Mostrando recursos 161 - 180 de 48.059

  1. Synthetic recording and in situ readout of lineage information in single cells

    Frieda, Kirsten L.; Linton, James M.; Hormoz, Sahand; Choi, Joonhyuk; Chow, Ke-Huan K.; Singer, Zachary S.; Budde, Mark W.; Elowitz, Michael B.; Cai, Long
    Reconstructing the lineage relationships and dynamic event histories of individual cells within their native spatial context is a long-standing challenge in biology. Many biological processes of interest occur in optically opaque or physically inaccessible contexts, necessitating approaches other than direct imaging. Here, we describe a new synthetic system that enables cells to record lineage information and event histories in the genome in a format that can be subsequently read out in single cells in situ. This system, termed Memory by Engineered Mutagenesis with Optical In situ Readout (MEMOIR), is based on a set of barcoded recording elements termed scratchpads. The...

  2. Documenting Disremembrance: Histories of Loss in Contemporary Chinese Representation

    Schreiber, Kimberly
    In places like contemporary China, where legal adjudication for past wrongdoings is impossible, an aesthetic engagement with the experience of loss has become essential to activating these historical remains and undermining violent narratives of progress. Tracing several generations’ aesthetic responses to the Cultural Revolution, the Tiananmen Square Massacre, and the present day influx of global capital, I advocate for a specific type of aesthetic practice that elides the distinction between the documentary method and abstract practice. By deliberately conflating these categories I argue that these works are united in their quest to dismantle dominant ideologies, and undermine authoritative narratives by...

  3. Ornamenting Fingernails and Roads: Beautification and the Embodiment of Authenticity in Post-War Eastern Sri Lanka

    Kolor, Kimberly
    In post-conflict Sri Lanka, communal tensions continue to be negotiated, contested, and remade. Color codes virtually every aspect of daily life in salient local idioms. Scholars rarely focus on the lived visual semiotics of local, everyday exchanges from how women ornament their nails to how communities beautify their open—and sometimes contested—spaces. I draw on my ethnographic data from Eastern Sri Lanka and explore ‘color’ as negotiated through personal and public ornaments and notions of beauty with a material culture focus. I argue for a broad view of ‘public,’ which includes often marginalized and feminized public modalities. This view also explores...

  4. Carte d'Asie : divisée en ses principaux Etats : assujettie aux Observations Astronomiques de Mrs. de l'Academie Royale des Sciences et Dressée sur les Memoires les plus récents

    Clouet, Jean Baptiste Louis
    [Carte d'Asie]; Mondhare, L; Museo Naval (Madrid). Archivo

    Escala hallada a partir de cinco gracos de latitud, equivalentes a 100 leguas marinas o 125 leguas comunes de Francia [= 3,6 cm]. Coordenadas referidas al parecer, al meridiano de Hierro (E 22°00'-E 108°00'/N 88°02'-S 13°00'). Red geográfica de 5° en 5°

  5. La exploración del Pacífico : 500 años de historia : exposición conmemorativa del 2 de octubre de 2013 al 2 de febrero de 2014, Casa América

    España. Ministerio de Defensa
    [La exploración del Pacífico]; España. Ministerio de Defensa. Secretaría General Técnica; Museo Naval (Madrid); Casa de América (Madrid)

    Precede a título: Museo Naval

  6. A cohort analysis of trends in the labor force participation of men and women in the United States: 1890 to 1985

    Robinson, James Gregory
    This dissertation expands upon previous studies of labor force participation in the United States by conducting a detailed analysis of participation trends in the twentieth century from a cohort perspective. The work accomplishes four objectives: (1) the construction of labor force participation histories of cohorts of men and women in the United States, classified in 5-year age groups, covering all quinquennial periods between 1890 and 1985, (2) the analysis of changes in the age patterns of participation of cohorts and the comparison of cohort participation trends with those displayed by traditional "period" analyses, (3) the examination of variations in cohort...

  7. A Molecular Anthropological Study of Altaian Histories Utilizing Population Genetics and Phylogeography

    Dulik, Matthew
    This dissertation explores the genetic histories of several populations living in the Altai Republic of Russia. It employs an approach combining methods from population genetics and phylogeography to characterize genetic diversity in these populations, and places the results in a molecular anthropological context. Previously, researchers used anthropological, historical, ethnographic and linguistic evidence to categorize the indigenous inhabitants of the Altai into two groups – northern and southern Altaians. Genetic data obtained in this study were therefore used to determine whether these anthropological groupings resulted from historical processes involving different source populations, and if the observed geographical and anthropological separation between...

