Mostrando recursos 1 - 20 de 16.011

  1. Una aportación al estudio del comercio marítimo antiguo gaditano a partir de un conjunto de ánforas halladas en aguas del área de La Caleta (Cádiz)

    Sáez Romero, Antonio M.; González Cesteros, Horacio; Higueras-Milena Castellano, Aurora
    La Caleta (Cadiz) has been addressed in the last decades as part of the port facilities of the ancient city of Gadir/Gades. The research in the area has provided interesting data regarding the distribution of amphorae on the basis of the study of a heterogeneous set of evidence from archaeological campaigns or from museum collections. The role of La Caleta and its surrounding shoals as anchorage and commercial port should have been very important in Antiquity, at least from the Phoenician period to the Late Roman Empire. Therefore, the analysis of the ceramic evidence from the site is quite relevant not only to contribute to a better understanding of the use of this...

  2. Elementos estratégicos de la gestión del conocimiento organizacional para la innovación. Caso: Red de agrometeorología

    Olivares, Barlin; Cortez, Adriana; Muñetones, Aurora Carolina; Casana, Sheyla
    This teaching experience seeks to propose an organizational knowledge management model for the training program developed by the Agrometeorology Department of the National Institute for Agricultural Research (INAI, in Spanish) of the State of Anzoátegui, Venezuela. The problem solution protocol deriving from the application of learning cycles, TADIR (Translation, Analysis, Design, Implementation and Revision), was used. An array of different ways to promote activities, tasks, results, and products generated by the project was established before, during and after the execution in an easy and complete manner. The population was also made aware of the advantages of agrometeorology and its importance...

  3. RESEARCH ARTICLE Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure

    Chromosome Biorientation
    ☯ These authors contributed equally to this work.

  4. Guinet C. Foraging fidelity as a recipe for a long life: Foraging strategy and longevity in male southern elephant seals

    Matthieu Authier; Ilham Bentaleb; Aurore Ponchon; Christophe Guinet
    Identifying individual factors affecting life-span has long been of interest for biologists and demographers: how do some individuals manage to dodge the forces of mortality when the vast majority does not? Answering this question is not straightforward, partly because of the arduous task of accurately estimating longevity in wild animals, and of the statistical difficulties in correlating time-varying ecological covariables with a single number (time-to-event). Here we investigated the relationship between foraging strategy and life-span in an elusive and large marine predator: the Southern Elephant Seal (Mirounga leonina). Using teeth recovered from dead males on ı̂les Kerguelen, Southern Ocean, we...

  5. Research Article Voice Activity Detection in Noisy Environments Based on Double-Combined Fourier Transform and Line Fitting


    Copyright © 2014 Jinsoo Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A new voice activity detector for noisy environments is proposed. In conventional algorithms, the endpoint of speech is found by applying an edge detection filter that finds the abrupt changing point in a feature domain. However, since the frame energy feature is unstable in noisy environments, it is difficult to accurately find the endpoint of speech. Therefore, a novel feature extraction algorithm based...

  6. London, UK Reviewed by:

    Mathilde Ménoret; Aurore Curie; Vincent Des Portes; Tatjana A. Nazir; Yves Paulignan; Sukhvinder Obhi; Wilfrid Laurier; Mathilde Ménoret
    Motor resonance facilitates movement execution: an ERP

  7. GenoSets: Visual Analytic Methods for Comparative

    Aurora A. Cain; Robert Kosara; Cynthia J. Gibas
    Many important questions in biology are, fundamentally, comparative, and this extends to our analysis of a growing number of sequenced genomes. Existing genomic analysis tools are often organized around literal views of genomes as linear strings. Even when information is highly condensed, these views grow cumbersome as larger numbers of genomes are added. Data aggregation and summarization methods from the field of visual analytics can provide abstracted comparative views, suitable for sifting large multi-genome datasets to identify critical similarities and differences. We introduce a software system for visual analysis of comparative genomics data. The system automates the process of data...

