana supercontinent, very little is known about the origin, the tempo and the speciation mode its unique fauna (vicariance, colonization or intra-island diversification). The genus Haemodracon from Socotra include two species of endemic geckos, H. trachyrhinus and H. ribeckii, which are distributed in three different Socotran Islands (Socotra, Darsa and Samha). The two taxa are mostly found in sympatry and greatly differ in their behaviour, morphology and ecology. Yet we know little about their origin and evolutionary relationships, and in the particular case of H. trachyrhinus (Boulenger, 1899), it has never been included in...

15. Parasitic species of the Genus Blastodinium (Blastodiniphyceae) are Peridinioid Dinoflagellates - Skovgaard, Alf; Massana, Ramon; Saiz, Enric
The taxonomic position of Blastodinium navicula Chatton and B. contortum Chatton, parasites of marine copepods, was investigated on the basis of morphological observations and molecular data. The life cycle of Blastodinium includes a parasitic stage, a trophont, and free-swimming dinospores. The individual cells in the trophont, as well as the dinospores that they produced, were thecate. Dinospores of B. contortum and B. navicula had peridinioid plate tabulation formula, demonstrating an affiliation to the order Peridiniales Heackel (subdivision Dinokaryota Fensome et al.). This systematic position is in contrast to current classifications, in which the order Blastodiniales Chatton is thought to represent...

16. Control biológico de Mycosphaerella graminicola, patógeno del trigo, con cepas de Trichoderma harzianum caracterizadas por su morfología, fisiología, actividad enzimática y molecular - Stocco, Marina Celeste
Frente a las consecuencias indeseables del control químico, la demanda pública de alimentos más sanos y el cambio actual de los paradigmas productivos, la tendencia es sustituir total o parcialmente los fungicidas sintéticos por métodos alternativos no contaminantes, en el marco del Manejo Integrado. El trigo es el cereal de mayor distribución geográfica en el mundo y su demanda irá en aumento debido al incremento de la población mundial. La región triguera en la Argentina abarca una zona muy amplia con condiciones favorables para la aparición de diversas enfermedades. Una de ellas, de origen fúngico, es la Septoriosis ó Mancha...

17. Effect of dietary fiber, genetic strain and age on the digestive metabolism of broiler chickens - Kras, Rodrigo Vieira; Kessler, Alexandre de Mello; Ribeiro, Andrea Machado Leal; Henn, João Dionísio; Bockor, Luciane; Sbrissia, André Fischer
In this study, 360 male broilers, out of which 240 of a fast-growing strain (Cobb500), and 120 of a slow-growing strain (Label Rouge), were used to evaluate the effect of dietary fiber on digesta transit time and digestive metabolism during the period of 1 to 42 days of age. A completely randomized experimental design with a 3x2 factorial arrangement was applied, consisting of three groups of birds (slow-growing – SG; fast-growing fed ad libitum – FGAL; and fast-growing pair-fed with SG broilers – FGPF) and two iso-protein diets (a 3100 kcal ME/kg low-fiber diet –LFD- and a 2800 kcal ME/...

18. Reprodução do pessegueiro : efeito genético, ambiental e de manejo das plantas - Nava, Gilmar Antônio; Marodin, Gilmar Arduino Bettio; Santos, Rinaldo Pires dos
Há uma grande carência de pesquisas e literatura no Brasil sobre a reprodução do pessegueiro. A presente revisão de literatura aborda e confronta inúmeros resultados de pesquisas acerca dos principais fatores envolvidos na reprodução dessa frutífera, com o intuito de subsidiar futuras pesquisas que visam ao melhor entendimento e/ou à solução de problemas associados à sua reprodução. Através da presente revisão, foi possível verifi car que o processo de fi xação de frutos se mostra complexo para algumas cultivares, sendo dependente da passagem, com êxito, por cada estádio fenológico. Com isso, a habilidade dos técnicos e produtores em integrar os...

19. Intensidade e épocas de poda verde em pereira 'Abate Fetel' sobre dois porta-enxertos - Rufato, Leo; Marcon Filho, José Luiz; Marodin, Gilmar Arduino Bettio; Kretzschmar, Aike Anneliese; Miquelluti, David Jose
O Brasil é um dos maiores importadores mundiais de pera europeias. A falta de material genético adaptado e a deficiência de tecnologias de manejo, bem como o abortamento de gemas florais das cultivares europeias plantadas têm desestimulado os produtores, ocasionando a redução de áreas plantadas. O objetivo deste estudo foi estabelecer uma metodologia de poda verde na cultivar Abate Fetel a fim de aumentar a frutificação e controlar o vigor das plantas. O trabalho foi desenvolvido nos pomares da Frutirol Agrícola Ltda., em Vacaria-RS, nas safras de 2006/2007 e 2007/2008. Utilizou-se a cultivar Abate Fetel sobre dois porta enxertos: marmeleiros...

20. Arabidopsis thaliana : uma pequena planta um grande papel - Delatorre, Carla Andrea; Silva, Adriano Alves da
Arabidopsis thaliana é uma das espécies mais utilizadas na pesquisa científica atualmente. Apesar de não apresentar importância econômica direta, esta espécie é o foco de pesquisas na área da genética, bioquímica e fisiologia. O número de trabalhos publicados sobre a mesma aumentou significativamente após o seqüenciamento de seu genoma. Apesar do grande número de estudos existe ainda muita desinformação sobre qual o seu verdadeiro papel na pesquisa científica de espécies cultivadas e de que maneira o avanço no conhecimento adquirido com A. thaliana pode auxiliar o desenvolvimento de cultivares cada vez mais resistentes, adaptados e produtivos. Os objetivos deste trabalho...

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