  8. Contributo para a história da saúde no Algarve


    Terá sido Descartes, no Discurso do Método, que alvitrou que um edifício ficaria muito melhor construído se fosse edificado por um só do que por muitos1. Se, por acaso, esse princípio se aplicava ao próprio ou aos homens que dele fossem contemporâneos, não restará qualquer dúvida, no entanto, hoje, para nós, seres humanos do século XXI, tal conceito não é claro, nem evidente. De facto, o contributo multifacetado de diferentes perspetivas é, se é que existe algum critério (questão que não é, neste momento, objeto das nossas preocupações), a norma da modernidade. Não será motivo de surpresa que a história hodierna,...

  9. Fragmentos para a história do turismo no Algarve


    Está, então, na altura de entrar no conteúdo destes Fragmentos para a História do Turismo no Algarve. Este opúsculo dividir-se-á em três segmentos, um primeiro, que investigará as relações entre o Património/Cultura e o Turismo, consistindo naquilo a que Vítor Neto vai chamar, de forma pertinente e acutilante, de Turismo Sustentável, o único que, ainda na sua perspetiva, pode ser inteiramente viável; um seguinte, que se irá debruçar sobre os primórdios do Turismo no Algarve nas suas variadas manifestações, desde a promoção da Região até à constituição dos primeiros Operadores Turísticos e estâncias balneares; e um derradeiro, que analisará a questão das acessibilidades no desenvolvimento do Turismo,...

  10. The highly variable microbiota associated to intestinal mucosa correlates with growth and hypoxia resistance of sea bass, Dicentrarchus labrax, submitted to different nutritional histories

    Gatesoupe, Francois-joel; Huelvan, Christine; Le Bayon, Nicolas; Le Delliou, Herve; Madec, Lauriane; Mouchel, Olivier; Quazuguel, Patrick; Mazurais, David; Zambonino-infante, Jose-luis
    Background The better understanding of how intestinal microbiota interacts with fish health is one of the key to sustainable aquaculture development. The present experiment aimed at correlating active microbiota associated to intestinal mucosa with Specific Growth Rate (SGR) and Hypoxia Resistance Time (HRT) in European sea bass individuals submitted to different nutritional histories: the fish were fed either standard or unbalanced diets at first feeding, and then mixed before repeating the dietary challenge in a common garden approach at the juvenile stage. Results A diet deficient in essential fatty acids (LH) lowered both SGR and HRT in sea bass, especially when the deficiency...

  11. Digital Histories of Disasters: History of Technology through Social Media

    Onaga, Lisa; Shell, Hanna Rose
    On 11 March 2011, a giant earthquake and tsunami off the coast of Japan triggered the Fukushima Daiichi nuclear disaster. Failure of the plant’s heating and cooling system and an inability to properly stabilize the reactors post-meltdown led to the displacement of over 150,000 people. In its wake, three historians and sociologists of science and technology with ties to Asia came together to attempt to use social media as a way to create a community in response to the disaster and its aftermath. Together Honghong Tinn and Tyson Vaughan, along with Lisa Onaga, set out to make an online collective...

  12. Ferro-carril de los Alduides : Consideraciones sobre el origen, historia trazado y demás circunstancias del ferrocarril de los Alduides. Artículos publicados en la España de los días 21, 23, 25, 26, 27 y 28 de Febrero

    Echevarría, Ramón de
    [Ferrocarril de los Alduides]; Imprenta de J. M. Ducazcal

    Incluido en una caja con otros documentos

  13. Shells & Nails on the Wampum Trail

    Bruchac, Margaret
    In May, my research assistants Stephanie Mach and Lise Puyo joined me for field research in the northeastern US and Canada, visiting nine museums, four tribal communities, and several private collectors to examine colonial-era wampum (woven shell bead) belts and collars. (For more details, see our blog, On the Wampum Trail.) Our travels on the wampum trail were charted, in part, by following a track that Frank G. Speck (one of the founders of the Penn Department of Anthropology) laid a century earlier, when he collected examples of visual, ephemeral, and material culture among Algonkian and Iroquoian communities. By creating...