  8. Page number not for citation purposes 1 Healthcare in Equatorial Guinea, West Africa: obstacles and barriers to care

    Kim Eleanor Reuter; Aurora Geysimonyan; Gabriela Molina; Peter Robert Reuter
    Introduction: The provision of healthcare services in developing countries has received increasing attention, but inequalities persist. One nation with potential inequalities in healthcare services is Equatorial Guinea (Central-West Africa). Mitigating these inequalities is difficult, as the Equatoguinean healthcare system remains relatively understudied. Methods: In this study, we interviewed members of the healthcare community in order to: 1) learn which diseases are most common and the most common cause of death from the perspective of healthcare workers; and 2) gain an understanding of the healthcare community in Equatorial Guinea by describing how: a) healthcare workers gain their professional

  9. Method for Obtaining Committed Adult Mesenchymal Precursors from Skin and Lung Tissue

    Aurora Bernal; Laura M. Pérez; Nuria San Martı́n; Beatriz G. Gálvez
    Aims: The present study reports an easy and efficient method for obtaining adult mesenchymal precursors from different adult mouse tissues. Materials and Methods: We describe the isolation and expansion of mesenchymal precursors from skin and lung by a non-enzymatic method. Skin and lung mesenchymal precursors isolated by a modified explant technique were characterized in vitro by defined morphology and by a specific gene expression profile and surface markers. Results and Conclusions: Our results show that these precursors express stem cell and mesenchymal surface markers as well as epithelial markers. However, they are negative for markers of endothelium, cardiac and skeletal...

  10. REVIEW


    lung protect rp io ca re ssi pressure (PEEP) are now considered routine for ICU pa- other postoperative pulmonary complications. Although Fernandez-Bustamante et al. BMC Anesthesiology (2015) 15:56 DOI 10.1186/s12871-015-0032-xsuch as asthma or sleep apnea, and/or concerns regardingColorado SOM, Aurora, CO, USA Full list of author information is available at the end of the articletients, the implementation of protective ventilation strat-egies in the operating room is not widespread [3-5]. These practices may reflect the shortage of convincing pro-spective trials showing a significant negative impact of non-protective ventilation of short duration on clinical postoperative ARDS is rare in patients at low...

  11. RESEARCH ARTICLE Prospective study of recov


    ea Approximately 8,500 people are treated in emergency departments (EDs) in the United States (US) each year which the species is known, approximately 51 % are due to copperheads (Agkistrodon contortrix) [2]. However, Lavonas and Gerardo BMC Emergency Medicine (2015) 15:9 DOI 10.1186/s12873-015-0033-62007 received antivenom) than in rattlesnake victims (55%)Medicine, Aurora, CO, USA Full list of author information is available at the end of the articlefor evaluation of potentially venomous snakebite [1]. The vast majority of venomous bites are caused by cro-taline snakes (pit vipers: rattlesnakes, cottonmouths, only rattlesnake and cottonmouth victims were enrolled in the premarketing trials for the...

  12. Phosphorylation of Sli15 by Ipl1 Is Important for Proper CPC Localization and Chromosome Stability in

    Saccharomyces Cerevisiae; Stephen J. Corbishley; Nicholas A. Morrice¤c; David A. Robinson; Michael J. R. Stark
    The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we have identified multiple sites of CPC autophosphorylation on yeast Sli15 that are located within its central microtubule-binding domain and examined the functional significance of their phosphorylation by Ipl1 through mutation of these sites, either to non-phosphorylatable alanine (sli15-20A) or to acidic residues to mimic constitutive phosphorylation (sli15-20D). Both mutant sli15 alleles confer chromosome instability, but this is mediated neither by changes in the capacity of...

  13. Article Danusertib Induces Apoptosis, Cell Cycle Arrest, and Autophagy but Inhibits Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR Signaling Pathway in Human Ovarian Cancer Cells

    Dan Zi; Zhi-wei Zhou; Ying-jie Yang; Lin Huang; Zun-lun Zhou; Shu-ming He; Zhi-xu He; Shu-feng Zhou
    Abstract: Ovarian carcinoma (OC) is one of the most common gynecological malignancies, with a poor prognosis for patients at advanced stage. Danusertib (Danu) is a pan-inhibitor of the Aurora kinases with unclear anticancer effect and underlying mechanisms in OC treatment. This study aimed to examine the cancer cell killing effect and explore the possible mechanisms with a focus on proliferation, cell cycle progression, apoptosis, autophagy, and epithelial to mesenchymal transition (EMT) in human OC cell lines C13 and A2780cp. The results showed that Danu remarkably inhibited cell proliferation, induced apoptosis and autophagy, and suppressed EMT in both cell lines. Danu...

  14. A MEKindependent role for CRAF in mitosis and tumor progression. Nat Med 17(12):1641–5

    Ainhoa Mielgo; Laetitia Seguin; Miller Huang; Maria Fern; A Camargo; Ra Franovic; Sara M. Weis; Sunil J. Advani; Eric A. Murphy; A. Cheresh
    RAF kinases regulate cell proliferation and survival and can be dysregulated in tumors1,2. A role for RAF in cell proliferation has been linked to its ability to activate MEK and ERK. Here, we identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on serine 338 and localizes to the mitotic spindle of proliferating tumor cells in vitro and in murine tumor models or biopsies from cancer patients. Treatment of tumors with allosteric, but not ATP-competitive RAF inhibitors prevents CRAF phosphorylation on serine 338, localization to the mitotic spindle and causes cell cycle arrest...

