Mostrando recursos 1 - 20 de 16.773

  1. Food & Function REVIEW

    Paloma Manzanares; A Juan B. Salom; C Aurora García-tejedor Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond

  2. Arsenic in Foods

    Aurora A. Saulo
    national origin, ancestry, disability, marital status, arrest and court record, sexual orientation, or status as a covered veteran. Find CTAHR publications at

  3. Age-dependent vulnerability to carotid chemodenervation in piglets

    Aurore Cote; Hernan Porras; Brian Meehan; Hernan Porras; Brian Meehan
    Age-dependent vulnerability to carotid chemodenervation in piglets. J. AppZ. physiol. 80 ( 1): 323-331, 1996.-We sought to determine the age of greatest vulnerability in piglets to the loss of carotid chemoreceptor function. We studied four groups of carotid body-denervated (CBD) piglets whose ca-rotid bodies were surgically removed at 4-5, 9-10, 12-15, and 21-22 days and who are herein referred to, respectively, as the CBD5, CBDlO, CBD15, and CBD20 groups. Four intact groups, at corresponding ages, underwent a sham surgical procedure. After a postsurgery recovery of at least 7 days, we studied all animals to detect the presence of apnea and...


    Aurore Gorlas; See Profile; Mart Krupovic; Patrick Forterre; Claire Geslin; Aurore Gorlas; A Mart Krupovic; B Patrick Forterre; C Claire Geslina
    Microbial cells often serve as an evolutionary battlefield for different types of mobile genetic elements, such as viruses and plas-mids. Here, we describe the isolation and characterization of two new archaeal plasmids which share the host with the spindle-shaped Thermococcus prieurii virus 1 (TPV1). The two plasmids, pTP1 and pTP2, were isolated from the hyperthermophilic ar-chaeon Thermococcus prieurii (phylum Euryarchaeota), a resident of a deep-sea hydrothermal vent located at the East Pacific Rise at 2,700-m depth (7°25=24 S, 107°47=66W). pTP1 (3.1 kb) and pTP2 (2.0 kb) are among the smallest known plasmids of hy-perthermophilic archaea, and both are predicted to...


    R. S. Stolarski
    Abstract-The primary electron energy spectrum in an aurora has been determined by fitting the altitude profile of the 3914 8, emission. This spectrum has been degraded through the atmosphere and the secondary electron energy spectra have been calculated at various altitudes. From these spectra the excitation and emission rate profiles of many important lines have been calculated. These include the oxygen 5577 A and 6300 A lines and the N, 1st and 2nd positive and Vegard-Kaplan bands. The heat input to the ambient electrons and the resultant electron temperature have also been calculated. 1.

  6. Behr’s Syndrome is Typically Associated with Disturbed Mitochondrial Translation and Mutations in the C12orf65 Gene

    Aurora Gomez-durana; Agnes Herczegfalvic; Emma L. Blakelyd; Tania Smertenkoa; Jennifer Duffa; Gail Eglona; David Moorea; Patrick Yu; Wai Mana; Konstantinos Douroudisa; Mauro Santibanez-koreff; Helen Griffina; Veronika Karcagie; Robert W. Taylord; Patrick F. Chinnerya
    Abstract. Background: Behr’s syndrome is a classical phenotypic description of childhood-onset optic atrophy combined with various neurological symptoms, including ophthalmoparesis, nystagmus, spastic paraparesis, ataxia, peripheral neuropathy and learning difficulties. Objective: Here we describe 4 patients with the classical Behr’s syndrome phenotype from 3 unrelated families who carry homozygous nonsense mutations in the C12orf65 gene encoding a protein involved in mitochondrial translation. Methods: Whole exome sequencing was performed in genomic DNA and oxygen consumption was measured in patient cell lines. Results: We detected 2 different homozygous C12orf65 nonsense mutations in 4 patients with a homogeneous clinical pre-sentation matching the historical description...

  7. $rec.titulo

    The final separation of daughter cells during cytokinesis is the ancestral function of the endosomal sorting complex required for transport (ESCRT) machinery (1–5) which also acts to resolve equivalent mem-brane scission events in multivesicular body (MVB) formation (6, 7) and human immunodeficiency virus-1 (HIV-1) budding (8, 9). Midbody recruitment of ESCRT-III, the filament-forming scission machinery, is an essential event in cytokinesis that is thought to provide constrictive force during abscission (2, 10–12). An Aurora B-dependent abscission checkpoint (NoCut) is thought to retard abscission to prevent damage of lagging chromosomes that are trapped in the midbody (13–15) and may function more...

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    monomers because of their ability to participate in established such as aurora kinase inhibitors,5 antiinammatory,6 anti-bronchospastic,7 antiulcer,8 anticancer9 and controlling allergic reactions.10 A variety of classical method functionalization of imidazo[1, 8-methoxy or 8-methylthio-6-bro 3-aryl/alkylamino and 2-aryl/alk pyrazines,12 diarylurea,13 8-morph imidazo[1,2-a]pyrazines15 throug dibromopyrazine 2 (ref. 16) in 90 % yield followed by cyclization with chloroacetaldehyde in the absence of base to obtain 6,8-dibromo-imidazo[1,2-a]pyrazine 3 in 80 % yield (Scheme 1).

