Main Text: 750-1000 words excluding...
Gorgas Memorial Institute of Tropical and Preventive Medicine. Hearing, Ninety-third Congress, second session. March 13, 1974.
- United States.
Committee on Foreign Affairs.
Subcommittee on Inter-American Affairs.
Mode of access: Internet.
Plan de vigilancia entomológica en zona de operaciones. Aproximación al estudio de anofelinos (Diptera: Culicidae) y riesgo entomológico asociado en las bases de Herat y Qala I Naw
- J. Lacasa Navarro; R. Melero Alcíbar; A. Pérez Rico; A. Santos Ramírez; F.J. Salgado Morcillo; S. Fuentes Gutiérrez; J.M. Rubio Muñoz; S. Ruiz Contreras; R. Molina Moreno; J.L. Vega Pla
Introducción: Cualquier información obtenida para contribuir a la evaluación del riesgo de aparición de brotes de malaria en la fuerza desplegada en zonas de operaciones es de máximo interés para los servicios de medicina preventiva. Tras un estudio piloto de vigilancia entomológica, realizado en la base de Herat (Afganistán) en 2008, se han realizado ahora nuevos estudios protocolizados y con más medios en dicha base, así como en la situada en Qala i Naw (Afganistán). Material y métodos: Entre junio y octubre de 2010 se realizaron muestreos entomológicos en las bases de Herat y Qala i Naw, empleando trampas luminosas...
QUARTER OF A CENTURY IN THE LOOKING FOR OPTIMAL WAYS TO PREVENT NONINFECTIOUS DISEASES AND NEW TASKS FUTURE (TO THE 25TH ANNIVERSARY OF THE STATE RESEARCH CENTER FOR PREVENTIVE MEDICINE FOUNDING)
DIFFERENTIAL DIAGNOSIS OF HEREDITARY SYNDROME OF HYPOCHOLESTEROLEMIA BY USING EXOMIC SEQUENCING
- A. I. Yershova; N. V. Shcherbakova; A. A. Suvorova; E. Y. Hlebus; I. V. Sidonets; A. N. Meshkov; S. A. Boytsov
Clinical case study is described. Patient D, 55 years old, applied to the Lipid clinic of State Research Centre for Preventive Medicine because of low blood cholesterol level. Results of the differential diagnosis of the hypocholesterolemia syndrome by using exomic sequencing are presented. This method allows to sequence the majority of regions of genome containing exons, protein-coding parts of genes. Heterozygous mutation in the gene for APOB (5 nucleotides deletion) was found out in the patient by using exomic sequencing. This mutation leads to a premature stop codon with violation of apolipoprotein B-100 synthesis and causes inherited monogenic disease -...
THE FIRST EXPERIENCE OF LEFT ATRIAL APPENDAGE OCCLUDING DEVICES IMPLANTATION FOR PREVENTION OF STROKE IN THE STATE RESEARCH CENTRE FOR PREVENTIVE MEDICINE
- K. V. Davtyan; O. N. Tkacheva; A. A. Kalemberg; S. N. Koretsky
Some aspects of prevention of thromboembolic events in patients with atrial fibrillation, in particular, the use of implantable left atrial appendage occluding devices are discussed. Along with the literature review on this issue, the results of authors own experience of left atrial appendage occluding devices implantation is presented.
PHARMACOGENETIC TESTING OPPORTUNITIES IN CARDIOLOGY BASED ON EXOME SEQUENCING
- N. V. Shcherbakova; A. I. Ershova; A. A. Suvorova; E. Y. Hlebus; A. N. Meshkov; S. A. Boytsov
Aim. To study what cardiac drugs currently have any comments on biomarkers and what information can be obtained by pharmacogenetic testing using data exome sequencing in patients with cardiac diseases.
Material and methods. Exome sequencing in random participant of the ATEROGEN IVANOVO study and bioinformatics analysis of the data were performed. Point mutations were annotated using ANNOVAR program, as well as comparison with a number of specialized databases was done on the basis of user protocols.
Results. 11 cardiac drugs and 7 genes which variants can influence cardiac drug metabolism were analyzed. According to exome sequencing of the participant we did not...
Assessment of lipid profile when using lipid-lowering therapy (statins) in patients with coronary atherosclerosis
- N. E. Gavrilova; V. A. Metelskaya; E. B. Yarovaya; N. V. Gomyranova; S. A. Boytsov
Aim. To assess of lipid-lowering therapy with statins in very high cardiovascular risk patients admitted to hospital for coronary angiography and analyze lipid profiles depending on the intensity of lipid-lowering therapy.
Material and methods. A total of 502 patients aged 25-86 years (mean age 61.2±9.4 years) who admitted to the clinic of State Research Center for Preventive Medicine were consecutively included into the study. All of them were examined and underwent coronary angiography. Plasma lipid levels were determined by standard laboratory methods. Results. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol) and non-high-density lipoprotein cholesterol...
ASSESSMENT OF AWARENESS LEVEL OF OWN DISEASE IN PATIENTS WITH STABLE ARTERIAL HYPERTENSION
- G. F. Andreeva; V. M. Gorbunov; S. Y. Martsevich
Arterial hypertension (AH) is the most frequent risk factor of cardiovascular diseases and related mortality in all developed countries. Altough therapy with antihypertensive drugs significantly reduces this risk, patients with stable mild hypertension have poor compliance with the treatment. The reasons and levels of inadequacy of antihypertensive therapy in this group of patients are well-known.
Aim. To evaluate the awareness level of own disease, adequacy of therapy only in those patients with stable mild arterial hypertension, who are complied with recommendations of physicians concerning AH treatment and changing of mode of life. It was also planned to reveal possible grounds for...
Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages
- Emeric Limagne; Allan Lançon; Dominique Delmas; Mustapha Cherkaoui-Malki; Norbert Latruffe
State of the art. Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation and osteophyte formation. OA physiopathology is multifactorial and involves mechanical and hereditary factors. So far, there is neither preventive medicine to delay cartilage breakdown nor curative treatment. Objectives. To investigate pro-inflammatory paracrine interactions between human primary chondrocytes and macrophages following interleukin-1-β (IL-1β) treatment; to evaluate the molecular mechanism responsible for the inhibitory effect of resveratrol. Results. The activation of NF-κB in chondrocytes by IL-1β induced IL-6 secretion. The latter will then activate STAT3 protein in macrophages. Moreover, STAT3 was able to positively regulate IL-6 secretion,...
The fiction of health services
- Oscar Echeverry