  15. CLINICAL AND EPIDEMIOLOGICAL STUDY Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project)

    M. T. Montagna; G. Caggiano; G. Lovero; O. De; Giglio C. Coretti; T. Cuna; R. Iatta; M. Giglio; L. Dalfino; F. Bruno; F. Puntillo
    Purpose The aims of this study are to evaluate the epi-demiology of invasive fungal infections (IFIs) in patients admitted to an intensive care unit (ICU) in Southern Italy and the in vitro antifungal susceptibility of isolates. Methods A surveillance program was implemented in 18 ICUs. IFI cases were recorded using a standardized form. Results A total of 105 episodes of IFIs occurred in 5,561 patients during the 18-month study. The main infections were caused by yeasts, more than filamentous fungi (overall incidence of 16.5 cases per 1,000 admissions and 2.3 cases per 1,000 admissions, respectively). The overall crude mortality rate...

  16. Global transcriptome profile of Cryptococcus neoformans during exposure to hydrogen peroxide induced oxidative stress. PLoS One 8(1):e55110. http:// dx.doi.org/10.1371/journal.pone.0055110

    Rajendra Upadhya; Leona T. Campbell; Maureen J. Donlin; Rajeev Aurora; Jennifer K. Lodge
    The ability of the opportunistic fungal pathogen Cryptococcus neoformans to resist oxidative stress is one of its most important virulence related traits. To cope with the deleterious effect of cellular damage caused by the oxidative burst inside the macrophages, C. neoformans has developed multilayered redundant molecular responses to neutralize the stress, to repair the damage and to eventually grow inside the hostile environment of the phagosome. We used microarray analysis of cells treated with hydrogen peroxide (H2O2) at multiple time points in a nutrient defined medium to identify a transcriptional signature associated with oxidative stress. We discovered that the composition...

  17. found in human oocytes

    Jessica E. Fellmeth; Derek Gordon; Christian E. Robins; Richard T. Scott; Nathan R. Treff; Karen Schindler
    abstract: Chromosome segregation is an extensively choreographed process yet errors still occur frequently in female meiosis, leading to implantation failure, miscarriage or offspring with developmental disorders. Aurora kinase C (AURKC) is a component of the chromosome pas-senger complex and is highly expressed in gametes. Studies in mouse oocytes indicate that AURKC is required to regulate chromosome segre-gation during meiosis I; however, little is known about the functional significance of AURKC in human oocytes. Three splice variants of AURKC exist in testis tissue.Todeterminewhich splice variants humanoocytes express,weperformedquantitative real-timePCRusing single oocytes and found expression of all three variants. To evaluate the functional...

  18. A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest

    Makoto T. Hayashi; Anthony J. Cesare; James A. J. Fitzpatrick; Eros Lazzerini-denchi; Jan Karlseder
    Telomere shortening and disruption of telomeric components are pathways that induce telomere deprotection. Here we describe another pathway, where prolonged mitotic arrest induces damage signals at telomeres in human cells. Exposure to microtubule drugs, kinesin inhibitors, proteasome inhibitors or the disruption of proper chromosome cohesion resulted in the formation of damage-foci at telomeres. Induction of mitotic telomere deprotection coincided with dissociation of TRF2 (Telomere Repeat binding Factor 2) from telomeres, telomeric 3’-overhang degradation and ATM (Ataxia Telangiectasia Mutated) activation, and could be suppressed by TRF2 overexpression or inhibition of Aurora B kinase. Normal cells that escape from prolonged mitotic arrest...

  19. Aurora A’s Functions During Mitotic Exit: The Guess Who Game

    Marcos Malumbres; Centro Nacional De Investigaciones; Thomas Joseph Maresca; Y Y. C. Poon; David Reboutier; Claude Prigent; Reboutier D; Benaud C; David Reboutier; Christelle Benaud; Claude Prigent
    This article was submitted to

  20. for Hyperalgic Duodenal Crohn’s Disease Fistulized in the Pancreatic Gland

    Avenue Claude Vellefaux; Cephalic Duodenopancreatectomy; Sabra Guellouza; Benjamin Parientea; Claire Benetb; Clotilde Baudrya; Nelson Lourencoa; Aurore Kraemerc; Matthieu Alleza; Jean-marc Gorneta
    www.karger.com/crg This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.

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