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Copyright © 2012 Gian Paolo Giuliari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To present the case of an aggressive orbital Burkitt’s lymphoma. Methods. Chart review. Case Presentation. A 24-year-old Haitian man came to our clinic complaining of rapidly progressive right eye proptosis. On examination, a large friable exophytic mass with necrotic areas and exudative/hemorrhagic secretions was noted protruding from his right orbit. A biopsy revealed the characteristic “starry-sky ” appearance of a Burkitt...
REVIEW Open Access Knowledge Discovery and interactive Data Mining in Bioinformatics- State-of-the-Art, future
Andreas Holzinger; Matthias Dehmer; Igor Jurisica
Computers are incredibly fast, accurate, and stupid. Human beings are incredibly slow, inaccurate, and brilliant. Together they are powerful beyond imagination (Einstein never said that ). Background The life sciences, biomedicine and health care are increasingly turning into a data intensive science [2-4]. Particularly in bioinformatics and computational biology we face not only increased volume and a diversity of highly complex, multi-dimensional and often weakly-structured and noisy data [5-8], but also the growing need for integrative analysis and modeling [9-14]. Due to the increasing trend towards personalized and precision medicine (P4 medicine: Predictive, Preventive,
1389-2029/08 $55.00+.00 ©2008 Bentham Science Publishers Ltd. Computational Challenges of Personal Genomics
Abstract: It is widely predicted that cost and efficiency gains in sequencing will usher in an era of personal genomics and personalized, predictive, preventive, and participatory medicine within a decade. I review the computational challenges ahead and propose general and specific directions for research and development. There is an urgent need to develop se-mantic ontologies that span genomics, molecular systems biology, and medical data. Although the development of such ontologies would be costly and difficult, the benefits will far outweigh the costs. I argue that availability of such ontolo-gies would allow a revolution in web-services for personal genomics and medicine.
article which permits unrestricted noncommercial use, provided the original work is properly cited. International Journal of General Medicine 2012:5 917–921 International Journal of General Medicine Pivot and cluster strategy: a preventive measure
Taro Shimizu; Yasuharu Tokuda; Correspondence Taro Shimizu
Abstract: Diagnostic errors constitute a substantial portion of preventable medical errors. The accumulation of evidence shows that most errors result from one or more cognitive biases and a variety of debiasing strategies have been introduced. In this article, we introduce a new diagnostic strategy, the pivot and cluster strategy (PCS), encompassing both of the two mental processes in making diagnosis referred to as the intuitive process (System 1) and analytical process (System 2) in one strategy. With PCS, physicians can recall a set of most likely differential diagnoses (System 2) of an initial diagnosis made by the physicians ’ intuitive...
Medicina Preventiva; Salud Pública; Ana G; Mª Felicitas Domínguez-berjón; Mercè Gotsens; Natividad Izco; Mª Concepción Moreno; Marc Sáez; Carmen Martos; Pablo Sánchez-villegas; Carme Borrell
preventable mortality in urban areas of 33 men than in women. There were socioeconomic inequalities in mortality in most cities analysed, associating a higher risk of death with higher levels of deprivation. Inequalities have remained over the two periods analysed. This study Nolasco et al. International Journal for Equity in Health (2015) 14:33 DOI 10.1186/s12939-015-0164-0Universidad de Alicante, 03080 Alicante, España Full list of author information is available at the end of the articlemakes it possible to identify those areas where excess preventable mortality was associated with more deprived zones. It is in these deprived zones where actions to reduce and...
Paz Fernández, Xesús B.
De febrer a març de 1980 es va realitzar a Nicaragua la Croada Nacional d'Alfabetització (CNA). Prèviament, un cens havia posat de manifest l'existència d'un 50,4% analfabets entre la població major de deu anys. El projecte es va dur a terme amb finançament nacional i diverses col · laboracions procedents de països estrangers i organismes internacionals. La campanya va ser planificada com un projecte polític-sustentat en les organitzacions revolucionàries-entre els objectius s'explicava, a més de l'eradicació a l'analfabetisme, la incorporació de les masses al procés revolucionària en curs. Alhora es pretenia una millora de les condicions de vida del camperol,...
