Genetic polymorphisms associated with lipid metabolism involved in the pathophysiology of ischemic stroke
- Tamires Flauzino; Daniela Frizon Alfieri; Ana Paula Kallaur; Elaine Regina Delicato de Almeida; Edna Maria Vissoci Reiche
The stroke is a complex, multifactorial, and polygenic disorder that results from the interaction between the individual genetic components and environmental factors. Previous studies have established hypertension, smoking, diabetes mellitus, dyslipidemia, elevated body mass index, disturbances of coagulation and increasing age as predictors of stroke risk factors. The stroke is a more crippling than deadly disease that requires long-term institutionalization, as it decreases the quality of life of patients, resulting in higher costs to social and economic levels. It thus becomes increasingly important to emphasize the Preventive Medicine strategies. Dyslipidemia has been associated with pathophysiology of ischemic stroke and genetic...
Preventive Veterinary Medicine
- Amy Gilbert; Lauren Greenberg; David Moran; Danilo Alvarez; Marlon Alvarado; Ministerio De Agricultura; Amy Gilbert; Lauren Greenberg; David Moran; Danilo Alvarez; Marlon Alvarado; Daniel L. Garcia; Leonard Peruski; Amy Gilberta; Lauren Greenbergb; David Moranc; Danilo Alvarezc
Antibody response of cattle to vaccination with commercialmodified live rabies vaccines in
Preventive Veterinary Medicine 110 (2013) 119 – 132
- Ryan S. Miller; Mathew L. Farnsworth; Jennifer L. Malmberg; Ryan S. Miller; Matthew L. Farnsworth; Jennifer L. Malmberg
Diseases at the livestock–wildlife interface: Status, challenges, and opportunities in the United States
Preventive Veterinary Medicine
- Ian A. Gardner; Søren S. Nielsen; Richard J. Whittington; Michael T. Collins; Douwe Bakker; Ian A. Gardner; Søren S. Nielsen; Richard J. Whittington; Michael T. Collins; Douwe Bakker; Beth Harris; Jason E. Lombard; Raymond Sweeney; David L. Smith; Jerie Gavalchin
Consensus-based reporting standards for diagnostic test accuracy studies for paratuberculosis in ruminants
Rhazes Contribution to the Role of Nutrition in Preventive Medicine and Public Health.
- Arman Zargaran; Amir Azizi; Gholamreza Kordafshari; Afshin Borhani-Haghighi
Assessment of lipid profile when using lipid-lowering therapy (statins) in patients with coronary atherosclerosis
- N.E. Gavrilova; V.A. Metelskaya; E.B. Yarovaya; N.V. Gomyranova; S.A. Boytsov
Aim. To assess of lipid-lowering therapy with statins in very high cardiovascular risk patients admitted to hospital for coronary angiography and analyze lipid profiles depending on the intensity of lipid-lowering therapy.
Material and methods. A total of 502 patients aged 25-86 years (mean age 61.2±9.4 years) who admitted to the clinic of State Research Center for Preventive Medicine were consecutively included into the study. All of them were examined and underwent coronary angiography. Plasma lipid levels were determined by standard laboratory methods.
Results. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol) and non-high-density lipoprotein cholesterol (HDL-cholesterol) were significantly higher among...
Vaccinia Outbreak — Newfoundland
Newfoundland. They resulted from exposure to a recently vaccinated female member °f the Canadian Forces on leave over the Christmas-New Year season. The Preventive Medicine Directorate, Surgeon General's Office, Department of Na tional Defence, reported that the vaccinee was an 18-year-old female recruit at Canadian Forces Base (CFB) Cornwallis, Nova Scotia, who had had a good "p rim ary " reaction following smallpox vaccination on December 12, 1980. While on leave in Newfoundland, she was seen by a physician on December 22 because of discomfort in her arm and a vaccinial lesion on her lower lip. Within 24 hours, further...
Annals of Internal Medicine Low Cardiorespiratory Fitness and Physical Inactivity as Predictors of Mortality in Men with Type 2 Diabetes
- Ming Wei; Milton Z. Nichaman; Steven N. Blair
Background: Although physical activity is recommended as a basic treatment for patients with diabetes, its long-term association with mortality in these patients is un-known. Objective: To evaluate the association of low cardiorespi-ratory fitness and physical inactivity with mortality in men with type 2 diabetes. Design: Prospective cohort study. Setting: Preventive medicine clinic. Patients: 1263 men (50 6 10 years of age) with type 2 diabetes who received a thorough medical examination between 1970 and 1993 and were followed for mortality
Health Care Cost Savings Resulting from the Targeted Use of Dietary Supplements BACKGROUND
A common question among policymakers, public health experts, and consumers that is, in many ways, still unaddressed is whether health care costs can be avoided if more preventive measures are adopted. On the surface, it seems that the answer would be a logical yes, in that preventing diseases is a better option than having to pay for costly treatments. According to the Centers for Disease Control and Prevention (CDC), approximately three quarters of total U.S. health care expenditures are spent on preventable diseases, including such conditions as coronary heart disease, diabetes, age-related eye disease, and osteoporosis (Centers for Disease Control...
REVIEW ‘‘Combination-oriented molecular-targeting prevention’’ of cancer: a model involving the combination of TRAIL and a DR5 inducer
- Tatsushi Yoshida; Mano Horinaka; Toshiyuki Sakai
Abstract Malignant tumors carry a high risk of death, and the prevention of malignant tumors is a crucial issue in preventive medicine. To this end, many chemopreventive agents have been tested, but the effects of single agents have been found to be insufficient to justify clinical trials. We have therefore hypothesized that combinations of different chemopreventive agents may synergistically enhance the preventive effect of chemopreventive agents used singly. To provide the treating physician with some guideline by which to choose the most effective agents to be combined, we propose a strategy which we have termed the ‘‘combination-oriented molecular-targeting preven-tion’ ’...