  14. The Speck Connection: Recovering Histories of Indigenous Objects

    Bruchac, Margaret
    Frank Gouldsmith Speck (1881–1950), acknowledged as one of the most prolific anthropologists of the early 20th century, served as chair of the Department of Anthropology at the University of Pennsylvania for nearly four decades (1913–1949). He conducted ground-breaking ethnographic research, working closely with Indigenous informants from a wide range of communities (Cherokee, Haudenosaunee, Mohegan, Nanticoke, Penobscot, etc.) and amassed thousands of objects. Although his collections contain seminal data on tribal nations, languages, art, technology, and customs, public understandings of that data and those peoples are often flawed or incomplete, and the objects he collected are widely distributed among various museums.

  15. Considering the Feather Headdress

    Bruchac, Margaret
    During the Spring 2016 course Ethnohistory of the Native Northeast, students are studying Native American objects in the Penn Museum collections by combining close material analyses (elements, construction, design, condition, etc.) with other forms of evidence: textual, photographic, historical, and ethnographic. In many cases, the objects we’re studying have little to no provenance data. So, we are seeking out similar objects, reaching out to consult with Indigenous cultural experts, and considering non-material evidence, such as community identity, memory, oral traditions, and other Indigenous knowledges that might illuminate these objects. By sharing this research via social media, we hope to recover...

  16. Patterns of selectivity in introductions of mammal species worldwide

    Blackburn, TM
    Humans have an extremely long history of transporting and introducing mammal species outside their native geographic range. The characteristics of the species introduced (taxonomy, life-history, ecology, environment) can all influence which traits are available (and selected) for establishment, and subsequent invasive spread. Understanding the non-randomness in species introductions is therefore key to understanding invasions by alien species. Here, we test for selectivity in the identities and traits of mammal species introduced worldwide. We compiled and analysed a comprehensive database of introduced mammal species, including information on a broad range of life history, ecological, distributional and environmental variables that we predicted...

  17. Valorização do Património Edificado de Ponta Delgada : estudo em torno da memória dos lugares

    Cunha, Filipe de Sousa
    Dissertação de Mestrado, Património, Museologia e Desenvolvimento, 29 de Setembro de 2016, Universidade dos Açores.

  18. Technological breakthroughs, entry, and the direction of scientific progress : evidence from CRISPR/Cas9

    Zyontz, Samantha
    Understanding the direction of technical progress is a central issue for the study of innovation. In this paper, I examine how the introduction of a breakthrough research tool affects the trajectory of a scientific field through new entry and project selection. Specifically, I examine the impact of the genome editing system CRISPR/Cas9 (CRISPR), called the "biggest game changer to hit biology since PCR" (Ledford 2015). Introduced in 2012, CRISPR/Cas9 enables precise DNA editing and carries the potential to develop everything from blight resistant crops to targeted genetic drug therapies. Although biologically CRISPR/Cas9 provides more benefits to researchers working on mammalian...

  19. Intervenção para a inovação organizacional: um estudo de caso.

    Sousa, Fernando; Monteiro, Ileana Pardal; Pissarra, João
    O presente artigo relata uma intervenção numa PME do sector informático, tendo em vista um processo de mudança organizacional no sentido de uma maior proatividade dos colaboradores. A apresentação do caso inclui o diagnóstico, a intervenção propriamente dita e o início da execução dos projetos de inovação, baseando-se num modelo adaptado dos métodos de mudança organizacional de terceira geração, com grupos grandes. Em complemento dos passos seguidos, foram utilizadas técnicas de análise das redes sociais, no sentido de determinar as redes de comunicação existentes, bem como de análise de conteúdo a histórias de sucesso entretanto recolhidas, para definir os pontos fortes de uma futura cultura organizacional. Os...

  20. Gender, Education and Russia's tobacco epidemic: a lifecourse approach

    Quirmbach, D; Gerry, CJ
    While a number of studies, based on cross-sectional data for Russia, have documented strong increases in female smoking during the past two decades, the analysis of longer-term trends in smoking prevalence is hampered by the lack of representative data for the Soviet era. In this paper we create life-course smoking histories based on retrospective data from the Russia Longitudinal Monitoring Survey of HSE (RLMS-HSE) and the Global Adult Tobacco Survey (GATS) which allow us to examine the dynamics of smoking patterns over the past 7 decades. We find that smoking rates differ most strongly by gender within all cohorts, but...

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