Full list of author information is available at the end of the articleinsurance systems in an effort to broaden access to care and support preventive medicine. By contrast, most other developed and developing countries are advancing policies to stabilize or even reduce national health spending, espe-cially on prescription drugs . While the United States are the world’s two largest national economies and occupy the peak attention of strategic planners at multinational pharmaceutical and other global healthcare firms. Second, both are encountering policy tensions between access to care and costs of treatment as they broaden health insur-ance coverage. Third, both countries...
John J. Millichap; Bernard T. Sy; Rodney O. Leacock
Spinal cord infarction is uncommon and usually pre-sents with sudden onset of paralysis and sensory disturbances. A variety of causes are described, but rarely with multiple factors involved. We report a case of a 63-year-old man with a history of diabetes mellitus, hypertension, and osteoarthritis who presented with acute onset of chest pain, numbness, and weakness associated with episodic hypotension. He had incom-plete tetraplegia and was areflexic without spasticity. Pain and temperature sensations were impaired below the C7 dermatome and absent below the T4 dermatome bilaterally. Proprioception and vibration sensations were diminished on the right below the C6 dermatome. Magnetic...
An impressive progress in dentistry has been recorded in the last decades. In order to reconsider guidelines in dentistry, it is required to introduce new concepts of personalised patient treatments: the wave of predictive, preventive and personalised medicine is rapidly incoming in dentistry. Worldwide dentists have to make a big cultural effort in changing the actual ‘reactive ’ therapeutic point of view, belonging to the last century, into a futuristic ‘predictive ’ one. The first cause of tooth loss in industrialised world is periodontitis, a Gram-negative anaerobic infection whose pathogenesis is genetically determined and characterised by complex immune reactions. Chairside...
2Department of Epidemiology and Preventive Medicine, Monash University,characteristics at the time, where fluctuating heroin availabaseline and twelve-month follow-up results
Danielle Horyniak; Peter Higgs; Rebecca Jenkinson; Louisa Degenhardt; Mark Stoové; Thomas Kerr; Matthew Hickman; Campbell Aitken; Paul Dietze
cohort study (MIX): rationale, methods, and threshold OST. Nevertheless, this study of Australian injectors will provide valuable data on the natural history of Horyniak et al. Harm Reduction Journal 2013, 10:11
Full list of author information is available at the end of the articleBackground In health care, prevention of disease is always better than cure. It is undeniable that vaccines have been an important part in preventive medicine based on their successes in controlling vaccine-preventable diseases in the developed world. The eradication, elimination, and significant reduction in the number of cases of child-hood communicable diseases as well as the fact that they extend life expectancy in the United States and many other parts of the world are some of the examples of im-munizations ’ success in the 20th century . Ehreth...
Prevention of Neural Tube Defects: A Cross-Sectional Study of the Uptake of Folic Acid Supplementation in Nearly Half a Million Women
Jonathan P. Bestwick; Wayne J. Huttly; Joan K. Morris; Nicholas J. Wald
Background: Taking folic acid supplements before pregnancy to reduce the risk of a neural tube defect (NTD) is especially important in countries without universal folic acid fortification. The extent of folic acid supplementation among women who had antenatal screening for Down’s syndrome and NTDs at the Wolfson Institute of Preventive Medicine, London between 1999 and 2012 was assessed. Methods and Findings: 466,860 women screened provided details on folic acid supplementation. The proportion of women who took folic acid supplements before pregnancy was determined according to year and characteristics of the women. The proportion of women taking folic acid supplements before...
Journal of Preventive Medicine & Public Health 235Copyright © 2012 The Korean Society for Preventive Medicine Nail DNA and Possible Biomarkers: A Pilot Study
Joshua Park; Debbie Liang; Jung Woo Kim; Yongjun Luo; Taesheng Huang; Soo-young Kim; Seong-sil Chang
Objectives: Nail has been a substitute DNA source for genotyping. To investigate the integrity and consistency of nail DNA amplifica-tion for biomarker study, nail clippings from 12 subjects were collected at monthly intervals. The possibility of longer amplification and existence of GAPDH RNA/protein, were also investigated with three nail samples. Methods: Three primer sets were designed for quantitative amplification of nuclear and mitochondrial genes and analysis of their consis-tency. The mean threshold cycles in amplification of the target genes were compared to test the consistency of polymerase chain reaction (PCR) performance among individual factors including age groups, sex, family, the...