REVIEW ARTICLE Does the “new philosophy ” in predictive, preventive and personalised medicine require new ethics?
- Eugenijus Gefenas; Asta Cekanauskaite; Egle Tuzaite; Vilius Dranseika; Dainius Characiejus
Abstract This paper maps the ethical issues that arise in the context of personalised medicine. First, it highlights the ethical problems related to increased predictive power of modern diagnostic interventions. Such problems emerge because the ability to identify individuals or groups of individuals that can potentially benefit from a particular therapeutic intervention also raises a question of personal responsibility for health-related behaviour and lifestyle. The second major area of ethical concern is related to health prevention and distributive justice. The paper discusses the ethical challenges brought by the personalised medicine in the context of the Additional Protocol to the Convention...
The Association Between Midlife Cardiorespiratory Fitness Levels and Later-Life Dementia A Cohort Study
- Myron F. Weiner; Jarett D. Berry
types of dementia (all-cause dementia) is an important public health goal. Evidence to date is insufficient to recommend any lifestyle change to prevent or delay the onset of dementia. Objective: To assess the association between objectively measured midlife cardiorespiratory fitness (“fitness”) levels and development of all-cause dementia in advanced age. Design: Prospective, observational cohort study. Setting: Preventive medicine clinic.
RESEARCH ARTICLE “These issues aren’t talked e
Full list of author information is available at the end of the articleBackground Onset of sexual activity is common during adolescence but is often unsafe, characterised by risky sexual behav-iour and inconsistent use of condoms and contraceptives . Sexuality education is key to reducing risks and im-proving adolescent sexual and reproductive health (SRH) outcomes, however many young people lack adequate knowledge and experience poor access to comprehensive SRH information [2,3]. The few studies exploring SRH knowledge among adolescents in the Pacific indicate that while young people in this region are generally aware of HIV, sexually transmitted infections (STIs) and family...
The concept of analytical and diagnostic “metabolomics” originated as “metabolic profiling ” in the 1970s. Largely ignored by the $100 billion commercial clinical laboratory industry and the medical monopoly that it serves, this discipline can now be brought to fruition, as a result of miniaturization of analytical devices, advances in personal computer technology, and development of the Internet. With these tools, metabolic profiling, as well as on-person monitoring, medical imaging, and other powerful diagnostic tools, can be placed in the hands of consumers, who will then be able to control the quality of the information and medical care that they...
1Injury Prevention Research Unit, Department of Preventive and Social Medicine,Conclusion: Our study, comparing recovery outcomes fornon-work-related injury in a universal injury compensation system? Findings from the New Zealand Prospective Outcomes of I
- Rebbecca Lilley; Gabrielle Davie; John Langley; Shanthi Ameratunga; Sarah Derrett
outcomes differ between work and entitlement injury compensation scheme, found mixed support for the hypothesis tested. After adjustment for possible Lilley et al. BMC Public Health 2013, 13:995
Menu Labeling Regulations and Calories Purchased at Chain Restaurants
- James W. Krieger; Nadine L. Chan Phd; Brian E. Saelens
Background: The federal menu labeling law will require chain restaurants to post caloric information on menus, but the impact of labeling is uncertain. Purpose: The goal of the current study was to examine the effect of menu labeling on calories purchased, and secondarily, to assess self-reported awareness and use of labels. Design: Single-community pre–post–post cross-sectional study. Data were collected in 2008–2010 and analyzed in 2011–2012. Setting/participants: 50 sites from 10 chain restaurants in King County, Washington, selected through stratified, two-stage cluster random sampling. A total of 7325 customers participated. Eligibility criteria were: being an English speaker, aged Z14 years, and...
Preventive Veterinary Medicine
Contents lists available at ScienceDirect
Systems Biology and P4 Medicine: Past, Present, and Future
- Leroy Hood
Studying complex biological systems in a holistic rather than a “one gene or one protein” at a time approach requires the concerted effort of scientists from a wide variety of disciplines. The Institute for Systems Biology (ISB) has seamlessly integrated these disparate fields to create a cross-disciplinary platform and culture in which “biology drives technology drives computation.” To achieve this platform/culture, it has been necessary for cross-disciplinary ISB scientists to learn one another’s languages and work together effectively in teams. The focus of this “systems” approach on disease has led to a discipline denoted systems medicine. The advent of technological...
La tríada salud, política y sociedad: análisis del discurso en las políticas de salud del estado y en las universidades autónomas venezolanas
- Rodríguez, Yajaira
En este artículo se estudia la tríada salud, política y sociedad desde el Estado y las universidades autónomas venezolanas, como generadores de políticas y de investigaciones científicas, dada la gran heterogeneidad humana requerida de diversos y múltiples beneficios; así, la participación de ambos actores resulta relevante, ya que el primero será emisor de políticas sanitarias y las segundas crean conocimiento convertible en soluciones de medicina predictiva, preventiva y curativa. Metodológicamente es una investigación cualitativa hermenéutica en diseño documental, en el que se emplea como técnica el análisis de contenido del discurso (Rodríguez, 2003), interpretándose los discursos y su sintonía, el...
Genomics is changing personal healthcare and medicine: the dawn of iPH (individualized preventive healthcare)
- Mehrian-Shai, Ruty; Reichardt, Juergen K. V.
This opinion piece focuses on the convergence of information technology (IT) in the form of personal monitors, especially smart phones and possibly also smart watches, individual genomic information and preventive healthcare and medicine. This may benefit each one of us not only individually but also society as a whole through iPH (individualized preventive healthcare). This shift driven by genomic and other technologies may well also change the relationship between patient and physician by empowering the former but giving him/her also much more individual responsibility.