  9. Over the last few years, there has been a glob...

    Carina Araújo; Aurora Teixeira
    How to cite Complete issue More information about this article Journal's homepage in Scientific Information System

  10. tris(2-pyridylmethyl)amine-type ligands: O2 coordination and

    Dominique M; Hassen Jaafar; Aurore Thibon
    a quest for superoxidew

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    Bone Loss In Mice; Richard J Dipaolo; Deborah V Novack; Rajeev Aurora
    All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.

  12. Rosario Ortega Ruiz

    Psicología Educativa; José Antonio León; Inmaculada Escudero Domínguez; Robert F. Lorch; José Antonio; Luengo Latorre; Pamela Maras; Manuel Martín-loeches; María José Navas; Fernando Sánchez-sánchez; Paul Van Den Broek; Lieven Verschaffel; Psicología Educativa; Peter W. Van Rijna; E. Aurora Grafb; Paul Deaneb
    Revista de los Psicólogos de la Educación

  13. Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells. Mol. Cancer Ther

    Steven L. Warner; Ruben M. Munoz; Daniel D. Von Hoff; Haiyong Han
    To address the increased need to understand the similarities and differences in targeting Aurora A or Aurora B for the treatment of cancer, we systematically evaluated the relative importance of Aurora A and/or Aurora B as molecular targets using antisense oligonucleotides. It was found that perturbations in Aurora A and Aurora B signaling result in growth arrest and apoptosis preferen-tially in cancer cells. The biological fingerprints of Aurora A and Aurora B inhibition were compared and contrasted in efforts to identify the superior therapeutic target. Due to the different biological responses, we conclude that each Aurora kinase should be treated...

  14. $rec.titulo

    Daniel R. Carrasco
    Aurora kinase A is a target of Wnt/-catenin involved in multiple myeloma disease progression

  15. Supervised by:

    Sara Cristina; Santos Cruz; Aurora A. C. Teixeira; Björn T. Asheim

  16. Summary

    Ly-thuy-tram Le; Hong-lien Vu; Chi-hung Nguyen; Annie Molla
    Histone H3 phosphorylation is the hallmark of mitosis deposited by aurora kinase B. Benzo[e]pyridoindoles are a family of potent, broad, ATP-competitive aurora kinase inhibitors. However, benzo[e]pyridoindole C4 only inhibits histone H3 phosphorylation in prophase but not in metaphase. Under the C4 treatment, the cells enter into mitosis with dephosphorylated histone H3, assemble chromosomes normally and progress to metaphase, and then to anaphase. C4 also induces lagging chromosome in anaphase but we demonstrated that these chromosome compaction defects are not related to the absence of H3 phosphorylation in prophase. As a result of C4 action, mitosis lasts longer and the cell...

  17. 1 Allograft Fascia Lata as an Augmentation Device for Musculoskeletal Repairs

    K. A. Derwin; A. Aurora; J. P. Iannotti
    Musculoskeletal soft tissue injuries during combat are a source of debilitating pain, the treatment and evaluation of which pose a significant challenge to the orthopedic community. Extracellular matrix (ECM) scaffolds derived from various sources and species are being explored for the repair of musculoskeletal tendon injuries. In this paper we demonstrate that amongst these ECM scaffolds, only tensor fascia lata has structural and tensile material properties comparable to tendon, but fascia has poor suture retention properties. We have devised a novel means to increase the suture retention properties of fascia lata by developing a composite of the ECM tissue and...

  18. The Repressing Function of the Oncoprotein BCL-3 Requires CtBP, while Its Polyubiquitination and Degradation Involve

    The E Ligase Tblr; Aurore Keutgens; Kateryna Shostak; Pierre Close; Xin Zhang; Benoît Hennuy; Marie Aussems; Jean-paul Chapelle; Patrick Viatour; Andre ́ Gothot; Marianne Fillet; Alain Chariot
    The nuclear and oncogenic BCL-3 protein activates or represses gene transcription when bound to NF-B proteins p50 and p52, yet the molecules that specifically interact with BCL-3 and drive BCL-3-mediated effects on gene expression remain largely uncharacterized. Moreover, GSK3-mediated phosphorylation of BCL-3 triggers its degradation through the proteasome, but the proteins involved in this degradative pathway are poorly characterized. Biochemical purification of interacting partners of BCL-3 led to the identification of CtBP as a molecule required for the ability of BCL-3 to repress gene transcription. CtBP is also required for the oncogenic potential of BCL-3 and for its ability to...

  19. 2006;5:2450-2458. Mol Cancer Ther

    Steven Lawrence Warner; Tolero Pharmaceuticals Inc; See Profile; Phillip Stafford; Erich Koller; Daniel D. Von Hoff; Steven L. Warner; Ruben M. Munoz; Phillip Stafford; Et Al
    Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells

  20. Leadership and authority in

    Patricia Flatley Brennan; Gail Casper; Laura Burke; Aurora Healthcare; Kathy Johnson; Roger L. Brown; Patricia Flatley Brennan; Gail Casper; Laura Burke; Kathy Johnson; Roger L. Brown; Rupa Valdez; Oscar Perez; Billie Sturgeon
    NOTICE: this is the author’s version of a work that was accepted for publication in Heart and Lung. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was

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