Retraction Retracted: Immunization Coverage: Role of Sociodemographic Variables Advances in Preventive Medicine
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The paper titled “Immunization Coverage: Role of Sociode-mographic Variables ” , published in Advances in Preven-tive Medicine, has been retracted upon the authors ’ request due to a flaw in data acquisition. References  B. Sharma,H.Mahajan, andG.D.Velhal, “Immunization cover-age: role of sociodemographic variables,”Advances in Preventive
Department Of Preventive Medicine; School Of Medicine; José M Belizán
Full list of author information is available at the end of the articleBackground Preterm birth is the main cause of four million neonatal deaths each year worldwide, 99 % of which occur in low-and middle-income countries . Antenatal corticosteroid administered to women at risk of preterm birth is an intervention which has proved to reduce the risk of respiratory distress syn-drome, intraventricular hemorrhage, and neonatal mor-tality by 50 % or more [2-4]. There is a significant gap in the literature regarding the prevalence of the use of antenatal corticosteroids in Latin American countries; very few studies have been published and...
Guglielmo M. Trovato
Suggestions for a sustainable medical quality-centered approach within a predictive, preventive and personalized medicine: the promotion of alternatives to conventional hospitalization in an era of financial constraint
ORIGINAL RESEARCH ARTICLE Open Access Determination of Cutoff Values for DEXA-Based Body Composition Measurements for Determining Metabolic and Cardiovascular Health
The two components of the body weight (i.e., fat mass and muscle mass) appeared to be of high interest to consider in predicting metabolic health related risks. We aimed to determine cutoff values for fat mass index (FMI) and muscle mass index (MMI), FM/MM, and BMI for metabolic and cardiovascular health. This study was a cross-sectional analysis study conducted in a center of preventive medicine. It included 616 consecutive out-patients: mean age was 56.0 – 10.0 years (74.6 % aged ‡ 50), and 61.4 % were female. Fat and muscle mass were obtained with dual energy X-ray absorptiometry scan analyses....
Birth Weight and Long-Term Overweight Risk: Systematic Review and a Meta-Analysis Including 643,902 Persons from 66 Studies and 26 Countries Globally
Karen Schellong; Ra Schulz; Thomas Harder; Andreas Plagemann
Background: Overweight is among the major challenging health risk factors. It has been claimed that birth weight, being a critical indicator of prenatal developmental conditions, is related to long-term overweight risk. In order to check this important assumption of developmental and preventive medicine, we performed a systematic review and comprehensive meta-analysis. Methods and Findings: Relevant studies published up to January 2011 that investigated the relation between birth weight and later risk of overweight were identified through literature searches using MEDLINE and EMBASE. For meta-analysis, 66 studies from 26 countries and five continents were identified to be eligible, including 643,902 persons...
Sciences, Jeonju, Republic of Korea; ‡Department of Preventive Medicine, Chonbuk National University Medical
P ular re sing p east ND e n of Address al
Ziad A. Memish; Shamsudeen F. Fagbo; Ahmed Osman Ali; Rafat Alhakeem; Fathelrhman M. Elnagi; Elijah A. Bamgboye
Background: The epidemiology of Alkhurma hemorrhagic fever disease is yet to be fully understood since the virus was isolated in 1994 in the Kingdom of Saudi Arabia. Setting: Preventive Medicine department, Ministry of Health, Kingdom of Saudi Arabia. Design: Retrospective analysis of all laboratory confirmed cases of Alkhurma hemorrhagic fever disease collected through active and passive surveillance from 1st-January 2009 to December, 31, 2011. Results: Alkhurma hemorrhagic fever (AHFV) disease increased from 59 cases in 2009 to 93 cases in 2011. Cases are being discovered outside of the region where it was initially diagnosed in Saudi Arabia. About a third...